Chemical Engineering Commons^™

An Overview Of How To Measure The Kinetic Properties Of An Anode Material For The Chlorine Evolution Reaction, Cameron Vann

Reviews, Analyses, and Instructional Studies in Electrochemistry (RAISE)

The process of generating chlorine gas using electrolysis in aqueous systems is well established. However, a new process requires chlorine to be generated at high temperatures using molten salt. This harsh environment requires a new study of anode materials for the chlorine evolution reaction. Anode materials can be compared by their kinetic parameters, the transfer coefficient α and the exchange current i0. The basic theory of these properties as they relate to the chlorine evolution reaction has been detailed and an analysis method for finding these effective parameters has been shown and demonstrated.

Ionic Conductivity, Li+ Transference Number, And Diffusion Coefficient Of A Solid-State Electrolyte Composite, Lizbeth Zurita

Reviews, Analyses, and Instructional Studies in Electrochemistry (RAISE)

The design of solid-state electrolyte (SSE) composites involves the fundamental study of transport properties, such as ionic conductivity. This transport property is influenced by the transport mechanisms of the charge species inside the composite, such as diffusion and migration. In this work, we perform the measurement of these three parameters through defined techniques. The resulting parameters were: ionic conductivity, the diffusion coefficient, and the Li+ transference number.

Enhancing Curcumin’S Therapeutic Potential In Cancer Treatment Through Ultrasound Mediated Liposomal Delivery, Remya Radha, Vinod Paul, Shabana Anjum, Ayache Bouakaz, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained release of therapeutic drugs to cancer cells can reduce the whole-body cytotoxicity of the agent and deliver a safe localized treatment to the patient. There is growing interest in herbal drugs, such as curcumin, which is highly noted as a promising anti-tumor drug, considering its wide range of bioactivities and therapeutic properties against various tumors. Conversely, the clinical efficacy of curcumin is limited because of poor oral bioavailability, low water …

Techno-Economic Optimization Of A Hybrid Energy System With Limited Grid Connection In Pursuit Of Net Zero Carbon Emissions For New Zealand, Daniel Hill, Shafiqur Rahman Tito, Michael Walmsley, John Hedengren

Faculty Publications

As New Zealand moves towards net zero carbon emissions by 2050, multiple factors must be considered including increased electrical load due to electrification, variability of renewable energy generators, required storage capacity, system economics and limitations on grid transmission capacity. Complex and region-specific interactions between the various design choices involved are likely to require an understanding of a range of optimal and near-optimal designs for proposed micro-grid systems as opposed to a single optimal point. This work develops a novel multiscale optimization algorithm for optimization from a univariate capacity optimization approach to a multivariate one. This enhanced algorithm is applied to …

Acoustothermal Transfection For Cell Therapy, Xiufang Liu, Ning Rong, Zhenhua Tian, Joseph Rich, Lili Niu, Pengqi Li, Laixin Huang, Yandai Dong, Wei Zhou, Pengfei Zhang, Yizhao Chen, Congzhi Wang, Long Meng, Tony Jun Huang, Hairong Zheng

Faculty Publications

Transfected stem cells and T cells are promising in personalized cell therapy and immunotherapy against various diseases. However, existing transfection techniques face a fundamental trade-off between transfection efficiency and cell viability; achieving both simultaneously remains a substantial challenge. This study presents an acoustothermal transfection method that leverages acoustic and thermal effects on cells to enhance the permeability of both the cell membrane and nuclear envelope to achieve safe, efficient, and high-throughput transfection of primary T cells and stem cells. With this method, two types of plasmids were simultaneously delivered into the nuclei of mesenchymal stem cells (MSCs) with efficiencies of …

Encapsulation And Release Of Calcein From Herceptin-Conjugated Eliposomes, Mah Noor Zafar, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side effects. To achieve the desired control over the target site, active targeting of HER2-positive breast cancer cells can be achieved by conjugating liposomal vesicles with Human Epidermal growth factor Receptor 2 (HER2) and inducing release of the encapsulated drug using ultrasound. To further enhance the delivery efficiency, nanoemulsion droplets exhibiting responsiveness to low-frequency ultrasound are encapsulated within these lipid vesicles. In this study, we prepared four different liposomal formulations, namely pegylated liposomes …

In Situ Chlorine Generation And Rare Earth Chlorination By Molten Salt Electrolysis, Mark Schvaneveldt, Tyler Williams, Ranon Fuller, Devin Rappleye

Faculty Publications

Chloride volatility processes for purifying actinide and rare earth elements have historically required the use of Cl₂ tanks. To minimize the hazards associated with these processes, an apparatus was designed to produce Cl₂ via molten salt electrolysis. Within this apparatus, one can generate Cl₂, chlorinate metals, and consume excess Cl₂. Here, electrode materials were tested for their ability to generate Cl₂, the composition of the gaseous electrolysis product was evaluated using a quadrupole mass spectrometer, and a Ce foil sample was successfully chlorinated using the electrochemically generated Cl₂.

Experimental Determination Of The Electrochemical Properties Of Bismuth Chloride In Eutectic Licl-Kcl And Licl-Kcl-Cacl2 Molten Salts, Greg Chipman, Bryant Johnson, Cameron Vann, Lance Whitesides, Devin Rappleye

Faculty Publications

Bismuth has been investigated as a potential liquid electrode for molten salt electrorefining, but the electrochemical behavior of Bi³⁺/Bi redox couple has received scant attention in eutectic LiCl-KCl melts and no studies were found in the ternary LiCl-KCl-CaCl₂ melts. LiCl-KCl-CaCl₂ melts offer some advantages over eutectic LiCl-KCl, such as a lower melting point. Cyclic voltammetry, square wave voltammetry, chronoamperometry, chronopotentiometry and open-circuit chronopotentiometry were used to measure electrochemical parameters, such as diffusivity and standard apparent potential of bismuth electrodeposition, in LiCl-KCl and LiCl-KCl-CaCl₂ eutectics. The mean diffusivity values of 6.71 x 10^-6 cm^{2 …}

High-Yield And Rapid Isolation Of Extracellular Vesicles By Flocculation Via Orbital Acoustic Trapping: Float, Joseph Rufo, Peiran Zhang, Zeyu Wang, Yuyang Gu, Kaichun Yang, Joseph Rich, Chuyi Chen, Ruoyu Zhong, Ke Jin, Je He, Jianping Xia, Ke Li, Jiarong Wu, Yingshi Ouyang, Yoel Sadovsky, Luke P. Lee, Tony Jun Huang

Faculty Publications

Extracellular vesicles (EVs) have been identified as promising biomarkers for the noninvasive diagnosis of various diseases. However, challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low purities. Here, we report a high-yield ( > 90%) and rapid ( <  10 min) EV isolation method called FLocculation via Orbital Acoustic Trapping (FLOAT). The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid droplets. By adding a thermoresponsive polymer flocculant, nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the droplet. We demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein, addressing a significant obstacle in the development of EV-based liquid biopsies. Due to its high-yield nature, FLOAT reduces biofluid starting volume requirements by a factor of 100 (from 20 mL to 200 µL), demonstrating its promising potential in point-of-care diagnostics.

Scaffold-Based 3d Cell Culture Models In Cancer Research, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions …

Model Predictive Control Of A Lab-Scale Thermal Energy Storage System In Relap5-3d, Jaron Wallace, Daniel Hill, David Thurston, John Hedengren, Matthew Memmott

Faculty Publications

Increased renewable energy penetration of an electrical grid generally creates more supply fluctuations. Traditional base-load systems, such as nuclear power, can be retrofitted with thermal energy storage (TES) systems to meet supply demand fluctuations. These systems can store energy during low electricity demand times to allow the reactor to operate at constant power while simultaneously fluctuating electricity output. The control of these systems is of vital importance and Model Predictive Control (MPC) is a leading control mechanism for optimized production plans with forecast information. This study combines high fidelity RELAP5-3D models with MPC to control an experimental benchtop system that …

Xylan Fast Pyrolysis: An Experimental And Modelling Study Of Particle Changes And Volatiles Release, F Cerciello, E Freisewinkel, A Coppola, C Ontyd, D Tarlinski, Martin Schiemann, Osvalda Senneca, Pierro Salatino, C Allouis, Victor Scherer, Thomas H. Fletcher

Faculty Publications

Biomass char particles produced by pyrolysis may have different morphologies, which has important implications on burning mode, conversion rate and boiler efficiency. These features are difficult to address due to the complexity of biomass structure and pyrolysis reaction models. The present work reports preliminary results on the morphological changes and volatile release that solid particles of Xylan experience upon fast heating in a Drop Tube Reactor (DTR) and in a Heated Strip Reactor (HSR) in a range of temperature between 1100 and 1573 K under inert atmosphere with heating rate in the order of 10³ K/s. Two different Xylan …

Aerosol Jet Printing Of Surface Acoustic Wave Microfluidic Devices, Joseph Rich, Brian Cole, Teng Li, Brandon Lu, Hanyu Fu, Brittany N. Smith, Jianping Xia, Shujie Yang, Ruoyu Zhong, James L. Doherty, Kanji Kaneko, Hiroaki Suzuki, Zhenhua Tian, Aaron D. Franklin, Tony Jun Huang

Faculty Publications

The addition of surface acoustic wave (SAW) technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes, including high-precision manipulation, versatility, integrability, biocompatibility, contactless nature, and rapid actuation. However, the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based processing. To simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions, we utilized the additive manufacturing technique of aerosol jet printing. We successfully fabricated customized SAW microfluidic devices of varying materials, including silver nanowires, graphene, and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate …

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …

Biodegradable Magnesium Alloys For Biomedical Implants: Properties, Challenges, And Surface Modifications With A Focus On Orthopedic Fixation Repair, Kevin Koshy Thomas, Mah Noor Zafar, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Biomedical devices made from high-modulus and hardness materials play a critical role in enhancing the quality of life for people with bone-related ailments. While these materials have been successfully used in orthopedic applications, concerns including stress-shielding have necessitated the exploration of alternative solutions. An ideal biomedical implant requires a delicate balance of mechanical performance, corrosion resistance, tissue biocompatibility, and other properties such as tribological performance and osseointegration. This review explores the suitability of biodegradable magnesium (Mg) alloys as a promising material for biomedical implants. It delves into the essential properties of biomedical implants, emphasizing the importance of matching mechanical characteristics …

Coarsening Dynamics Of Ternary Polymer Solutions With Mobility And Viscosity Contrasts, Jan Ulric Garcia, Douglas R. Tree, Alyssa Bagoyo, Tatsuhiro Iwama, Kris T. Delaney, Glenn H. Fredrickson

Faculty Publications

Using phase-field simulations, we investigate the bulk coarsening dynamics of ternary polymer solutions undergoing a glass transition for two models of phase separation: diffusion only and with hydrodynamics. The glass transition is incorporated in both models by imposing mobility and viscosity contrasts between the polymer-rich and polymer-poor phases of the evolving microstructure. For microstructures composed of polymer-poor clusters in a polymer-rich matrix, the mobility and viscosity contrasts significantly hinder coarsening, effectively leading to structural arrest. For microstructures composed of polymer-rich clusters in a polymer-poor matrix, the mobility and viscosity contrasts do not impede domain growth; rather, they change the transient …

Equation-Based And Data-Driven Modeling: Open-Source Software Current State And Future Directions, Lagrande Gunnell, Bethany Nicholson, John Hedengren

Faculty Publications

A review of current trends in scientific computing reveals a broad shift to open-source and higher-level programming languages such as Python and growing career opportunities over the next decade. Open-source modeling tools accelerate innovation in equation-based and data-driven applications. Significant resources have been deployed to develop data-driven tools (PyTorch, TensorFlow, Scikit-learn) from tech companies that rely on machine learning services to meet business needs while keeping the foundational tools open. Open-source equation-based tools such as Pyomo, CasADi, Gekko, and JuMP are also gaining momentum according to user community and development pace metrics. Integration of data-driven and principles-based tools is emerging. …

A Novel Application Of Spinning Disk Technology To Collect Plasma From Whole Blood Prior To Quantifying Plasma Rna, Naomi Rapier-Sharman, Mae-Lynn L. Hutchinson, Carlos M. Moreno, Abraham Quaye, Brian D. Poole, K. Scott Weber, William G. Pitt, Brett E. Pickett

Faculty Publications

The spinning disk technology has previously been utilized to isolate bacterial components from blood in hours instead of days. We hypothesized that this platform could be applied as an alternative approach to isolating plasma RNA from a whole blood sample. We consequently tested the efficacy of the spinning disk technology to extract plasma from whole blood upstream of RNA isolation and analysis. To do so, we collected plasma using either the spinning disk or the typical two-spin centrifuge method. We found that the spinning disk method results in significantly more hemolysis during collection than the conventional two-spin centrifuge method. However, …

Neutronic Analysis Of The Byu Molten Salt Micro Reactor, Collin Bradford, Edward Mercado, Braden Clayton, Lagrande Gunnell, Andrew Larsen, Matthew Memmott

Faculty Publications

Background: With the rising need for reliable and clean energy, researchers at Brigham Young University created a molten salt microreactor (MSMR) concept to help meet the world’s growing energy demands. The MSMR is rated at 45 MWth and is uniquely capable of passively dissipating all decay heat using conduction only.

Methods: This work presents the results of the simulated neutronic behavior of the MSMR using the Monte Carlo neutronics code OpenMC with the ENDF/B-VII.1 cross-section library at steady state conditions. The specific characteristics discussed in this work are: keff, power profile, axial and radial peak power factors, Doppler coefficient of …

Streamlining The Detection Of Human Thyroid Receptor Ligand Interactions With Xl1-Blue Cell-Free Protein Synthesis And Beta-Galactosidase Fusion Protein Biosensors, J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley Charles Bundy

Faculty Publications

Thyroid receptor signaling controls major physiological processes and disrupted signaling can cause severe disorders that negatively impact human life. Consequently, methods to detect thyroid receptor ligands are of great toxicologic and pharmacologic importance. Previously, we reported thyroid receptor ligand detection with cell-free protein synthesis of a chimeric fusion protein composed of the human thyroid receptor beta (hTRβ) receptor activator and a β-lactamase reporter. Here, we report a 60% reduction in sensing cost by reengineering the chimeric fusion protein biosensor to include a reporter system composed of either the full-length beta galactosidase (β-gal), the alpha fragment of β-gal (β-gal-α), or a …

A Probabilistic View Of Protein Stability, Conformational Specificity, And Design, Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley Charles Bundy, Joshua L. Price, David Wingate, Dnnis Della Corte

Faculty Publications

Various approaches have used neural networks as probabilistic models for the design of protein sequences. These "inverse folding" models employ different objective functions, which come with trade-offs that have not been assessed in detail before. This study introduces probabilistic definitions of protein stability and conformational specificity and demonstrates the relationship between these chemical properties and the p(stucture|seq) Boltzmann probability objective. This links the Boltzmann probability objective function to experimentally verifiable outcomes. We propose a novel sequence decoding algorithm, referred to as “BayesDesign”, that leverages Bayes’ Rule to maximize the p(stucture|seq) objective instead of the p(seq|structure) objective common in inverse folding …

Recent Breakthroughs In Using Quantum Dots For Cancer Imaging And Drug Delivery Purposes, Aisha Hamidu, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Cancer is one of the leading causes of death worldwide. Because each person’s cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly investigate tumor cells at a cellular level in contrast to prior diagnostic techniques. Quantum dots (QDs) are functional nanoparticles reported to be useful for diagnosis. QDs are semiconducting tiny nanocrystals, 2–10 nm in diameter, with exceptional and useful optoelectronic properties that can be tailored to sensitively report on their environment. This review highlights these exceptional semiconducting QDs and their properties and synthesis methods when used …

Bacterial Extraction And Concentration From Blood Through Filtration Processes, Ryan L. Wood, Rebecca Prymak, Evelyn Welling, Alayna Bedwell, Jordan T. Wood, Damian E. Teasley, Magdalena Crofts, Hope Callister Anderson, Clifton M. Anderson, W Cameron Beard, Jacob Stepan, Alexandra Carter, William G. Pitt

Faculty Publications

Blood stream infections (BSIs) are challenging to rapidly and precisely diagnose. Current clinical diagnostic methods for BSI identification require culturing the blood sample for many hours prior to identifying the bacteria and possible antibiotic resistance. Removing the culturing step from the bacterial identification process of a BSI provides a significant reduction in the processing time, but shifts the rate-limiting step from the growth time to the concentration procedure, since CFU levels in clinical blood samples can be as low as 10 CFU/mL in blood. This study developed a novel whole blood filtration method to concentrate bacteria from a BSI without …

Transferrin-Targeted Liposomes In Glioblastoma Therapy: A Review, Paul Kawak, Nour M Al Sawaftah, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown potential in addressing the limitations of chemotherapy, such as poor bioavailability and toxicity to healthy cells. However, passive targeting strategies based solely on the physicochemical properties of liposomes have proven ineffective due to a lack of tissue specificity. Accordingly, the upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics. …

Recommended Separation Distances For 1.3 Ammunition And Explosives, Clint Guymon, Ming Liu, Josephine Covino

Faculty Publications

Separation Distances are used throughout the world to protect people and assets from the potential hazardous effects from propellants, explosives, and pyrotechnics. The current separation distances for Hazard Division (HD) 1.3 substances and articles used in the United States, in some cases, may not adequately protect against the effects from heat flux and debris when those substances and articles are ignited in a confined structure. Multiple tests in such a confined scenario with HD 1.3 substances have shown that the heat flux and debris hazards could result in injury at distances beyond the current specified explosives safety separation distance (ESSD). …

Simultaneous Multistep Transformer Architecture For Model Predictive Control, Junho Park, Mohammad Reza Babaei, Samuel Arce Munoz, Ashwin N. Venkat, John Hedengren

Faculty Publications

Transformer neural networks have revolutionized natural language processing by effectively addressing the vanishing gradient problem. This study focuses on applying Transformer models to time-series forecasting and customizing them for a simultaneous multistep-ahead prediction model in surrogate model predictive control (MPC). The proposed method showcases improved control performance and computational efficiency compared to LSTM-based MPC and one-step-ahead prediction models using both LSTM and Transformer networks. The study introduces three key contributions: (1) a new MPC system based on a Transformer time-series architecture, (2) a training method enabling multistep-ahead prediction for time-series machine learning models, and (3) validation of the enhanced time …

Determination Of A Surrogate For Plutonium Electrorefining, Greg Chipman, Bryant Johnson, Suhee Choi, Chao Zhang, Michael Simpson, Devin Rappleye

Faculty Publications

Conducting research experiments on plutonium electrorefining is difficult due to the significant hazards and regulations associated with nuclear materials. Finding a surrogate for plutonium electrorefining studies would enable more fundamental research to be conducted. Potential surrogates were first identified by determining the physical properties required to conduct electrorefining at the same conditions commonly used in plutonium electrorefining, a molten metal and molten CaCl₂ at 1123 K. Ce-CeCl₃, In-InCl₃, and Pb-PbCl₂ were the only potential surrogates identified using these constraints. Sn-SnCl₂ was also tested at these same conditions. More potential surrogates were identified by …

Liposomes For The Treatment Of Brain Cancer—A Review, Richu Raju, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed …

A Review On Membrane Fouling Prediction Using Artificial Neural Networks (Anns), Waad H. Abuwatfa, Nour Al Sawaftah, Naif Darwish, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of particles, organic and inorganic matter, and microbial cells on the membrane’s external and internal surface, which reduces the permeate flux and increases the needed transmembrane pressure. Various factors affect membrane fouling, including feed water quality, membrane characteristics, operating conditions, and cleaning protocols. Several models have been developed to predict membrane fouling in pressure-driven processes. These models can be divided into traditional empirical, mechanistic, and artificial intelligence (AI)-based models. Artificial neural networks …

A Multi-Scale Method For Combined Design And Dispatch Optimization Of Nuclear Hybrid Energy Systems Including Storage, Daniel Hill, Dawson Mccrea, An Ho, Matthew Memmott, Kody Powell, John Hedengren

Faculty Publications

Reliable, carbon-free power generation is increasing in importance. Nuclear-renewable hybrid energy systems (NHES) are a potential solution for current generation challenges, but design and dispatch optimization for these systems remains challenging particularly when stochastic effects, long time horizons and nonlinear modeling are needed. This work presents a multi-scale method for combining the design and dispatch optimization problems for nonlinear NHES over long time horizons. Rather than treating the entire horizon as a single optimization problem, a large number of combined optimization problems are solved for shorter samples of the horizon resulting in distributions of optimal capacities for each of the …