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Molecular, Cellular, and Tissue Engineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Electroporation (2)
- Animal (1)
- Animals (1)
- Apoptosis (1)
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- CXCR4 (1)
- Cell Division (1)
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- Pancreas (1)
- Pancreatic Ducts (1)
- Protein-Serine-Threonine Kinases (1)
- Proto-Oncogene Proteins (1)
- Proto-Oncogene Proteins c-akt (1)
- Receptors (1)
- Regeneration (1)
- Src-Family Kinases (1)
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Articles 1 - 3 of 3
Full-Text Articles in Molecular, Cellular, and Tissue Engineering
The Stromal Cell-Derived Factor-1alpha/Cxcr4 Ligand-Receptor Axis Is Critical For Progenitor Survival And Migration In The Pancreas., Ayse G. Kayali, Kurt Van Gunst, Iain L. Campbell, Aleksandr Stotland, Marcie Kritzik, Guoxun Liu, Malin Flodström-Tullberg, You-Qing Zhang, Nora Sarvetnick
The Stromal Cell-Derived Factor-1alpha/Cxcr4 Ligand-Receptor Axis Is Critical For Progenitor Survival And Migration In The Pancreas., Ayse G. Kayali, Kurt Van Gunst, Iain L. Campbell, Aleksandr Stotland, Marcie Kritzik, Guoxun Liu, Malin Flodström-Tullberg, You-Qing Zhang, Nora Sarvetnick
Journal Articles: Regenerative Medicine
The SDF-1alpha/CXCR4 ligand/chemokine receptor pair is required for appropriate patterning during ontogeny and stimulates the growth and differentiation of critical cell types. Here, we demonstrate SDF-1alpha and CXCR4 expression in fetal pancreas. We have found that SDF-1alpha and its receptor CXCR4 are expressed in islets, also CXCR4 is expressed in and around the proliferating duct epithelium of the regenerating pancreas of the interferon (IFN) gamma-nonobese diabetic mouse. We show that SDF-1alpha stimulates the phosphorylation of Akt, mitogen-activated protein kinase, and Src in pancreatic duct cells. Furthermore, migration assays indicate a stimulatory effect of SDF-1alpha on ductal cell migration. Importantly, blocking …
Brownian Dynamics Simulation Studies Of Ion Throughput During Cellular Electroporation, Juan A. Gonzalez-Cuevas
Brownian Dynamics Simulation Studies Of Ion Throughput During Cellular Electroporation, Juan A. Gonzalez-Cuevas
Electrical & Computer Engineering Theses & Dissertations
The purpose of the present research work is to analyze the flow of ions through pores formed in the plasma membrane of biological cells during electroporation. In this regard, simulations have been conducted to track the movement of ions in 3-D space based on a Brownian dynamics model, which is mostly deterministic but has some stochastic properties to account for ionic scattering. From the Brownian dynamics simulations, it has been possible to estimate the pore's conductance as well as transport parameters such as the diffusion coefficient and mobility within the pore region, of which there is no experimental data currently …
Time Domain Dielectric Spectroscopy Analysis Of Hl-60 Cell Suspensions After Microsecond And Submicrosecond Pulsed Electric Fields, Allen Laurence Garner
Time Domain Dielectric Spectroscopy Analysis Of Hl-60 Cell Suspensions After Microsecond And Submicrosecond Pulsed Electric Fields, Allen Laurence Garner
Electrical & Computer Engineering Theses & Dissertations
Pulsed electric fields (PEF's) above a certain voltage threshold cause electroporation for microsecond pulses and intracellular effects for submicrosecond pulses. Models describing these effects often depend on the electrical properties of the cell, which are altered by the PEF. Time domain dielectric spectroscopy was used to provide data for these models and to measure changes in the conductivity of HL-60 cell suspensions due to single 50 μs and 10 ns PEF's of the same energy. For 1.1 kV/cm, 50 μs pulses, the conductivity rose within a minute after the pulse and dropped dramatically approximately forty minutes after the pulse. For …