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Molecular, Cellular, and Tissue Engineering Commons™
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Articles 1 - 5 of 5
Full-Text Articles in Molecular, Cellular, and Tissue Engineering
A Collagen Based Tissue Engineered Heart Valve Shows Excellent Functionality And Remodelling After Dynamic Conditioning, Claire Brougham, Ricardo Moreira, Tanya J. Levingstone, Stefan Jockenhoevel, Petra Mela, Fergal J. O'Brien
A Collagen Based Tissue Engineered Heart Valve Shows Excellent Functionality And Remodelling After Dynamic Conditioning, Claire Brougham, Ricardo Moreira, Tanya J. Levingstone, Stefan Jockenhoevel, Petra Mela, Fergal J. O'Brien
Conference Papers
No abstract provided.
Incorporation Of Fibrin Into A Collagen–Glycosaminoglycan Matrix Results In A Scaffold With Improved Mechanical Properties And Enhanced Capacity To Resist Cell-Mediated Contraction, Claire Brougham, Tanya J. Levingstone, Stefan Jockenhoevel, Thomas C. Flanagan, Fergal J. O'Brien
Incorporation Of Fibrin Into A Collagen–Glycosaminoglycan Matrix Results In A Scaffold With Improved Mechanical Properties And Enhanced Capacity To Resist Cell-Mediated Contraction, Claire Brougham, Tanya J. Levingstone, Stefan Jockenhoevel, Thomas C. Flanagan, Fergal J. O'Brien
Articles
Fibrin has many uses as a tissue engineering scaffold, however many in vivo studies have shown a reduction in function resulting from the susceptibility of fibrin to cell-mediated contraction. The overall aim of the present study was to develop and characterise a reinforced natural scaffold using fibrin, collagen and glycosaminoglycan (FCG), and to examine the cell-mediated contraction of this scaffold in comparison to fibrin gels. Through the use of an injection loading technique, a homogenous FCG scaffold was developed. Mechanical testing showed a sixfold increase in compressive modulus and a thirtyfold increase in tensile modulus of fibrin when reinforced with …
Investigation Of Membrane Mechanics Using Spring Networks: Application To Red-Blood-Cell Modelling, Mingzhu Chen, Fergal Boyle
Investigation Of Membrane Mechanics Using Spring Networks: Application To Red-Blood-Cell Modelling, Mingzhu Chen, Fergal Boyle
Articles
In recent years a number of red-blood-cell (RBC) models have been proposed using spring networks to represent the RBC membrane. Some results predicted by these models agree well with experimental measurements. How- ever, the suitability of these membrane models has been questioned. The RBC membrane, like a continuum mem- brane, is mechanically isotropic throughout its surface, but the mechanical properties of a spring network vary on the network surface and change with deformation. In this work spring-network mechanics are investigated in large deformation for the first time via an assessment of the effect of network parameters, i.e. network mesh, spring …
Investigation Of A New Material For Heart Valve Tissue Engineering, Claire Brougham, Gerard Cooney, Thomas Flanagan, Stefan Jockenhoevel, Fergal O'Brien
Investigation Of A New Material For Heart Valve Tissue Engineering, Claire Brougham, Gerard Cooney, Thomas Flanagan, Stefan Jockenhoevel, Fergal O'Brien
Conference Papers
No abstract provided.
Mechano-Biological Interactions Of Endothelial Cells, Claire Brougham, Karen Coughlan, Valerie Barron, Peter Mchugh
Mechano-Biological Interactions Of Endothelial Cells, Claire Brougham, Karen Coughlan, Valerie Barron, Peter Mchugh
Conference Papers
Atherosclerosis is an ever-increasing cause of morbidity in the western world. Current surgical treatments include bypass grafts and coronary artery stents. However, there is still a need for alternative approaches especially for those who cannot receive conventional therapy. Tissue engineering is one such approach that may hold the key to the repair and regeneration. Tissue engineering is one such approach that may hold the key to the repair and regeneration of coronary arteries. Nevertheless, many questions need to be answered before a vialbe vascular tissie with the inherent properties of native tissue becomes a real contender with the surgical therapies …