Molecular, Cellular, and Tissue Engineering Commons^™

Improvements In Microdialysis Sampling Extraction Efficiency Using Recycled Flow, Justin Cole Deaton

Graduate Theses and Dissertations

Incomplete recovery during microdialysis sampling is hindering important research in neurology, proteomics, and immunology. Although the current generalized solution, decreasing volumetric flow rates (Q), has been and will remain to be a useful strategy it has reached it's a physical limitation due to evaporation at the collection site. Consequently, many important signaling molecules, such as signaling proteins, remain difficult to study. It is more fundamental to consider relative recovery as a function of the interaction time between the perfusate and the environment surrounding the probe.

In this work an increase in relative recovery was predicted by a mathematical model. Using …

Simulation Of Temperature Distributions In Tissue Upon Laser Pulse Irradiation Including Water Mass Transfer, Deepthi Nagulapally

Electrical & Computer Engineering Theses & Dissertations

Lasers, due to their unique characteristics, have tremendous applications in the medical field. Generally all laser applications in hie-medicine involve the propagation of laser energy through tissue. Energy is deposited giving rise to many physical, hie-chemical, and mechanical effects. Among these are dynamical changes in the local temperature distributions within the tissue. Analysis of the temperature changes requires the creation of an appropriate optical transmission and heat flow model that incorporates user specified laser parameters. Here, a numerical simulation model was developed to study both steady state and time dependent temperature distributions due to pulsed laser radiation within user specified …

Influence Of Van Der Waals Forces On Increasing The Strength And Toughness In Dynamic Fracture Of Nanofibre Networks: A Peridynamic Approach, Florin Bobaru Ph.D.

Department of Engineering Mechanics: Faculty Publications

The peridynamic method is used here to analyse the effect of van der Waals forces on the mechanical behaviour and strength and toughness properties of three-dimensional nanofibre networks under imposed stretch deformation. The peridynamic formulation allows for a natural inclusion of long-range forces (such as van der Waals forces) by considering all interactions as ‘long-range’. We use van der Waals interactions only between different fibres and do not need to model individual atoms. Fracture is introduced at the microstructural (peridynamic bond) level for the microelastic type bonds, while van der Waals bonds can reform at any time. We conduct statistical …