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Articles 1 - 12 of 12
Full-Text Articles in Biological Engineering
Stentrx, Emma Barna, Minuthi Cooray, Bruce Newlands, Joseph A. Sabetta
Stentrx, Emma Barna, Minuthi Cooray, Bruce Newlands, Joseph A. Sabetta
Williams Honors College, Honors Research Projects
This project aims to develop a biodegradable, drug-eluting biliary stent for the treatment of biliary cancers. Current metal stents that restore bile flow bit are non-degradable, prone to migration, and unable to deliver drugs locally. The proposed stent will be biocompatible, biodegradable, and capable of controlled drug release to both maintain bile flow and treat tumors. The end goal is to produce a functional prototype that can be deployed via a minimally invasive catheter and maintain bile duct patency for at least three months. The project is expected to be involved in the NEOMED Bench-to-Bedside competition and provisionally patented.
The Role Of Laminin Isoforms In Glioblastoma Migration, Aseel Ahmed, Faezeh Ghobadi, Hanna Devillier, Qi Cai
The Role Of Laminin Isoforms In Glioblastoma Migration, Aseel Ahmed, Faezeh Ghobadi, Hanna Devillier, Qi Cai
Distinguished Undergraduate Researcher Program
Glioblastoma (GBM) remains the most prevalent and lethal invasive brain tumor, denoted by a median survival of 12-15 months despite standard procedures such as safe surgical resection, radiotherapy, and chemotherapy. This limited effectiveness largely arises from the infiltrative nature of GBM cells, which interact with the brain’s extracellular matrix (ECM) by migrating along blood vessels and axonal pathways. The ECM contains the interstitial matrix (IM) and the
basement membrane (BM) made up of proteins and glycans which interact with the malignant cells. While research has mainly been focused on understanding how GBM cells interact with IM components, our knowledge about …
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Theses and Dissertations
Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …
Microwave Imaging Technique For Breast Cancer Detection, Nure Alam Chowdhury
Microwave Imaging Technique For Breast Cancer Detection, Nure Alam Chowdhury
Theses and Dissertations
Breast cancer is a global problem, and it is inevitable to detect cancerous cells at early stages. In recent years, microwave imaging technology has been widely applied in biomedical applications for its non-ionizing radiation. In this study, we design a micro-strip patch antenna with an inverted T-type notch in the partial ground to detect tumor cells inside the human breast. The size of the current antenna is small enough (18 mm × 21 mm × 1.6 mm) to distribute around the breast phantom. The operating frequency has been observed from 6–14 GHz with a minimum return loss of −61.18 dB …
Profiling Of Voltage-Gated Sodium Channel Subtype Expression And Resulting Susceptibility To Targeted Osmotic Lysis In Cancer, Spencer Gerard Lemoine
Profiling Of Voltage-Gated Sodium Channel Subtype Expression And Resulting Susceptibility To Targeted Osmotic Lysis In Cancer, Spencer Gerard Lemoine
LSU Doctoral Dissertations
Cancer is a disease characterized by a wide array of dysregulated cellular function, activity, and growth. At times, specific dysregulations associated with cancer can be exploited as avenues of potential treatment. The sodium handling mechanisms and their associated proteins in cancer have received closer attention recently closely as such a potential mechanism to exploit for treating advanced cancer. Some novel treatments aim to inhibit the expression or activity of these sodium handling proteins in an attempt to prevent the cancer from advancing or becoming more aggressive; however, such approaches have had limited success. Targeted osmotic lysis (TOL) is a new …
Engineered Exosomes For The Multimodal Imaging Directed Photo-Immunotherapy Of Colorectal Cancer, Deepak S. Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Engineered Exosomes For The Multimodal Imaging Directed Photo-Immunotherapy Of Colorectal Cancer, Deepak S. Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Research Symposium
Background: Rio Grande Valley experience severe cancer health disparity. A novel therapeutic modality may serve as better therapeutic option. Nanohybrids endowed with multifunctionality, longer circulation time, large surface area have emerged as an active preference for cancer research. However, rising concern of nanomaterials toxicity and scalability issues has slowed their translation to clinics. Exosomes (Exo) are endogenous endocytic origin 40-100 nm vesicles found in various body fluids, which in comparison to synthetic nanoparticles, are biodegradable, highly biocompatible as well as immunocompatible in nature. Although bulk isolation of exosomes from human body fluids is still a problem and engineering of exosomes …
Enhanced Label Free Normal And Cancer Cells Classification Using Combined Parametric Modeling And Optical Techniques, Ayshathul Fouzia Abdul Gani
Enhanced Label Free Normal And Cancer Cells Classification Using Combined Parametric Modeling And Optical Techniques, Ayshathul Fouzia Abdul Gani
Dissertations
The development of label-free methods for cell classifications has been driven by the importance of early detection and identification of cancer disease. The future point-of-care (POC) treatment methods require rapid and real-time cancer screening techniques. As the labelled methods of cell classification are time-consuming processes and require a large amount of sample preparation along with skilled persons, they do not appear to be suitable for POC treatment methods. This necessitates the importance of such development. The label-free methods incorporate the biophysical properties of cells instead of biomarkers. The optical properties of cells have been frequently utilized for cell classification. This …
Fundamental Characterization Of Oxygen Nanobubbles, John Hamlin, Yi Wen, Joseph Irudayaraj
Fundamental Characterization Of Oxygen Nanobubbles, John Hamlin, Yi Wen, Joseph Irudayaraj
The Summer Undergraduate Research Fellowship (SURF) Symposium
A hypoxic environment is created by tumors’ incredible growth rate. Hypoxia provides radioresistance to the tumors, thus making radiation treatment less effective. The issue is that increasing the radiation leads to increased side effects in patients. Our goal for the oxygen-filled nanobubble is to deliver oxygen to the tumor to lessen radioresistance and make radiation treatment more efficient. However, we need preliminary research to understand and improve the nanobubbles before further research and implementation. To do this, we synthesized different batches of nanobubbles to optimize the production method and find the best container and temperature to store nanobubbles. We measured …
Establishing A Lung Model For Evaluation Of Engineered Lung Microbiome Therapies, Kathryn F. Atherton, Stephen Miloro, Jenna Rickus
Establishing A Lung Model For Evaluation Of Engineered Lung Microbiome Therapies, Kathryn F. Atherton, Stephen Miloro, Jenna Rickus
The Summer Undergraduate Research Fellowship (SURF) Symposium
Benzene, a toxin and carcinogen found in air polluted by cigarette smoke, car exhaust, and industrial processes, is associated with the development of leukemia and lymphoma. Other than avoiding exposure, there is no current method to deter the effects of benzene. One potential strategy to prevent these effects is to engineer the bacteria of the human lung microbiome to degrade benzene. To evaluate this novel approach, we must verify that the bacteria remain viable within the lung microenvironment. To do so, lungs were harvested from rats and swabbed to determine the contents of the original lung microbiome. Then green fluorescent …
Nanobubbles Provide Theranostic Relief To Cancer Hypoxia, Christopher M. Long, Pushpak N. Bhandari, Joseph Irudayaraj
Nanobubbles Provide Theranostic Relief To Cancer Hypoxia, Christopher M. Long, Pushpak N. Bhandari, Joseph Irudayaraj
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hypoxia is a common motif among tumors, contributing to metastasis, angiogenesis, cellular epigenetic abnormality, and resistance to cancer therapy. Hypoxia also plays a pivotal role in oncological studies, where it can be used as a principal target for new anti-cancer therapeutic methods. Oxygen nanobubbles were designed in an effort to target the hypoxic tumor regions, thus interrupting the hypoxia-inducible factor-1α (HIF-1α) regulatory pathway and inhibiting tumor progression. At less than 100nm, oxygen nanobubbles act as a vehicle for site-specific oxygen delivery, while also serving as an ultrasound contrast agent for advanced imaging purposes. Through in vitro and in vivo studies, …
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
University Scholar Projects
Somatic mutations may drive tumorigenesis or lead to new, immunogenic epitopes (neoantigens). The immune system is thought to represses neoplastic growths through the recognition of neoantigens presented only by tumor cells. To study mutations as well as the immune response to mutation-generated antigens, we have created a conditional knockin mouse line with a gene encoding, 5’ to 3’, yellow fluorescent protein (YFP), ovalbumin (which is processed to the immunologically recognizable peptide, SIINFEKL), and cyan fluorescent protein (CFP), or, YFP-ovalbumin-CFP. A frame shift mutation has been created at the 5’ end of the ovalbumin gene, hence YFP should always be expressed, …
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
Honors Scholar Theses
Somatic mutations may drive tumorigenesis or lead to new, immunogenic epitopes (neoantigens). The immune system is thought to represses neoplastic growths through the recognition of neoantigens presented only by tumor cells. To study mutations as well as the immune response to mutation-generated antigens, we have created a conditional knockin mouse line with a gene encoding, 5’ to 3’, yellow fluorescent protein (YFP), ovalbumin (which is processed to the immunologically recognizable peptide, SIINFEKL), and cyan fluorescent protein (CFP), or, YFP-ovalbumin-CFP. A frame shift mutation has been created at the 5’ end of the ovalbumin gene, hence YFP should always be expressed, …