Biological Engineering Commons^™

Evaluating The Effects Of Oxidative Stress On Primary Retinal Pigment Epithelial Cells, Sophia Hessami

Student Research Symposium

Introduction

Age-Related Macular Degeneration (AMD) is the leading cause of vision loss worldwide, affecting 200 million adults over the age of 40

• Affects subretinal layers: retinal pigment epithelium (RPE), Bruch’s membrane, and choroid (Fig. 1)

Problem: Early mechanisms of AMD are not well understood; oxidative stress is often cited as a key contributing factor to the development of AMD.3 Current studies neglect to use primary RPE cells when investigating oxidative stress.

Oxidative Stress occurs when there is an imbalance between reactive oxygen species (ROS) production and cellular antioxidant defenses

• Overabundance of ROS results in damage to tissue and …

Effects Of Uv Radiation On Algae Biofilms Of Rotating Algae Biofilm Reactors, Rebecca Sweeten

Student Research Symposium

Goal: Discover effects of UV-A and UV-B radiation on the biofilm production of algae using a Rotating Algae Biofilm Reactor (RABR)

Method: Expose 3 RABRs in triplicate to UV-A, UV-B, and PAR to identify differences in biomass, nutrient uptake and pH levels.

Results: RABR’s under UV-B light have the highest productivity

Induction Of Diabetic Cardiomyopathy In A Three-Dimensional Myocardial Model, Maelyn Andreasen

Student Research Symposium

Diabetic cardiomyopathy: Impairs and damages heart tissue through chronic exposure to hyperglycemia, or high blood sugar, in diabetic individuals

The Effects Of The Action Rate And Binding Density On Sensitivity In Lateral Flow, Mona Soroush

Student Research Symposium

Lateral Flow Assays (LFAs) offer rapid diagnostics, yet sensitivity remains a critical limitation. This study used a mathematical framework—the Convection-Diffusion-Reaction (CDR) equation—to optimize sensitivity by adjusting parameters such as flow velocity (U), association and dissociation rates (k_on and k_off), and nanoparticle valency. Our simulation results closely matched literature data (Berli & Kler, 2016), demonstrating significant enhancements in sensitivity with optimized parameters.

Preparing A Bioreactor For Avian Cell Culture, Joshua Bell, Taylor Davis, Payton Larsen, Abbie Smith, Joshua Thompson

Student Research Symposium

This project, in collaboration with Upside Foods and Thermo Fisher, focuses on optimizing a 50L bioreactor for avian cell growth. Thermo Fisher has assembled the bioreactor while Upside Foods has provided design specifications and avian specific growth media.

Effects Of Inhibitor Diffusion And Threshold Limits On Edge Detection With Reaction-Diffusion Equations, Zachary Hastings

Student Research Symposium

The purpose of this project is to model edge detection using the Nomura et al's¹ reaction-diffusion equation. Edge detection is an important visual processing tool for human sight, allowing for object detection and visual enhancement. This project explored the effects of inhibitor diffusion, D_i, and threshold limits, a, on edge detection in this model. This project also discovered the limit of Nomura et al's¹ model on the simultaneous detection of multiple edges in a step-wise intensity gradient and attempted to overcome that limitation.

Utilizing Enzymatic Microalgae Hydrolysates For Cellular Agriculture, Maelyn Andreasen, Sophia Hessami, Eli Sheley, Elise Barton

Student Research Symposium

UPSIDE Foods is working to produce chicken products to address the growing global food insecurity crisis.¹ Industrial scalability is limited due to the requirements of cell culture. Through collaboration with the company, we are working to supplement their existing media to drive costs down and improve cell viability.

Mathematical Modeling Of Color Perception Using Differential Equation, Siavash Pooretemad

Student Research Symposium

Color perception begins in the retina, where three cone types (L, M, S) detect light and initiate neural signals. These signals are processed by horizontal and bipolar cells to form opponent color channels: red-green (RG), yellow-blue (YB), and light-dark (LD). Perception is not solely based on physical input but also shaped by neural adaptation and context.

This project models color perception using a differential equation approach, simulating how color contrast and adaptation emerge from interactions between photoreceptors and lateral inhibition.

We hypothesize that a system of differential equations can model how retinal cone cells respond to and process light intensity, …

Laparoscopic Articulating Arm: In Collaboration With The Xenocor Saberscope, Zac Hastings, Lizbeth Pugliese, Rebecca Sweeten, Dallin Thomas, Dallin Treasure-Areno

Student Research Symposium

• Laparoscopy a minimally invasive procedure performed through small incisions using a laparoscope, a camera-equipped instrument, along with specialized tools.

• Laparotomy or "open" surgery, requires a large incision to perform an abdominal operation.

Testing Resilience Of Microalgae Biofilms When Exposed To Hydrothermal Liquefaction Aqueous Phase, Davis Haag

Student Research Symposium

Hydrothermal liquefaction (HTL) is a process that transforms wet biomass into a mixture of aqueous phase (AP), biochar solids, biocrude oil, and biogas.

The HTL process is not economically viable on a large scale partially because the HTL-AP is a toxic waste product with no current use.

The HTL-AQ contains high amounts of nitrogen (N) and phosphorus (P), but also environmental toxins such as phenolic compounds. The N and P could potentially be used to grow algae if it can survive the toxins.

Rotating algal biofilm reactors (RABRs) provide a method to grow algae biomass as a biofilm on plastic …

Optimizing Treatment Of Cytomegalovirus, Alisa Dabb

Student Research Symposium

The current treatment to Cytomegalovirus, ganciclovir, kills neutrophils, a type of cell in the immune system. In an effort to reduce the concentration of ganciclovir, quercetin and poloxamer 188 have been added in treatment in a cellular and mouse model. This treatment has been successful, but can be further optimized by reworking the ratio of quercetin to poloxamer 188 and by adding vitamin c to prevent oxidation.

Arakniprint: 3d Printing Of Synthetic Spider Silk To Produce Biocompatible And Resorbable Biomaterials, Ashley Ruben, Brianne Bell, Chase Spencer, Craig Soelberg, Dan Gil, Thomas Harris, Richard Decker, Timothy A. Taylor, Randolph V. Lewis

Student Research Symposium

At $3.07 billion in 2013, the 3D printing industry was projected to reach $12.8 billion in 2018 and exceed $21 billion by 2020 (Wohlers and Caffrey, 2013). A lucrative part of this expanding industry includes printing biocompatible medical implants, devices, and tissue scaffolds. A common problem encountered with traditional devices, implants, and tissue scaffolds is that they are not unique to the patient and lack the necessary strength and biocompatibility. To answer these demands, customizable devices are being produced from patient medical scans and CAD designs using 3D printers. These printers traditionally use thermoplastics because of the ease with which …

Secretion Of Bioplastic Polymers From Methanotrophic Bacteria Grown Using Natural Gas, Chad L. Nielsen, Charles D. Miller

Student Research Symposium

Biodegradable bioplastics show promise as a replacement for traditional plastics. Cost of production due to the cost of feedstocks and separation/purification processes are the main obstacles to widespread use of bioplastics. The possibility of reducing these costs through using methane gas as a feedstock and genetically transforming a methanotrophic bacterium to secrete bioplastics was investigated through experimentation. The bacteria are a promising option for bioplastic production.

Computational Capabilities Of Leaky Integrate-And-Fire Neural Networks For Liquid State Machines, Amin Almassian, Christof Teuscher

Student Research Symposium

We analyze the computational capability of Leaky Integrate-and-Fire (LIF) Neural Networks used as a reservoir (liquid) in the framework of Liquid State Machines (LSM). Maass et. al. investigated LIF neurons in LSM and their results showed that they are capable of noise-robust, parallel, and real-time computation. However, it still remains an open question how the network topology affects the computational capability of a reservoir. To address that question, we investigate the performance of the reservoir as a function of the average reservoir connectivity. We also show that the dynamics of the LIF reservoir is sensitive to changes in the average …