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Articles 1 - 30 of 35
Full-Text Articles in Biological Engineering
Change Of Carbohydrate Concentration In Reactors From Spring To Fall 2022 After Refrigeration, Amanda Ventura
Change Of Carbohydrate Concentration In Reactors From Spring To Fall 2022 After Refrigeration, Amanda Ventura
The Journal of Purdue Undergraduate Research
No abstract provided.
Identification Of Conserved Eukaryotic Gene Products In Novel Mycobacteriophage, Brandon Mar, Jade Coxon, Lily Esterline, Sydney Clifford, Gabriella Burke, Mallory Motz, Alaina Gartner, Kioni Bush, James Lin, Lizzie Adams, Sophia Palant
Identification Of Conserved Eukaryotic Gene Products In Novel Mycobacteriophage, Brandon Mar, Jade Coxon, Lily Esterline, Sydney Clifford, Gabriella Burke, Mallory Motz, Alaina Gartner, Kioni Bush, James Lin, Lizzie Adams, Sophia Palant
The Journal of Purdue Undergraduate Research
Bacteriophage, a type of virus that infects bacteria, was discovered 100 years ago, initially isolated with a plaque assay in the 1940s. A mycobacteriophage is a subtype of bacteriophage that specifically infects mycobacteria. Since the introduction of DNA technologies and efforts to identify a plethora of bacteriophages, over 10,000 bacteriophages have been identified with 1,500 sequenced. Bacteriophage discovery has aided in genetic editing techniques, the development of synthetic biology tools, and disease treatment. However, to be able to expand on these capabilities, there is a need to identify more bacteriophages and sequence the genomes of these viruses, as they outnumber …
Jovial Family Farm Facilitates Intergenerational Learning Opportunities Through Urban Farming, Maera Williams
Jovial Family Farm Facilitates Intergenerational Learning Opportunities Through Urban Farming, Maera Williams
Purdue Journal of Service-Learning and International Engagement
Maera Williams is a sophomore in Environmental and Ecological Engineering at Purdue University. She joined the Engineering Projects in Community Service (EPICS) Urban Farming team as a freshman and now serves as project manager of ten undergraduate students collaborating with Jovial Family Farm to design and develop three indoor hydroponics systems for a laboratory space on their property in Broad Ripple, IN. Jovial Family Farm is a nonprofit organization founded by Drs. Bobbie and Brian Jellison with the mission to provide senior citizens, their families, and their communities with meaningful engagement opportunities on an intergenerational scale through urban agricultural activities. …
Raman Spectroscopy - An Analytical Tool For Biologics, Cindy Mayorga, Shreya Milind Athalye, Mohit Verma
Raman Spectroscopy - An Analytical Tool For Biologics, Cindy Mayorga, Shreya Milind Athalye, Mohit Verma
Graduate Industrial Research Symposium
Raman Spectroscopy (RS) is a non-invasive technique that analyses biomolecules qualitatively and quantitatively. Raman spectroscopy measures the inelastic scattering of light due to molecular vibrations. It can be applied to liquid, solid, or semi-solid forms of the biological sample reducing the sample preparation measures. The minimal sample preparation and non-invasive nature of Raman Spectroscopy can be applied in developing a Process analytical technology (PAT) tool and as a diagnostic tool. We demonstrated qualitative and quantitative measurements of biologics with Raman spectroscopy through our previous studies. Our results indicate that RS distinguishes various Gram-positive and Gram-negative bacteria, fungi, and a mixture …
Sea-Phages Course-Based Undergraduate Research Experience For Creating A Biotechnology Workforce Development Pipeline, Daphne Fauber, Kari Clase, Carol Weaver
Sea-Phages Course-Based Undergraduate Research Experience For Creating A Biotechnology Workforce Development Pipeline, Daphne Fauber, Kari Clase, Carol Weaver
Graduate Industrial Research Symposium
Purdue University has been a member of the SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) program since 2011. This program, created in conjunction with the Howard Hughes Medical Institute (HHMI), facilitates undergraduate curriculum for the authentic discovery of novel bacteriophages within the classroom. Since joining the program, undergraduates at Purdue have harnessed wet lab and bioinformatics principles to contribute over 200 previously uncharacterized bacteriophages and 25 novel genomes to the wider scientific literature. The SEA-PHAGES classes at Purdue have resulted in tangible professional deliverables for students through conference presentations and publications. Student outcomes also include transferable skills …
The Next-Gen Crop Nutrient Stress Identification With High-Precision Sensing Technology In Digital Agriculture, Zhihang Song, Ziling Chen, Xing Wei, Jian Jin
The Next-Gen Crop Nutrient Stress Identification With High-Precision Sensing Technology In Digital Agriculture, Zhihang Song, Ziling Chen, Xing Wei, Jian Jin
Graduate Industrial Research Symposium
Crop yields are facing significant losses from nutrient deficiencies. Over-fertilizing also has negative economic and environmental impacts. It is challenging to optimize fertilizing without an accurate diagnosis. Recently, plant phenotyping has demonstrated outstanding capabilities in estimating crop traits. As one of the leading technologies, LeafSpec, provides high-quality crop image data for improving phenotyping quality. In this study, novel algorithms are developed for LeafSpec to identify crop nutrient deficiencies more accurately. Combined with UAV system, this technology will bring growers a robust solution for fertilizing diagnosis and scientific crop management.
Visualizing Bacteriophage Evolution Through Sequence And Structural Phylogeny Of Lysin A And Terminase Proteins: An Analysis Of Protein Structure Across Phage Clusters, Maansi Asthana, Alyssa Easton, Julia Mollenhauer, Sean Renwick, Anita Golpalrathnam
Visualizing Bacteriophage Evolution Through Sequence And Structural Phylogeny Of Lysin A And Terminase Proteins: An Analysis Of Protein Structure Across Phage Clusters, Maansi Asthana, Alyssa Easton, Julia Mollenhauer, Sean Renwick, Anita Golpalrathnam
The Journal of Purdue Undergraduate Research
Understanding how genes evolve and persist is a critical part of viral genomics. Bacteriophages can provide unique insight about viral evolution because of their abundance and largely unexplored history. Traditionally, phylogenetic trees have used DNA sequence comparison to visualize evolutionary paths between organisms. However, DNA sequence similarity does not reflect key alterations to protein structure and therefore how the protein performs its function. Phylogenetic trees based on predicted protein structure could provide an alternative lens through which to view evolutionary paths. From each of the 10 largest clusters included in the Actinobacteriophage Database, three mycobacteriophage genomes were selected. Lysin A …
Framework For Water Management In The Food-Energy-Water (Few) Nexus In Mixed Land-Use Watersheds In Colombia, Camilo Torres, Margaret Gitau, Jaime Lara-Borrero, Diego Paredes-Cuervo
Framework For Water Management In The Food-Energy-Water (Few) Nexus In Mixed Land-Use Watersheds In Colombia, Camilo Torres, Margaret Gitau, Jaime Lara-Borrero, Diego Paredes-Cuervo
Purdue University Libraries Open Access Publishing Fund
The food-energy-water (FEW) nexus approach has emerged as an alternative for managing these resources more efficiently. Work from studies conducted in the FEW nexus in Latin America is scarce in the scholarly literature. This study aims to develop a framework for water management at the FEW Nexus, with a focus on Colombia. The study focuses on a typical mixed land-use watershed in the Andean region with specific objectives being to: (1) characterize the watershed with respect to land use, climate, water resources, and other factors pertinent to the nexus; (2) explore the relationship between factors in the FEW nexus that …
Raman Spectra-Based Deep Learning: A Tool To Identify Microbial Contamination, Murali K. Maruthamuthu, Amir Hossein Raffiee, Denilson Mendes De Oliveira, Arezoo M. Ardekani, Mohit S. Verma
Raman Spectra-Based Deep Learning: A Tool To Identify Microbial Contamination, Murali K. Maruthamuthu, Amir Hossein Raffiee, Denilson Mendes De Oliveira, Arezoo M. Ardekani, Mohit S. Verma
Purdue University Libraries Open Access Publishing Fund
Deep learning has the potential to enhance the output of in-line, on-line, and at-line instrumentation used for process analytical technology in the pharmaceutical industry. Here, we used Raman spectroscopy-based deep learning strategies to develop a tool for detecting microbial contamination. We built a Raman dataset for microorganisms that are common contaminants in the pharmaceutical industry for Chinese Hamster Ovary (CHO) cells, which are often used in the production of biologics. Using a convolution neural network (CNN), we classified the different samples comprising individual microbes and microbes mixed with CHO cells with an accuracy of 95%–100%. The set of 12 microbes …
Quantified Measurement Of The Tilt Effect In A Family Of Café Wall Illusions, Nasim Nematzadeh Dr., David Martin Powers Prof.
Quantified Measurement Of The Tilt Effect In A Family Of Café Wall Illusions, Nasim Nematzadeh Dr., David Martin Powers Prof.
MODVIS Workshop
This abstract explores the tilt effect in a family of Café Wall illusions using a Classical Gaussian Receptive Field model (CRF). Our model constructs an intermediate representation called edge map at multiple scales (Fig. 1) that reveals tilt cues and clues involved in the illusory perception of the Café Wall pattern. We investigate a wide range of parameters of the stimulus including mortar width, luminance, tiles contrast, and phase of the tile displacement (the stimuli in Fig. 2). We show that this simple bioplausible model, simulating the contrast sensitivity of the retinal ganglion cells, can not only detect the tilts …
Rapid Sample Processing Of Foodborne Pathogens Using Cross-Flow Microfiltration, Casey Bomrad, Michael R. Ladisch, Linda Liu, Jessica Lynn Zuponcic, Eduardo Ximenes
Rapid Sample Processing Of Foodborne Pathogens Using Cross-Flow Microfiltration, Casey Bomrad, Michael R. Ladisch, Linda Liu, Jessica Lynn Zuponcic, Eduardo Ximenes
The Summer Undergraduate Research Fellowship (SURF) Symposium
Foodborne illnesses are a prominent issue, causing 48 million illnesses annually. The Escherichia coli O157:H7 outbreak in romaine lettuce is a recent example. The source of the pathogen was contaminated irrigation water. The most common methods for detecting foodborne pathogens involve cultivation and enrichment of food samples. The enrichment steps are time-consuming, taking 24 to 72 hours to complete. Our study aims to accelerate irrigation water sample preparation for pathogenic microorganism fast detection through cross-flow microfiltration. This is accomplished by a device called a continuous cell concentration and recovery device (C3D). The C3D uses cross-flow microfiltration in a hollow fiber …
Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala
Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala
The Summer Undergraduate Research Fellowship (SURF) Symposium
The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …
Improving Biomanufacturing Production With Novel Elp-Based Transcriptional Regulators, Juya Jeon, Logan R. Readnour, Kevin V. Solomon
Improving Biomanufacturing Production With Novel Elp-Based Transcriptional Regulators, Juya Jeon, Logan R. Readnour, Kevin V. Solomon
The Summer Undergraduate Research Fellowship (SURF) Symposium
Microbes can be used to produce valuable drugs, chemicals, and biofuels, but their potential has not been fully realized due to low production yields. To improve biomanufacturing processes and yield, we are developing novel, transcriptional regulators using biosynthesis technology in order to improve cellular health and overall production. Our regulator contains elastin-like polypeptides (ELPs), which make ideal sensors since they exhibit a sharp, inverse phase transition to indicators of cell health such as intracellular pH and ionic strength, and external stimuli such as temperature. We hypothesize that ELP can be fused to transcription factors to control expression of target genes. …
Gender And Participation In An Engineering Problem-Based Learning Environment, Laura Hirshfield, Milo D. Koretsky
Gender And Participation In An Engineering Problem-Based Learning Environment, Laura Hirshfield, Milo D. Koretsky
Interdisciplinary Journal of Problem-Based Learning
The use of problem-based learning (PBL) is gaining attention in the engineering classroom as a way to help students synthesize foundational knowledge and to better prepare students for practice. In this work, we study the discourse interactions between 27 student teams and two instructors in an engineering PBL environment to analyze how participation is distributed among team members, paying particular attention to the differences between male and female students. There were no statistically significant differences between the amount that male and female students spoke; however, stereotypical gender roles and traditional gendered behavior did manifest in the discussion. Also, regardless of …
Fundamental Characterization Of Oxygen Nanobubbles, John Hamlin, Yi Wen, Joseph Irudayaraj
Fundamental Characterization Of Oxygen Nanobubbles, John Hamlin, Yi Wen, Joseph Irudayaraj
The Summer Undergraduate Research Fellowship (SURF) Symposium
A hypoxic environment is created by tumors’ incredible growth rate. Hypoxia provides radioresistance to the tumors, thus making radiation treatment less effective. The issue is that increasing the radiation leads to increased side effects in patients. Our goal for the oxygen-filled nanobubble is to deliver oxygen to the tumor to lessen radioresistance and make radiation treatment more efficient. However, we need preliminary research to understand and improve the nanobubbles before further research and implementation. To do this, we synthesized different batches of nanobubbles to optimize the production method and find the best container and temperature to store nanobubbles. We measured …
Establishing A Lung Model For Evaluation Of Engineered Lung Microbiome Therapies, Kathryn F. Atherton, Stephen Miloro, Jenna Rickus
Establishing A Lung Model For Evaluation Of Engineered Lung Microbiome Therapies, Kathryn F. Atherton, Stephen Miloro, Jenna Rickus
The Summer Undergraduate Research Fellowship (SURF) Symposium
Benzene, a toxin and carcinogen found in air polluted by cigarette smoke, car exhaust, and industrial processes, is associated with the development of leukemia and lymphoma. Other than avoiding exposure, there is no current method to deter the effects of benzene. One potential strategy to prevent these effects is to engineer the bacteria of the human lung microbiome to degrade benzene. To evaluate this novel approach, we must verify that the bacteria remain viable within the lung microenvironment. To do so, lungs were harvested from rats and swabbed to determine the contents of the original lung microbiome. Then green fluorescent …
Pathogenic Dna Detection Using Dna Hairpins: A Non-Linear Hybridization Chain Reaction Platform, Lance Novak, Tamara L. Kinzer-Ursem
Pathogenic Dna Detection Using Dna Hairpins: A Non-Linear Hybridization Chain Reaction Platform, Lance Novak, Tamara L. Kinzer-Ursem
The Summer Undergraduate Research Fellowship (SURF) Symposium
Currently, 3.2 billion people are at risk of being infected with malaria, with 1.2 billion of those being at high risk (>1 in 1000 chance of getting malaria in a year). Thus, there is a need for a biosensor that is highly sensitive, cost effective, and simple to use for point-of-care diagnosis. The biosensing platform, PathVis, has achieved this by measuring changes in fluid properties after a loop-mediated isothermal amplification (LAMP). LAMP is a DNA amplification system that requires enzymes and a temperature of 65degrees C. LAMP currently limits PathVis by being costly, requiring refrigeration, and difficult to design. …
Localized Blood Occlusion Generation In An In-Vitro Circulatory Catheter System, Ryan D. Harris, Qi Yang, Hyowon Lee
Localized Blood Occlusion Generation In An In-Vitro Circulatory Catheter System, Ryan D. Harris, Qi Yang, Hyowon Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrocephalus is a debilitating neurological disorder that involves the accumulation of cerebrospinal fluid in a ventricle of the brain. The implantation of a catheter commonly treats hydrocephalus with drainage. These catheters have a short lifespan due to obstruction from biological materials. Shunt systems have an extremely high failure rate of more than 40% failed within 1 year and up to 85% failed within 10 years. Previously, polymer-based flexible implantable magnetic micro-actuators were developed to clean up the catheter by mechanical vibration. We have demonstrated clearing of bacteria attachment and are proceeding to examine clearing effects on larger clotting materials, such …
The Response Of Schwann Cells To Weak Dc Electric Fields, Alexander T. Lai, Jianming Li
The Response Of Schwann Cells To Weak Dc Electric Fields, Alexander T. Lai, Jianming Li
The Summer Undergraduate Research Fellowship (SURF) Symposium
Schwann cells are glial cells that serve the vital role of supporting neurons in the peripheral nervous system. While their primary function is to provide insulation (myelin) for axons, they also help regenerate injured axons by digesting severed axons and providing scaffolding to guide the regeneration process. This specific role of Schwann cells makes them highly important cellular targets following nerve injury. Although some efforts have been made to encourage Schwann cell migration after nerve damage, the use of electric fields to control cell responses remain unexplored; therefore, this experiment serves to characterize the behavior of Schwann cells to weak …
Nanobubbles Provide Theranostic Relief To Cancer Hypoxia, Christopher M. Long, Pushpak N. Bhandari, Joseph Irudayaraj
Nanobubbles Provide Theranostic Relief To Cancer Hypoxia, Christopher M. Long, Pushpak N. Bhandari, Joseph Irudayaraj
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hypoxia is a common motif among tumors, contributing to metastasis, angiogenesis, cellular epigenetic abnormality, and resistance to cancer therapy. Hypoxia also plays a pivotal role in oncological studies, where it can be used as a principal target for new anti-cancer therapeutic methods. Oxygen nanobubbles were designed in an effort to target the hypoxic tumor regions, thus interrupting the hypoxia-inducible factor-1α (HIF-1α) regulatory pathway and inhibiting tumor progression. At less than 100nm, oxygen nanobubbles act as a vehicle for site-specific oxygen delivery, while also serving as an ultrasound contrast agent for advanced imaging purposes. Through in vitro and in vivo studies, …
Role Of Sumoylation In Mitochondrial Division In Tetrahymena Thermophila, Ramya Modi, James Forney
Role Of Sumoylation In Mitochondrial Division In Tetrahymena Thermophila, Ramya Modi, James Forney
The Summer Undergraduate Research Fellowship (SURF) Symposium
SUMOylation is a post translation modification that involves the addition of a small protein called SUMO, Small Ubiquitin-like MOdifier to a target protein. It is an important mechanism for the regulation of gene expression, the maintenance of genomic stability and in modifying nuclear proteins. More recently evidence has emerged for its importance in regulating mitochondrial fission and fusion in mammalian cells. This study evaluates the parameters for optimal staining of Tetrahymena thermophila mitochondria using two different dyes and then examines different cell lines with defects in the SUMOylation pathway. The first staining method uses Mitotracker Green, a vital stain that …
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term …
Using Elastin-Like Polypeptides For Better Retention Of Biofuels, Yu Hong Wang, Ethan T. Hilman, Kevin V. Solomon
Using Elastin-Like Polypeptides For Better Retention Of Biofuels, Yu Hong Wang, Ethan T. Hilman, Kevin V. Solomon
The Summer Undergraduate Research Fellowship (SURF) Symposium
Elastin-like polypeptides (ELPs) are synthetic molecules that exhibit an interesting property of inverse temperature phase transition; they exist as soluble monomers at low temperatures and form insoluble aggregates at higher temperatures. The transition temperature depends on the pH, salt concentration, and the amino acid sequence of the ELP. This unique and reversible behavior, along with their high biocompatibility has made them a strategic tool for various biomedical applications. However, their hydrophobic properties also make them a prime candidate for biofuel production. As high levels of many commercially important organic solvents are toxic to the cells that make them, ELPs can …
Bioengineered Cell Niche For Skeletal Muscle Regeneration, Nicole M. Whittern, Naagarajan Narayanan, Chunhui Jiang, Owen Jones, Jay Gilbert, Michael Whittern, Shihuan Kuang, Meng Deng
Bioengineered Cell Niche For Skeletal Muscle Regeneration, Nicole M. Whittern, Naagarajan Narayanan, Chunhui Jiang, Owen Jones, Jay Gilbert, Michael Whittern, Shihuan Kuang, Meng Deng
The Summer Undergraduate Research Fellowship (SURF) Symposium
Skeletal muscles can self-repair minor strains, lacerations, and contusions; however, in cases of volumetric muscle lossand muscle degenerative diseases, tissue fails to regenerate. Current cell-based therapies, such as myoblast transplantation, have significant drawbacks of low survival rates and engraftment efficacy, mainly due to the absence of supportive cell microenvironment. Scaffolds that mimic the natural cell microenvironment provide a robust platform to support cell adhesion, migration, proliferation, and differentiation. Electrospinning is a versatile technology platform used for fabricating the fiber scaffold that mimics the extracellular matrix. Thus, we aim to reconstitute the cell microenvironment through development of aligned fiber scaffolds by …
A Novel Synthetic Yeast For Enzymatic Biodigester Pretreatment, Tianyu Tan, Mark S. Aronson, Arren Liu, Jill H. Osterhus, Melissa Robins, Suraj Mohan, Erich Leazer, Bowman Clark, Alexa Petrucciani, Katherine Lowery, James Welch, Casey Martin, Helena Lysandrou, Michael E. Scharf, Jenna Rickus
A Novel Synthetic Yeast For Enzymatic Biodigester Pretreatment, Tianyu Tan, Mark S. Aronson, Arren Liu, Jill H. Osterhus, Melissa Robins, Suraj Mohan, Erich Leazer, Bowman Clark, Alexa Petrucciani, Katherine Lowery, James Welch, Casey Martin, Helena Lysandrou, Michael E. Scharf, Jenna Rickus
The Summer Undergraduate Research Fellowship (SURF) Symposium
Lignin, a complex organic polymer, is a major roadblock to the efficiency of biofuel conversion as it both physically blocks carbohydrate substrates and poisons biomass degrading enzymes, even if broken down to monomer units. A pretreatment process is often applied to separate the lignin from biomass prior to biofuel conversion. However, contemporary methods of pretreatment require large amounts of energy, which may be economically uncompelling or unfeasible. Taking inspiration from several genes that have been isolated from termites and fungi which translate to enzymes that degrade lignin, we want to establish a novel “enzymatic pretreatment” system where microbes secrete these …
Proteoglycan Mimic Of The Glycocalyx To Treat Endothelial Dysfunction, Victoria Messerschmidt, Alyssa Panitch, James R. Wodicka
Proteoglycan Mimic Of The Glycocalyx To Treat Endothelial Dysfunction, Victoria Messerschmidt, Alyssa Panitch, James R. Wodicka
The Summer Undergraduate Research Fellowship (SURF) Symposium
Patients with kidney failure usually undergo hemodialysis, a process by which toxins produced by the body are filtered from the blood, in order to survive. The preferred form for vascular access is called an arteriovenousfistula (AVF), a surgically created connection between an artery and vein that is utilized to undergo dialysis. However, AVFs have a failure rate of 50-60%. One of the contributions to AVF failure is endothelial cell dysfunction and loss of glycocalyx, which allows neutrophils and other native cells into the media of the vessel, which causes an inflammatory response. Our lab addresses endothelial dysfunction by mimicking the …
Development Of A Novel Enzymatic Pre-Treatment For Lignocellulosic Biomass, Melissa Robins, Jenna Rickus
Development Of A Novel Enzymatic Pre-Treatment For Lignocellulosic Biomass, Melissa Robins, Jenna Rickus
The Summer Undergraduate Research Fellowship (SURF) Symposium
Biofuels, fuels derived directly from living matter, present a renewable and environmentally friendly alternative to petroleum based fuels. Bioethanol produced from low input energy crops or agricultural waste is a promising fuel source because it does not interfere with the human food supply chain and the ethanol produced can be blended with gasoline. These potential sources of bioethanol are not yet commercially viable due to a polymer called lignin present in the plant’s cell wall which impedes the conversion of cellulose to glucose and the eventual fermentation of glucose to ethanol. Developing new methods for the pretreatment of lignocellulosic biomass …
Harnessing Notch Signaling For Biomaterial Scaffold-Based Bone Regeneration, Helena P. Lysandrou, Chunhui Jiang, Naagarajan Narayanan, Shihuan Kuang, Meng Deng
Harnessing Notch Signaling For Biomaterial Scaffold-Based Bone Regeneration, Helena P. Lysandrou, Chunhui Jiang, Naagarajan Narayanan, Shihuan Kuang, Meng Deng
The Summer Undergraduate Research Fellowship (SURF) Symposium
Bone fracture has recently become prevalent, especially with an increasingly aging population. Current bone grafts procedures, including autografts and allografts, are hindered by multiple factors, such as limited supplies and inconsistent bone healing. Scaffold-based bone tissue engineering emerges as a prospective strategy to aid in bone regeneration through delivery of growth factors such as bone morphogenic proteins (BMPs). However, the use of BMPs suffers from several drawbacks such as protein instability and immunogenicity. Therefore, there exists a great need for the development of novel therapies to promote bone healing. Notch signaling, a pathway critical for cell-fate determination has been shown …
Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang
Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang
The Summer Undergraduate Research Fellowship (SURF) Symposium
Disease and injury to human tissue, especially musculoskeletal tissue, is a prevalent concern to the public, affecting millions of people each year. Current treatment options involving autografts and allografts are hindered by limited availability and risk of immunogenicity, respectively. In order to overcome these limitations, a transdisiplinary regenerative engineering strategy has emerged with a focus on the development of biomimetic scaffolds that closely mimic the properties of the native tissues. For example, the structure of muscle tissue is characterized by oriented muscle fibers. However, fabrication of aligned nanofiber structures that mimic the anisotropic organization of muscle presents significant engineering challenges. …
Wirelessly Powered And Transmitting Current Sensing Device, Christopher Quinkert, Steven Lee, Pedro Irazoqui
Wirelessly Powered And Transmitting Current Sensing Device, Christopher Quinkert, Steven Lee, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
As the rate of incidence of diabetes increases in the modern world, more accurate and reliable methods of glucose detection must be developed for patients with diabetes. Currently, 25.8 million people have diabetes in the United States alone and account for $174 billion in healthcare costs annually [1]. Devices that can be used without the need for as much patient interaction, regular replacement, or great patient expenses would be a large step forward in the ability of doctors and patients to effectively manage diabetes. To measure glucose concentrations in vivo, a biosensor is used to transduce glucose to an electrical …