Biomedical Engineering and Bioengineering | Open Access Articles

Engr 1010: Engineering Problem Solving (Syllabus), Stephen Strain

Biomedical Engineering Syllabi Archive

Course Description: Introduction to the methods of engineering problem solving. Application of mathematical concepts to solve engineering problems.

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Biom 3110(Honors): Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

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Biom 4906: Tissue Engineering (Syllabus), Gary L. Bowlin

Biomedical Engineering Syllabi Archive

Course Description: To study the design, development, and implantation of tissue engineered components. Analysis of the basis for cell growth and differentiation, control of tissue development (in vivo & in vitro), models for tissue engineering, and transplantation of engineered cells and tissues. The emphasis of these analyses will be focused on the cardiovascular system (blood vessels and cardiac prostheses), musculoskeletal system (Bone, cartilage, and tendons), and skin.

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Biom 4801/6801: Introduction To Medical Imaging (Syllabus), Aaryani Sajja

Biomedical Engineering Syllabi Archive

Course Description: This course will introduce fundamentals of the four most-important clinical medical imaging modalities: X-ray, Radionuclide, Ultrasound, and MRI. The primary focus is on the physical principles, instrumentation methods, imaging algorithms, and clinical applications of each imaging modality.

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Engr 1009: Preparation For Engineering Problem Solving (Syllabus), Stephen Strain

Biomedical Engineering Syllabi Archive

Course Description: Applications of algebra and trigonometry to engineering problems. Accelerated preparation for an engineering or technology major.

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การเปรียบเทียบการวินิจฉัยโรคสมองเสื่อมด้วยภาพซ้อนทับ Pet-T1 และ Pet-Dti, ปรเมษฐ์ วงษา

Chulalongkorn University Theses and Dissertations (Chula ETD)

จุดประสงค์ของงานวิจัยนี้ เพื่อสร้างแม่แบบภาพเพทมาตรฐานบริเวณสมองขึ้นมาใหม่ และเพื่อเปรียบเทียบประสิทธิภาพในการกระบวนการซ้อนทับภาพเพทระหว่างแม่แบบภาพเพทบริเวณสมองที่สร้างขึ้นกับแม่ภาพเพทบริเวณสมองแบบเดิมที่มีการใช้งานอยู่ในปัจจุบัน แม่แบบภาพเพทมาตรฐานบริเวณสมองสร้างขึ้นมาจากภาพเพท กับภาพเอ็มอาร์ไอแบบ DTI จากข้อมูลภาพถ่ายทางรังสีจากกลุ่มอาสาสมัครที่มีภาวะความจำปกติ จำนวน 24 คน อายุระหว่าง 42-79 ปี ซึ่งกลุ่มอาสาสมัครดังกล่าวจะต้องทำการถ่ายเพทบริเวณสมองที่มีการฉีดสารเภสัชรังสี 11C-PIB เข้าไปในร่างกาย และทำการถ่ายภาพเอ็มอาร์ไอบริเวณสมองด้วยเทคนิค T1 และเทคนิค DTI จากนั้นทำการแก้ไขค่ากระแสไฟฟ้ารบกวน การกำจัดคลื่นสัญญาณรบกวน และการสร้างแผนที่โดยวิธี Whole-brain probabilistic tractography จากภาพถ่ายเอ็มอาร์ไอเทคนิค DTI โดยแผนที่ดังกล่าวที่ถูกสร้างขึ้นมาจะถูกนำไปใช้ในขั้นตอนการซ้อนทับ และขั้นตอนการ Normalize กับภาพเพทเพื่อช่วยในการกำหนดขอบเขตภายในบริเวณเนื้อสมอง หลังจากนั้นทำการประเมินความถูกต้องของการซ้อนทับของภาพแม่แบบภาพเพทมาตรฐาน โดยการประเมินการซ้อนทับกับภาพเพทในกลุ่มผู้ป่วยที่มีภาวะสมองเสื่อมในระยะเริ่มต้นที่เข้ารับการถ่ายภาพเพทบริเวณสมองด้วยการตรวจแบบเดียวกัน จากนั้นทำการประเมินและให้คะแนนความถูกต้องในการซ้อนทับของภาพเพทกับแม่แบบภาพเพทมาตรฐานบริเวณสมองโดยรังสีแพทย์ผู้เชี่ยวชาญทางด้านเวชศาสตร์นิวเคลียร์จำนวน 3 คน ด้วยวิธีการแบบปกปิดข้อมูล แล้วทำการเปรียบเทียบค่าคะแนนดังกล่าวโดยใช้การทดสอบทางสถิติแบบ Wilcoxon Signed Ranks test การประเมินความสอดคล้องภายในโดยใช้สถิติ Fleiss Kappa test และสถิติ Cohen’s weighted Kappa test ผ่านโปรแกรม SPSS ที่ระดับความเชื่อมั่น ร้อยละ 95 นอกจากนี้ในงานวิจัยได้ทำการหาค่า Dice similarly coefficient เพิ่มเติม เพื่อเปรียบเทียบความถูกต้องของการซ้อนทับดังกล่าว ผลการศึกษาวิจัยพบว่าคะแนนประเมินความถูกต้องในการซ้อนทับของภาพเพทกับแม่แบบมาตรฐานภาพเพทบริเวณสมองที่สร้างขึ้นด้วยวิธีการใหม่มีค่าสูงกว่าแม่แบบมาตรฐานภาพเพทบริเวณสมองที่สร้างขึ้นด้วยวิธีการเดิมอย่างมีนัยสำคัญทางสถิติ ซึ่งสอดคล้องกับค่า Dice similarly coefficient ที่พบว่ามีค่าสูงสุดในแม่แบบมาตรฐานภาพเพทบริเวณสมองที่สร้างขึ้นด้วยวิธีการใหม่ อย่างไรก็ตามพบว่าผลการประเมินค่าความสอดคล้องภายในอยู่ในระดับสอดคล้องกันแบบเล็กน้อย ซึ่งจากผลการศึกษาวิจัยดังกล่าวสรุปได้ว่า แม่แบบมาตรฐานภาพเพทบริเวณสมองที่สร้างขึ้นมาใหม่โดยใช้ภาพเอ็มอาร์ไอเทคนิค DTI มาร่วมด้วย มีการซ้อนทับของภาพที่ดีกว่าเดิมและเหมาะสมในการที่จะนำไปใช้ในการช่วยวินิจฉัยผู้ป่วยที่มีสภาวะโรคสมองเสื่อม

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การพัฒนาระบบฝึกเดินพร้อมการประเมินผลการเดินด้วยอุปกรณ์ไลดาร์, ศุภรักษ์ ศักดารักษ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้มีวัตถุประสงค์เพื่อพัฒนาอุปกรณ์ฝึกเดินที่มีการนำอุปกรณ์วัดระยะทางด้วยแสง หรือ อุปกรณ์ไลดาร์ มาประยุกต์ใช้ในการเก็บข้อมูลการเดิน และนำข้อมูลการเดินที่อุปกรณ์ไลดาร์เก็บได้ มาทำการประมวลผลเป็นตัวแปรการเดินต่าง ๆ ได้อย่างแม่นยำโดยไม่จำเป็นต้องทำการปรับเทียบทุกครั้งก่อนใช้งาน และ ไม่จำเป็นต้องติดวัตถุลงบนร่างกายของผู้ใช้งานก็สามารถเก็บข้อมูลได้อย่างแม่นยำ โดยในการศึกษาครั้งนี้ ได้ทำการทดสอบความถูกต้องและความแม่นยำในการเก็บข้อมูลโดยเปรียบเทียบกับอุปกรณ์ถ่ายภาพความเคลื่อนไหวทางคลินิก โดยจากการทดสอบพบว่า จากความคลาดเคลื่อนในการวิเคราะห์ตัวแปรเชิงระยะทาง และ ความคลาดเคลื่อนในการวิเคราะห์ตัวแปรเชิงเวลา ที่ต่ำกว่า 10% โดยสรุป จากการทดสอบกับระบบเก็บข้อมูลการเดินมาตรฐานทางการแพทย์ มีความเป็นไปได้ที่จะนำอุปกรณ์ฝึกเดินพร้อมระบบวัดระยะทางด้วยแสงที่พัฒนาขึ้นนี้ มาใช้งานในการเก็บข้อมูลการเดินจริงได้ ซึ่งระบบฝึกเดินที่พัฒนาขึ้นนี้ จะมีประโยชน์ในการกายภาพบำบัดและการฟื้นฟูร่างกายแบบทางไกล

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The Role Of Pro-Longevity Micrornas In Aging, Sarah Noureddine

Electronic Theses and Dissertations, 2020-2023

Cellular senescence, a hallmark of aging, has been implicated in the pathogenesis of many major age-related disorders, including atherosclerosis, metabolic disease, and neurodegenerative disorders such as Alzheimer's disease (AD). AD is characterized by increased cognitive impairment and treatment options available provide minimal disease attenuation. Additionally, diagnostic methods for AD are not conclusive with definitive diagnoses requiring postmortem brain evaluations. Therefore, miRNAs, a class of small, non-coding RNAs, have garnered attention for their ability to regulate a variety of mRNAs and their potential to serve as both therapeutic targets and biomarkers of disease. Several miRNAs have already been implicated with AD …

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Exploring Cell Differentiation Vs. Localization In Engineered Ligament-To-Bone Entheses, Saagar N. Sheth, Michael E. Brown, Jennifer L. Puetzer

UROP Posters

The anterior cruciate ligament (ACL) connects to bone via structurally complex insertions known as entheses that translate load from elastic ligament and stiff bone via gradients in organization, composition, and cell phenotype [1]. These gradients are not recreated in graft repair or engineered replacements, yielding limited repair options and high failure rates [2]. Previously, we developed a culture system that uses a tensile-compressive interface to guide ligament fibroblasts to develop early postnatal-like entheses by 6 weeks [3]; however, cells used were isolated from the entirety of the neonatal bovine ACL from bone to bone and likely contained multiple cell phenotypes …

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Patient-Specific Cardiovascular Superelastic Niti Stents Produced By Laser Powder Bed Fusion, Valentina Finazzi, Francesca Berti, Roger J. Guillory Ii, Lorenza Petrini, Barbara Previtali, Ali Gökhan Demir

Michigan Tech Publications, Part 1

To date, there is a general lack of customizability within the selection of endovascular devices for catheter-based vascular interventions. Laser powder bed fusion (LPBF) has been flexibly exploited to produce customized implants using conventional biomedical alloys for orthopedic and dental applications. Applying LPBF for cardiovascular applications, patient-specific stents can be produced with small struts (approximately 100-300 µm), variable geometries, and clinically used metals capable of superelastic behaviour at body temperature (eg. equiatomic nickel-titanium alloys, NiTi). Additionally, the growing availability and use of patient-specific 3D models provides a unique opportunity to outline the necessary manufacturing process that would be required for …

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Neuromotor Changes In Participants With A Concussion History Can Be Detected With A Custom Smartphone App, Christopher K. Rhea, Masahiro Yamada, Nikita A. Kuznetsov, Jason T. Jakiela, Chanel T. Lojacono, Scott E. Ross, F. J. Haran, Jason M. Bailie, W. Geoffrey Wright

Rehabilitation Sciences Faculty Publications

Neuromotor dysfunction after a concussion is common, but balance tests used to assess neuromotor dysfunction are typically subjective. Current objective balance tests are either cost- or space-prohibitive, or utilize a static balance protocol, which may mask neuromotor dysfunction due to the simplicity of the task. To address this gap, our team developed an Android-based smartphone app (portable and cost-effective) that uses the sensors in the device (objective) to record movement profiles during a stepping-in-place task (dynamic movement). The purpose of this study was to examine the extent to which our custom smartphone app and protocol could discriminate neuromotor behavior between …

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The Lognometer: A New Normalized And Computerized Device For Assessing The Neurodevelopment Of Fine Motor Control In Children, Christian O'Reilly, Rejean Plamondon, Nadir Faci

Publications

Motor skills are fundamental for the development of children. Neurodevelopmental tests currently used by professionals for measuring motor control maturity exhibit several limitations. To address some of these, we have designed the Lognometer, a tablet-based device that can run computerized neuromotor tests. To normalize this tool against a representative population, we collected handwritten triangles from 780 children. We used the Sigma-Lognormal model and a prototype-based parameter estimation algorithm to analyze these movements. To ensure clinical acceptance, we developed an explainable solution relying on statistical regression. We evaluated how well the proposed lognormal decomposition captures the motor control maturation between 6 …

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The Aquatic Particle Number Quandry, Alexander B. Bochdansky, Huanqing Huang, Maureen H. Conte

OES Faculty Publications

Optical surveys of aquatic particles and their particle size spectra have become important tools in studies of light propagation in water, classification of water masses, and the dynamics of trophic interactions affecting particle aggregation and flux. Here, we demonstrate that typical settings used in image analysis vastly underestimate particle numbers due to the particle – gel continuum. Applying a wide range of threshold values to change the sensitivity of our detection system, we show that macrogels cannot be separated from more dense particles, and that a true particle number per volume cannot be ascertained; only relative numbers in relation to …

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In-Flow Dynamics Of An Area-Difference-Energy Spring-Particle Red Blood Cell Model On Non-Uniform Grids, Brendan Walsh, Fergal Boyle

Articles

In this paper the area-difference-energy spring-particle (ADE-SP) red blood cell (RBC) structural model developed by Chen and Boyle is coupled with a lattice Boltzmann flux solver to simulate RBC dynamics. The novel ADE-SP model accounts for bending resistance due to the membrane area difference of RBCs while the lattice Boltzmann flux solver offers reduced computational runtimes through GPU parallelisation and enabling the employment of non-uniform meshes. This coupled model is used to simulate RBC dynamics and predictions are compared with existing experimental measurements. The simulations successfully predict tumbling, tank-treading, swinging and intermittent behaviour of an RBC in shear flow, and …

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Multimodal Ultrasound Imaging For Improved Metastatic Lymph Node Detection, Sidhartha Jandhyala

Dartmouth College Ph.D Dissertations

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is complex in nature due to the variety of organs located in the head and neck region. Knowing the metastatic state of the lymph nodes is paramount in accurately staging and treating HNSCC patients. Currently, metastatic lymph node detection involves the use of magnetic resonance imaging and/or x-ray computed tomography, followed by biopsies for histological confirmation. The main diagnostic criteria is the size of the nodes; however, current imaging methods are not 100% accurate due natural lymph node variability. Ultrasound imaging is able to provide …

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Advancing Combined Radiological And Optical Scanning For Breast-Conserving Surgery Margin Guidance, Samuel Stewart Streeter

Dartmouth College Ph.D Dissertations

Breast cancer is one of the most common types of cancer worldwide, and standard-of-care for early-stage disease typically involves a lumpectomy or breast-conserving surgery (BCS). BCS involves the local resection of cancerous tissue, while sparring as much healthy tissue as possible. State-of-the-art methods for intraoperatively evaluating BCS margins are limited. Approximately 20% of BCS cases result in a tissue resection with cancer at or near the resection surface (i.e., a positive margin). A two-fold increase in ipsilateral breast cancer recurrence is associated with the presence of one or more positive margins. Consequently, positive margins often necessitate costly re-excision procedures to …

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Eye Movement And Pupil Measures: A Review, Bhanuka Mahanama, Yasith Jayawardana, Sundararaman Rengarajan, Gavindya Jayawardena, Leanne Chukoskie, Joseph Snider, Sampath Jayarathna

Computer Science Faculty Publications

Our subjective visual experiences involve complex interaction between our eyes, our brain, and the surrounding world. It gives us the sense of sight, color, stereopsis, distance, pattern recognition, motor coordination, and more. The increasing ubiquity of gaze-aware technology brings with it the ability to track gaze and pupil measures with varying degrees of fidelity. With this in mind, a review that considers the various gaze measures becomes increasingly relevant, especially considering our ability to make sense of these signals given different spatio-temporal sampling capacities. In this paper, we selectively review prior work on eye movements and pupil measures. We first …

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Minimally Invasive In Vivo Endoscopic Monitoring Of Dextran Sulfate Sodium-Induced Murine Colitis, Elizabeth A. Bullard, Ariel I. Mundo, Shelby N. Bess, Kathryn Miller Priest, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Ulcerative colitis (UC) is a gastrointestinal, autoimmune disease that causes ulceration and inflammation of the colon with an incidence of 10 out of every 100,000 people in North America and Western Europe. Though the specific cause is unknown, several studies have demonstrated that inflammatory cells as well as environmental variables, genetics, and lifestyle behaviors can play a role in the long-term inflammatory response. Researchers have commonly used immunohistochemistry, western blotting and gene sequencing to establish the cellular processes behind UC relapse and remission. However, because these destructive methods necessitate the removal of a sample, they can only be used on …

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Raman Spectroscopy Reveals Phenotype Switches In Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman

Biomedical Engineering Faculty Publications and Presentations

The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling metastatic progression of cancer. Here, we report a label-free optical strategy using Raman spectroscopy and machine learning to identify distinct metastatic phenotypes observed in tumors formed by isogenic murine breast cancer cell lines of progressively increasing metastatic propensities. Methods: We employed the 4T1 isogenic panel of murine breast cancer cells to grow tumors of varying metastatic potential and acquired label-free spectra using a fiber probe-based portable Raman spectroscopy system. We used MCR-ALS and random forests classifiers to identify putative spectral …

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Customer Gaze Estimation In Retail Using Deep Learning, Shashimal Senarath, Primesh Pathirana, Dulani Meedeniya, Sampath Jayarathna

Computer Science Faculty Publications

At present, intelligent computing applications are widely used in different domains, including retail stores. The analysis of customer behaviour has become crucial for the benefit of both customers and retailers. In this regard, the concept of remote gaze estimation using deep learning has shown promising results in analyzing customer behaviour in retail due to its scalability, robustness, low cost, and uninterrupted nature. This study presents a three-stage, three-attention-based deep convolutional neural network for remote gaze estimation in retail using image data. In the first stage, we design a mechanism to estimate the 3D gaze of the subject using image data …

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Combinatorial Approaches For Effective Design, Synthesis, And Optimization Of Enzyme-Based Conjugates, Jordan Scott Chapman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The specificity and efficiency with which enzymes catalyze selective chemical reactions far exceeds the performance of traditional heterogeneous catalysts that are predominant in industrial applications such as conversion of commodity chemicals to value-added products, fuel cells, and petroleum refinement. Moreover, biocatalysts exhibit exceptionally high product turnover at ambient conditions with little health and environmental burden. These advantageous qualities have led to the prolific use of enzyme catalysis in pharmaceutical, detergents, and food preservation industries wherein their use has greatly reduced waste generation, Unfortunately, the full slate of benefits that enzymes can impart to a broader range of chemical processes is …

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Load Sharing Assessment Of Osseoligamentous Structures Within A Thoracic Spine Segment During Surgical Release, Michael Polanco, James Bennett, Austin Tapp, Michel Audette, Stacie Ringleb, Sebastian Bawab

Electrical & Computer Engineering Faculty Publications

Spinal surgical procedures often require release of intervertebral discs and ligaments to optimally achieve postural correction on a patient-specific basis. In this paper, a T7-T8 Finite Element (FE) model is utilized to examine internal load sharing during resection steps performed in a Ponte osteotomy. The FE model was rotated bidirectionally along three anatomical planes using an externally applied moment. In each step, the Ranges of Motion (RoM), Instantaneous Centers of Rotation (ICR), and forces from ligaments, discs, facet, and costovertebral joints were calculated. The product of each component’s force and the distance between the ICR and their position were used …

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Revision Total Hip Femoral Stem Micromotion And Statistical Shape Modeling Of The Knee, William Fugit

Electronic Theses and Dissertations

The first purpose of this thesis was to compare the amount of micromotion seen in the femoral stem in a revision total hip arthroplasty between simple loading conditions and loading conditions derived from activities of daily living, through the use of experimental and computational methods. The amount of micromotion at the bone-implant interface was larger for activities of daily living, with ranges of 200μm more than the largest simple loading conditions. The second purpose of this thesis was to compare measurements of accuracy in a statistical shape model between individual bone and joint-level models, specifically for the knee. Using computational …

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An Investigation Into The Plate Fixation For Periprosthetic Femoral Fractures, Xiang Chen

Electronic Theses and Dissertations

Periprosthetic femoral fractures are the third most reason for reoperation after the total hip arthroplasty with an incident rate of approximately 6%. The Vancouver type B periprosthetic femoral fractures account for over 70% of all cases, while the sub-type B1 fracture (when the total hip stem is stable) has remained a clinical challenge due to incidences of severe complications after the standard plate-screw fixation. To seek biomechanically sound fixations for the Vancouver type B1 fracture, this dissertation developed a combined modeling and testing framework to investigate the efficacy of fixation for a Vancouver type B1 fracture using different construct lengths …

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Contact Simulation For Evaluating Patient Specific Surgical Guide Stability, Vincent Nierste

Electronic Theses and Dissertations

This study proposes a novel computational method to quantify guide stability for Patient Specific Instrumentation (PSI) guides. A finite element contact model was used to analyze the final position of PSI guides on a femur across a range of loading parameters representing forces applied by a surgeon during operative use. Separate segmentation methods were used for the guide and bone geometry to represent differences between segmentation and actual patient geometry. The region of loading parameters over which the guide exhibited a consistent final position was measured and reported as Guide Stability Score. The model was verified using cadaver specimens for …

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Immunomodulatory Functions Of Human Mesenchymal Stromal Cells Are Enhanced When Cultured On Hep/Col Multilayers Supplemented With Interferon-Gamma, Mahsa Letter-Mahsa Haseli, David A. Castilla-Casadiego, Luis Carlos Pinzon-Herrera, Alexander Hillsley, Katherine A. Miranda-Munoz, Srikanth Sivaraman, Adrianne M. Rosales, Raj R. Rao, Jorge Almodovar

Chemical Engineering Faculty Publications and Presentations

Human mesenchymal stromal cells (hMSCs) are multipotent cells that have been proposed for cell therapies due to their immunosuppressive capacity that can be enhanced in the presence of interferon-gamma (IFN-γ). In this study, multilayers of heparin (HEP) and collagen (COL) (HEP/COL) were used as a bioactive surface to enhance the immunomodulatory activity of hMSCs using soluble IFN-γ. Multilayers were formed, via layer-by-layer assembly, varying the final layer between COL and HEP and supplemented with IFN-γ in the culture medium. We evaluated the viability, adhesion, real-time growth, differentiation, and immunomodulatory activity of hMSCs on (HEP/COL) multilayers. HMSCs viability, adhesion, and growth …

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Phase-Changing Nanodroplets As Nanotheranostic Platform For Combination Cancer Therapy, Catalina-Paula Spatarelu

Dartmouth College Ph.D Dissertations

Cancer is a cluster of diseases, and 1.8 million Americans are newly diagnosed each year. Treatment issues such as drug instability, the occurrence of severe side effects, as well as resistance make the need for solutions to improve conventional methods, like chemotherapy, apparent. Nano-sized drug-delivery platforms, particles loaded with therapeutic molecules that escape the immune system clearance and accumulate at the tumor site, were proposed as one of these solutions. Despite the expansion of the field, several aspects still need to be addressed: inconsistent delivery of the drugs, inability of measuring the effective dose being delivered to the tumor, lack …

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An Antimicrobial Polydopamine Surface Coating To Reduce Biofouling On Telemetry Tags Used In Marine Conservation Practices, Ariana Smies

Dissertations, Master's Theses and Master's Reports

Satellite telemetry tags are used to track the migration patterns of large cetaceans. These tags penetrate the dermis and remain embedded in the underlying blubber tissue. As the dermis of cetaceans is host to a diverse microbiome, and it is impossible to clean the skin before implanting the devices, the potential for infection is increased when the tags penetrate through the skin. H₂O₂ is a potential antimicrobial agent that, in addition to showing broad-spectrum efficacy against gram-negative and gram-positive bacteria, can promote wound healing outcomes by promoting proliferative factors and peptides that protect against oxidative stress. However, …

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Acute Magnetic Resonance Imaging Predictors Of Chronic Motor Function And Tissue Sparing In Rat Cervical Spinal Cord Injury, Seung-Yi Lee, Brian D. Schmit, Shekar N. Kurpad, Matthew D. Budde

Biomedical Engineering Faculty Research and Publications

Predicting functional outcomes from spinal cord injury (SCI) at the acute setting is important for patient management. This work investigated the relationship of early magnetic resonance imaging (MRI) biomarkers in a rat model of cervical contusion SCI with long-term functional outcome and tissue sparing. Forty rats with contusion injury at C5 at either the spinal cord midline (bilateral) or over the lateral cord (unilateral) were examined using in vivo multi-modal quantitative MRI at 1 day post-injury. The extent of T₂-weighted hyperintensity reflecting edema was greater in the bilateral model compared with the unilateral injury. Diffusion tensor imaging (DTI) …

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Reconstruction Of Vectorcardiogram From Standard 12-Lead Electrocardiogram Using Convolutional Neural Network, Tanawan Tearwattanarattikal

Chulalongkorn University Theses and Dissertations (Chula ETD)

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Acute Magnetic Resonance Imaging Predictors Of Chronic Motor Function And Tissue Sparing In Rat Cervical Spinal Cord Injury, Seung-Yi Lee, Brian D. Schmit, Shekar N. Kurpad, Matthew D. Budde

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Reconstruction Of Vectorcardiogram From Standard 12-Lead Electrocardiogram Using Convolutional Neural Network, Tanawan Tearwattanarattikal

Chulalongkorn University Theses and Dissertations (Chula ETD)