Biomedical Engineering and Bioengineering Commons^™

Development Of A Foot Interface To Control Supernumerary Robotics Limbs, Emma Morris

Rose-Hulman Summer Undergraduate Research Fellowships

Supernumerary robotic limbs (SRLs) can be used to provide a person with extra arms to help with difficult tasks. For example, a task that normally requires three hands to complete could be accomplished by just one person with an SRL. One way to control an SRL and still leave both hands available is to use the foot. This paper describes two parts of developing this foot interface: characterizing the range of forces that the foot can apply, and prototyping systems for different control methods. First, a small sample of data was collected to learn how much force the foot can …

Identification And Analysis Of Behavioral Phenotypes In Autism Spectrum Disorder Via Unsupervised Machine Learning, Elizabeth Stevens, Dennis R. Dixon, Marlena N. Novack, Doreen Granpeesheh, Tristram Smith, Erik Linstead

Engineering Faculty Articles and Research

Background and objective: Autism spectrum disorder (ASD) is a heterogeneous disorder. Research has explored potential ASD subgroups with preliminary evidence supporting the existence of behaviorally and genetically distinct subgroups; however, research has yet to leverage machine learning to identify phenotypes on a scale large enough to robustly examine treatment response across such subgroups. The purpose of the present study was to apply Gaussian Mixture Models and Hierarchical Clustering to identify behavioral phenotypes of ASD and examine treatment response across the learned phenotypes.

Materials and methods: The present study included a sample of children with ASD (N = 2400), …

Cellular Modification And Artificial Cell Construction, Jimin Guo

Chemical and Biological Engineering ETDs

With all its complexities and different biofunctionalities, a cell is the basic structural and functional unit of all living organisms with the exception of viruses. In this dissertation, I demonstrated gain of function strategies of modifying mammalian cells using silicification and modular nanoparticle (NP) exoskeletons. In addition, I used a modular design concept to build a multifunctional artificial RBC system which can mimic the unique characteristics (e.g. shape, flexibility, the ability to carry oxygen, and long circulation times) of the native RBCs. Together, these cell modification or artificial cell construction strategies are expected to generate new mammalian cell-like structures with …

The Effect Of Heterobifunctional Crosslinkers On Hema Hydrogel Modulus And Toughness, Elizabeth M. Boazak, Vaughn K. Greene Jr., Debra T. Auguste

Publications and Research

The use of hydrogels in load bearing applications is often limited by insufficient toughness. 2-Hydroxyethyl methacrylate (HEMA) based hydrogels are appealing for translational work, as they are affordable and the use of HEMA is FDA approved. Furthermore, HEMA is photopolymerizable, providing spatiotemporal control over mechanical properties. We evaluated the ability of vinyl methacrylate (VM), allyl methacrylate (AM), and 3-(Acryloyloxy)-2-hydroxypropyl methacrylate (AHPM) to tune hydrogel toughness and Young’s modulus. The crosslinkers were selected due to their heterobifunctionality (vinyl and methacrylate) and similar size and structure to EGDMA, which was shown previously to increase toughness as compared to longer crosslinkers. Vinyl methacrylate …

Using The Xenopus Developmental Eye Regrowth Stystem To Distinguish The Role Of Developmental Versus Regenerative Mechanisms, Cindy X. Kha, Dylan J. Guerin, Kelly Ai-Sun Tseng

Life Sciences Faculty Research

A longstanding challenge in regeneration biology is to understand the role of developmental mechanisms in restoring lost or damaged tissues and organs. As these body structures were built during embryogenesis, it is not surprising that a number of developmental mechanisms are also active during regeneration. However, it remains unclear whether developmental mechanisms act similarly or differently during regeneration as compared to development. Since regeneration is studied in the context of mature, differentiated tissues, it is difficult to evaluate comparative studies with developmental processes due to the latter’s highly proliferative environment. We have taken a more direct approach to study regeneration …

Development Of A Sonically Powered Biodegradable Nanogenerator For Bone Regeneration, Avi S. Patel

University Scholar Projects

Background: Reconstruction of bone fractures and defects remains a big challenge in orthopedic surgery. While regenerative engineering has advanced the field greatly using a combination of biomaterial scaffolds and stem cells, one matter of difficulty is inducing osteogenesis in these cells. Recent works have shown electricity’s ability to promote osteogenesis in stem cell lines when seeded in bone scaffolds; however, typical electrical stimulators are either (a) externally housed and require overcomplex percutaneous wires be connected to the implanted scaffold or (b) implanted non-degradable devices which contain toxic batteries and require invasive removal surgeries.

Objective: Here, we establish a biodegradable, piezoelectric …

Development Of A Sonically Powered Biodegradable Nanogenerator For Bone Regeneration, Avi Patel

Honors Scholar Theses

Background: Reconstruction of bone fractures and defects remains a big challenge in orthopedic surgery. While regenerative engineering has advanced the field greatly using a combination of biomaterial scaffolds and stem cells, one matter of difficulty is inducing osteogenesis in these cells. Recent works have shown electricity’s ability to promote osteogenesis in stem cell lines when seeded in bone scaffolds; however, typical electrical stimulators are either (a) externally housed and require overcomplex percutaneous wires be connected to the implanted scaffold or (b) implanted non-degradable devices which contain toxic batteries and require invasive removal surgeries.

Objective: Here, we establish a biodegradable, piezoelectric …

Diagnosing Growth In Low-Grade Gliomas With And Without Longitudinal Volume Measurements: A Retrospective Observational Study., Hassan M Fathallah-Shaykh, Andrew Deatkine, Elizabeth Coffee, Elias Khayat, Asim K Bag, Xiaosi Han, Paula Province Warren, Markus Bredel, John Fiveash, James Markert, Nidhal Carla Bouaynaya, Louis B Nabors

Henry M. Rowan College of Engineering Departmental Research

BACKGROUND: Low-grade gliomas cause significant neurological morbidity by brain invasion. There is no universally accepted objective technique available for detection of enlargement of low-grade gliomas in the clinical setting; subjective evaluation by clinicians using visual comparison of longitudinal radiological studies is the gold standard. The aim of this study is to determine whether a computer-assisted diagnosis (CAD) method helps physicians detect earlier growth of low-grade gliomas.

METHODS AND FINDINGS: We reviewed 165 patients diagnosed with grade 2 gliomas, seen at the University of Alabama at Birmingham clinics from 1 July 2017 to 14 May 2018. MRI scans were collected during …

Energy Expenditure And Stability During Self-Paced Walking On Different Slopes, Alanna Raffaelli

Electronic Theses and Dissertations

Metabolic power and cost of transport (COT) are common quantifiers for effort when performing tasks including walking and running. Most studies focus on using a range of normal walking speeds over level ground or varied slopes. However, these studies use fixed-speed conditions. Fatigue, stability, metabolic expenditure, heart rate, and many other factors contribute to normal walking speed varying over time. This study aimed to show that allowing a subject to walk with a self-paced speed should correlate to a minimum COT at a given slope. This study also aimed to determine if a preferred slope exists based on minimizing metabolic …

Role Of Angiotensin I And Ii On The Tissue Mechanics Of The Aortic Heart Valve Via Receptor Binding And Converting Enzymes, Josh Fahy

Biomedical Engineering Undergraduate Honors Theses

The renin-angiotensin system (RAS) plays a crucial role in the regulation of renal, cardiac, and vascular physiology. This system regulates in vivo blood pressure and fluid balance. As renal blood flow decreases, the kidneys convert prorenin into renin and secrete it into the circulatory system. Renin then converts angiotensinogen into angiotensin I (ang-I). The ang-I is then converted into angiotensin II (ang-II) by the angiotensin-converting enzyme (ACE). Ang-II, a vasoconstrictor, increases blood pressure by causing the blood vessels to narrow. Recent evidence suggests that RAS may be involved in the progression of valve disease, most notably, aortic stenosis.

The first …

Investigation Of Acute Radiation-Induced Changes In Oxygenation In A Murine Breast Tumor Model, Alaa Abdelgawad

Biomedical Engineering Undergraduate Honors Theses

Around 50-60% of all cancer patients undergo radiation therapy. Although some patients show complete response with no recurrence, a significant proportion of the population still develop radiation resistance. It is important to identify tumor resistance at early stages of therapy in order to adjust treatment protocol and avoid extra exposure to radiation. Current methods to assess treatment response are only limited to anatomical measurements of tumor volume after therapy. Novel approaches that shed the light on any functional information during the course of radiotherapy could significantly improve our ability to identify patients who do not respond to radiation therapy. Diffuse …

Mathematical Modeling Of Blood Pressure And Cerebral Blood Flow Using Photoplethysmography Signal, Armin Soltan Zadi

Bioengineering Dissertations - Archive

Continuous and non-invasive monitoring of blood pressure (BP) and cerebral blood flow (CBF) has numerous clinical and health maintenance applications. Of particular interest is monitoring of BP and CBF during events that stress the cardiovascular system such as cessation of breathing during sleep apnea. Current means and methods of continuous measurement of these signals are either invasive or require expensive equipment. Therefore, investigation of new methods of continuous estimation of the BP and CBF are of high interest. One attractive alternative is to use photoplethysmography (PPG) technique to estimate BP and CBF, as PPG is shown to be able to …

The Hip-Spine Effect: How Pathological Femoro-Pelvic Interactions Contribute To Abnormal Lumbar Spine Loading, Anthony Nicholas Khoury

Bioengineering Dissertations - Archive

ABSTRACT THE HIP-SPINE EFFECT: HOW PATHOLOGICAL FEMORO-PELVIC INTERACTIONS CONTRIBUTE TO ABNORMAL LUMBAR SPINE LOADING Anthony Nicholas Khoury, Ph.D. The University of Texas at Arlington, 2019 Supervising Professor: Hal David Martin Cheng-Jen Chuong Lumbar pathology has been shown to explain hip pain, as hip pathology is involved in the development of lumbar pain by the disruption of normal lumbopelvic kinematics. Hip pathologies that contribute to lumbar pain include flexion deformities, osteoarthritis, congenital hip dislocation, and limited hip range of motion. To date there is a paucity of research that actively looks to investigate the symbiotic relationship between the hip and the …

3d Printing A Microfluidic Chip Capable Of Droplet Emulsion Using Ninjaflex Filament, Robert Andrews

Mechanical Engineering Undergraduate Honors Theses

This paper details an investigation into methods and designs of 3D printing a microfluidic system capable of droplet emulsion using NinjaFlex filament. The specific field in which this paper’s experiment is rooted is dubbed “BioMEMS,” short for bio microelectromechanical systems. One prominent research area in BioMEMS is developing a “lab on a chip.” Essentially, the goal is to miniaturize common lab processes to the micro scale, rendering it possible to include these processes in a small chip. Reducing necessary sample sizes, shortening the reaction times of lab processes, and increasing mobility of lab processes can all be realized through microfluidic …

Understanding Scalp Eeg In Response To Newsvendor Decision-Making And Feedback, Mobasshir Hossain Akash

Bioengineering Theses - Archive

Neuroeconomics is an emerging field integrating economic theories with neuroscience to enhance the understanding on how humans make decisions under different cost-effective conditions. Understanding the brain network associated with different cognitive tasks, to investigate the basic neural processes that underlie complex higher-order cognitive operations, has become an important research topic in behavioral neuroscience. Newsvendor problem plays a vital role among all prevalent concepts. This study is designed based on Newsvendor problem incorporating 40 trials for each subject at a randomly chosen low-profit or high-profit margin treatments to investigate how electrophysiological signals in the human brain are differentiated under the two …

Classifying And Predicting Walking Speed From Electroencephalography Data, Allen Rahrooh

Electronic Theses and Dissertations

Electroencephalography (EEG) non-invasively records electrocortical activity and can be used to understand how the brain functions to control movements and walking. Studies have shown that electrocortical dynamics are coupled with the gait cycle and change when walking at different speeds. Thus, EEG signals likely contain information regarding walking speed that could potentially be used to predict walking speed using just EEG signals recorded during walking. The purpose of this study was to determine whether walking speed could be predicted from EEG recorded as subjects walked on a treadmill with a range of speeds (0.5 m/s, 0.75 m/s, 1.0 m/s, 1.25 …

Investigating Virus Clearance Via Ph Inactivation During Biomanufacturing, Wenbo Xu

Biomedical Engineering Undergraduate Honors Theses

In the processing of biopharmaceuticals, viral clearance and viral safety are important for the development of monoclonal antibodies. Murine xenotropic leukemia virus (XMuLV) is one of the retroviruses, recommended by Food and Drug Administration (FDA) as a model virus for viral clearance via inactivation from therapeutics derived from Chinese hamster ovary cells (CHO). A robust and effective method was investigated to clear or inactivate endogenous viruses by low pH inactivation. The effects of different conductivity and inactivated time on XMuLV clearance was determined. Acetate buffer was prepared with different conductivity, and 2% XMuLV was spiked into acetate buffer. XMuLV virus …

Effect Of Polymer Composition Of Injectable Hydrogels On Programmable Release Of Methylene Blue, Mary Brandecker

Biomedical Engineering Undergraduate Honors Theses

Temperature sensitive hydrogels have been used as injectable hydrogels because the polymer solutions can be liquid at room temperature and gel at body temperature. Injectable hydrogels have been used in biomedical applications to deliver drugs and other small molecules throughout the body. Methylene Blue was used as the drug in this study for its antioxidant and neuroprotective properties. PluronicⓇ F127 (PF127) is a copolymer consisting of repeating units of polyethylene oxide and polypropylene oxide in the form PEO-PPO-PEO. PF127 in solution is a temperature sensitive hydrogel that transitions to a gel at body temperature at specific polymer compositions. A standard …

Phenotypic Characterization Of Differentiation Of Human Mesenchymal Stem Cells To Smooth Muscle Cells, Jackson Hedrick

Biomedical Engineering Undergraduate Honors Theses

Abdominal aortic aneurysms (AAAs) are expansions in the aortic wall with an increased tendency to rupture. These expansions are triggered by the breakdown of key aortic extracellular matrix (ECM) proteins—elastin and collagen. The degradation of aortic ECM proteins is the consequence of overexpressed matrix metalloproteases (MMPs)–MMP-2 and MMP-9. Adult vascular smooth muscle cells (SMCs) lack the ability to repair the elastic matrix assembly; thus, it is imperative to find a solution to both restore the imbalance of essential ECM proteins in the aorta and mitigate the effects of MMPs. Previous studies have revealed that bone marrow derived mesenchymal stem cells …

The 3d Scaffold Design Of De Novo Anterior Cruciate Ligament Graft, Dominique Angibeau

Honors Capstones

No abstract provided.

Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre

Honors Scholar Theses

Abnormal ocular motility is a common manifestation of many underlying pathologies particularly those that are neurological. Dynamics of saccades, when the eye rapidly changes its point of fixation, have been characterized for many neurological disorders including concussions, traumatic brain injuries (TBI), and Parkinson’s disease. However, widespread saccade analysis for diagnostic and research purposes requires the recognition of certain eye movement parameters. Key information such as velocity and duration must be determined from data based on a wide set of patients’ characteristics that may range in eye shapes and iris, hair and skin pigmentation [36]. Previous work on saccade analysis has …

Stability Analysis Of A More General Class Of Systems With Delay-Dependent Coefficients, Chi Jin, Keqin Gu, Islam Boussaada, Silviu-Iulian Niculescu

SIUE Faculty Research, Scholarship, and Creative Activity

This paper presents a systematic method to analyse the stability of systems with single delay in which the coefficient polynomials of the characteristic equation depend on the delay. Such systems often arise in, for example, life science and engineering systems. A method to analyze such systems was presented by Beretta and Kuang in a 2002 paper, but with some very restrictive assumptions. This work extends their results to the general case with the exception of some degenerate cases. It is found that a much richer behavior is possible when the restrictive assumptions are removed. The interval of interest for the …

Design Of Microporous Membranes For The Development Of Brain-On-Chip Devices, Andre Figueroa Milla

Biomedical Engineering Undergraduate Honors Theses

Traumatic brain injuries (TBIs) are a major global health concern that have an economic impact of $60 billion in the United States in related costs annually. Developing drugs for TBI treatment is an approach that currently faces limitations involving the permeability of the blood-brain barrier (BBB). The BBB naturally limits molecules from reaching the brain as a protective mechanism against disease, acting as a barrier during drug delivery. Understanding the BBB mechanically and chemically following a TBI could potentially assist future studies to alleviate the symptoms and long-term effects of TBI by pharmaceuticals. The Mechanobiology and Soft Materials Laboratory (MSML) …

A Bioinstrumentation Active Learning Educational Module: The Design Of A Working Temperature Sensor Using A Ntc Thermistor, Baylor Bush

Biomedical Engineering Undergraduate Honors Theses

The Department of Biomedical Engineering at the University of Arkansas has continued to develop over the years, with more students enrolling in the program each year. Within the first biomedical engineering course, Introduction to Biomedical Engineering, various topics are introduced to students, and the topic of bioinstrumentation has been one of the most complex and difficult topics for students to comprehend through just a few lectures. In order to aid students in grasping these intricate concepts, an active learning module was developed in which students can work in groups to build a simple thermistor circuit as a temperature sensor. The …

Comparing The Effects Of Fibroblast Growth Factors On Growth Rate Of Human Fibroblast Cell Lines, Tasha Repella

Biomedical Engineering Undergraduate Honors Theses

Numerous studies have demonstrated the usefulness of growth factors in medium formulations to promote proliferation and viability of human fibroblasts in laboratory settings. However, due to the differences in the source and age of fibroblasts, the ability of growth factors like hFGF1 to promote proliferation varies. Equally difficult is the ability of hFGF1 to promote proliferation of diseased fibroblasts due to complexities associated with specific mitochondrial diseases. In this context, we decided to evaluate the potential for novel hyper stable growth factors super hFGF and hFGF1 (shFGF and hFGF1 respectively), to contribute to proliferation of different normal and diseased fibroblasts. …

Development Of A Model For Accelerated Fatigue Testing In Venous Valves, Olga Brazhkina

Biomedical Engineering Undergraduate Honors Theses

Malfunctioning venous cause issues ranging from cosmetic to life threatening situations for millions of people in the U.S. (1). Venous valve bioprosthetics often fail due to a loss in leaflet tissue flexibility following chemical fixation of donor tissue (2). A viable solution for testing venous valves prior to and post chemical fixation is in high demand for the development of a more durable prosthetic replacement. As a result, this research aims to create a fatigue apparatus that provides a means to model the durability of venous valves. The design criteria for this project included modeling physiological conditions in an accelerated …

Modeling And Validation Of Tissue Optical Properties In The Photon Transport Regime, Katelyn Heath

Biomedical Engineering Undergraduate Honors Theses

Early detection of changes in epithelial cells, such as the development of neoplastic formations seen in epithelial dysplasia, can indicate regions of the epithelial tissue that are at a high risk for cancerous formation. Using concepts from diffuse reflectance spectroscopy, a Monte Carlo model was developed to predict the reflectance measured by a detector at a small source-detector separation on a microendoscope. The Monte Carlo results were then used to calculate a mathematical relationship between the reflectance and distance that can be used to determine optical properties in a tissue sample. This model was validated with liquid phantoms of specified …

Conceptualization And Fabrication Of A Bioinspired Mobile Robot Actuated By Shape Memory Alloy Springs, Lietsel Richardson

Electronic Theses and Dissertations

This work is an experimental study and fabrication of design concepts to validate the feasibility of smart materials and their applications in bio-inspired robotics. Shape-Memory Alloy (SMA) springs are selected as the smart material actuators of interest to achieve locomotion in the proposed mobile robot. Based on a previous design of the robot, this work focuses on both implementing a new locomotion concept and reducing size and weight of the previous design, both using SMA based actuators. Objectives are met in consideration of the conceptual mechanics of circular robot locomotion. The first prototype is a variation of the original design. …

Fluctuations In Walking Speeds And Spatiotemporal Gait Parameters When Walking On A Self-Paced Treadmill At Level, Incline, And Decline Slopes, Cesar Castano

Electronic Theses and Dissertations

On a daily basis, humans walk over a variety of terrains. Studies have shown that spatiotemporal gait parameters, such as stride length, stride frequency, stride variability, etc., change when humans walk down a decline and up an incline compared to level ground. However, these studies have been limited to using fixed speed treadmills or analyzing a small number of strides when conducted over ground. Thus, there is a need to investigate the fluctuations in spatiotemporal gait parameters of humans walking at their self-selected speed, which requires recording hundreds of strides. Here we hypothesized that subjects will walk with a slower …

Ecological Co2 Flux Of A Green Roof Ecosystem And A Typical Grassland Ecosystem, Madeline Oxner

Biological and Agricultural Engineering Undergraduate Honors Theses

The Hillside Auditorium Green Roof is a low impact development feature on the University of Arkansas campus. It retains storm water and allows plants living on the roof to take up and transpire the water. Green roofs work to mimic natural ecosystems in urban environments. A key property is ecosystem respiration, which plays a large role in the global carbon cycle and is an important biologic activity indicator. The ecosystem respiration of Hillside Auditorium Green Roof was compared to a typical grassland ecosystem at the University of Arkansas farm to determine how closely the green roof is able to mimic …