Biomedical Engineering and Bioengineering Commons^™

Bacillus Thuringiensis: Transgenic Crops, Julie A. Peterson, John J. Obrycki, James D. Harwood

Department of Entomology: Faculty Publications

Bacillus thuringiensis (Bt) crops, genetically modified to express insecticidal toxins that target key pests of corn, cotton, rice, potato, and other crops, have been rapidly adopted and have become dominant fixtures in agroecosystems throughout the world. Due to the constitutive nature of Bt toxin expression, insecticidal proteins may be found in nearly all plant tissues, presenting multiple sources for Bt toxins to enter the environment, thus creating complex direct and indirect pathways for non-target organisms to be exposed to insecticidal proteins. The environmental impacts of Bt crops have been widely debated, although both benefits and risks do exist. Benefits of …

Evaluating And Training Intraoperative Analysis Of The Mitral Valve, Neil A. Tenenholtz

Link Foundation Modeling, Simulation and Training Fellowship Reports

Mitral valve repair is the recommended method of treating valve incompetency. However, the procedure is quite difficult and, as a result, underperformed due to surgeon’s need to predict the closed valve shape of the patient’s arrested heart. While the interactive process of predicting closed valve shape is achieved by physically manipulating valve tissue (known as valve analysis), surgical training consists of traditional, non-interactive pedagogy (e.g., book-based learning and lectures) followed by an apprenticeship model where the trainee is gradually given hands-on experience, resulting in post-medical school training that is often 10 years or greater. The continuing education of practicing cardiac …

Functional Near Infrared Detection Of Real And Imagined Finger Taps Using Support Vector Machine, Linear Discriminant Analysis, And Decision Tree Classification Methods, Eugene A. Stoudenmire

Computational Modeling & Simulation Engineering Theses & Dissertations

This study investigates the thesis that given cerebral response samples of an individual's left, right, both, and imagined finger tapping, continuous wave (CW) functional Near Infrared (fNIR), unregistered with fMRI, can differentiate between any two of the four categories.

Fifty subjects were outfitted with a single source/detector attached to a single, square pad, affixed to their heads using devices such as elastic bands and caps for light shielding. Slides depicting arrows pointing left, right, both directions, or made of dashed lines were presented to each subject, with a slide of text interspersed between each. Subjects tapped with their left finger, …

Automated Detection Of Incomplete Exhalation As An Indirect Detection Of Auto-Peep On Mechanically Ventilated Adults, Nyimas Arief

Theses and Dissertations

Auto-PEEP is auto positive end-expiratory pressure due to excessive amounts of alveolar gas produced by sustained recurrent incomplete exhalation. Incomplete exhalation occurs when the exhaled breath never reaches a flow rate of 0 L/min. The objective of this dissertation is to develop an automated detection system of auto-PEEP through incomplete exhalation as revealed by ventilator graphics for mechanically ventilated adults. Auto-PEEP can cause adverse effects if allowed to linger and if not quickly identified. An automated detection system will be instrumental in helping to quickly identify auto-PEEP. A computerized algorithm was developed to detect incomplete exhalation based on the following …

3d Visualization Of Reference-Point Indentation In Human And Murine Bone, John Jameson, Alex Proctor, Carolyne Albert, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Brittle Bone Fracture Risk With Transverse Isotropy, Jessica M. Fritz, Nicole M. Grosland, Peter A. Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Biomechanical Modeling Of Pediatric Clubfoot, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Improving Brain–Machine Interface Performance By Decoding Intended Future Movements, Francis R. Willett, Aaron J. Suminski, Andrew H. Fagg, Nicholas G. Hatsopoulos

Biomedical Engineering Faculty Research and Publications

Objective. A brain–machine interface (BMI) records neural signals in real time from a subject's brain, interprets them as motor commands, and reroutes them to a device such as a robotic arm, so as to restore lost motor function. Our objective here is to improve BMI performance by minimizing the deleterious effects of delay in the BMI control loop. We mitigate the effects of delay by decoding the subject's intended movements a short time lead in the future. Approach. We use the decoded, intended future movements of the subject as the control signal that drives the movement of our BMI. This …

Bone Properties By Nanoindentation In Mild And Severe Osteogenesis Imperfecta, Carolyne Albert, John Jameson, Jeffrey M. Toth, Peter Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Background

Osteogenesis imperfecta is a heterogeneous genetic disorder characterized by bone fragility. Previous research suggests that impaired collagen network and abnormal mineralization affect bone tissue properties, however, little data is yet available to describe bone material properties in individuals with this disorder. Bone material properties have not been characterized in individuals with the most common form of osteogenesis imperfecta, type I.

Methods

Bone tissue elastic modulus and hardness were measured by nanoindentation in eleven osteotomy specimens that were harvested from children with osteogenesis imperfecta during routine surgeries. These properties were compared between osteogenesis imperfecta types I (mild, n = …

Comparison Of Randomized Multifocal Mapping And Temporal Phase Mapping Of Visual Cortex For Clinical Use, Yan Ma, B. Douglas Ward, Kristina M. Ropella, Edgar A. Deyoe

Biomedical Engineering Faculty Research and Publications

fMRI is becoming an important clinical tool for planning and guidance of surgery to treat brain tumors, arteriovenous malformations, and epileptic foci. For visual cortex mapping, the most popular paradigm by far is temporal phase mapping, although random multifocal stimulation paradigms have drawn increased attention due to their ability to identify complex response fields and their random properties. In this study we directly compared temporal phase and multifocal vision mapping paradigms with respect to clinically relevant factors including: time efficiency, mapping completeness, and the effects of noise. Randomized, multifocal mapping accurately decomposed the response of single voxels to multiple stimulus …

A Hands-On, Active Learning Approach To Increasing Manufacturing Knowledge In Engineering Students, Jay R. Goldberg, David B. Rank

Biomedical Engineering Faculty Research and Publications

This paper describes a new learning module implemented as part of the senior capstone design course at Marquette University to teach engineering students about basic manufacturing processes, lean manufacturing principles, and design for manufacturability. The module includes several examples of active and student centered learning as part of an in-class assembly line simulation exercise. Students reflected on this experience, and suggested process improvements to save time, reduce cost and waste, and improve the assembly line process. They learned of the importance of manufacturing documentation, process design, and design for assembly. At the end of the module, students understood the importance …

In Vivo Dark-Field Imaging Of The Retinal Pigment Epithelium Cell Mosaic, Drew Scoles, Yusufu N. Sulai, Alfredo Dubra

Biomedical Engineering Faculty Research and Publications

Non-invasive reflectance imaging of the human RPE cell mosaic is demonstrated using a modified confocal adaptive optics scanning light ophthalmoscope (AOSLO). The confocal circular aperture in front of the imaging detector was replaced with a combination of a circular aperture 4 to 16 Airy disks in diameter and an opaque filament, 1 or 3 Airy disks thick. This arrangement reveals the RPE cell mosaic by dramatically attenuating the light backscattered by the photoreceptors. The RPE cell mosaic was visualized in all 7 recruited subjects at multiple retinal locations with varying degrees of contrast and cross-talk from the photoreceptors. Various experimental …

Safety And Efficacy Of Ranolazine For The Treatment Of Chronic Angina Pectoris, Mohammed Aldakkak, David F. Stowe, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Coronary heart disease is a global malady and it is the leading cause of death in the United States. Chronic stable angina is the most common manifestation of coronary heart disease and it results from the imbalance between myocardial oxygen supply and demand due to reduction in coronary blood flow. Therefore, in addition to lifestyle changes, commonly used pharmaceutical treatments for angina (nitrates, ß-blockers, Ca2+ channel blockers) are aimed at increasing blood flow or decreasing O2 demand. However, patients may continue to experience symptoms of angina. Ranolazine is a relatively new drug with anti-anginal and anti-arrhythmic effects. Its anti-anginal mechanism …

Experimental Study Of Optimal Energy Weighting In Energy-Resolved Ct Using A Czt Detector, Franco Rupcich, Taly Gilat-Schmidt

Biomedical Engineering Faculty Research and Publications

Recent advances in energy-resolved CT can potentially improve contrast-to-noise ratio (CNR), which could subsequently reduce dose in conventional and dedicated breast CT. Two methods have been proposed for optimal energy weighting: weighting the energy-bin data prior to log normalization (projection-based weighting) and weighting the energy-bin data after log normalization (image-based weighting). Previous studies suggested that optimal projection-based and image-based energy weighting provide similar CNR improvements for energy-resolved CT compared to photon-counting or conventional energy-integrating CT. This study experimentally investigated the improvement in CNR of projection-based and image-based weighted images relative to photon-counting for six different energy-bin combinations using a bench …