Biomedical Engineering and Bioengineering Commons^™

An Investigation Of Position And Force During Gait-Mimicking Finger Motions, Matthew Stephen Noesner

Theses

Spinal cord injuries are extremely debilitating, often leaving the injured person without the ability to use their legs (paraplegia) and sometimes, without the ability to use their arms and legs (tetraplegia or quadriplegia). Currently, primitive forms of feed-forward functional electrical stimulation (FES) and special orthotics are available for persons with paraplegia. However, these forms of FES do not allow the individual to actually control their movements on a real-time basis, nor do they offer the ability for the injured person to sense the ground on which they stand.

It is the goal of the researchers at the Neuromuscular Engineering Laboratory, …

Voice Onset Time Variation In Stop Consonant To Vowel Transitions, Abhishek Gunvant Parikh

Theses

Reduced duration, increased consistency, and improved intelligibility are goals of reducing the motor complexity of speech for individuals with cerebral palsy having dysarthria. In this study, measurement and analysis were made to compare an individual with spastic Cerebral Palsy (CP) having dysarthria to an individual with athetoid CP having dysarthria as well as to a non-dysarthric individual. Each participant's normal speech, whispering, and speech using an artificial larynx was evaluated, utilizing the source-filter theory methodology. The plausibility of dysarthric speech duration reduction by minimizing vocalization is tested by stop consonant "P,, to vowel transitions. The data suggest that speech duration …

Extrusion And Evaluation Of Degradation Rate And Porosity Of Small Diameter Collagen Tubes, Bipinkumar G. Patel

Theses

The limited availability of autografts and failure of small diameter synthetic vascular grafts has stimulated continuing efforts to develop small diameter vascular grafts based on natural materials. The small diameter collagen tubes were extruded using bovine collagen type I. The biodegradation rate was determined and compared for small diameter collagen tubes crosslinked with glutaraldehyde and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and Nhydroxysuccinimide (NHS) to evaluate physio-chemical properties. The samples were also evaluated for their surface area and porosity using mercury porosimeter. The noncrosslinked tubes almost completely degraded after 2 hours. The tubes crosslinked with EDC/NHS degraded slower than the ones crosslinked with …

Fabrication Of Nanofiber Scaffolds By Electrospinning And It's Potential For Tissue Engineering, Shobana Shanmugasundaram

Theses

Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers on to a target substrate. This electrospinning strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to tens of nanometers. This study assesses the potential of electrospinning, as an alternative scaffold fabrication technique for tissue engineering applications. In this study, electrospinning is adapted to produce tissue-engineering scaffolds of two different size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was …

A Kinematic Analysis Of Hand Configurations In Static And Dynamic Fingerspelling, Gillian B. Sherry

Theses

The focus of this study was the investigation of target handshapes in American Sign Language fingerspelling in order to determine whether there was a difference between static canonical structures and structures produced in the context of a movement sequence. This was achieved by measuring the joint angles of a signing hand with an 18-sensor CyberGlove® by Virtual Technologies, Inc.

A discriminant analysis was used to identify targets that occurred at points of minimum angular joint velocity. A multivariate analysis of variance with planned compansons was then applied to these dynamic data along with the static data to test the hypothesis. …

Biomimetic Sensor For In-Vivo Applications, Daya I. Sooryadas

Theses

The development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic molecule that performs two distinct functions in detecting target molecules. The sensor molecule recognizes a target molecule and specifically binds to it. This specific binding generates a signal in response to the event of target binding that can be then detected. The long term vision of this thesis research work is to develop a specific recognition ligand for detecting …

The Influence Of Strontium Substitution In Fluorapatite Glasses And Glass-Ceramics, R. G. Hill, A. Stamboulis, R. V. Law, A. Clifford, Mark R. Towler, C. Crowley

Chemical and Biochemical Engineering Faculty Research & Creative Works

Strontium is often substituted for calcium in order to confer radio-opacity in glasses used for dental cements, Biocomposites and bio glass-ceramics. The present paper investigates the influence of substituting strontium for calcium in a glass of the following composition: 4.5SiO₂3Al₂O ₃1.5P₂O₅3CaO2CaF₂, having a Ca:P ratio of 1.67 corresponding to calcium fluorapatite (Ca5(PO 4)3F). The glasses were characterized by magic angle spinning nuclear magnetic resonance (MAS-NMR), by differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD). The ²⁹Si, ²⁷Al and ³¹P NMR spectra for the glasses with …

Transdermal Delivery Of Phosphorodiamidate Morpholino Oligomers Across Hairless Mouse Skin, Angela K. Pannier, Vikram Arora, Patrick L. Iversen, Rhonda M. Brand

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The skin is the largest organ in the body and an obvious route for both local and systemic drug delivery. Antisense oligomers have tremendous potential as therapeutic agents for numerous diseases. The objective of this study was to investigate the influence of vehicle on the transdermal delivery of several phosphorodiamidate Morpholino oligomers (PMOs) with different sizes, lengths, base compositions, sequences, and lipophilicities. Eleven different PMOs were synthesized complementary to biologically relevant gene targets and delivered across hairless mouse skin in vitro using vehicles composed of 95% propylene glycol, 5% linoleic acid (PG/LA), water, 50% water:50% PG/LA, and 75% water:25% PG/LA. …

A Vocalisation-Based Drawing Interface For Disabled Children, Ted Burke

Articles

In our work with disabled children at Ireland’s National Rehabilitation Hospital, a problem we have experienced in the facilitation of art activities is that traditional art materials and standard computer drawing programs sometimes prove inaccessible. In this paper, an original system, called “PaintMyVoice” is presented which facilitates the creation of two or three-dimensional images using a variety of novel input modalities. In particular, vocalisations can be used to create original images of a variety of objects, including trees, flowers and landscape elements. Additional input to the system can optionally be provided via mouse, keyboard, switch interface or digital camera depending …

Characterisation Of The Glass Fraction Of A Selection Of European Coal Fly Ashes, J. Henry, Mark R. Towler, K. T. Stanton, X. Querol, N. Moreno

Chemical and Biochemical Engineering Faculty Research & Creative Works

Fly ash largely consists of the inorganic content of coal that remains after combustion. The crystalline phases present in fly ash may form upon cooling of a molten alumino-silicate glass. This view is supported by the spherical shape of many fly ash particles, inferring that they have gone through a viscous fluid state. The amorphous content in fly ash is believed to dominate reactivity behaviour, under both alkaline and acid conditions, because glasses have a higher potential energy than the equivalent crystal structure and the variation of bond angles and distances in a glass makes the bond breakage easier. It …

Immobilized Pseudornonas Cepacia Lipase For Biodiesel Fuel Production From Soybean Oil,, Hossein Noureddini, X Gao, R S. Philkana

Papers in Biomaterials

No abstract provided.

Geometry Analysis Of An Inverse-Geometry Volumetric Ct System With Multiple Detector Arrays, Samuel R. Mazin, Taly Gilat Schmidt, Edward G. Solomon, Rebecca Fahrig, Norbert J. Pelc

Biomedical Engineering Faculty Research and Publications

An inverse-geometry volumetric CT (IGCT) system for imaging in a single fast rotation without cone-beam artifacts is being developed. It employs a large scanned source array and a smaller detector array. For a single-source/single-detector implementation, the FOV is limited to a fraction of the source size. Here we explore options to increase the FOV without increasing the source size by using multiple detectors spaced apart laterally to increase the range of radial distances sampled. We also look at multiple source array systems for faster scans. To properly reconstruct the FOV, Radon space must be sufficiently covered and sampled in a …

Gsbs News, Spring 2003-2004, Graduate School Of Biomedical Sciences, University Of Texas Health Science Center At Houston/M.D. Anderson Cancer Center

GSBS News

No abstract provided.

Controlled Release Systems For Non-Viral Vectors, Angela K. Pannier, Lonnie D. Shea

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Adapting controlled release technologies to the delivery of non-viral vectors has the potential to overcome barriers that limit gene therapy. Controlled release systems can enhance gene delivery and increase the extent and duration of transgene expression relative to more traditional delivery methods. Delivery vehicles for controlled release are fabricated from natural and synthetic polymers, which function either by releasing the vector into the local tissue environment or by maintaining the vector at the polymer surface. Vector release or binding is regulated by the effective affinity of the vector for the polymer, which depends upon the strength of molecular interactions. These …

Fabrication, Characterization, And Chemical Sensing Of Silicon Dioxide Microcantilevers, Yanjun Tang

Doctoral Dissertations

The objective of this work is to design and fabricate an advanced silicon dioxide microcantilever sensor and to investigate chemical and biological sensing by microtechnology.

Microcantilever sensor technology has many advantages including fast response time, lower cost of fabrication, the possibility of sensor arrays with small overall dimensions, the ability to explore microenvironments, and improved portability for field applications. For all of these advantages, microcantilever chemical and biological sensors have drawn more and more attention.

So far, all other microcantilevers were designed and fabricated for AFM applications. We developed a novel SiO2 microcantilever especially for chemical and biological sensor applications. …

Astronaut Eva Exposure Estimates From Cad Model Spacesuit Geometry, Giovanni De Angelis, Brooke M. Anderson, William Atwell, John E. Nealy, Gary D. Qualls, John W. Wilson

Mathematics & Statistics Faculty Publications

Ongoing assembly and maintenance activities at the International Space Station (ISS) require much more extravehicular activity (EVA) than did the earlier U.S. Space Shuttle missions. It is thus desirable to determine and analyze, and possibly foresee, as accurately as possible what radiation exposures crew members involved in EVAs will experience in order to minimize risks and to establish exposure limits that must not to be exceeded. A detailed CAD model of the U.S. Space Shuttle EVA Spacesuit, developed at NASA Langley Research Center (LaRC), is used to represent the directional shielding of an astronaut; it has detailed helmet and backpack …

Changes In Pulmonary Arterial Wall Mechanical Properties And Lumenal Architecture With Induced Vascular Remodeling, Robert C. Molthen, Amy Heinrich, Steven Thomas Haworth, Christopher A. Dawson

Biomedical Engineering Faculty Research and Publications

To explore and quantify pulmonary arterial remodeling we used various methods including micro-CT, high-resolution 3-dimensional x-ray imaging, to examine the structure and function of intact pulmonary vessels in isolated rat lungs. The rat is commonly used as an animal model for studies of pulmonary hypertension (PH) and the accompanying vascular remodeling, where vascular remodeling has been defined primarily by changes in the vessel wall composition in response to hypertension inducing stimuli such as chronic hypoxic exposure (CHE) or monocrotaline (MCT) injection. Little information has been provided as to how such changes affect the vessel wall mechanical properties or the lumenal …

Quantification Of Bronchial Circulation Perfusion In Rats, Christian Wieholt, Robert C. Molthen, Steven Thomas Haworth, David L. Roerig, Christopher A. Dawson, Anne V. Clough

Biomedical Engineering Faculty Research and Publications

The bronchial circulation is thought to be the primary blood supply for pulmonary carcinomas. Thus, we have developed a method for imaging and quantifying changes in perfusion in the rat lung due to development of the bronchial circulation. A dual-modality micro-CT/SPECT system was used to detect change in perfusion in two groups of rats: controls and those with a surgically occluded left pulmonary artery. Both groups were imaged following injections on separate days i) 2mCi of Tc99m labeled macroaggregated albumin (MAA) into the left carotid artery (IA) and ii) a similar injection into the femoral vein (IV). The IA injection …

Post-Acquisition Small-Animal Respiratory Gated Imaging Using Micro Cone-Beam Ct, Jicun Hu, Steven Thomas Haworth, Robert C. Molthen, Christopher A. Dawson

Biomedical Engineering Faculty Research and Publications

On many occasions, it is desirable to image lungs in vivo to perform a pulmonary physiology study. Since the lungs are moving, gating with respect to the ventilatory phase has to be performed in order to minimize motion artifacts. Gating can be done in real time, similar to cardiac imaging in clinical applications, however, there are technical problems that have lead us to investigate different approaches. The problems include breath-to-breath inconsistencies in tidal volume, which makes the precise detection of ventilatory phase difficult, and the relatively high ventilation rates seen in small animals (rats and mice have ventilation rates in …

Fatty Acid Composition And Oxidation Of Lipids In Korean Catfish, K. T. Hwang, J. E. Kim, S. G. Kang, S. T. Jung, H. J. Park, Curtis L. Weller

Department of Agricultural and Biological Systems Engineering: Faculty Publications

This study determined the lipid content and FA composition of muscle and a mixture of muscle and viscera from Korean catfish as well as lipid oxidation and hydrolysis. Lipid content and FA compositions in Korean catfish, which were purchased every month or two during September 1999–July 2000, were analyzed. Lipid oxidation and hydrolysis were determined as PV, thiobarbituric acid value, and FFA in the muscle and the mixture during storage at 2°C for 12 d and –14°C for 9 wk. Lipid contents of the muscle and the mixture were 3.2 (w/w) and 5.4%, respectively. Oleic acid was the most abundant …

A Continuous Process For The Glycerolysis Of Soybean Oil , Hossein Noureddini, D W. Harkey, M R. Gutsman

Papers in Biomaterials

A continuous process for the glycerolysis of soybean oil with pure and crude glycerol, the co-product from the transesterification of soybean oil was investigated in a pilot plant. The process was equipped with a motionless and a high-shear mixer. The experimental studies explored the effects of variations in mixing intensity, temperature, reactant flow rates, and reactant stoichiometry on the formation of MG and DC. The developed process resulted in high conversion of TC to MC. The most favorable conditions were 230°C, 40 mL/min total flow, 25 mm of reaction time, 2.5:1 molar ratio of glycerol/soybean oil, and 3600 rpm for …

Development Of Fmri Compatible Lower Body Negative Pressure System, Pratap Singh Kunwar

Theses

The lower body negative pressure (LBNP) system provides a controlled, measured orthostatic stress to the cardiovascular system, which can be used with a magnetic resonance imaging (MRI) machine to study cardiovascular and cerebrovascular responses to graded LBNP. In the past, even though functional MRI (fMRI) was considered as one of the best modalities with which to measure small metabolic changes in the brain, it has not been used with an LBNP system to measure cerebrovascular changes. This was due to the lack of an fMRI compatible LBNP system.

In this project, an tMRI compatible LBNP system was first constructed without …

Wavelet Transform Methods For Identifying Onset Of Semg Activity, Janina Wilen

Theses

Quantifying improvements in motor control is predicated on the accurate identification of the onset of surface electromyograpic (sEMG) activity. Applying methods from wavelet theory developed in the past decade to digitized signals, a robust algorithm has been designed for use with sEMG collected during reaching tasks executed with the less-affected arm of stroke patients. The method applied both Discretized Continuous Wavelet Transforms (CWT) and Discrete Wavelet Transforms (DWT) for event detection and no-lag filtering, respectively. Input parameters were extracted from the assessed signals.

The onset times found in the sEMG signals using the wavelet method were compared with physiological instants …

A Labview Program To Obtain The Initiating Component Of A Vergence Eye Movement In An Open-Loop Experiment, Anuj P. Daftari

Theses

The vergence oculomotor system is used in viewing objects moving in depth, such as when a baseball player tracks a ball moving towards him. It is composed of two components according to the Dual Mode Theory; a fast preprogrammed initiating component and a slow feedback-controlled sustaining component. The initiating component is described with open-loop control and the sustaining component is described as a closed-loop feedback control system. Previously, several languages have been utilized to develop programs to study and isolate the open-loop portion of vergence eye movements. Presenting a subject with a stimulus, which initiates an open-loop response has been …

Evaluation Of Postural Stability Using Sensory Organization Test, Tiffany Sims

Theses

Poor postural stability of the elderly and other patients has been a major concern.The cost of treating injuries due to poor stability is expected to rise to $32.4 Billion by 2020. Many interventions have been proposed and used to improve stability. In order to determine the efficacy of these interventions, an objective evaluation of postural stability before and after intervention is important.

The aim of this thesis was to scientifically analyze the ambiguities in the equilibrium score (ES) given by the Neurocom Smart Equitest (NSE) machine, and compare it to a new measure of stability that has been proposed by …

Investigation Of Heart Rate Variability During Sleep Apnea, Sekar Subramanian

Theses

Sleep apnea is a disorder, where there are repetitive pauses in respiratory flow of at least 10 seconds or longer duration, and which occur more than five times per hour. Apnea has strong modulating effects on the autonomic nervous system, with prominent heart rate variation. It can be assumed that during sleep, internal influences (sympathetic and parasympathetic nervous system activities) dominate the autonomic nervous system; in addition repetitive apneas are accompanied by a pronounced increase in average heart rate. The aim of this study was to investigate the heart rate variability using spectral analysis and time-frequency analysis during sleep apnea. …

Transmission Of Light And Audible Sound In A Synthetic Fog Medium, Bhavin Babaria

Theses

The primary goal of the thesis was to study the propagation of visible light and auditory sound through a synthetic fog medium compared to an ambient air environment. It is known that the fog substantially decreases the visibility however; this has not been studied quantitatively. Further information regarding other energies such as sound is also needed to understand how the energy reacts in the fog medium. The extent of visual and auditory degradation in humans needs to be investigated. Researchers have studied light transmitted through water, air; however, no one has studied how light or sound is transmitted through a …

Mechano-Biological Interactions Of Endothelial Cells, Claire Brougham, Karen Coughlan, Valerie Barron, Peter Mchugh

Conference Papers

Atherosclerosis is an ever-increasing cause of morbidity in the western world. Current surgical treatments include bypass grafts and coronary artery stents. However, there is still a need for alternative approaches especially for those who cannot receive conventional therapy. Tissue engineering is one such approach that may hold the key to the repair and regeneration. Tissue engineering is one such approach that may hold the key to the repair and regeneration of coronary arteries. Nevertheless, many questions need to be answered before a vialbe vascular tissie with the inherent properties of native tissue becomes a real contender with the surgical therapies …

Total Reduced Sulfur Concentrations In The Vicinity Of Beef Cattle Feedlots, Richard K. Koelsch, Bryan L. Woodbury, David E. Stenberg, Daniel N. Miller, Dennis D. Schulte

Department of Agricultural and Biological Systems Engineering: Faculty Publications

A field survey of total reduced sulfur (TRS) concentrations in the vicinity of beef cattle feedlots was conducted to compare field observations against current regulatory thresholds. In addition, environmental factors that may contribute to increased TRS emissions were evaluated. It was observed that TRS levels in the vicinity of beef cattle feedlots are not likely to exceed current regulatory thresholds used by midwestern states. It was further noted that concentration of TRS varies with air temperature and time of day. However, wet feedlot surface conditions and wind speed had almost no impact upon observed concentrations.

Bie6810 - Biochemical Engineering, Spring 2004, Ron Sims

Biological and Irrigation Engineering - OCW

Biochemical processes, thermodynamics, and kinetics are used in the application of engineering principles to analyze, design, and develop processes using biocatalysts. Processes covered in the course include those that are involved in the formation of desirable compounds and products or in the transformation, or destruction of unwanted or toxic substances.