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Biomedical Engineering and Bioengineering Commons™
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Articles 31 - 60 of 119
Full-Text Articles in Biomedical Engineering and Bioengineering
Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto
Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto
ETD Archive
Elastin-like polypeptides (ELPs) are environmentally responsive biopolymers. These protein based polymers are specific in that they exhibit phase separation in response to a number of stimuli. Some of these stimuli include temperature, light, and pH. There are a large number of factors to consider when designing ELP constructs that allow for control of the transitioning behavior, some of which include amino acid sequences, protein concentration, salt concentration, and the polymer chain length. Elastin-like polypeptides are soluble in water at low temperatures, however, upon an increase in temperature, the proteins become insoluble in water and phase separate. This point of temperature …
Evaluation Of The Performance Of A Downward Flow Inclined Gravity Settler For Algae Dewatering, Dustin D. Bowden
Evaluation Of The Performance Of A Downward Flow Inclined Gravity Settler For Algae Dewatering, Dustin D. Bowden
ETD Archive
With recent concerns over the environmental implications of burning fossil fuels coupled with the depletion of fossil fuel reserves an alternative source of energy isneeded. Algae derived biofuels may be an effective replacement for transportation fuels as they are carbon neutral and have a high area productivity. Algae is superior to terrestrial plants as a biofuel source due to its high oil productivity and efficiency along with the fact that it will not displace food production. Currently the largest obstacle to the implementation of commercial algae to biofuel processes is algae dewatering. The separation of algae from water is difficult …
Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak
Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak
ETD Archive
Quantitative research concerning the impact of mechanical loading on the transport properties of bone has several critical applications. One such application is the effect of a microgravity environment, where the lack of mechanical forces on bone has been shown to negatively impact both growth and repair. A method has been developed in our lab that can potentially allow for the measurement of the effective permeability of large molecules (i.e., 300-15,000 Da in size) in bone tissue under both unloaded and mechanically loaded conditions. In proof-of-concept experiments, previous students have measured the effective diffusivity of the model solute, sodium fluorescein (376 …
Design Of Recombinant Tenebrio Molitor Antifreeze Protein For Purification Using Elastin-Like Polypeptide Tag, Joongseok Oh
Design Of Recombinant Tenebrio Molitor Antifreeze Protein For Purification Using Elastin-Like Polypeptide Tag, Joongseok Oh
ETD Archive
Fusion protein technologies can aid to improve solubility of recombinant protein from microorganisms and help recombinant protein purification. Elastin-like polypeptides (ELP) as a fusion tag can be utilized to facilitate the purification of recombinant proteins because ELP can provide its thermally responsive behavior to ELP tagged proteins. An ELP tag can be used as the purification carrier through inverse transition cycling (ITC), which is a simple and non chromatographic separation process. The purification through ITC can reduce cost and can be quickly performed compared to other purification methods. However, we further considered ELP tag removal because it may possibly hinder …
Human Hair Keratin Protein, Hair Fibers And Hydroxyapatite (Ha) Composite Scaffold For Bone Tissue Regeneration, Samuel Siyum
Human Hair Keratin Protein, Hair Fibers And Hydroxyapatite (Ha) Composite Scaffold For Bone Tissue Regeneration, Samuel Siyum
ETD Archive
The field of tissue engineering aims at promoting the regeneration of tissues or replacement of failing or malfunctioning tissue by means of combining a scaffold material, adequate cells and bioactive molecules. Different materials have been proposed for use as three-dimensional porous scaffolds for bone tissue engineering procedures. Among them, polymers of natural origin are one of the most attractive options mainly due to their similarities with the extracellular matrix (ECM), chemical versatility as well as typically good biological performance. In this study, two biocompatible composite scaffolds were developed from natural polymer by tissue engineering approach and tested in vitro. The …
Validation Of An Accelerometry Based Method Of Human Gait Analysis, Obinna Nwanna
Validation Of An Accelerometry Based Method Of Human Gait Analysis, Obinna Nwanna
ETD Archive
Gait analysis is the quantification of locomotion. Understanding the science behind the way we move is of interest to a wide variety of fields. Medical professionals might use gait analysis to track the rehabilitation progress of a patient. An engineer may want to design wearable robotics to augment a human operator. Use cases even extend into the sport and entertainment industries. Typically, a gait analysis is performed in a highly specialized laboratory containing cumbersome expensive equipment. The process is tedious and requires specially trained operators. Continued development of small and cheap inertial measurement units (IMUs) over an alternative to current …
Computation Of Fifteen Thermodynamic Properties Along Arbitrary Paths From Fundamental Equations Of State Correlations, Prashanth Krishnamoorthy
Computation Of Fifteen Thermodynamic Properties Along Arbitrary Paths From Fundamental Equations Of State Correlations, Prashanth Krishnamoorthy
ETD Archive
In this work, a set of fifteen thermodynamic properties for thirty pure compounds has been estimated using fundamental equations of state (FEOS). A computer program was written which allows to input any two of four fundamental thermodynamic properties entropy, pressure, temperature and density to fix a state point and then use the FEOS to generate any other property at that given state. The program further applies the FEOS to trace thermodynamic processes like isochoric, isobaric, isenthalpic, isothermal and isentropic state changes to find the final state of the compound. The program subsequently displays the initial, final and intermediate state points …
Potential Optimal Gait Performance Of Mauch S-N-S Prosthetic Knee Configurations As Predicted By Dynamic Modeling, Chih-Hao Chien
Potential Optimal Gait Performance Of Mauch S-N-S Prosthetic Knee Configurations As Predicted By Dynamic Modeling, Chih-Hao Chien
ETD Archive
Patients with prosthetic legs routinely suffer from abnormal gait patterns which can cause health issues and eventually lower the quality of their lives. Despite the half-century advance in the technology of prosthetic knees, from the purely mechanical to microprocessor controlled systems, patient testing suggests that very little progress has been made in the quality of the kinetics and kinematics of amputee gait. Moreover, the cost of microprocessor controlled prosthetic knees may be 10 times more than the purely mechanical knees. While prosthetic knees have become more complex and expensive, it is not proven that the prosthetic knee is a central …
Mineral Uptake Rates And Yield Coefficients Of The Green Microalgae Scenedesmus Dimorphus, Grace N. Mahfouz
Mineral Uptake Rates And Yield Coefficients Of The Green Microalgae Scenedesmus Dimorphus, Grace N. Mahfouz
ETD Archive
The need for renewable sources of energy has become critical as fossil fuel resources, which include oil, coal, and natural gas, are known to contribute to climate change and will eventually be depleted. Biofuels that originate from the fat of plants, animals, microalgae, and bacteria are an attractive alternative. Microalgae, in particular, are strong candidates for biofuel production since they have a high growth rate and lipid content (up to 50 in some species). The goal of this research was to optimize 3N-BBM+V recipe (Bold Basal Medium with 3-fold Nitrogen and Vitamins) in an effort of reducing the amount of …
Evolutionary Optimization Of Atrial Fibrillation Diagnostic Algorithms, Aref Smiley
Evolutionary Optimization Of Atrial Fibrillation Diagnostic Algorithms, Aref Smiley
ETD Archive
The goal of this research is to introduce an improved method for detecting atrial fibrillation (AF). The foundation of our algorithm is the irregularity of the RR intervals in the electrocardiogram (ECG) signal, and their correlation with AF. Three statistical techniques, including root mean squares of successive differences (RMSSD), turning points ratio (TPR), and Shannon entropy (SE), are used to detect RR interval irregularity. We use the Massachusetts Institution of Technology / Beth Israel Hospital (MIT-BIH) atrial fibrillation databases and their annotations to tune the parameters of the statistical methods by biogeography-based optimization (BBO), which is an evolutionary optimization algorithm. …
A Psa Process For An Oxygen Concentrator, Aaron A. Moran
A Psa Process For An Oxygen Concentrator, Aaron A. Moran
ETD Archive
Oxygen is used in a variety of chemical processes and for medical purposes throughout the world. Pressure swing adsorption (PSA) has become a viable alternative to cryogenic distillation for the separation of oxygen from air with the development of advanced adsorbents like zeolites. PSA processes are inherently complex because it is a dynamic process. Efficient operation of a PSA process is necessary in order to utilize the capacity of the adsorbent as much as possible and reduce the power requirements of the process.In this thesis, a novel zeolite adsorbent was utilized in a PSA process for oxygen generation with the …
Benefits Of Nitric Oxide Cues To Matrix Synthesis By Healthy And Aneurysmal Human Smooth Muscle Cells Within 3d Cocultures, Phillip Simmers
Benefits Of Nitric Oxide Cues To Matrix Synthesis By Healthy And Aneurysmal Human Smooth Muscle Cells Within 3d Cocultures, Phillip Simmers
ETD Archive
Vascular diseases such as atherosclerosis and aneurysms are characterized by the over-proliferation and migration of aortic smooth muscle cells (SMCs), and degradation of extracellular matrix (ECM) within the vessel wall, leading to compromise in cell-cell and cell-matrix signaling pathways. Recent tissue engineering approaches to regulate SMC over-proliferation and enhance healthy ECM synthesis showed promise, but resulted in low crosslinking efficiency and matrix deposition yields. In this study, the benefits of exogenous nitric oxide cues, delivered from S-Nitrosoglutathione (GSNO), to cell proliferation and matrix deposition by adult human aortic SMCs (HA-SMCs) within 3D biomimetic cultures have been explored. The first experiment …
Effects Of Environmental Heavy Metals On Neural Stem Cell Survival And Differentiation, Sameera S. Clev Tasneem
Effects Of Environmental Heavy Metals On Neural Stem Cell Survival And Differentiation, Sameera S. Clev Tasneem
ETD Archive
No abstract provided.
Pure Component Adsorption Of Methane, Ethylene, Propylene And Carbon Dioxide In Silicalite, Qianqian Zhou
Pure Component Adsorption Of Methane, Ethylene, Propylene And Carbon Dioxide In Silicalite, Qianqian Zhou
ETD Archive
Adsorption isotherms are measured for pure methane, ethylene, propylene and carbon dioxide in silicalite. Isotherm data are collected using a volumetric method at three different temperatures of 10C, 35C and 65C at pressure up to 100psi. The Virial equation and Langmuir equation have been applied to represent excess amount adsorbed in each pure component system. The binary adsorption equilibrium for various mixtures are predicted from the pure component adsorption data, using the Ideal Adsorption Solution Theory (IAST)
State Estimation Based On Nested Particle Filters, Swathi Srinivasan
State Estimation Based On Nested Particle Filters, Swathi Srinivasan
ETD Archive
In reality many processes are nonlinear and in order to have a knowledge about the true process conditions, it is important to make decisions based on the state of the system. Process measurements such as pressure, temperature, and pH, are available at time instances and this information is necessary in order to obtain the state of the system. Filtering is a state estimation technique by which the estimate is obtained at a time instant, given the process measurements at their respective time instances. Several lters have been developed so far for the estimation of the states of the system. Kalman …
Method For Determination Of Kinematic Sensor Position And Orientation From Magnetic Resonance Images, Caglar Ozturk
Method For Determination Of Kinematic Sensor Position And Orientation From Magnetic Resonance Images, Caglar Ozturk
ETD Archive
Concussion and mild traumatic brain injury risk remain high for young athletes participating in helmeted and non-helmeted sports. Because of the short and potential long-term effects on young athletes and early onset Alzheimer's and Parkinson's disease, there is a dire need to correlate a relationship between head impact intensity, frequency, duration and athlete brain health. To address this need, the Cleveland Clinic is developing a custom mouthguard embedded with flexible circuitry and sensors, known as the 'Intelligent Mouthguard'(IMG). To accurately quantify peak values of head impacts or concussions, orientation and position of each sensor relative to CG (Center of Gravity) …
Biomechanics Of Prosthetic Knee Systems : Role Of Dampening And Energy Storage Systems, Hande Argunsah Bayram
Biomechanics Of Prosthetic Knee Systems : Role Of Dampening And Energy Storage Systems, Hande Argunsah Bayram
ETD Archive
One significant drawback of the commercial passive and microprocessored prosthetic devices, the inability of delivering positive energy when needed, is due to the absence of the knee flexion during stance phase. Moreover, consequences such as circumduction and disturbed gait pattern take place due to the improper energy flow at the knee and the absence of the positive energy delivery during the swing phase. Current generation powered design has solved these problems by delivering the needed energy with heavy battery demanding motors, which increase the mass of the device significantly. Hence, the gait quality of transfemoral amputees has not improved significantly …
Scalp Eeg And Tms Based Electrophysiological Study Of Brain Function Of Motor Control In Aging, Mehmed Satuk Bayram
Scalp Eeg And Tms Based Electrophysiological Study Of Brain Function Of Motor Control In Aging, Mehmed Satuk Bayram
ETD Archive
Voluntary movements of human body are controlled by the brain through corticomuscular pathways. Although neuromuscular control mechanisms of voluntary movements have been studied extensively, many remain to be learned, especially neuromuscular adaptations related to clinical conditions such as neurological disorders and aging. This research aims at a better understanding of functional connection between the brain and muscle during voluntary motor activities in aging and the extent to which this connection can be changed by training the neuromuscular system. Three research projects were conducted to achieve this aim. The analyses in the first two projects are based on comparisons of non-invasive …
An In Silico Liver: Model Of Gluconeogenesis, Elie R. Chalhoub
An In Silico Liver: Model Of Gluconeogenesis, Elie R. Chalhoub
ETD Archive
An in silico liver was developed in attempt to represent the in vivo state of the fasted liver. It featured two conceptual models. The first one represented carbohydrate metabolism of the human liver, which included the heterogeneous nature of the liver by incorporating spatial variation of key enzyme activities. This model was able to predict the overall fluxes in tissue and the effect of high intensity exercise on the various hepatic fluxes. A second model of hepatic metabolism was developed to represent the complex interplay between gluconeogenesis, lipid metabolism, and alcohol metabolism in the fasted rat liver. Biochemical pathways are …
A Robotic Neuro-Musculoskeletal Simulator For Spine Research, Robb W. Colbrunn
A Robotic Neuro-Musculoskeletal Simulator For Spine Research, Robb W. Colbrunn
ETD Archive
An influential conceptual framework advanced by Panjabi represents the living spine as a complex neuromusculoskeletal system whose biomechanical functioning is rather finely dependent upon the interactions among and between three principal subsystems: the passive musculoskeletal subsystem (osteoligamentous spine plus passive mechanical contributions of the muscles), the active musculoskeletal subsystem (muscles and tendons), and the neural and feedback subsystem (neural control centers and feedback elements such as mechanoreceptors located in the soft tissues) [1]. The interplay between subsystems readily encourages "thought experiments" of how pathologic changes in one subsystem might influence another--for example, prompting one to speculate how painful arthritic changes …
Radial Diffusion Of Florescein Molecules (376 Da) In Canine Bone Tissue, Daniel O'Conor
Radial Diffusion Of Florescein Molecules (376 Da) In Canine Bone Tissue, Daniel O'Conor
ETD Archive
No abstract provided.
Lipid Production By Scenedesmus Dimorphus: Comparison Of Extraction Techniques And Effect Of Sodium Nitrate Concentration, Bahareh Kanani
Lipid Production By Scenedesmus Dimorphus: Comparison Of Extraction Techniques And Effect Of Sodium Nitrate Concentration, Bahareh Kanani
ETD Archive
No abstract provided.
Synthesis And Characterization Of Ph-Responsive Elastin-Like Polypeptides With Different Configurations, Mingjie Tang
Synthesis And Characterization Of Ph-Responsive Elastin-Like Polypeptides With Different Configurations, Mingjie Tang
ETD Archive
Elastin-like polypeptides (ELP) are environmentally responsive polymers that exhibit phase transition behavior in response to various stimuli such as temperature, pH and irradiation. In this work, we focused on pH-responsive ELPs. It has been shown that pH value, configurations of ELPs, ELP concentration, and salt concentration can impact the phase transition behavior of pH-responsive ELPs. Quantitative models have been developed to engineer various linear ELPs, but there has not been any detailed study for engineering ionizable ELP with non-linear configurations. In this study, we designed, synthesized, and characterized pH-responsive ELPs with two different configurations. One is linear ELP, (GVGVPGEGVPGVGVP)12, and …
External Control Interface, Dynamic Modeling And Parameter Estimation Of A Research Treadmill, Omer Sirin
External Control Interface, Dynamic Modeling And Parameter Estimation Of A Research Treadmill, Omer Sirin
ETD Archive
Treadmills providing linear continuous movement are used for robotic testing of prostheses in order to study their operating characteristics. However, traditional exercise treadmills are not able to simulate various conditions such as avoiding an obstacle, climbing, descending, reversing direction, or stopping instantly. The focus of this thesis is to examine control algorithms (position, speed and force) for the drive mechanism of a research treadmill to fulll the gap in the situations described above. The system consists of a power supply, a computer with Matlab, and the treadmill that includes a DC motor, a pulley and belt. Also, an external encoder …
Bench-Top Validation Of "Intelligent" Mouth Guard, Alper Aksu
Bench-Top Validation Of "Intelligent" Mouth Guard, Alper Aksu
ETD Archive
Concussion is the signature athletics injury of the 21st Century. Scientists are hard at work monitoring effects of hard impacts on the human brain. However, existing tools and devices are inadequate to screen the effects. Hence, a new approach is required to accurately quantify peak values of head impacts or concussions and relate these values to clinical brain health outcomes. A new head impact dosimeter, the "Intelligent Mouth Guard" (IMG) has been developed and can be conveniently located inside the mouth. In this study, the IMG printed circuit board (PCB) including four (4) high-quality shock resistant sensors has been developed …
Scaffold Composition And Architecture Critically Regulate Extracellular Matrix Synthesis By Cardiomyocytes, Arsela Gishto
Scaffold Composition And Architecture Critically Regulate Extracellular Matrix Synthesis By Cardiomyocytes, Arsela Gishto
ETD Archive
Heart failure accounts for over 5 million cases in the U.S. A major onset of this is myocardial infarction, which causes the myocardium to loose cardiomyocytes and transform into a scar tissue. Given that the adult infarcted cardiac tissue has a limited ability to regenerate, alternative methods to restore the damaged area need to be developed. The goal of these approaches is to design an optimal scaffold that can retain and deliver cardiomyocytes at the site of damaged myocardium. This tissue engineering approach would allow cardiac reconstruction by replacing the lost cardiomyocytes, delivering the required biomolecules, as well as remodeling …
Computational Fluid Dynamics Modeling Of A Gravity Settler For Algae Dewatering, Scott A. Hug
Computational Fluid Dynamics Modeling Of A Gravity Settler For Algae Dewatering, Scott A. Hug
ETD Archive
Algae are the future of lipid sources for biodiesel production. Algae can produce more biodiesel than soybean and canola oil and can be grown in more diverse locations. Algae concentrations are naturally around 0.1 by weight. Enough water must be removed for the algae level to reach 5 , the minimum concentration in which lipids can be used in the transesterification process for biofuel production is 5 . Current dewatering methods involve the use of settling tanks and centrifugation. The costs of centrifugation limit the commercial viability of algae based biodiesel. A novel inclined gravity settler design at Cleveland State …
Moving Horizon Estimation With Dynamic Programming, Mohan Kumar Ramalingam
Moving Horizon Estimation With Dynamic Programming, Mohan Kumar Ramalingam
ETD Archive
Moving Horizon Estimation(MHE) is a optimization based strategy to state estimation. It involves computation of arrival cost, a penalty term, based on the MHE cost function. Minimization of this arrival cost is done through various methods. All these methods use nonlinear programming optimization technique which gives the estimate. The main idea of MHE revolves around minimizing the estimation cost function. The cost function is dependent on prediction error computation from data and arrival cost summarization. The major issue that hampers the MHE is choosing the arrival cost for ensuring stability of the overall estimation and computational time. In order to …
A Microfluidic Platform To Quantify Spatio-Temporal Diffusion Of Chemo-Gradients Within 3d Scaffolds: Applications In Axonal Biology, Michael A. Sawonik
A Microfluidic Platform To Quantify Spatio-Temporal Diffusion Of Chemo-Gradients Within 3d Scaffolds: Applications In Axonal Biology, Michael A. Sawonik
ETD Archive
Axonal outgrowth and guidance play an important role in wiring the developing and regenerating nervous system. The critical role of biomolecular gradients in facilitating this axonal sensitivity and directionality along specific trajectories needs to be elucidated for designing effective therapeutic treatments under injury or disease conditions. However, previous in vitro approaches based on micropipette assay or gel-turning assay proved to be unsuitable or inefficient for precise generation and quantification of diffusive gradients. In this study, we utilized a microfluidic device to generate and quantify physiologically-relevant biomolecular gradients in a simple and reliable manner. Using a combination of computational and experimental …
7d Cardiac Flow Mri: Techniques & Automation Of Reconstruction, Michael G. Ambrosia
7d Cardiac Flow Mri: Techniques & Automation Of Reconstruction, Michael G. Ambrosia
ETD Archive
Advances in magnetic resonance imaging to quantify the blood flow in the heart and major vessels stemming from the heart has recently allowed for advanced clinical applications for patients suffering from cardiac valve problems and aortic abnormalities. 7D cardiac flow quantification is relatively new, but has already shown potential in several clinical applications, including bicuspid valve and aortic coarctation characterization. In addition radiologists diagnosing valvular regurgitation may benefit from insight provided by the 7D cardiac flow quantification protocol. 7D cardiac flow quantification using magnetic resonance imaging will provide direction flow quantification in the anterior / posterior, head / foot, and …