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Articles 31 - 60 of 214
Full-Text Articles in Biomedical Engineering and Bioengineering
Semi-Quantitative Elemental Imaging Of Corrosion Products From Bioabsorbable Mg Vascular Implants In Vivo, Weilue He, Keith W. Macrenaris, Adam Griebel, Maria P. Kwesiga, Erico Freitas, Amani Gillette, Jeremy Schaffer, Thomas V. O'Halloran, Roger J. Guillory Ii
Semi-Quantitative Elemental Imaging Of Corrosion Products From Bioabsorbable Mg Vascular Implants In Vivo, Weilue He, Keith W. Macrenaris, Adam Griebel, Maria P. Kwesiga, Erico Freitas, Amani Gillette, Jeremy Schaffer, Thomas V. O'Halloran, Roger J. Guillory Ii
Michigan Tech Publications
While metal materials historically have served as permanent implants and were designed to avoid degradation, next generation bioabsorbable metals for medical devices such as vascular stents are under development, which would elute metal ions and corrosion byproducts into tissues. The fate of these eluted products and their local distribution in vascular tissue largely under studied. In this study, we employ a high spatial resolution spectrometric imaging modality, laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOF-MS) to map the metal distribution, (herein refered to as laser ablation mapping, or LAM) from Mg alloys within the mouse vascular system and approximate …
Developing A Nearly Automated Open-Source Pipeline For Conducting Computational Fluid Dynamics Simulations In Anterior Brain Vasculature: A Feasibility Study, Mostafa Rezaeitaleshmahalleh, Nan Mu, Zonghan Lyu, Joseph Gemmete, Aditya Pandey, Jingfeng Jiang
Developing A Nearly Automated Open-Source Pipeline For Conducting Computational Fluid Dynamics Simulations In Anterior Brain Vasculature: A Feasibility Study, Mostafa Rezaeitaleshmahalleh, Nan Mu, Zonghan Lyu, Joseph Gemmete, Aditya Pandey, Jingfeng Jiang
Michigan Tech Publications
Intracranial aneurysms (IA) pose significant health risks and are often challenging to manage. Computational fluid dynamics (CFD) simulation has emerged as a powerful tool for understanding lesion-specific hemodynamics in and around IAs, aiding in the clinical management of patients with an IA. However, the current workflow of CFD simulations is time-consuming, complex, and labor-intensive and, thus, does not fit the clinical environment. To address these challenges, we have developed a semi-automated pipeline integrating multiple open-source software packages to streamline the CFD simulation process. Specifically, the study utilized medical angiography data from 18 patients. An in-house open-source DL image segmentation model …
Ptsd Increases Risk For Hypertension Development Through Pvn Activation And Vascular Dysfunction In Sprague Dawley Rats, Xinqian Chen, Xin Yan, Chunxiu Yu, Qing-Hui Chen, Lanrong Bi, Zhiying Shan
Ptsd Increases Risk For Hypertension Development Through Pvn Activation And Vascular Dysfunction In Sprague Dawley Rats, Xinqian Chen, Xin Yan, Chunxiu Yu, Qing-Hui Chen, Lanrong Bi, Zhiying Shan
Michigan Tech Publications
This study investigates the impact of single prolonged stress (SPS), a model of post-traumatic stress disorder (PTSD), on cardiovascular responses, hypothalamic paraventricular nucleus (PVN) activity, and vascular function to elucidate the mechanisms linking traumatic stress to hypertension. Although SPS did not directly cause chronic hypertension in male Sprague Dawley (SD) rats, it induced acute but transient increases in blood pressure and heart rate and significantly altered the expression of hypertension-associated genes, such as vasopressin, angiotensin II type 1 receptor (AT1R), and FOSL1 in the PVN. Notably, mitochondrial reactive oxygen species (mtROS) were predominantly elevated in the pre-autonomic regions of the …
Multi-Modal Investigation Of The Bone Micro- And Ultrastructure, And Elemental Distribution In The Presence Of Mg-Xgd Screws At Mid-Term Healing Stages, Kamila Iskhakova, Hanna Cwieka, Svenja Meers, Heike Helmholz, Anton Davydok, Malte Storm, Ivo Matteo Baltruschat, Silvia Galli, Daniel Pröfrock, Olga Will, Mirko Gerle, Timo Damm, Sandra Sefa, Weilue He, Keith Macrenaris, Malte Soujon, Felix Beckmann, Julian Moosmann, Thomas O'Hallaran, Roger J. Guillory, D. C.Florian Wieland, Berit Zeller-Plumhoff, Regine Willumeit-Römer
Multi-Modal Investigation Of The Bone Micro- And Ultrastructure, And Elemental Distribution In The Presence Of Mg-Xgd Screws At Mid-Term Healing Stages, Kamila Iskhakova, Hanna Cwieka, Svenja Meers, Heike Helmholz, Anton Davydok, Malte Storm, Ivo Matteo Baltruschat, Silvia Galli, Daniel Pröfrock, Olga Will, Mirko Gerle, Timo Damm, Sandra Sefa, Weilue He, Keith Macrenaris, Malte Soujon, Felix Beckmann, Julian Moosmann, Thomas O'Hallaran, Roger J. Guillory, D. C.Florian Wieland, Berit Zeller-Plumhoff, Regine Willumeit-Römer
Michigan Tech Publications
Magnesium (Mg) – based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing, e.g. as a suture anchor. Due to their mechanical properties and biocompatibility, they may replace titanium or stainless-steel implants, commonly used in orthopedic field. Nevertheless, patient safety has to be assured by finding a long-term balance between metal degradation, osseointegration, bone ultrastructure adaptation and element distribution in organs. In order to determine the implant behavior and its influence on bone and tissues, we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to …
Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion, Brennan Vogl, Emily Vitale, Sunyoung Ahn, Agata Sularz, Alejandra Chavez Ponce, Gerardo V. Lo Russo, Jeremy Collins, Alessandra Maria Bavo, Ahmed El Shaer, Anders Kramer, Yuheng Jia, Davorka Lulic, Matthieu De Beule, Jens Erik Nielsen-Kudsk, Ole De Backer, Mohamad Alkhouli, Hoda Hatoum
Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion, Brennan Vogl, Emily Vitale, Sunyoung Ahn, Agata Sularz, Alejandra Chavez Ponce, Gerardo V. Lo Russo, Jeremy Collins, Alessandra Maria Bavo, Ahmed El Shaer, Anders Kramer, Yuheng Jia, Davorka Lulic, Matthieu De Beule, Jens Erik Nielsen-Kudsk, Ole De Backer, Mohamad Alkhouli, Hoda Hatoum
Michigan Tech Publications
Background: Device-related thrombosis (DRT) occurs in up to 4% of patients undergoing left atrial appendage occlusion (LAAO) and is associated with substantial morbidity and mortality. However, its pathophysiology, predictors, and optimal management remain unclear. Objectives: This study aims to assess flow dynamic factors correlating to DRT. Methods: A multicenter registry of patients who underwent LAAO and had pre- and post-computed tomography imaging was used. Patient-specific 3-dimensional digital models of the left atrium were created, and finite element simulations were performed to implant an LAAO device into each model in a position that matched the clinical deployment. Computational fluid dynamic simulations …
Radiopaque Femnn-Mo Composite Drawn Filled Tubing Wires For Braided Absorbable Neurovascular Devices, Adam J. Griebel, Petra Maier, Henry D. Summers, Benjamin Clausius, Isabella Kanasty, Weilue He, Nicholas Peterson, Carolyn Czerniak, Alexander A. Oliver, David F. Kallmes, Ramanathan Kadirvel, Jeremy E. Schaffer, Roger J. Guillory
Radiopaque Femnn-Mo Composite Drawn Filled Tubing Wires For Braided Absorbable Neurovascular Devices, Adam J. Griebel, Petra Maier, Henry D. Summers, Benjamin Clausius, Isabella Kanasty, Weilue He, Nicholas Peterson, Carolyn Czerniak, Alexander A. Oliver, David F. Kallmes, Ramanathan Kadirvel, Jeremy E. Schaffer, Roger J. Guillory
Michigan Tech Publications
Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain, stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture. Current devices are formed from thin (∼25 μm) wires which will remain in place long after the aneurysm has been mitigated. As their continued presence could lead to secondary complications, an absorbable flow diverter which dissolves into the body after aneurysm occlusion is desirable. The absorbable metals investigated to date struggle to achieve the necessary combination of strength, elasticity, corrosion rate, fragmentation resistance, radiopacity, and biocompatibility. This work proposes and …
Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim, Cody Tuftee, Asma Talib Qureshi, Rachel Callaghan, Moira L. Geary, Mithun Santra, Vaibhav Pal, Ilayda Namli, Gary Hin Fai Yam, Ibrahim T. Ozbolat, Muhammad Rizwan
Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim, Cody Tuftee, Asma Talib Qureshi, Rachel Callaghan, Moira L. Geary, Mithun Santra, Vaibhav Pal, Ilayda Namli, Gary Hin Fai Yam, Ibrahim T. Ozbolat, Muhammad Rizwan
Michigan Tech Publications
Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM) microenvironment to support cellular growth, and adhere robustly to damaged tissues are highly needed to advance tissue engineering. Protein-based biomaterials are promising due to their inherent biocompatibility, biomimicry, biodegradation, and cell-supportive properties. Herein, by leveraging the unique ability of dithiolanes to generate on-demand in situ thiols, a new class of dithiolane-modified, protein-based biomaterial that combines unique, seemingly opposing functions for tissue engineering is developed. Dithiolane-modified gelatin, a model protein used herein, enabled photoinitiator-free photo-crosslinking to form multi-functional gelatin-dithiolane (GelDT) hydrogels, which displayed exceptional long-term stability in cell culture media ( …
Salicylhydroxamic Acid Containing Structural Adhesive, Md Saleh Akram Bhuiyan, Kan Wang, Seyedehfatemeh Razaviamri, Bruce Lee
Salicylhydroxamic Acid Containing Structural Adhesive, Md Saleh Akram Bhuiyan, Kan Wang, Seyedehfatemeh Razaviamri, Bruce Lee
Michigan Tech Publications
The feasibility of utilizing salicylhydroxamic acid (SHAM) as a new adhesive molecule for designing structural adhesives is investigated in this study. SHAM-containing polymers were prepared with a hydroxyethyl methacrylate (HEMA) or methoxyethyl acrylate (MEA) backbone and mixed with polyvinylidene fluoride (PVDF). PVDF was included to increase the cohesive property of the adhesive through hydrogen bond (H-bond) formation with the adhesive polymers. SHAM-containing adhesive demonstrated lap shear adhesion strength (S ) greater than 0.9 MPa to glass, metal, and polymeric surfaces. Adhesive formulations with elevated SHAM-content also demonstrated increased adhesive properties with S values reaching as high as 4.8 MPa. Due …
High-Throughput Analysis Of Topographical Cues For The Expansion Of Murine Pluripotent Stem Cells, Abigail Anne Conner, Yuan Yao, Sarah W. Chan, Deepak Jain, Suzanne M. Wong, Evelyn K. Yim, Muhammad Rizwan
High-Throughput Analysis Of Topographical Cues For The Expansion Of Murine Pluripotent Stem Cells, Abigail Anne Conner, Yuan Yao, Sarah W. Chan, Deepak Jain, Suzanne M. Wong, Evelyn K. Yim, Muhammad Rizwan
Michigan Tech Publications
The expansion of pluripotent stem cells (PSCs) in vitro remains a critical barrier to their use in tissue engineering and regenerative medicine. Biochemical methods for PSC expansion are known to produce heterogeneous cell populations with varying states of pluripotency and are cost-intensive, hindering their clinical translation. Engineering biomaterials to physically control PSC fate offers an alternative approach. Surface or substrate topography is a promising design parameter for engineering biomaterials. Topographical cues have been shown to elicit profound effects on stem cell differentiation and proliferation. Previous reports have shown isotropic substrate topographies to be promising in expanding PSCs. However, the optimal …
Thrombogenicity Of Biodegradable Metals, D. E.J. Anderson, H. H. Le, H. Vu, J. Johnson, J. E. Aslan, J. Goldman, M. T. Hinds
Thrombogenicity Of Biodegradable Metals, D. E.J. Anderson, H. H. Le, H. Vu, J. Johnson, J. E. Aslan, J. Goldman, M. T. Hinds
Michigan Tech Publications
Biodegradable metals offer a promising means to ameliorate many of the long-term risks associated with vascular devices made of conventional biostable stent metals. While numerous biodegradable metal alloys have been developed and characterized in animal models, knowledge of their blood reactivity and thrombogenicity remains unknown. Metal hemocompatibility is particularly valuable because current generation drug-eluting stents pose a significant long-term thrombosis risk. In this study, four pure metals, widely used as degradable base materials (Fe, Zn, Mg, and Mo), and three alloys commonly used in cardiovascular devices [NiTi, CoCr, and stainless steel (SS)] were evaluated. This work examined how each of …
Editorial: Mitral Valve Disease: Mechanisms To Therapies, Maria Carmo Nunes, Hoda Hatoum, Alison M. Pouch, Muralidhar Padala
Editorial: Mitral Valve Disease: Mechanisms To Therapies, Maria Carmo Nunes, Hoda Hatoum, Alison M. Pouch, Muralidhar Padala
Michigan Tech Publications
No abstract provided.
Aerobic Exercise Improves Depressive Symptoms In The Unilateral 6-Ohda-Lesioned Rat Model Of Parkinson's Disease, Hannah Loughlin, Jacob Jackson, Chloe Looman, Alayna Starll, Jeremy Goldman, Zhiying Shan, Chunxiu Yu
Aerobic Exercise Improves Depressive Symptoms In The Unilateral 6-Ohda-Lesioned Rat Model Of Parkinson's Disease, Hannah Loughlin, Jacob Jackson, Chloe Looman, Alayna Starll, Jeremy Goldman, Zhiying Shan, Chunxiu Yu
Michigan Tech Publications
Aerobic exercise has been shown to have established benefits on motor function in Parkinson's disease (PD). However, the impact of exercise on depressive symptoms in PD remains unclear. This study aimed to investigate the effects of regular exercise, specifically using a forced running wheel, on both motor performance and the prevalence of depression in a unilateral 6-OHDA-lesioned rat model of PD. The behavioral outcomes of exercise were assessed through the rotarod test (RT), forelimb adjusting step test (FAST), sucrose consumption test (SCT), and novelty sucrose splash test (NSST). Our data revealed evident depressive symptoms in the PD animals, characterized by …
Association Of Bovine Arch Anatomy With Incident Stroke After Transcatheter Aortic Valve Replacement, Gerardo V. Lo Russo, Hasan S. Alarouri, Abdulah Al-Abcha, Brennan Vogl, Abdulah Mahayni, Agata Sularz, Hoda Hatoum, Jeremy Collins, Juan A. Crestanello, Mohamad Alkhouli
Association Of Bovine Arch Anatomy With Incident Stroke After Transcatheter Aortic Valve Replacement, Gerardo V. Lo Russo, Hasan S. Alarouri, Abdulah Al-Abcha, Brennan Vogl, Abdulah Mahayni, Agata Sularz, Hoda Hatoum, Jeremy Collins, Juan A. Crestanello, Mohamad Alkhouli
Michigan Tech Publications
BACKGROUND: Acute ischemic stroke complicates 2 % to 3 % of transcatheter aortic valve replacements (TAVRs). This study aimed to identify the aortic anatomic correlates in patients after TAVR stroke. METHODS AND RESULTS: This is a single-center, retrospective study of patients who underwent TAVR at the Mayo Clinic between 2012 and 2022. The aortic arch morphology was determined via a manual review of the pre-TAVR computed tomography images. An "a priori" approach was used to select the covariates for the following: (1) the logistic regression model assessing the association between a bovine arch and periprocedural stroke (defined as stroke within …
Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han
Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han
Michigan Tech Publications
Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction-a measure of …
Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish K. Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han
Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish K. Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han
Michigan Tech Publications
Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction—a measure of …
Polymerizing Actin Regulates Myosin-Independent Mechanosensing By Modulating Actin Elasticity And Flow Fluctuation, Nikhil Mittal, Etienne Michels, Kathleen Pakenas, Shaina P. Royer-Weeden, Sangyoon J. Han
Polymerizing Actin Regulates Myosin-Independent Mechanosensing By Modulating Actin Elasticity And Flow Fluctuation, Nikhil Mittal, Etienne Michels, Kathleen Pakenas, Shaina P. Royer-Weeden, Sangyoon J. Han
Michigan Tech Publications
The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions. However, it has been unclear if the stiffness-dependent differential tension is induced solely by myosin activity. Here, we report that in the absence of myosin contractility, 3T3 fibroblasts still transmit stiffness-dependent differential levels of traction. This myosin-independent differential traction is regulated by polymerizing actin assisted by actin nucleators Arp2/3 and formin where formin has stronger contribution than Arp2/3. Interestingly, we report a four-fold reduction in traction of cells when both Arp2/3 and myosin were inhibited, compared to cells with only myosin inhibition, while there was only a slight …
Heterologous Expression Of Arabidopsis Laccase2, Laccase4 And Peroxidase52 Driven Under Developing Xylem Specific Promoter Dx15 Improves Saccharification In Populus, Yogesh Ahlawat, Ajaya K. Biswal, Sarahani Harun, Anne E. Harman-Ware, Crissa Doeppke, Nisha Sharma, Chandrashekhar P. Joshi, Bertrand B. Hankoua
Heterologous Expression Of Arabidopsis Laccase2, Laccase4 And Peroxidase52 Driven Under Developing Xylem Specific Promoter Dx15 Improves Saccharification In Populus, Yogesh Ahlawat, Ajaya K. Biswal, Sarahani Harun, Anne E. Harman-Ware, Crissa Doeppke, Nisha Sharma, Chandrashekhar P. Joshi, Bertrand B. Hankoua
Michigan Tech Publications
Background: Secondary cell wall holds considerable potential as it has gained immense momentum to replace the lignocellulosic feedstock into fuels. Lignin one of the components of secondary cell wall tightly holds the polysaccharides thereby enhancing the recalcitrance and complexity in the biomass. Laccases (LAC) and peroxidases (PRX) are the major phenyl-oxidases playing key functions during the polymerization of monolignols into lignin. Yet, the functions of laccase and peroxidases gene families remained largely unknown. Hence, the objective of this conducted study is to understand the role of specific LAC and PRX in Populus wood formation and to further investigate how the …
Myosin-Independent Stiffness Sensing By Fibroblasts Is Regulated By The Viscoelasticity Of Flowing Actin, Nikhil Mittal, Etienne B. Michels, Andrew E. Massey, Yunxiu Qiu, Shaina P. Royer-Weeden, Bryan R. Smith, Alexander X. Cartagena-Rivera, Sangyoon J. Han
Myosin-Independent Stiffness Sensing By Fibroblasts Is Regulated By The Viscoelasticity Of Flowing Actin, Nikhil Mittal, Etienne B. Michels, Andrew E. Massey, Yunxiu Qiu, Shaina P. Royer-Weeden, Bryan R. Smith, Alexander X. Cartagena-Rivera, Sangyoon J. Han
Michigan Tech Publications
The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions, triggering differential mechanoresponses. However, it has been unclear if the stiffness-dependent differential tension is induced solely by myosin activity. Here, we report that in the absence of myosin contractility, 3T3 fibroblasts still transmit stiffness-dependent differential levels of traction. This myosin-independent differential traction is regulated by polymerizing actin assisted by actin nucleators Arp2/3 and formin where formin has a stronger contribution than Arp2/3 to both traction and actin flow. Intriguingly, despite only slight changes in F-actin flow speed observed in cells with the combined inhibition of Arp2/3 and myosin …
Matrix Stiffness Sensing By Nascent Adhesions And The Role Of Riam In Adhesion Assembly, Nikhil Mittal
Matrix Stiffness Sensing By Nascent Adhesions And The Role Of Riam In Adhesion Assembly, Nikhil Mittal
Dissertations, Master's Theses and Master's Reports
Mechanical stiffness of the extracellular matrix (ECM) impacts many cellular functions such as proliferation, migration, and differentiation. ECM stiffness is sensed by a cell via integrin-based focal adhesions (FAs) by changing conformation and biochemical activities of molecules within FAs by the exchange of the force between the ECM and filamentous actin (F-actin). Cells in turn respond to this stiffness by generating traction force that plays an important role in many biological events such as tissue morphogenesis, stem cell differentiation, wound healing, and cancer cell metastasis. The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions. Understanding stiffness sensing …
Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim
Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim
Dissertations, Master's Theses and Master's Reports
Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM) microenvironment to support cellular growth, and adhere robustly to damaged tissues are highly needed to advance tissue engineering. Protein-based biomaterials are promising due to their inherent biocompatibility, biomimicry, biodegradation, and cell-supportive properties. Herein, by leveraging the unique ability of dithiolanes to generate on-demand in-situ thiols, we developed a new class of dithiolane-modified, protein-based biomaterial that combines unique, seemingly opposing functions for tissue engineering. Dithiolane-modified gelatin, a model protein used herein, enabled photoinitiator-free photo-crosslinking to form multi-functional gelatin-dithiolane (GelDT) hydrogels, which displayed exceptional long-term stability in cell culture media (>28 …
Computational Analysis Of Vascular Aneurysms, Seyedmostafa Rezaeitaleshmahalleh
Computational Analysis Of Vascular Aneurysms, Seyedmostafa Rezaeitaleshmahalleh
Dissertations, Master's Theses and Master's Reports
Vascular aneurysms, such as intracranial aneurysms (IAs) and abdominal aortic aneurysms (AAAs), pose significant health risks, particularly upon rupture. Disturbed hemodynamics, characterized by swirling flow patterns, can lead to cellular and structural changes that disrupt normal physiological processes and contribute to destructive vascular remodeling. Integrating hemodynamic analysis into clinical assessments of aneurysms has become crucial, especially through patient-specific computational fluid dynamics (CFD) simulations based on medical imaging. However, the complexity of CFD tools presents challenges in model creation and post-simulation analysis, limiting their accessibility to clinicians.
This project aimed to advance aneurysm management by exploring the role of intraluminal thrombus …
Modular Open-Source Design Of Pyrolysis Reactor Monitoring And Control Electronics, Finn K. Hafting, Daniel G. Kulas, Etienne Michels, Sarvada Chipkar, Stefan Wisniewski, David Shonnard, Joshua M. Pearce
Modular Open-Source Design Of Pyrolysis Reactor Monitoring And Control Electronics, Finn K. Hafting, Daniel G. Kulas, Etienne Michels, Sarvada Chipkar, Stefan Wisniewski, David Shonnard, Joshua M. Pearce
Michigan Tech Publications
Industrial pilot projects often rely on proprietary and expensive electronic hardware to control and monitor experiments. This raises costs and retards innovation. Open-source hardware tools exist for implementing these processes individually; however, they are not easily integrated with other designs. The Broadly Reconfigurable and Expandable Automation Device (BREAD) is a framework that provides many open-source devices which can be connected to create more complex data acquisition and control systems. This article explores the feasibility of using BREAD plug-and-play open hardware to quickly design and test monitoring and control electronics for an industrial materials processing prototype pyrolysis reactor. Generally, pilot-scale pyrolysis …
Perfusability And Immunogenicity Of Implantable Pre-Vascularized Tissues Recapitulating Features Of Native Capillary Network, Dhavan Sharma, Archita Sharma, Linghao Hu, Te An Chen, Sarah Voon, Kayla J. Bayless, Jeremy Goldman, Alex J. Walsh, Feng Zhao
Perfusability And Immunogenicity Of Implantable Pre-Vascularized Tissues Recapitulating Features Of Native Capillary Network, Dhavan Sharma, Archita Sharma, Linghao Hu, Te An Chen, Sarah Voon, Kayla J. Bayless, Jeremy Goldman, Alex J. Walsh, Feng Zhao
Michigan Tech Publications
Vascularization is a key pre-requisite to engineered anatomical scale three dimensional (3-D) constructs to ensure their nutrient and oxygen supply upon implantation. Presently, engineered pre-vascularized 3-D tissues are limited to only micro-scale hydrogels, which meet neither the anatomical scale needs nor the complexity of natural extracellular matrix (ECM) environments. Anatomical scale perfusable constructs are critically needed for translational applications. To overcome this challenge, we previously developed pre-vascularized ECM sheets with long and oriented dense microvascular networks. The present study further evaluated the patency, perfusability and innate immune response toward these pre-vascularized constructs. Macrophage-co-cultured pre-vascularized constructs were evaluated in vitro to …
Differential Impact Of Blood Pressure Control Targets On Epicardial Coronary Flow After Transcatheter Aortic Valve Replacement, Brennan Vogl, Alejandra Chavez-Ponce, Adam Wentworth, Eric Erie, Pradeep Yadav, Vinod H. Thourani, Lakshmi Prasad Dasi, Brian Lindman, Mohamad Alkhouli, Hoda Hatoum
Differential Impact Of Blood Pressure Control Targets On Epicardial Coronary Flow After Transcatheter Aortic Valve Replacement, Brennan Vogl, Alejandra Chavez-Ponce, Adam Wentworth, Eric Erie, Pradeep Yadav, Vinod H. Thourani, Lakshmi Prasad Dasi, Brian Lindman, Mohamad Alkhouli, Hoda Hatoum
Michigan Tech Publications
Background: The cause for the association between increased cardiovascular mortality rates and lower blood pressure (BP) after aortic valve replacement (AVR) is unclear. This study aims to assess how the epicardial coronary flow (ECF) after AVR varies as BP levels are changed in the presence of a right coronary lesion. Methods: The hemodynamics of a 3D printed aortic root model with a SAPIEN 3 26 deployed were evaluated in an in vitro left heart simulator under a range of varying systolic blood pressure (SBP) and diastolic blood pressure (DBP). ECF and the flow ratio index were calculated. Flow index value …
S-Net: A Multiple Cross Aggregation Convolutional Architecture For Automatic Segmentation Of Small/Thin Structures For Cardiovascular Applications, Nan Mu, Zonghan Lyu, Mostafa Rezaeitaleshmahalleh, Cassie Bonifas, Jordan Gosnell, Marcus Haw, Joseph Vettukattil, Jingfeng Jiang
S-Net: A Multiple Cross Aggregation Convolutional Architecture For Automatic Segmentation Of Small/Thin Structures For Cardiovascular Applications, Nan Mu, Zonghan Lyu, Mostafa Rezaeitaleshmahalleh, Cassie Bonifas, Jordan Gosnell, Marcus Haw, Joseph Vettukattil, Jingfeng Jiang
Michigan Tech Publications
With the success of U-Net or its variants in automatic medical image segmentation, building a fully convolutional network (FCN) based on an encoder-decoder structure has become an effective end-to-end learning approach. However, the intrinsic property of FCNs is that as the encoder deepens, higher-level features are learned, and the receptive field size of the network increases, which results in unsatisfactory performance for detecting low-level small/thin structures such as atrial walls and small arteries. To address this issue, we propose to keep the different encoding layer features at their original sizes to constrain the receptive field from increasing as the network …
Bioinspired Materials For Underwater Adhesion With Pathways To Switchability, Chanhong Lee, Huiqi Shi, Jiyoung Jung, Bowen Zheng, Kan Wang, Ravi Tutika, Rong Long, Bruce Lee, Grace X. Gu, Michael D. Bartlett
Bioinspired Materials For Underwater Adhesion With Pathways To Switchability, Chanhong Lee, Huiqi Shi, Jiyoung Jung, Bowen Zheng, Kan Wang, Ravi Tutika, Rong Long, Bruce Lee, Grace X. Gu, Michael D. Bartlett
Michigan Tech Publications
Strong adherence to underwater or wet surfaces for applications like tissue adhesion and underwater robotics is a significant challenge. This is especially apparent when switchable adhesion is required that demands rapid attachment, high adhesive capacity, and easy release. Nature displays a spectrum of permanent to reversible attachment from organisms ranging from the mussel to the octopus, providing inspiration for underwater adhesion design that has yet to be fully leveraged in synthetic systems. Here, we review the challenges and opportunities for creating underwater adhesives with a pathway to switchability. We discuss key material, geometric, modeling, and design tools necessary to achieve …
The Effect Of Slow Strain Rate Tension And Cyclic Loading On Biodegradable Zn–2%Fe–0.8%Mn Alloy In A Simulated Physiological Environment, Lital Ben Tzion-Mottye, Adi Bahar, Tomer Ron, Galit Katarivas Levy, Jeremy Goldman, Dan Eliezer, Eli Aghion
The Effect Of Slow Strain Rate Tension And Cyclic Loading On Biodegradable Zn–2%Fe–0.8%Mn Alloy In A Simulated Physiological Environment, Lital Ben Tzion-Mottye, Adi Bahar, Tomer Ron, Galit Katarivas Levy, Jeremy Goldman, Dan Eliezer, Eli Aghion
Michigan Tech Publications
Zinc-based alloys have gained increased interest as biodegradable structural materials for medical applications due to their adequate biocompatibility, crucial roles in many physiological functions and attractive antibacterial properties. However, the major drawbacks of zinc alloys relate to their inadequate mechanical properties and tendency to provoke fibrous encapsulation due to relatively high standard potential. Based on the promising effect of Mn on properties of Zn-based alloys, the present study aimed at evaluating the suitability of Zn–2%Fe–0.8%Mn alloy as a potential biodegradable implant under in-vitro conditions. This evaluation focused on the passivation characteristics as determined by cyclic potentiodynamic polarization analysis, immersion test, …
Magnesium-Based Nanocomposites: A Review From Mechanical, Creep And Fatigue Properties, S. Abazari, A. Shamsipur, H. R. Bakhsheshi-Rad, J. W. Drelich, J. Goldman, S. Sharif, A. F. Ismail, M. Razzaghi
Magnesium-Based Nanocomposites: A Review From Mechanical, Creep And Fatigue Properties, S. Abazari, A. Shamsipur, H. R. Bakhsheshi-Rad, J. W. Drelich, J. Goldman, S. Sharif, A. F. Ismail, M. Razzaghi
Michigan Tech Publications
The addition of nanoscale additions to magnesium (Mg) based alloys can boost mechanical characteristics without noticeably decreasing ductility. Since Mg is the lightest structural material, the Mg-based nanocomposites (NCs) with improved mechanical properties are appealing materials for lightweight structural applications. In contrast to conventional Mg-based composites, the incorporation of nano-sized reinforcing particles noticeably boosts the strength of Mg-based nanocomposites without significantly reducing the formability. The present article reviews Mg-based metal matrix nanocomposites (MMNCs) with metallic and ceramic additions, fabricated via both solid-based (sintering and powder metallurgy) and liquid-based (disintegrated melt deposition) technologies. It also reviews strengthening models and mechanisms that …
Conventional Platinum Metal Implants Provoke Restenosis Responses In Atherogenic But Not Healthy Arteries, Lea M. Morath, Roger J. Guillory Ii, Alexander A. Oliver, Shu Q. Liu, Martin L. Bocks, Galit Katarivas Levy, Jaroslaw Drelich, Jeremy Goldman
Conventional Platinum Metal Implants Provoke Restenosis Responses In Atherogenic But Not Healthy Arteries, Lea M. Morath, Roger J. Guillory Ii, Alexander A. Oliver, Shu Q. Liu, Martin L. Bocks, Galit Katarivas Levy, Jaroslaw Drelich, Jeremy Goldman
Michigan Tech Publications, Part 1
Platinum-containing stents are commonly used in humans with hypercholesterolemia, whereas preclinical stent evaluation has commonly been performed in healthy animal models, providing inadequate information about stent performance under hypercholesterolemic conditions. In this investigation, we used an ApoE−/− mouse model to test the impact of hypercholesterolemia on neointima formation on platinum-containing implants. We implanted 125 μm diameter platinum wires into the abdominal aortas of ApoE−/− and ApoE+/+ mice for 6 months, followed by histological and immunofluorescence examination of neointimal size and composition. It was found that ApoE−/− mice developed neointimas with four times larger area and ten times greater thickness than …
Biodegradable Magnesium Materials Regulate Ros-Rns Balance In Pro-Inflammatory Macrophage Environment, Maria Paula Kwesiga, Amani A. Gillette, Seyedehfatemeh Razaviamri, Margaret E. Plank, Alexia L. Canull, Zachary Alesch, Weilue He, Bruce Lee, Roger J. Guillory Ii
Biodegradable Magnesium Materials Regulate Ros-Rns Balance In Pro-Inflammatory Macrophage Environment, Maria Paula Kwesiga, Amani A. Gillette, Seyedehfatemeh Razaviamri, Margaret E. Plank, Alexia L. Canull, Zachary Alesch, Weilue He, Bruce Lee, Roger J. Guillory Ii
Michigan Tech Publications, Part 1
The relationship between reactive oxygen and nitrogen species (ROS-RNS) secretion and the concomitant biocorrosion of degradable magnesium (Mg) materials is poorly understood. We found that Mg foils implanted short term in vivo (24 h) displayed large amounts of proinflammatory F4/80+/iNOS + macrophages at the interface. We sought to investigate the interplay between biodegrading Mg materials (98.6% Mg, AZ31 & AZ61) and macrophages (RAW 264.7) stimulated with lipopolysaccharide (RAW 264.7LPS) to induce ROS-RNS secretion. To test how these proinflammatory ROS-RNS secreting cells interact with Mg corrosion in vitro, Mg and AZ61 discs were suspended approximately 2 mm above a monolayer of …