Biomedical Engineering and Bioengineering Commons^™

Force Mapping Wand For Individuals With Upper-Limb Amputations, Max Bosse, Cole Capitani, Eddie Grassini

Biomedical Engineering

Technology relating to upper-limb amputations has seen many advances in recent years, especially in terms of function and aesthetic appeal. Although these improvements exist, comfort is often a primary concern among prosthetic users and can lead to prosthetic abandonment [1]. Without a standardized method of measuring force concentrations in patients, high rates of discomfort and potential tissue damage remain. The goal of this project is to create a force mapping system for upper-limb amputees to help minimize discomfort in socket fit during the fitting process using real-time data and software to view force concentrations. To accomplish this goal, background research …

Cruising On The Beach (Cob), Juan Diego Molina Ii, Ashley Kianna Burga

Biomedical Engineering

This report details the design and development process of Cruising on the Beach (COB), a modular motorized wheelchair intended to improve beach accessibility for high school students with mobility impairments. The project aimed to create an affordable, portable, and sand-capable device using balloon wheels, an adjustable control panel, and a customizable base. Extensive background research, market analysis, design modeling, and test plans were completed. However, final fabrication was not achieved due to financial constraints and limited access to industrial machining tools needed for custom metal components. Despite these setbacks, the project delivered a robust conceptual design and a fully …

Investigating The Effects Of Hepatocyte Growth Factor On Primary Myoblast Proliferation, Grace Heller

Biomedical Engineering

Peripheral artery occlusive disease (PAOD) is a progressive vascular condition that affects over 200 million people worldwide and approximately 8 million in the United States. It is characterized by atherosclerotic narrowing of peripheral arteries, leading to reduced blood flow, ischemia, and, in severe cases, tissue loss and limb amputation. Although surgical revascularization is the gold standard, many patients—particularly those with comorbidities like diabetes— continue to experience poor outcomes, emphasizing the need for alternative therapies. One promising strategy is to enhance collateral arteriogenesis, the remodeling and enlargement of collateral arterioles that naturally bypass occluded vessels. Satellite cells (SCs), which give rise …

Assessing Arterial Compliance: Utilizing A Surrogate Arm Bench Top Model For Oscillometric Blood Pressure Monitoring, Krystal Cardenas

Master's Theses

A study was conducted to evaluate the compliance of artificial artery systems utilizing an adaptation of the Yong-Geddes Surrogate Arm model, composed of a blood pressure cuff, artificial artery, pressure transducers, and flow to replicate physiological conditions to validate oscillometric non-invasive blood pressure measurement methods. The experiment phases included tube, blood pressure cuff, and the surrogate arm compliance tests both in static and dynamic conditions. Tube compliance tests showed that larger diameters resulted in increased compliance, with Sample 1 (smaller inner diameter, ID) resulting in an average compliance of 0.0912 mL/mmHg, and Sample 2 (bigger ID) resulting in 0.1597 mL/mmHg. …

Realistic Bionic Arm Development For Transradial Amputation, Bailey A. Wall, Lilly Noel Curdy, Ruthie Mccall, Courtney Mahoney, Andres Trejo

Biomedical Engineering

The VeraLimb realistic bionic arm is intended for use by individuals with a trans-radial amputation or congenital limb deficiency below the elbow to provide functional hand and arm movements. This advanced prosthetic device is designed to mimic a biological hand's natural motion, dexterity, control, and aesthetic, giving the user a higher sense of restored limb functionality. It offers an experience that closely restores motor function in a way that resembles having a natural hand rather than interacting with a mechanical device. The VeraLimb is suitable for daily activities, allowing users to grasp, manipulate, and interact with objects. It is designed …

Operating Room Forcing Function, Olivia Rankin, Makena Moragne, Sasha Rovinsky

Biomedical Engineering

The Operating Room Forcing Function system aims to address the persistent issue of wrong-site, wrong-procedure, and wrong-patient errors (WSPEs) in surgical settings. WSPEs are largely caused by circumvention of the timeout procedure (a planned pause before incision to stop and confirm crucial details of the procedure to be performed known as ‘The Universal Protocol’). The goal set forth by our sponsor, Dr. Robert Turbow, is to develop a lock-out mechanism that requires a timeout to be performed by all appropriate personnel before an operation can begin.

Hospitals are extremely complex systems with competing values, productivity pressures, fast paced work, tight-coupled …

The Suture Guide, Nicole Schnettler, Ciara Murphy, Jocelyn Corona Cabrera

Biomedical Engineering

In the surgical field and specifically wound closure, there is a growing demand for techniques that allow surgeons to quickly, accurately, and ergonomically close surgical wounds while still optimizing patient recovery and not compromising the cosmetic appearance in wound closure. Currently more advanced and developed products exist for laparoscopic suturing, but not for superficial suturing. This project aims to find a way to close the most superficial layer of the skin in surgical incisions that is faster and more comfortable than current suturing techniques. The design process began with stakeholder interviews and market research, identifying key shortcomings of current manual …

Treating Ground Water For Agricultural And Individual Consumption, Gabby Miller, Bronson Scott, Michael Clawson

Biomedical Engineering

This project, conducted in collaboration with Cal Poly seniors and Da Vinci High School students, aims to develop a solar-powered groundwater purification system. This system is designed to provide clean water for agricultural use and individual consumption, addressing the growing concerns of groundwater contamination and accessibility needs. The final prototype integrates a gravity filtration system combined with chemical purification, utilizing aluminum sulfate and chlorine to remove particulates, bacteria, and organic compounds.

The research phase involved an extensive review of groundwater contamination issues, existing filtration technologies, and market analysis. Key design constraints included cost-effectiveness, ease of maintenance, and minimal energy consumption, …

Tiny Temp Neonatal Intensive Care Unit Infant Temperature Monitor, Alexandria Lukacsffi, Sydney Dedrick

Biomedical Engineering

This document outlines the key steps taken in the specification, design, and functionality of the Tiny Temp Neonatal Intensive Care Unit Infant Temperature Monitor. The BICEP team identified temperature monitors for infants in incubators in the NICU as an area of need after surveying hospitals in the San Luis Obispo area. Current thermometers are oversimplified in design, consisting of only the temperature probe and a piece of adhesive holding the probe directly onto the infant's skin. As a result, the adhesive is weak to prevent harm to the infant and, therefore, falls off the infant easily and frequently, posing a …

Peripheral Vagus Nerve Stimulation (Pvns) Device For Epilepsy, Logan P. Beckstrand, Alexander P. Crary, Grace E. Heller

Biomedical Engineering

Our research team developed a PVNS for Epilepsy device which is intended to act as a preventative measure against seizures for patients with epilepsy. The device is a less invasive alternative to the VNS device on the market using electroacupuncture at the Shenmen and Xin points along the posterior pinna to stimulate the vagus nerve.

Sprinter Start Block Training Aid, Kayla Lovejoy, Kevin Almontes

Biomedical Engineering

Currently, track and field sprinters ranging from beginner level to world-class have no practical tool that provides quantitative feedback of value on quality of start and quality of the three distinct phases of their sprint race, such that they can quantify the value of their adjustments. Our team will create a device that integrates with the sprint starting block to provide quantifiable data on the quality of a sprinter’s start. This Statement of Work describes drawbacks of current solutions, existing patents, customer requirements, engineering specifications, and our project plan.

Maglock - Electromagnetic Pedal Aid For Amputees, Minh Vo, Matthew Chew

Biomedical Engineering

For this project, we aimed to design components that could easily be swapped out and into vehicles, which would help them accomplish the task of locating and securing a prosthetic foot to a bike and/or car pedal. A common problem among cyclists and drivers with prosthetic legs is their foot slipping off the pedal while in use; these components could be used for other common applications such as cars, bikes, etc. Stakeholders for this product included automotive companies and handicap product distributors. The focused objective is to provide dexterity and quick attach/detach support for cyclists and drivers with lower limb …

Measuring Gait Of Total Knee Arthroplasty Patients Pre-Op And Post-Op Using A Smartphone, Celeste A. Thai

Master's Theses

Motion capture technology is a tool often used in orthopedic applications, including measuring gait dysfunctions. However, gait analysis research focused on total knee arthroplasty (TKA) patients is limited, especially using motion capture systems. This may be due to a multitude of factors, such as inaccessibility to gait labs to the general public, difficulty of travel post-surgery, and overall costs of care and maintenance of motion lab equipment. New emerging novel methods use wearable devices such as smartphones and inertial measurement devices (IMUs) to perform gait assessment and are becoming favorable due to their increasingly ubiquitous nature. One such method using …

Design And Testing Of A Prototype Prosthesis For Pediatric Upper-Limb Transradial Amputees To Provide Adjustable Size And Modular Characteristics, Paul Heli

Master's Theses

This study was conducted to develop a financially accessible body-powered upper-limb prosthetic socket that can be adjusted to maintain fit and function for a growing child with a transradial amputation. The main objectives of the study were to design, manufacture, and test a device that was comfortable, functional, affordable, and adjustable. The socket was designed to be comfortable using global variables controlling the computer-aided design (CAD) model size with user-specific measurements. Comfort was also incorporated using shape-forming of the socket for specific residual limb features. The device was designed to perform the two main functions of suspension, or attachment to …

Development Of A Pressure Sensing System Coupled With Deployable Machine Learning Models For Assessing Residual Limb Fit In Lower Limb Prosthetics, Maxwell D. Lewter

Master's Theses

Lower limb amputations pose significant challenges for patients, with over 150,000 cases annually in the U.S., leading to a high demand for effective prosthetics. However, only 43% of lower limb prosthetic users report satisfaction, primarily due to issues with socket fit, which is critical for comfort, stability, and preventing injury. This study presents a deployable sensing system for potentially real-time monitoring of prosthetic socket fit by using pressure sensors and convolutional neural networks (CNNs) to analyze the pressure distribution within the socket. A novel CNN architecture, utilizing both dilated and strided convolutions, is proposed to effectively capture spatial-temporal patterns in …

Hypoxic Incubator: Improving Robustness/Reliability And Demonstrating Physiological Efficacy, Damon Dennis Tan

Master's Theses

The Microphysiological Systems Laboratory aims to develop colorectal cancer tumor models under a hypoxic environment to assess model response to pharmaceutical compounds in vitro. To perform relevant studies, researchers have attempted to use different hypoxic inducing strategies such as a nitrogen pod and hypoxic incubator to recreate in vivo physiological responses to hypoxia. However, studies would be interrupted due to incubator functionality failure. To ensure successful and physiologically relevant studies, I improved and verified the robustness and reliability of a hypoxic incubator previously designed and manufactured in the lab. Through the testing and iterating design processes, I engineered and implemented …

3d Printed Microfluidic Fabrication Methodology, Characterization, Mechanical Design, And Applications In Electrostatic Artificial Muscles And Benthic Microbial Fuel Cells, Terak B. Hornik

Master's Theses

The fabrication of microfluidic devices often requires specialized methods. The development of these methods requires careful characterization and understanding of the processes involved. Using primarily PolyJet 3D printing technology, microfluidics offers a wide scope of applications such as microfluidic benthic microbial fuel cells (MBMFCs) and electrostatic artificial muscles. MBMFCs benefit from the confinement of the microbes resulting in close proximity between the electrode and the organisms. Using a modular design called the Sponge, assembly and upscaling is possible. Electrostatic artificial muscles benefit from a microfluidic approach due to the non-linearity of electrostatic attraction creating disproportionate benefits when miniaturized. When designed …

Biomechanical Effects Of Worn-Out Shoe Outsoles And Insoles On The Human Foot, Yuka M. Iwashita, James A. Engebretson, Shreeshan Jena

College of Engineering Summer Undergraduate Research Program

The combination of outsole, midsole and insole layers of new shoes provide proper cushioning to the foot during the daily activities of life. Subsequently, the wear-based degeneration or damage to one or more of these sole layers can reduce the cushioning effect to the plantar surface of the foot. This reduction of cushioning effect can impact the distribution of stress concentration regions along the foot plantar surfaces and lead to foot pathologies. The present proposed research intends to study these effects of shoe-wear on the plantar surface of the human foot, using FEA (ABAQUS) and experimental methods. Commonly, the worn-out …

Wearable Sensing Systems And Data Analytics For Pressure Sensing Socket Prostheses, Stacey Le, Mio Nakagawa

College of Engineering Summer Undergraduate Research Program

Prosthetics have been widely used as the primary solution for lower limb amputations, but residual limb volume fluctuations have posed challenges to the effectiveness and comfortability of these devices. In this project, we aim to observe pressure distribution patterns in the prosthetic socket during gait using sensing technology and investigate the performance of different machine learning algorithms on determining good or bad fit.

Wearable Sensor-Based Gait And Balance In Elementary And Middle Schools, Sofie Zalatimo, Catherine Semaan

College of Engineering Summer Undergraduate Research Program

No abstract provided.

Significance Of Noninvasive Endothelial Dysfunction And Other Cardiovascular Measurements In Various Communities, Sofi Z. David, Lily Wilcox, Kalia Richard

College of Engineering Summer Undergraduate Research Program

This pilot study aims to raise awareness of endothelial dysfunction in underrepresented communities, where cardiovascular disease is prevalent. By delivering educational presentations and materials, the study seeks to increase participants' understanding and interest in endothelial dysfunction, potentially leading to proactive health behaviors. The results will inform future initiatives to enhance public knowledge and reduce the burden of cardiovascular disease in these communities.

In the future, there will also be a 3 vs 5-minute hyperemia study. Thirty participants without a history of cardiovascular disease will undergo testing using the Cordex SmartCuff™ device. If the three-minute hold proves to accurately measure endothelial …

Finite Element Analysis Of The Bearing Component Of Total Ankle Replacement Implants During The Stance Phase Of The Gait Cycle, S J. Hazelwood, Mohammad N. Noori, Naudereh B. Noori, Timothy S. Jain, Amanda Anderson, Joseph Rencis

Biomedical Engineering

Total ankle arthroplasty (TAA) is a motion-preserving treatment for end-stage ankle arthritis. An effective tool for analyzing these implants’ mechanical performance and longevity in silico is finite element analysis (FEA). An FEA in ABAQUS was used to statically analyze the mechanical behavior of the ultra-high-molecular-weight polyethylene (UHMWPE) bearing component at varying dorsiflexion/plantarflexion ankle angles and axial loading conditions during the stance phase of the gait cycle for a single cycle. The von Mises stress and contact pressure were examined on the articulating surface of the bearing component in two newly installed fixed-bearing TAA implants (Wright Medical INBONE II and Exactech …

Dual Base Sige Is-Hbt For Use In Biosensing Applications, Liam Stephen Hayes

Master's Theses

The proposed research is for a novel SiGe-based Ion-Sensitive Dual Hetero-junction Bipolar Transistor (IS-HBT) to be used in both trans-dermal biological sensing as well as Lab-on-Chip (LOC) applications. The end goals for the device designed are two: For one, the research done for this work will be used to substantiate the claims made by Zafar et al. [1] that an HBT-style structure is better suited for biosensing application rather than a conventional Field Effect Transistor (FET) based geometries. Secondly, it provides the final element to be integrated along with a selectivity membrane, as well as with a reverse-iontophoresis system to …

Nasogastric Tube Insertion Aid, Lauren S. Ark, Angela D. Biezins, Zachary B. Crum, Claire E. Nodine, Morgan N. Pope, Natsumi L. Shudo

Biomedical Engineering

The Nasogastric Tube Insertion Aid project, developed under the sponsorship of the BiCEP Program at California Polytechnic State University, aims to enhance the accuracy and efficiency of nasogastric (NG) tube placement. This initiative was inspired by challenges observed during the BiCEP summer program, where difficulties in NG tube insertions led to multiple attempts, increased patient discomfort, and serious medical risks, including lung punctures and brain trauma. The project's goal was to design an insertion aid that improves placement accuracy while being cost-effective and user-friendly for medical professionals. The device features an external tensioning mechanism that allows controlled deflection of the …

Balance Assessment Using A Handheld Smartphone With Principal Component Analysis For Anatomical Calibration, Evan C. Anthony, Olivia K. Kam, Stephen M. Klisch, Scott Hazelwood, Britta Berg-Johansen

Biomedical Engineering

Most balance assessment studies using inertial measurement units (IMUs) in smartphones use a body strap and assume the alignment of the smartphone with the anatomical axes. To replace the need for a body strap, we have used an anatomical alignment method that employs a calibration maneuver and Principal Component Analysis (PCA) so that the smartphone can be held by the user in a comfortable position. The objectives of this study were to determine if correlations existed between angular velocity scores derived from a handheld smartphone with PCA functional alignment vs. a smartphone placed in a strap with assumed alignment, and …

A Study On The Effects Of Cementless Total Knee Arthroplasty Implants’ Surface Morphology Via Finite Element Analysis, Scott Hazelwood, Peter J. Hunt, Mohammad Noori, Naudereh B. Noori, Wael A. Altabey

Biomedical Engineering

Total knee arthroplasty (TKA) is one of the most commonly performed orthopedic surgeries, with nearly one million performed in 2020 in the United States alone. Changing patient demographics, predominately indicated by increases in younger, more active, and more obese patients undergoing TKA, poses a challenge to orthopedic surgeons as these factors present a greater risk of long-term complications. Historically, cemented TKA has been the gold standard for fixation, but long-term aseptic loosening continues to be a risk for cemented implants. Cementless TKA, which relies on the surface morphology of a porous coating for biologic fixation of implant to bone, may …

Development Of An Advanced Step Counting Algorithm With Integrated Activity Detection For Free Living Environments, Paige M. Dolan

Master's Theses

Physical activity plays a crucial role in maintaining overall health and reducing the risk of various chronic diseases. Step counting has emerged as a popular method for assessing physical activity levels, given its simplicity and ease of use. However, accurately measuring step counts in free-living environments presents significant challenges, with most activity trackers exhibiting a percent error above 20%. This study aims to address these challenges by creating a machine learning algorithm that leverages activity labels to improve step count accuracy in real-world conditions. Two approaches to balancing data were used: one employed a simpler oversampling technique, while the other …

Engineering An Injectable Hydrogel With Self-Assembling 3d Vasculature, Kendyl Cohn

Master's Theses

This research developed methods for culturing self-assembling capillaries in an injectable gel as a potential method for vascularizing tissue-on-a-chip models to mimic physiological drug delivery. Additionally, a mathematical model was developed as a tool for understanding nutrient delivery and comparison of potential delivery systems. Organs-on-a-chip provide novel platforms for studying biology and physiology in 3D, allow exploration of tissue engineering on a manageable scale, and serve as models for drug screening and drug-delivery testing.

Methods were first developed for co-culture of endothelial cells and fibroblasts (3T3s or HDFs) in 2D, evaluating culture time, seeding density and ratio of HUVECs and …

Thermal Preconditioning Effects On Perforation Propensity Of Transvenous Implantable Cardiac Leads Used For Pacing And Defibrillation, Diane Muff

Master's Theses

Thermal preconditioning to simulate shipping, handling and storage conditions did not affect distal tip stiffness values for permanently implantable cardiac leads used for pacing and defibrillation. Leads that were subjected to extreme temperatures and temperature cycling did not show changes in buckle force values compared with control specimens which were maintained at ambient room conditions. Absolute differences between all measurements were small, generally under 0.05 N and were attributable to measurement variability.

Buckle force values are used to assess the propensity of leads to perforate the heart, a rare but potentially serious complication of implantable pacing and defibrillation systems. Since …

Smart Cushion Device For Elderly Aging In Place, Anna Dion, Nate Colley, Leonardo Bravo

Biomedical Engineering

Our task at hand is to develop a consumer-focused solution for improving elder care to provide additional peace of mind for seniors and caregivers using technology to extend independent living. We intend to create a device that will improve the quality of life of elderly individuals living alone by encouraging periodical movement throughout the day, along with monitoring pressure distribution and alerting when pressure concentration is potentially harmful. It will also alert users to the presence of moisture which can arise from spills or incontinence. The key stakeholders of this project include elderly adults over the age of 65 who …