Biomedical Engineering and Bioengineering Commons^™

Mathematical Model Development Of Super-Resolution Image Wiener Restoration, Amr H. Yousef, Jiang Li, Mohammad A. Karim

Electrical & Computer Engineering Faculty Publications

In super-resolution (SR), a set of degraded low-resolution (LR) images are used to reconstruct a higher-resolution image that suffers from acquisition degradations. One way to boost SR images visual quality is to use restoration filters to remove reconstructed images artifacts. We propose an efficient method to optimally allocate the LR pixels on the high-resolution grid and introduce a mathematical derivation of a stochastic Wiener filter. It relies on the continuous-discrete-continuous model and is constrained by the periodic and nonperiodic interrelationships between the different frequency components of the proposed SR system. We analyze an end-to-end model and formulate the Wiener filter …

Fast Stochastic Wiener Filter For Super-Resolution Image Restoration With Information Theoretic Visual Quality Assessment, Amr Hussein Yousef, Jiang Li, Mohammad Karim, Mark Allen Neifeld (Ed.), Amit Ashok (Ed.)

Electrical & Computer Engineering Faculty Publications

Super-resolution (SR) refers to reconstructing a single high resolution (HR) image from a set of subsampled, blurred and noisy low resolution (LR) images. The reconstructed image suffers from degradations such as blur, aliasing, photo-detector noise and registration and fusion error. Wiener filter can be used to remove artifacts and enhance the visual quality of the reconstructed images. In this paper, we introduce a new fast stochastic Wiener filter for SR reconstruction and restoration that can be implemented efficiently in the frequency domain. Our derivation depends on the continuous-discrete-continuous (CDC) model that represents most of the degradations encountered during the image-gathering …

Field-Controlled Electron Transfer And Reaction Kinetics Of The Biological Catalytic System Of Microperoxidase-11 And Hydrogen Peroxide, Yongki Chou, Siu-Tung Yau

Electrical and Computer Engineering Faculty Publications

Controlled reaction kinetics of the bio-catalytic system of microperoxidase-11 and hydrogen peroxide has been achieved using an electrostatic technique. The technique allowed independent control of 1) the thermodynamics of the system using electrochemical setup and 2) the quantum mechanical tunneling at the interface between microperoxidase-11 and the working electrode by applying a gating voltage to the electrode. The cathodic currents of electrodes immobilized with microperoxidase-11 showed a dependence on the gating voltage in the presence of hydrogen peroxide, indicating a controllable reduction reaction. The measured kinetic parameters of the bio-catalytic reduction showed nonlinear dependences on the gating voltage as the …

Passive Micromixers And Organic Electrochemical Transistors For Biosensor Applications, Senaka Krishna Kanakamedala

Doctoral Dissertations

Fluid handling at the microscale has greatly affected different fields such as biomedical, pharmaceutical, biochemical engineering and environmental monitoring due to its reduced reagent consumption, portability, high throughput, lower hardware cost and shorter analysis time compared to large devices. The challenges associated with mixing of fluids in microscale enabled us in designing, simulating, fabricating and characterizing various micromixers on silicon and flexible polyester substrates. The mixing efficiency was evaluated by injecting the fluids through the two inlets and collecting the sample at outlet. The images collected from the microscope were analyzed, and the absorbance of the color product at the …

Cyberknife Radiation Modeling: Effects Of Relaxed Translational And Rotational Constraints On Healthy Tissue Irradiation, Sudha Bhavaroop Potineni

Electrical & Computer Engineering Theses & Dissertations

The Cyberknife system is a robotic radio surgery instrument that is used to treat cancers in different parts of the human body. Because of its accuracy and precision, it has become one of the best radio surgery systems in the world. However, even with Cyberknife the treatment time for one session takes from 30 minutes up to 120 minutes depending on the size, shape, and position of the tumor in the human body. In this research, a solution is presented to aid in reducing this long treatment time. An algorithm is developed which simulates the amount of the healthy tissue …

A Silicon Nanoparticle-Based Polymeric Nano-Composite Material For Glucose Sensing, Qiang Liu, Munir H. Nayfeh, Siu-Tung Yau

Electrical and Computer Engineering Faculty Publications

A novel non-enzyme glucose sensing material has been prepared by incorporating ultrasmall (1–3 nm) silicon nanoparticles in polyaniline, a conducting polymer, as a nano-composite material (NCM). When deposited on electrodes, the composite material with three-dimensional loading of the nanoparticles showed a significantly enhanced amperometric response to glucose, compared to the nanoparticles deposited on bare electrodes and electrodes immobilized with the enzyme, glucose oxidase. The linear range of the glucose response of NCM electrodes covered both the hypo- and hyper-glycaemic glucose levels. The sensitivity of the NCM electrodes was 2.5 μA cm⁻² mM⁻¹. The NCM electrodes’ selectivity for …

Statistical Optimizations Of Muscle Action Potentials Based On Modeling And Analysis Of Ion Channel Dynamics, Gyutae Kim

Electrical & Computer Engineering Theses & Dissertations

An Electromyogram (EMG) is an electrical signal, which is measured from a skeletal muscle during voluntary and involuntary contractions. EMGs are useful in interpreting pathological states of the musculoskeletal system. In particular, EMGs offer valuable information concerning the timing of muscular activity and its relative intensity. Various EMG models have developed with many different purposes from a pure mathematical model to a pattern structure model [17,46]. Sophisticated EMG models are necessary to examine the effects of small changes in muscular morphology and activities [46]. Due to the crucial importance of EMG models, all factors in the model should be precise …

Heart-Rate Monitoring Control System Using Photoplethysmography (Ppg), Wesley Nguyen, Ryan Horjus

Electrical Engineering

No abstract provided.

Universal Engineering Programmer – An In-House Development Tool For Developing And Testing Implantable Medical Devices In St. Jude Medical, Khoa Tat Do

Master's Theses

During development and testing of the functionality of the pacemaker and defibrillator device, engineers in the St. Jude Medical Cardiac Rhythm Management Division use an in-house development tool called Universal Engineering Programmer (UEP) to ensure the device functions as expected, before it can be used to test on an animal or a human during the implantation process.  In addition, some applications of UEP are incorporated into the official releases of the device product.  UEP has been developed and used by engineers across departments in the St. Jude Medical Cardiac Rhythm Management Division (CRMD).  This thesis covers the flexible and reusable …

Radio-Frequency Breast Cancer Imaging Results For A Simplified Cylindrical Phantom, Giuseppe Ruvio, Raffaele Solimene, Antonietta D'Alterio, Max Ammann, Rocco Pierri

Conference Papers

Microwave imaging is a pervasive research field and
is useful in numerous applicative diagnostic noninvasive contexts. This paper focuses on two aspects. First, we perform a numerical investigation to assess the role played by fundamental parameters (i.e. number of sensors, operating frequency bandwidth) on cancer detection. To this end, a simplified cylindrical phantom probed by ideal two-dimensional dipoles (i.e. infinitely long along the axis of invariance) is considered. Second, in order to focus on the role of the antennas, we analyze, still by numerical simulations and for a simplified breast model, how performances vary when a realistic antenna is adopted.

Sar Map Of Gel Phantom In A 64mhz Mri Birdcage By Fiber-Optic Thermometry And Fdtd Simulation, Chirag Mukesh Patel

Master's Theses

As implantable medical devices are being used more often to treat medical problems for which pharmaceuticals don’t suffice, it is important to understand their interactions with commonly used medical modalities. The interactions between medical implants and Magnetic Resonance Imaging machines have proven to be a risk for patients with implants.

Implanted medical devices with elongated metallic components can create harmful levels of local heating in a Magnetic Resonance Imaging (MRI) environment [1]. The heating of a biological medium under MRI is monitored via the Specific Absorption Rate (SAR). SAR, defined as power absorbed per unit mass (W/kg), can be calculated …

Novel Bioelectrical Measurement Using A Digital Biopotential Monode, Mark Nolan, Edward Burke, Eugene Coyle

Conference Papers

In conventional biopotential recording, two or more electrodes are placed on the body. A unipolar lead records the time-varying electrical potential at a single point (relative to a reference potential) via one signal electrode. A bipolar lead records the time-varying potential difference between two points via two signal electrodes. In each case, the signal electrodes are connected to high impedance amplifier inputs, while an additional electrode provides a low-impedance path between the amplifier and human subject. Bipolar leads are usually preferred since interference appearing at both signal electrodes can be eliminated using an instrumentation amplifier with high CMRR. A drawback …

Intelligibility Of Electrolarynx Speech Using A Novel Hands-Free Actuator, Brian Madden, Mark Nolan, Ted Burke, James Condron, Eugene Coyle

Conference Papers

During voiced speech, the larynx provides quasi-periodic acoustic excitation of the vocal tract. In most electrolarynxes, mechanical vibrations are produced by a linear electromechanical actuator, the armature of which percusses against a metal or plastic plate at a frequency within the range of glottal excitation. In this paper, the intelligibility of speech produced using a novel hands-free actuator is compared to speech produced using a conventional electrolarynx. Two able-bodied speakers (one male, one female) performed a closed response test containing 28 monosyllabic words, once using a conventional electrolarynx and a second time using the novel design. The resulting audio recordings …

Augmented Control Of A Hands-Free Electrolarynx, Brian Madden, James Condron, Eugene Coyle

Conference Papers

During voiced speech, the larynx acts as the sound source, providing a quasi-periodic excitation of the vocal tract. Following a total laryngectomy, some people speak using an electrolarynx which employs an electromechanical actuator to perform the excitatory function of the absent larynx. Drawbacks of conventional electrolarynx designs include the monotonic sound emitted, the need for a free-hand to operate the device, and the difficulty experienced by many laryngectomees in adapting to its use. One improvement to the electrolarynx, which clinicians and users frequently suggest, is the provision of a convenient hands-free control facility. This would allow more natural use of …

Using Thermally Coupled Reactive Distillation Columns In Biodiesel Production, Nghi Nguyen, Yaşar Demirel

Yaşar Demirel Publications

Production of ethyl dodecanoate (biodiesel) using lauric acid and methanol with a solid acid catalyst of sulfated zirconia is studied by using two distillation sequences. In the first sequence, the methanol recovery column follows the reactive distillation column. In the second sequence, the reactive distillation and methanol recovery columns are thermally coupled. Thermally coupled distillation sequences may consume less energy by allowing interconnecting vapor and liquid streams between the two columns to elminate reboiler or condenser or both. Here we study the thermally coupled side-stripper reactive distillation and eliminate the condenser of the reactive distillation column. Both the sequences are …

Role Of Hydrodynamic Behavior Of Dna Molecules In Dielectrophoretic Polarization Under The Action Of An Electric Field, Hui Zhao

Mechanical Engineering Faculty Research

A continuum model is developed to predict the dielectrophoretic polarizability of coiled DNA molecules under the action of an alternating current electric field. The model approximates the coiled DNA molecule as a charged porous spherical particle. The model explains the discrepancies among scaling laws of polarizability of different-sized DNA molecules with contour length and such discrepancies are attributed to different hydrodynamic behavior. With zero or one fitting parameter, theoretical predictions are in good agreement with various experimental data, even though in experiments there are some uncertainties in regard to certain parameters.

Guiding Electric Fields For Electroporation Applications, Jose Rey

USF Tampa Graduate Theses and Dissertations

Electroporation is the critical step in an electric field mediated drug or gene delivery protocol. Electroporation based protocols have been successfully demonstrated in cancer clinical trials, however, its impact in other applications is still under investigation. A significant roadblock to long term functioning of implantable biosensors in vivo is the tissue reaction in the form of fibrous encapsulation that results in reduced transport to the sensing element of the biosensor. In vivo gene electroporation has a great potential as a means to modify the transport properties of tissues in the proximity of the sensing element of implantable biosensors.

This dissertation …

Monitoring, Diagnosis, And Control For Advanced Anesthesia Management, Zhibin Tan

Wayne State University Dissertations

Modern anesthesia management is a comprehensive and the most critical issue in medical care. During the past dacades, a large amount of research works have been focused on the problems of monitoring anesthesia depth, modeling the dynamics of anesthesia patient for the purpose of control, prediction, and diagnosis.

Monitoring the anesthesia depth is not only for keeping the patient in adquate anesthesia level but also for preventing the patient from overdosing. Several EEG based indexes have been developed such as the BIS, and Entropy etc. for measuring depth. However, reports mentioned that those indexes in some cases fail in detecting …

Processing Random Signals In Neuroscience, Electrical Engineering And Operations Research, Kalyan Raman

Wayne State University Dissertations

The topic of this dissertation is the study of noise in electrical engineering, neuroscience, biomedical engineering, and operations research through mathematical models that describe, explain, predict and control dynamic phenomena. Noise is modeled through Brownian Motion and the research problems are mathematically addressed by different versions of a generalized Langevin equation. Our mathematical models utilize stochastic differential equations (SDEs) and stochastic optimal control, both of which were born in the soil of electrical engineering. Central to this dissertation is a brain-physics based model of cerebrospinal fluid (CSF) dynamics, whose structure is fundamentally determined by an electrical circuit analogy. Our general …

In-Silico Hyperthermia Performance Of A Near-Field Patch Antenna At Various Positions On A Human Body Model, Sergio Curto, Terrence See, Patrick Mcevoy, Max Ammann, Zhi Ning Chen

Articles

A compact patch applicator designed to enhance targeted energy coupling at 434 MHz is a key enabler for sensitizing temperature increments in body regions containing superficial tumours. A detailed FDTD body model is used to explore simulated RF coupling and temperature increments for typical clinical conditions. The antenna impedance matching, specific absorption rate and thermal distribution parameters are evaluated to identify applied performance outcomes. The analysis reveals physiological-RF coupling patterns for an optimised closely-coupled single element applicator.

Atrial Fibrillation Signal Analysis, Raja Sarath Chandra Prasad Vaizurs

USF Tampa Graduate Theses and Dissertations

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia encountered in clinical practice and is associated with an increased mortality and morbidity. Identification of the sources of AF has been a goal of researchers for over 20 years. Current treatment procedures such as Cardio version, Radio Frequency Ablation, and multiple drugs have reduced the incidence of AF. Nevertheless, the success rate of these treatments is only 35-40% of the AF patients as they have limited effect in maintaining the patient in normal sinus rhythm. The problem stems from the fact that there are no methods developed to analyze …

On Improving Electrooculogram-Based Computer Mouse Systems: The Accelerometer Trigger, Johnalan Keegan, Edward Burke, James Condron, Eugene Coyle

Conference Papers

Eye tracking is a well-established method of computer control for profoundly paralysed people (Anson et al., 2002). Cameras are commonly used to track eye movements (Morimoto et al., 2005) but one alternative is the bioelectrical signal known as the electrooculogram (EOG). There are some EOG mouse control systems that facilitate the use of GUI applications, but certain actions, which are straightforward using a conventional mouse, remain impossible. Unless the eyes are tracking a target, they move in saccades (jumps), making it impossible to voluntarily trace out smooth trajectories with one's gaze, as would be required to draw a smooth curve. …

Bcc Skin Cancer Diagnosis Based On Texture Analysis Techniques, Shao-Hui Chuang, Xiaoyan Sun, Wen-Yu Chang, Gwo-Shing Chen, Adam Huang, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

In this paper, we present a texture analysis based method for diagnosing the Basal Cell Carcinoma (BCC) skin cancer using optical images taken from the suspicious skin regions. We first extracted the Run Length Matrix and Haralick texture features from the images and used a feature selection algorithm to identify the most effective feature set for the diagnosis. We then utilized a Multi-Layer Perceptron (MLP) classifier to classify the images to BCC or normal cases. Experiments showed that detecting BCC cancer based on optical images is feasible. The best sensitivity and specificity we achieved on our data set were 94% …

On The Visual Quality Enhancement Of Super-Resolution Images, Amr Hussein Yousef, Jiang Li, Mohammad Karim, Andrew G. Tescher (Ed.)

Electrical & Computer Engineering Faculty Publications

Super-resolution (SR) is the process of obtaining a higher resolution image from a set of lower resolution (LR) blurred and noisy images. One may, then, envision a scenario where a set of LR images is acquired with a sensor on a moving platform. In such a case, an SR image can be reconstructed in an area of sufficient overlap between the LR images which generally have a relative shift with respect to each other by subpixel amounts. The visual quality of the SR image is affected by many factors such as the optics blur, the inherent signalto- noise ratio of …

Modeling Of Micro-Diaphragm For Optical Pressure Sensor For Human Artery Pulse Wave Detection., Khairunnisa Hasikin

Student Works (2010-2019)

This thesis presents the development of a micro-diaphragm for an optical pulse pressure sensor using Micro-electro-mechanical Systems (MEMS) technology. Modelling of the micro-diaphragm was conducted and the comparison of its performance was simulated for silicon nitride and polyirnide materials. In addition. diaphragm's radius and thickness were varied to further analyze the performance of the micro-diaphragm. There are three design parameters that affecting the micro-diaphragm performance namely diaphragms radius. thickness and material. Thus, an optimization analysis using Taguchi method was done to attain significant design parameters that give the best micro-diaphragm performance. Findings indicated that the best performance of the micro-diaphragm …

Return-Path, Multiple-Principal-Angle, Internal-Reflection Ellipsometer For Measuring Ir Optical Properties Of Aqueous Solutions, Rasheed M.A. Azzam

Electrical Engineering Faculty Publications

A retroreflection (return-path) spectroscopic ellipsometer without a wave plate is described that uses an IR-transparent high-refractive-index hemicylindrical semiconductor substrate to measure the optical properties of aqueous solutions from multiple principal angles and multiple principal azimuths of attenuated internal reflection (AIR) at the semiconductor–solution interface. The pseudo-Brewster angle of minimum reflectance for the p polarization is also readily measured using the same instrument. This wealth of data can also be used to characterize thin films at the solid–liquid interface. Simulated results of AIR at the Si–water interface over the 1.2–11 μm IR spectral range are presented in support of this concept. …

Multi-Frequency Processing For Lumen Enhancement With Wideband Intravascular Ultrasound, Rory A. Carrillo

Master's Theses

The application of high frequency ultrasound is the key to higher resolution intravascular ultrasound (IVUS) images. The need to further improve the IVUS spatial resolution may drive the transducer center frequency even higher than the current 40 MHz range. However, increasing the center frequency may be challenging as it leads to stronger scattering echoes from blood. The high level of blood scattering echoes may obscure the arterial lumen and make image interpretation difficult. Blood backscatter levels increase with transmission center frequency at a much greater rate compared to arterial tissue. These different frequency dependencies provide a potential method to distinguish …

A Monocular Marker-Free Gait Measurement System, Jane Courtney, Annraoi M. De Paor

Articles

This paper presents a new, user-friendly, portable motion capture and gait analysis system for capturing and analyzing human gait, designed as a telemedicine tool to monitor remotely the progress of patients through treatment. The system requires minimal user input and simple single-camera filming (which can be acquired from a basic webcam) making it very accessible to nontechnical, nonclinical personnel. This system can allow gait studies to acquire a much larger data set and allow trained gait analysts to focus their skills on the interpretation phase of gait analysis. The design uses a novel motion capture method derived from spatiotemporal segmentation …

Enhanced Anthocyanin Extraction From Red Cabbage Using Pulsed Electric Field Processing, Tanya K. Gachovska, David A. Cassada, Jeyamkondan Subbiah, Milford Hanna, Harshavardhan Thippareddi, Daniel D. Snow

Department of Agricultural and Biological Systems Engineering: Faculty Publications

This study was conducted to evaluate the effect of pulsed electric field (PEF) treatment on anthocyanin extraction from red cabbage using water as a solvent. Mashed cabbage was placed in a batch treatment chamber and subjected to PEF (2.5 kV/cm electric field strength; 15 μs pulse width and 50 pulses, specific energy 15.63 J/g). Extracted anthocyanin concentrations (16 to 889 μg/mL) were determined using HPLC. Heat and light stabilities of the control and PEF-treated samples, having approximately the same initial concentrations, were studied. PEF treatments enhanced total anthocyanin extraction in water from red cabbage by 2.15 times with a higher …

Application Of Signal Advance Technology To Electrophysiology, Chris M. Hymel

Dissertations and Theses (Open Access)

Medical instrumentation used in diagnosis and treatment relies on the accurate detection and processing of various physiological events and signals. While signal detection technology has improved greatly in recent years, there remain inherent delays in signal detection/ processing. These delays may have significant negative clinical consequences during various pathophysiological events. Reducing or eliminating such delays would increase the ability to provide successful early intervention in certain disorders thereby increasing the efficacy of treatment.

In recent years, a physical phenomenon referred to as Negative Group Delay (NGD), demonstrated in simple electronic circuits, has been shown to temporally advance the detection of …