Biomedical Engineering and Bioengineering Commons^™

Induction Of Differentiation Of Dental Pulp-Derived Mesenchymal Stem Cells (Dpsc), Aubrey Young

UNLV Theses, Dissertations, Professional Papers, and Capstones

Mesenchymal stem cells are derived from a variety of human tissues and are being bioengineered and studied for possible uses in the advancement of medicine. Recent efforts are being focused on Dental Pulp Stem Cells (DPSC's) due to the accessibility of this tissue. Many factors influence DPSC quality and quantity, including the specific methods used to isolate, collect, concentrate, and store these isolates once they are removed. Ancillary factors, such as the choice of media, the selection of early versus late passage cells, and cryopreservation techniques may also influence the differentiation potential and proliferative capacity of DPSC isolates.

The objective …

Algorithm-Circuit Co-Design For Detecting Symptomatic Patterns In Biological Signals, Himanshu Markandeya

Open Access Dissertations

The advancement in scaled Silicon technology has accelerated the development of a wide range of applications in various fields including medical technology. It has immensely contributed to finding solutions for monitoring general health as well as alleviating intractable disorders in the form of implantable and wearable systems. This necessitates the development of energy efficient and functionally efficacious systems. This thesis has explored the algorithm-circuit co-design approach for developing an energy efficient epileptic seizure detection processor which could be used for implantable epilepsy prosthesis. Novel wavelet transform based algorithms are proposed for accurate detection of epileptic seizures. Energy efficient techniques at …

Data Completion Methods For Improved Developmental Stage Annotation Of Drosophila Embryos In Images, Chitsanu Janyalikit

Electrical & Computer Engineering Theses & Dissertations

Drosophila melanogaster is a dominant model organism for studying the function of animal genes in initial stages of embryogenesis. Usually, images containing Drosophila gene expression patterns are captured at different developmental stages to study the interconnection of animal genes. To achieve most biologically meaningful results, gene expression images from a similar stage should be compared. Currently, biologists manually classify embryos in images into different stages, which is time intensive and infeasible for current massively produced gene expression images. Therefore, there is a need to develop an automatic system for the annotation.

Gene expression information in embryo images usually appears as …

Breast Cancer Detection Using Interferometric Music: Experimental And Numerical Assessment, Giuseppe Ruvio, Raffaele Solimene, Antonio Cuccaro, Domenico Gaetano, Jacinta Browne, Max Ammann

Articles

Purpose: In microwave breast cancer detection, it is often beneficial to arrange sensors in close proximity to the breast. The resultant coupling generally changes the antenna response. As an a priori characterization of the radio frequency system becomes difficult, this can lead to severe degradation of the detection efficacy. The purpose of this paper is to demonstrate the advantages of adopting an interferometric multiple signal classification (I-MUSIC) approach due to its limited dependence from a priori information on the antenna. The performance of I-MUSIC detection was measured in terms of signal-to-clutter ratio (SCR), signal-to-mean ratio (SMR), and spatial displacement (SD) …

Multi-Channel Analysis For Gradient Artifact Removal From Concurrent Eeg-Fmri Studies, Miguel R. Castellanos, Zhongming Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Concurrent electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) recordings are susceptible to large amounts of noise due to the static and dynamic magnetic fields present inside the MR scanner. EEG-fMRI studies are conducted to provide better spatial and temporal resolution for each recording, respectively, but the artifacts found in the EEG render the data impossible to interpret. Past studies have focused on signal post-processing techniques which are able to effectively remove noise upon the completion of a study, but there are no techniques able to process the data in real-time without extensive calibration. This research addresses this issue by …

Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Consistent powering is a limiting reagent for many medical implants and sensors. Powering in-vivo devices in animal studies requires either transcutaneous wiring (limiting mobility and increasing the chance of infection) or an implanted battery (limited lifetime and limits size of device). Wireless power transfer (WPT) would be able to overcome these challenges and permit the use of more advanced implantable devices in a research setting. Magnetic resonance coupling (MRC), an advanced form of inductive charging, allows good transfer efficiencies over significant air gaps, but works best a specific location and frequency, limiting mobility in animal studies. Using band-pass filter theory, …

Design, Characterization And Application Of A Multiple Input Stethoscope Apparatus, Spencer Geng Wong

Master's Theses

For this project, the design, implementation, characterization, calibration and possible applications of a multiple transducer stethoscope apparatus were investigated. The multi-transducer sensor array design consists of five standard stethoscope diaphragms mounted to a rigid frame for a-priori knowledge of their relative spatial locations in the x-y plane, with compliant z-direction positioning to ensure good contact and pressure against the subject’s skin for reliable acoustic coupling. When this apparatus is properly placed on the body, it can digitally capture the same important body sounds investigated with standard acoustic stethoscopes; especially heart sounds. Acoustic signal inputs from each diaphragm are converted to …

Improving Golf Putt Performance With Statistical Learning Of Eeg Signals, Qing Guo

Graduate Theses and Dissertations

In this thesis, a machine learning based method is proposed to predict the putt outcomes of golfers based on their electroencephalogram (EEG) data. The method can be used as a core building block of a brain-computer interface, which is designed to provide guidance to golf players based on their EEG patterns. The proposed method includes three steps. First, multi-channel 1-second EEG trials were extracted during golfers' preparation of putting. Second, different features are calculated such as correlation coefficient, power spectrum density and coherence, which are used as features for the classification algorithm. To predict golfers' performance, the support vector machine …

Cfd Simulation Of The Thermal Performance Of A Parallel Counter-Parallel Flow Heat Exchanger For The Treatment Of Hypothermia, Alex Heller

UNLV Theses, Dissertations, Professional Papers, and Capstones

Hypothermia is a life-threatening condition. Currently, active warming methods are the most effective treatment for dysthermic patients. The aim of this study is to investigate the use of computational fluid dynamics (CFD) in evaluating the thermal performance of a parallel/counter-parallel flow heat exchanger used as part of a fluid warmer to treat Hypothermia. The 3D model of the heat exchanger is divided into three regions; Infusate (fluid to be heated), Hot Water (heating fluid), and a Solid Region (wall). At the end of the heat exchanger, an elbow section is used to create the counter-parallel flow arrangement specific to this …

Design Of The High-Speed Stereo Radiography System, John C. Ivester Iv

Electronic Theses and Dissertations

Orthopaedic pathologies often involve disruption of the mechanical environment of a joint at/below the mm scale. The ability to measure biomechanical kinematics at the sub-mm scale is essential for obtaining valuable insight into pathologies, but small motions of the joints are difficult to quantify. Estimates of skeletal kinematics are commonly made from optical motion capture systems and markers placed on the skin. The error caused by external marker movement is largely avoided with x-ray motion capture. Dynamic radiography uses a series of x-ray images recorded at high-speed and captures in-vivo joint motion. Uncovering the mechanical foundation of orthopaedic pathologies requires …

Particle Swarm Optimization Using Multiple Neighborhood Connectivity And Winner Take All Activation Applied To Biophysical Models Of Inferior Colliculus Neurons, Brandon S. Coventry

Open Access Theses

Age-related hearing loss is a prevalent neurological disorder, affecting as many as 63% of adults over the age of 70. The inability to hear and understand speech is a cause of much distress in aged individuals and is becoming a major public health concern as age-related hearing loss has also been correlated with other neurological disorders such as Alzheimer's dementia. The Inferior Colliculus (IC) is a major integrative auditory center, receiving excitatory and inhibitory inputs from several brainstem nuclei. This complex balance of excitation and inhibition gives rise to complex neural responses, which are measured in terms of firing rate …

Numerical Study Of Poration And Ionic Conduction In Nanopores Caused By High-Intensity, Nanosecond Pulses In Cell, Hao Qiu

Electrical & Computer Engineering Theses & Dissertations

This dissertation focuses on the dynamics and bioeffects of electroporation of biological cell and ionic conduction in nanopores under high-intensity, nanosecond pulses. The electroporation model utilized the current continuity equation and the asymptotic Smoluchowski equation to explore the transmembrane potential and pore density of the plasma and intracellular membranes; the ionic conduction model employed the Poisson-Nernst-Planck equations and the Navier-Stokes equations to analyze the ionic current and ion concentration profile.

Nanosecond electric pulses of high-intensity amplitude can initiate electroporation of intracellular organelles. The pulse parameters and cell electrical properties, that can selectively electroporate liposomes but keep the plasma and nuclear …

Empirical Modeling Of Asynchronous Scalp Recorded And Intracranial Eeg Potentials, Komalpreet Kaur

Electrical & Computer Engineering Theses & Dissertations

A Brain-Computer Interface (BCI) is a system that allows people with severe neuromuscular disorders to communicate and control devices using their brain signals. BCIs based on scalp-recorded electroencephalography (s-EEG) have recently been demonstrated to provide a practical, long-term communication channel to severely disabled users. These BCIs use time-domain s-EEG features based on the P300 event-related potential to convey the user's intent. The performance of s-EEG-based BCIs has generally stagnated in recent years, and high day-to-day performance variability exists for some disabled users. Recently intracranial EEG (i-EEG), which is recorded from the cortical surface or the hippocampus, has been successfully used …

Preliminary Test Of A Real-Time, Interactive Silent Speech Interface Based On Electromagnetic Articulograph, Jun Wang, Ashok Samal, Jordan R. Green

School of Computing: Conference and Workshop Papers

A silent speech interface (SSI) maps articulatory movement data to speech output. Although still in experimental stages, silent speech interfaces hold significant potential for facilitating oral communication in persons after laryngectomy or with other severe voice impairments. Despite the recent efforts on silent speech recognition algorithm development using offline data analysis, online test of SSIs have rarely been conducted. In this paper, we present a preliminary, online test of a real-time, interactive SSI based on electromagnetic motion tracking. The SSI played back synthesized speech sounds in response to the user’s tongue and lip movements. Three English talkers participated in this …

Biomaterial Testing Methodology For Long-Term In Vivo Applications: Silicon Carbide Corrosion Resistance, Biocompatibility And Hemocompatibility, Maysam Nezafati

USF Tampa Graduate Theses and Dissertations

Biomedical devices that function in-vivo offer a tremendous promise to improve the quality of life for many who suffer from disease and trauma. The most important consideration for these devices is that they interact with the physiological environment as designed without initiating a deleterious inflammatory response. ISO 10993 outlines the current international guideline for investigating the biocompatibility of such devices. Numerous groups report the use of ISO 10993 as the basis for their experimental evaluation of candidate materials for neuroprosthetics, as well as other biomedical devices, however most of these reports fail to completely comply with the standard. This leads …

Clear Circuit Contact Lens, Paul Hecker Ii, Phillip Azar, Alexander Do, Benny Ng, Errol Leon

Electrical Engineering

The clear active contact lens project aims to address safety and hazard awareness with an unexplored field of eye wear technology. With advancements in nanotechnology and the advent of circuits on contact lens, this project is one of the first research and development into this new field, following University of Washington and Google. The team focuses on the safety and biocompatibility of the contact lens for a comfortable ease of use. The designs push the limits of thin film printed technology with its pursuit of fine designs of 250μm antennas. The project streamlines the manufacturing process for a combination substrate …

Team Omnimouse, Derek J. Halman, Josh B. Porter, Steven A. Silver, Ian S. Stemper

Computer Engineering

INFORMATION, DATA, FIGURES AND DRAWINGS EMBODIED IN THIS DOCUMENT ARE STRICTLY CONFIDENTIAL AND ARE SUPPLIED ON THE UNDERSTANDING THAT THEY WILL NOT BE DISCLOSED TO THIRD PARTIES WITHOUT THE PRIOR WRITTEN CONSENT OF QUALITY OF LIFE PLUS.

Sonar For The Visually Impaired, Anastasia Newark, Edwin Ng, Scott Terhorst

Biomedical Engineering

There are currently no inexpensive assistive devices that allow the visually impaired detect low hanging objects that are above waist height and may cause injury, such as a rope or tree branch. The challenge presented to the team by the Quality of Life Plus Lab (QL+) was to develop a Sonar Cane device that attaches to a traditional white cane to address this problem. This device must be lightweight, inexpensive to manufacture, have a long battery life, and accurately detect obstacles to prevent user injury.

Alternate Computer Input Device For Individuals With Quadriplegia, Tobais Elder, Michelle Martinez, David Sylvester

Biomedical Engineering

This project details the design development of an alternative computer input system that allows a person with quadriplegia to move a computer's cursor and activate left and right click button inputs. After researching and analyzing possible solutions, an end design was chosen that most appropriately satisfied all user requirements and engineering specifications. This final design employs a head mounted Inertial Measurement Unit (IMU) with 9 DoF (Degrees of Freedom) to track head movements and correlate these motions to computer cursor movements. A Sip-Puff Transducer monitors and interprets a user's application of negative and positive air pressure differentials to a vinyl …

Reading And Wirelessly Sending Eeg Signals Using Arduinos And Xbee Radios To Control A Robot, Andrew Paul Simms

Electrical Engineering Undergraduate Honors Theses

The objective of this project is to develop an EEG device that can read brainwaves from an individual, analyze the data, and use the result to send a wireless signal using Arduinos and XBee Radios to a Boe-bot to perform an action. One of the goals of this project is to read EEG data with a higher sampling frequency than a previously manufactured EEG device. The second part of the project used the device developed to differentiate an individual’s thinking between right and left and then send a simple signal to a robot using an XBee radio to perform an …

Computer Modeling And Simulation Of Implantable Medical Device Heating Due To Mri Gradient Coil Fields, Bryan David Stem

Open Access Theses

For patients with implantable medical devices, the ability to safely undergo MRI scanning is critical to ensuring the highest standard of care. The gradient coils of an MRI generate kilohertz frequency, time varying magnetic fields. These magnetic fields induce a voltage on the external case of metallic, implantable medical devices through electromagnetic induction. Since the magnetic field generated by a gradient coil is time varying, the induced voltage results in the flow of eddy currents which can cause heating effects. These heating effects have been successfully modeled using ANSYS Maxwell and ANSYS Mechanical software packages.

The multi-physics simulation and solution …

Developing A Hardware Platform For A Low-Power, Low-Cost, Size-Constrained Biomechanical Telemetry System, Aditya Balasubramanian

Open Access Theses

As sport-related traumatic brain injuries face increasing attention from the media and the general public, the need to be able to detect brain injury quickly, inexpensively and accurately is more important than ever. Commercially-available event-based systems exist that claim to achieve this goal; however, they collect little to no continuous-time data and primarily indicate when a pre-determined acceleration threshold has been exceeded under the unvalidated assumption that a potentially concussive blow has occurred. Recent findings by the Purdue Neurotrauma Group (PNG) have indicated that repeated exposure to both concussive and subconcussive blows can result in cumulative trauma disorder. To track …

Generation Of Bipolar Nanosecond Pulses, Sambasiva Rao Rajulapati

Electrical & Computer Engineering Theses & Dissertations

Bipolar pulse generation has been studied using transmission line technology, which was mainly used for monopolar pulse generation. In this thesis, low impedance, high current, nanosecond pulse generators were designed, constructed and tested. Five transmission lines were connected in parallel, so the impedance was 10 n. The transmission lines were switched by a spark gap switch operated in air. The closing of the switch creates a matched condition on one side of the transmission lines and a short circuit on the other side of the transmission lines. When the transmission lines are precharged, one of the two waves in opposite …

Sic For Advanced Biological Applications, Joseph Register

USF Tampa Graduate Theses and Dissertations

Silicon carbide (SiC) has been used for centuries as an industrial abrasive and has been

actively researched since the 1960's as a robust material for power electronic applications.

Despite being the first semiconductor to emit blue light in 1907, it has only recently been

discovered that the material has crucial properties ideal for long-term, implantable biomedical

devices. This is due to the fact that the material offers superior biocompatibility and

hemocompatibility while providing rigid mechanical and chemical stability. In addition, the material

is a wide-bandgap semiconductor that can be used for optoelectronics, light delivery, and optical

sensors, which is the …

Quantized Nonnegative Matrix Factorization, Ruairí De Fréin

Conference papers

Even though Nonnegative Matrix Factorization (NMF) in its original form performs rank reduction and signal compaction implicitly, it does not explicitly consider storage or transmission constraints. We propose a Frobenius-norm Quantized Nonnegative Matrix Factorization algorithm that is 1) almost as precise as traditional NMF for decomposition ranks of interest (with in 1-4dB), 2) admits to practical encoding techniques by learning a factorization which is simpler than NMF’s (by a factor of 20-70) and 3) exhibits a complexity which is comparable with state-of-the-art NMF methods. These properties are achieved by considering the quantization residual via an outer quantization optimization step, in …

Temporal Modulation Of Plasma Species In Atmospheric Dielectric Barrier Discharges, Aijun Yang, Xiaohua Wang, Dingxin Liu, Mingzhe Rong, Michael G. Kong

Bioelectrics Publications

The atmospheric pressure dielectric barrier discharge in helium is a pulsed discharge in nature and the moment of maximum species densities is almost consistent with peak discharge current density. In this paper, a one-dimensional fluid model is used to investigate the temporal structure of plasma species in an atmospheric He-N₂ dielectric barrier discharge (DBD). It is demonstrated that there exist microsecond delays of the moments of the maximum electron and ion densities from the peak of discharge current density. These time delays are caused by a competition between the electron impact and Penning ionizations, modulated by the N_{2 …}

Inorganic Biodegradable Devices For Temporary Implants, Kassan Unda

Masters Theses

"Implantable electronic devices have great potential to benefit many health care technologies. They comprise of two different categories. The first is permanent prosthetic devices like cardiac pacemakers or nerve stimulants. The other category includes temporary devices for interventional medical monitoring and control scenarios, which lose functionality and become unnecessary after their intended operational lifetime. This can cause serious electromagnetic and biomechanical safety concerns if not removed from the body by an additional surgical operation.

This thesis focuses on exploring the feasibility of implantable inorganic bioresorbable thin film resistive devices utilizing bioactive glass as the core structural material. This device will …

The Application Of Graphene Films In Biosensing And Electrowetting, Xuebin Tan

Wayne State University Dissertations

In recent years, graphene has been found to possess extraordinary electronic, optical, mechanical and electrochemical properties. Graphene is optically transparent and mechanically flexible, and has high electron mobility and conductivity. In this thesis, we propose to investigate graphene's properties in the detection of biomolecules as well as the manipulation of biological samples. Graphene without defects has high charge carrier mobility and surface areas, which is ideal for biosensors. However, literature shows a lot of variations in the measurements using graphene biosensors. In addition, the surface functionalization of graphene in order to enhance the specificity has not been fully investigated yet. …

High-Performance Accelerometer Based On Asymmetric Gapped Cantilevers For Physiological Acoustic Sensing, Yating Hu

Wayne State University Dissertations

Continuous or mobile monitoring of physiological sounds is expected to play important role in the emerging mobile healthcare field. Because of the miniature size, low cost, and easy installation, accelerometer is an excellent choice for continuous physiological acoustic signal monitoring. However, in order to capture the detailed information in the physiological signals for clinical diagnostic purpose, there are more demanding requirements on the sensitivity/noise performance of accelerometers. In this thesis, a unique piezoelectric accelerometer based on the asymmetric gapped cantilever which exhibits significantly improved sensitivity is extensively studied. A meso-scale prototype is developed for capturing the high quality cardio and …

A Method For Non-Invasive, Automated Behavior Classification In Mice, Using Piezoelectric Pressure Sensors, Steven R. Gooch

Theses and Dissertations--Electrical and Computer Engineering

While all mammals sleep, the functions and implications of sleep are not well understood, and are a strong area of investigation in the research community. Mice are utilized in many sleep studies, with electroencephalography (EEG) signals widely used for data acquisition and analysis. However, since EEG electrodes must be surgically implanted in the mice, the method is high cost and time intensive. This work presents an extension of a previously researched high throughput, low cost, non-invasive method for mouse behavior detection and classification. A novel hierarchical classifier is presented that classifies behavior states including NREM and REM sleep, as well …