Biomedical Engineering and Bioengineering Commons^™

Protein-Targeted Corona Phase Molecular Recognition, Gili Bisker, Juyao Dong, Hoyoung D. Park, Nicole M. Iverson, Jiyoung Ahn, Justin T. Nelson, Markita P. Landry, Sebastian Kruss, Michael S. Strano

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated …

Use Of Lidar In The Design Of Grassed Waterways: Case Study In Agricultural Management In Oklahoma, Annette Sparks

Dissertations, Master's Theses and Master's Reports

Before the advent of Light Detection and Ranging (LiDAR) technology, farm-level infrastructure for sustainable agriculture was designed using topographic maps. LiDAR is a remote sensing method whereby reflected laser pulses are measured to generate high-resolution 3D images of the terrain. This report compares these two methods in the design of grassed waterways for flood drainage and evaluates how the quantitative difference between the two methods can affect the overall hydrologic design. The benefits of LiDAR are expected to be higher accuracy and precision in design, as well as greater reproducibility or consistency, regardless of the designer. To carry out this …

Feasibility Of Using Raman-Based Techniques For Breast Cancer Detection, Sara Mollamohammada

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Breast cancer is one of the common types of cancer among women all over the world. Early diagnosis is an effective way that improve the treatment process and gives the patients a better chance of survival. Many of the patients infected by breast cancer choose breast conservation surgery (BCS). However, some of those will be subjected to mastectomy, and many will have tumor recurrence as there is no precise technique to show the tumor margins. Raman-based methods are powerful techniques with potential to rapidly differentiate normal from tumor tissues and provides a solution to detect tumor margin. This is because …

Stethoscope-Based Detection Of Detorqued Bolts Using Impact-Induced Acoustic Emissions, Joe Guarino, Robert Hamilton

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Results of a preliminary study investigating a simple method for detecting looseness in bolted fasteners of a steel structure are presented. Extensive research by many investigators demonstrates that the frequency response of a bolted structural member changes when one or more bolts are loosened. A simple and effective method for detecting looseness can be applied to bolted joints, using inexpensive and commonly-available equipment and software. The difference between spectrograms associated with tight and loose bolts is clearly apparent due to the presence of a tell-tale mode when one or more bolts are loosened. Further, a striking difference can be elucidated …

2013 Fall Engr333 Project Final Report, 2013 Fall Engr333

ENGR 333

During the fall of 2013, the Engineering 333 class was asked the question, “what would it take for Calvin College to operate a biofuel vehicle from campus resources?” The three primary considerations included:

• Determining the optimal biofuel feedstock in terms of availability, transportation, and processing.
• Selecting a biofuel vehicle for conversion or purchase to operate on the selected feedstock.
• Designing the infrastructure and process required for operating the selected biofuel vehicle. The design and research described below proposes an environmentally sustainable and cost-effective method for integrating a biofuel vehicle into Calvin’s existing infrastructure.

2013 Fall Engr333 Student Seminar Presentation, Claire Philippi, Karl Bratt, Mike Houtman, Brandon Koster

ENGR 333

File for student presentation, given by students in the Fall 2013 class of ENGR333.

2013 Fall Engr333 Vehicle Poster, 2013 Fall Engr333

ENGR 333

Waste vegetable oil (WVO) was chosen by the class as the best fuel source for the Calvin Biofuel Vehicle Project. The class then considered vehicle options and selected a lawnmower to be powered by WVO.

2013 Fall Engr333 Fuel And Facilities Poster, 2013 Fall Engr333

ENGR 333

The objective of the project was to answer the question: “What would it take for Calvin College to operate a biofuel vehicle from campus resources.” The class split into 3 teams:

• Fuel/Feedstock
• Facilities/Infrastructure
• Vehicle

2013 Fall Engr333 Project Assignment, Matthew K. Heun

ENGR 333

The Fall 2013 ENGR333 project focused on production and use of biofuels at Calvin University.

I asked the students “What would it take for Calvin College to operate a biofuel vehicle from campus resources?”

Customer

The customer for this project was Calvin’s Physical Plant director Phil Beezhold.

Young’S Modulus And Volume Porosity Relationships For Additive Manufacturing Applications, John Anthony Choren, Stephen M. Heinrich, M. Barbara Silver-Thorn

Civil and Environmental Engineering Faculty Research and Publications

Recent advancements in additive manufacturing (or rapid prototyping) technologies allow the fabrication of end-use components with defined porous structures. For example, one area of particular interest is the potential to modify the flexibility (bending stiffness) of orthopedic implants through the use of engineered porosity (i.e., design and placement of pores) and subsequent fabrication of the implant using additive manufacturing processes. However, applications of engineered porosity require the ability to accurately predict mechanical properties from knowledge or characterization of the pore structure and the existence of robust equations characterizing the property–porosity relationships. As Young’s modulus can be altered by variations in …

A Watershed Scale Evaluation Of Selected Second Generation Biofeedstocks On Water Quality, Gurdeep Singh

Graduate Theses and Dissertations

This study compares a novel simulation approach to the conventional Soil and Water Assessment Tool (SWAT) modeler's approach for targeting biofuel crop production on marginal lands. In conventional SWAT modeling approach, non-spatial definition of hydrological response units (HRUs) results in the simulation of biofuel crops on both marginal and non-marginal land. This study provides an alternative approach in which a marginal-land raster was integrated into the land use and land cover (LULC) raster in such a way that the land uses were divided into marginal and non-marginal components. This modified LULC was used for model setup which resulted in marginal …

A Study On Facility Planning Using Discrete Event Simulation: Case Study Of A Grain Delivery Terminal, Sarah M. Asio

Department of Industrial and Management Systems Engineering: Dissertations, Theses, and Student Research

The application of traditional approaches to the design of efficient facilities can be tedious and time consuming when uncertainty and a number of constraints exist. Queuing models and mathematical programming techniques are not able to capture the complex interaction between resources, the environment and space constraints for dynamic stochastic processes. In the following study discrete event simulation is applied to the facility planning process for a grain delivery terminal. The discrete event simulation approach has been applied to studies such as capacity planning and facility layout for a gasoline station and evaluating the resource requirements for a manufacturing facility. To …

Identifying Changes In Climatic Trends And The Fingerprints Of Landuse And Landcover Changes In The High Plains Of The Usa, Denis Mutiibwa

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Human activities such as conversion of natural ecosystem to croplands and urban-centers, deforestation and afforestation impact biophysical properties of land surface such as albedo, energy balance, and surface roughness. Alterations in these properties affect the heat and moisture exchanges between the land surface and atmospheric boundary layer. The objectives of this research were; (i) to quantitatively identify the High plains’ regional climate change in temperatures over the period 1895 to 2006, (ii) detect the signatures of anthropogenic forcing of LULC changes on the regional climate change of the High Plains, and (iii) examine the trends in evolving regional latent heat …

Development Of The Mask Scentometer, A Comparison Of Ambient Odor Assessment Methods, And Their Application In Ground Truthing Atmospheric Dispersion Models, Christopher G. Henry

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

This dissertation is organized as four stand-alone papers. Paper No. 1 describes the development of the Mask Scentometer and reports dilution ratios measured during use by twelve different people. Dilution ratios at the Mask Scentometer’s five dilution-to-threshold (D/T) settings were found to be 0.35, 1, 2, 4.5 and 18. In Paper No.’s 2 and 4, ambient odor assessment methods were compared in both controlled laboratory conditions and in the field. Laboratory analysis of ambient air samples using dynamic triangular forced-choice olfactometry (DTFCO) did not correlate well with any of the ambient odor assessment methods. Average intensity-predicted D/T was roughly five …

Procedure To Quantify Biofilm Activity In Carriers Used In Wastewater Treatment Systems, James Bolton, Archana Tummala, Chirag Kapadia, Manoj Dandamudi, Joanne M. Belovich

Chemical & Biomedical Engineering Faculty Publications

A procedure is presented for evaluating and comparing the biological activity of biofilms attached to various biofilm carriers by measurement of the glucose consumption rate. This technique allows for the economical design and selection of small particulate biofilm carriers that will maximize substrate removal when used in industrial-scale fluidized bioreactors. Methods for ensuring reproducible results are described. To support the glucose consumption rate findings, biofilm dry weights were obtained at the conclusion of activity rate experiments, and scanning electron micrographs were taken to evaluate the presence of biofilm and to view surface characteristics. Fourteen different biofilm carriers were evaluated ranging …