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Articles 6601 - 6630 of 9373
Full-Text Articles in Engineering
Current State Of The Workforce Demographics And Knowledge Transfer Strategies In The Southeast United States, Vivek Sharma, Dhaval Gajjar, Kapil Madathil, David Davis, Shreyas Patel
Current State Of The Workforce Demographics And Knowledge Transfer Strategies In The Southeast United States, Vivek Sharma, Dhaval Gajjar, Kapil Madathil, David Davis, Shreyas Patel
The Professional Constructor
The construction industry is a very diverse industry due to the unique nature of projects and expertise within various construction companies driven by multiple regional/national factors. The United States Department of Labor reported 44% of the current US employed population will be above 65 in eleven years by 2028, making workforce studies and knowledge transfer a key driver in leading construction business models. This study conducted an in-depth investigation in the southeast region of the US on the current state of workforce demographics and the need for knowledge transfer within the ranks of management coupled with trade personnel. The study …
Perceptions Of Remote Work Within The Construction Industry Resulting From The Covid-19 Pandemic In The South Central United States, Sara B. Overturf, Ben Bigelow, Matthew Reyes
Perceptions Of Remote Work Within The Construction Industry Resulting From The Covid-19 Pandemic In The South Central United States, Sara B. Overturf, Ben Bigelow, Matthew Reyes
The Professional Constructor
Working remotely became increasingly popular over the previous two years, given organization’s need to rapidly adjust to changing conditions as a result of the Coronavirus. It allowed companies to more easily adapt to stay-at home orders and create a safer environment for their employees. While working remotely can have a positive impact on employees, there are also challenges to overcome for both employees and organizations. This study focused on understanding both the prevalence and implementation of remote work within the commercial Construction industry to face the professional challenges resulting from the Coronavirus. This paper provides insight into companies that have …
Educating The Construction Client: Training Strategy For Buyers Of Commercial Design And Construction Services, Michael J. Emmer
Educating The Construction Client: Training Strategy For Buyers Of Commercial Design And Construction Services, Michael J. Emmer
The Professional Constructor
Business owners can face a myriad of challenges when venturing into a new construction project. Most of the design and construction process is unfamiliar territory as compared to their customary business operations and owners face a wide assortment of issues when making the decision to build a new facility. Consequently, the majority of owners are entirely out of their business element when deciding to enter into the undertaking of a new building project. Since most of the risk with any given project rests with the Owner, better training and strategies for owners will lead to a higher likelihood of project …
Computational Based Investigation Of Lattice Cell Optimization Under Uniaxial Compression Load, Derek G. Spear, Jeremiah S. Lane, Anthony N. Palazotto, Ryan A. Kemnitz
Computational Based Investigation Of Lattice Cell Optimization Under Uniaxial Compression Load, Derek G. Spear, Jeremiah S. Lane, Anthony N. Palazotto, Ryan A. Kemnitz
Faculty Publications
Structural optimization is a methodology used to generate novel structures within a design space by finding a maximum or minimum point within a set of constraints. Topology optimization, as a subset of structural optimization, is often used as a means for light-weighting a structure while maintaining mechanical performance. This article presents the mathematical basis for topology optimization, focused primarily on the Bi-directional Evolutionary Structural Optimization (BESO) and Solid Isotropic Material with Penalization (SIMP) methodologies, then applying the SIMP methodology to a case study of additively manufactured lattice cells. Three lattice designs were used: the Diamond, I-WP, and Primitive cells. These …
System Performance Model And Control System For A Small-Scale Horizontal Axis Wind Turbine, Niko Banks
System Performance Model And Control System For A Small-Scale Horizontal Axis Wind Turbine, Niko Banks
Master's Theses
Predicting the performance of wind turbines is a key part of the turbine design process and operation, as predictive models play a large role in determining potential power output and efficiency at different operating conditions to help maximize production. On small-scale wind turbines performance models become more complex, as the rotor aerodynamic performance depends not only on the tip speed ratio, but also on the flow Reynolds number. An accurate predictive model that includes this behavior on small-scale wind turbines can be used to find the optimal operating conditions for power output, and is also a critical component of the …
Evaluation Of Cost-Effective Alternative Designs For Rural Expressway Intersections, Jonathan Howard
Evaluation Of Cost-Effective Alternative Designs For Rural Expressway Intersections, Jonathan Howard
Master's Theses
Despite numerous studies demonstrating the effectiveness of Restricted Crossing U-Turn (RCUT) intersection design, its implementation remains uneven and close to zero in some large states such as California. This research provides a comprehensive framework to estimate the operational and safety performance of future RCUT designs in California. The framework is demonstrated for five intersections located on high-speed rural expressways in California using VISSIM microsimulation models to measure operational performance for each intersection including the base condition with the existing Two-Way Stop-Controlled (TWSC) intersection and two RCUT designs. To evaluate future safety performance, the microsimulation models were further utilized to compile …
The Design, Construction And Analysis Of A Large Round Bale Handling Implement, Garrett J. Forbes
The Design, Construction And Analysis Of A Large Round Bale Handling Implement, Garrett J. Forbes
Master's Theses
To entice a small-scale hay producer to purchase equipment that will improve their hay hauling operation, a more cost effective and more universal solution must be developed. The objectives of this project are to develop and test a prototype large round bale handler. The prototype was built to industry standards, using modern electronic controls and the latest design and fabrication methods. The prototype makes use of an existing trailer and by doing so can be a less expensive method of hauling hay when compared to other equipment currently on the market. While the combination of the prototype bale handler and …
Investigation Of Green Strawberry Detection Using R-Cnn With Various Architectures, Daniel W. Rivers
Investigation Of Green Strawberry Detection Using R-Cnn With Various Architectures, Daniel W. Rivers
Master's Theses
Traditional image processing solutions have been applied in the past to detect and count strawberries. These methods typically involve feature extraction followed by object detection using one or more features. Some object detection problems can be ambiguous as to what features are relevant and the solutions to many problems are only fully realized when the modern approach has been applied and tested, such as deep learning.
In this work, we investigate the use of R-CNN for green strawberry detection. The object detection involves finding regions of interest (ROIs) in field images using the selective segmentation algorithm and inputting these regions …
Impact Of Teaching Practices And Communication Climates On Participation In Computer Science Education, Jackie Krone
Impact Of Teaching Practices And Communication Climates On Participation In Computer Science Education, Jackie Krone
Master's Theses
One way to understand teaching is to view it as a people process rather than a presentation of knowledge. It follows that the role of an educator often extends beyond the primary subject matter and into the realm of classroom management. With this in mind, our research aimed to capture the various teaching practices, participation patterns, and communication climates that occur in virtual computer science classrooms. We sought to answer the following research questions related to virtual computer science classrooms at our institution: Who participates in virtual computer science classrooms, and is participation proportional to student demographics? Is there any …
High-Resistance Connection Diagnosis In Five-Phase Pmsms Based On The Method Of Magnetic Field Pendulous Oscillation And Symmetrical Components, Hao Chen, Jiangbiao He, Xing Guan, Nabeel Demerdash, Ayman M. El-Refaie, Christopher H.T. Lee
High-Resistance Connection Diagnosis In Five-Phase Pmsms Based On The Method Of Magnetic Field Pendulous Oscillation And Symmetrical Components, Hao Chen, Jiangbiao He, Xing Guan, Nabeel Demerdash, Ayman M. El-Refaie, Christopher H.T. Lee
Electrical and Computer Engineering Faculty Research and Publications
An online approach for diagnosing high-resistance connection (HRC) faults in five-phase permanent magnet synchronous motor drives is presented in this article. The development of this approach is based on a so-called “magnetic field pendulous oscillation (MFPO)” technique and symmetrical components method. Under HRC fault condition, a “swing-like” MFPO phenomenon is observed compared to the healthy condition. Furthermore, with the extracted current features in symmetrical components domain, different HRC fault types are successfully identified and distinguished. These fault types include single-phase faults, e.g., HRC fault in phase-A; two-phase nonadjacent faults, e.g., HRC fault in phase-A&C; and two-phase adjacent faults, e.g., HRC …
Feverdots, Kameryn Laureano, Heidi Silk, Rita Grigorian
Feverdots, Kameryn Laureano, Heidi Silk, Rita Grigorian
Biomedical Engineering
FeverDots are wearable temperature sensitive stickers that change color from black to pink at 99°F when placed on the temple or forehead. The objective of this project was to develop an efficient manufacturing method for FeverDots, and manufacture a device along with it. To create the FeverDots manufacturing device, the full design process was executed. The team went through a thorough ideation phase before ultimately defining and specifying the scope of the project.
The key customer requirements of this device include that it is lightweight, portable, durable, simple to assemble, easy to use, and able to generate uniform ink and …
Astm Test Fixture For Spinal Screws, Sarah K. Pickering, Matthew W. Rowen, Kaajal N. Khanna, Thomas A. Sunding
Astm Test Fixture For Spinal Screws, Sarah K. Pickering, Matthew W. Rowen, Kaajal N. Khanna, Thomas A. Sunding
Biomedical Engineering
This document is an overview report of the Cal Poly Senior Project ASTM Test Fixture for SeaSpine orthopedic bone screws. The main application of orthopedic screws is to fasten implants directly to the bone structure, enhancing structural integrity. Testing for breaking angle, insertion torque, removal torque, axial pullout strength, and self-tapping force as specified in the ASTM F543 Annexes provides the FDA with vital screw mechanics and ensures manufacturing uniformity. The test system is comprised of custom and off the shelf components allowing for interchangeability, in case of part failure, and a low overall cost. It is mechanically capable of …
Stochastic Knapsack Revisited: The Service Level Perspective, Guodong Lyu, Mabel C. Chou, Chung-Piaw Teo, Zhichao Zheng, Yuanguang Zhong
Stochastic Knapsack Revisited: The Service Level Perspective, Guodong Lyu, Mabel C. Chou, Chung-Piaw Teo, Zhichao Zheng, Yuanguang Zhong
Research Collection Lee Kong Chian School Of Business
A key challenge in the resource allocation problem is to find near-optimal policies to serve different customers with random demands/revenues, using a fixed pool of capacity (properly configured). In this paper, we study the properties of three classes of allocation policies-responsive (with perfect hindsight), adaptive (with information updates), and anticipative (with forecast information) policies. These policies differ in how the information on actual demand and revenue of each customer is being revealed and integrated into the allocation decisions. We show that the analysis of these policies can be unified through the notion of "persistency" (or service level) values-the probability that …
Impact Of Covid-19 On Sense Of Community / Student Engagement, Aaron Sauer, Richard Gebken, Richard Bruce
Impact Of Covid-19 On Sense Of Community / Student Engagement, Aaron Sauer, Richard Gebken, Richard Bruce
The Professional Constructor
The spring of 2020 was a time of unprecedented change for higher education institutions. The COVID-19 pandemic forced schools to re-think instructional delivery and the undergraduate experience as they implemented measures to protect students, faculty, and staff. Unraveling the impact of the pandemic on higher education will take many years. This study investigated how the institutional response in the return to campus following the pandemic influenced sense of community, a component of student engagement. A previously developed instrument was delivered at two construction management programs in the U.S. Midwest before and after the pandemic. The two schools were similar in …
Simultaneous Strength-Ductility Enhancement In As-Cast Ti6al4v Alloy By Trace Ce, K. M. Li, Y. J. Liu, X. C. Liu, X. Wu, S. F. Zhou, Laichang Zhang, W. Li, W. C. Zhang
Simultaneous Strength-Ductility Enhancement In As-Cast Ti6al4v Alloy By Trace Ce, K. M. Li, Y. J. Liu, X. C. Liu, X. Wu, S. F. Zhou, Laichang Zhang, W. Li, W. C. Zhang
Research outputs 2022 to 2026
Impurity elements always play a major role in hindering mechanical property improvement in Ti6Al4V, and specifically most of them e.g. O, P, Cl, and S dissolved in the matrix deteriorate the mechanical properties of Ti6Al4V. This work presents a strategy of enhancing the mechanical performance of as-cast Ti6Al4V alloy by adding a small amount of rare earth (i.e. 0.1 wt% Ce), where deleterious elements could be absorbed from the crystalline lattice during solidification process, forming uniformly distributed Ce-rich oxides or precipitates with ∼200 nm in size. The Ce-rich precipitates in turn refine the beta phase lamellae by introducing more nucleation …
Eeg And Fmri Coupling And Decoupling Based On Joint Independent Component Analysis (Jica), Nicholas Heugel, Scott A. Beardsley, Einat Liebenthal
Eeg And Fmri Coupling And Decoupling Based On Joint Independent Component Analysis (Jica), Nicholas Heugel, Scott A. Beardsley, Einat Liebenthal
Biomedical Engineering Faculty Research and Publications
Background
Meaningful integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) requires knowing whether these measurements reflect the activity of the same neural sources, i.e., estimating the degree of coupling and decoupling between the neuroimaging modalities.
New method
This paper proposes a method to quantify the coupling and decoupling of fMRI and EEG signals based on the mixing matrix produced by joint independent component analysis (jICA). The method is termed fMRI/EEG-jICA.
Results
fMRI and EEG acquired during a syllable detection task with variable syllable presentation rates (0.25–3 Hz) were separated with jICA into two spatiotemporally distinct components, a primary …
Multisector Dynamics: Advancing The Science Of Complex Adaptive Human-Earth Systems, Patrick M. Reed, Antonia Hadjimichael, Richard H. Moss, Christa Brelsford, Casey D. Burleyson, Stuart Cohen, Ana Dyreson, David F. Gold, Rohini S. Gupta, Klaus Keller, Megan Konar, Erwan Monier
Multisector Dynamics: Advancing The Science Of Complex Adaptive Human-Earth Systems, Patrick M. Reed, Antonia Hadjimichael, Richard H. Moss, Christa Brelsford, Casey D. Burleyson, Stuart Cohen, Ana Dyreson, David F. Gold, Rohini S. Gupta, Klaus Keller, Megan Konar, Erwan Monier
Michigan Tech Publications, Part 1
The field of MultiSector Dynamics (MSD) explores the dynamics and co-evolutionary pathways of human and Earth systems with a focus on critical goods, services, and amenities delivered to people through interdependent sectors. This commentary lays out core definitions and concepts, identifies MSD science questions in the context of the current state of knowledge, and describes ongoing activities to expand capacities for open science, leverage revolutions in data and computing, and grow and diversify the MSD workforce. Central to our vision is the ambition of advancing the next generation of complex adaptive human-Earth systems science to better address interconnected risks, increase …
Experimental Assessments Of Methanol-Based Foaming Agent In Latex Modified Foamed Binders And Warm Asphalt Mixtures, Mohd Rosli Mohd Hasan, Tai Guo, Hainian Wang, Zhanping You
Experimental Assessments Of Methanol-Based Foaming Agent In Latex Modified Foamed Binders And Warm Asphalt Mixtures, Mohd Rosli Mohd Hasan, Tai Guo, Hainian Wang, Zhanping You
Michigan Tech Publications, Part 1
Latex is one of the natural rubbers that is used to enhance the performance of asphalt pavement for the last few decades. The presence of latex, which is categorized as an elastomer, helps to improve pavement performance and durability. Conversely, higher viscosity of latex modified asphalt binder increases the production-temperatures of asphalt mixture, thus consuming higher energy during asphalt mixture’s production stage. In this study, the effectiveness of methanol as an energy-efficient foaming agent was assessed to reduce the viscosity and enhance the workability of the modified asphalt binder. The basic and rheological properties of the asphalt binders were determined …
Infrastructure Decision-Making Under Climate Change Uncertainty: Case Study Of Centralized Heating At Wright-Patterson Afb, Ohio, Tyler A. Ferry, Justin D. Delorit, Christopher M. Chini
Infrastructure Decision-Making Under Climate Change Uncertainty: Case Study Of Centralized Heating At Wright-Patterson Afb, Ohio, Tyler A. Ferry, Justin D. Delorit, Christopher M. Chini
Faculty Publications
Increased prevalence, lower cost, and reduced environmental impacts have granted natural gas status as a bridge fuel over the past decade in place of coal-fired heat and power generation across the United States. As a result, some coal facilities are retrofitting their systems to combust natural gas for heating and power. However, data and economic criteria surrounding these decisions are not widely available. Wright-Patterson Air Force Base (WPAFB) invested approximately $25 million, from 2014 to 2016, to retrofit two coal-fired steam-heat-generating plants with natural gas equipment. Economic analyses used to inform these long-term infrastructure decisions rarely consider the uncertainty of …
Thermo-Fluidic Transport Process In A Novel M-Shaped Cavity Packed With Non-Darcian Porous Medium And Hybrid Nanofluid: Application Of Artificial Neural Network (Ann), Dipak Kumar Mandal, Nirmalendu Biswas, Nirmal K. Manna, Dilip Kumar Gayen, Rama S. R. Gorla, Ali J. Chamkha
Thermo-Fluidic Transport Process In A Novel M-Shaped Cavity Packed With Non-Darcian Porous Medium And Hybrid Nanofluid: Application Of Artificial Neural Network (Ann), Dipak Kumar Mandal, Nirmalendu Biswas, Nirmal K. Manna, Dilip Kumar Gayen, Rama S. R. Gorla, Ali J. Chamkha
Faculty Publications
In this work, an attempt has been made to explore numerically the thermo-fluidic transport process in a novel M-shaped enclosure filled with permeable material along with Al2O3-Cu hybrid nanoparticles suspended in water under the influence of a horizontal magnetizing field. To exercise the influence of geometric parameters, a classical trapezoidal cavity is modified with an inverted triangle at the top to construct an M-shaped cavity. The cavity is heated isothermally from the bottom and cooled from the top, whereas the inclined sidewalls are insulated. The role of geometric parameters on the thermal performance is scrutinized thoroughly …
Performance Assessment Of Existing Rc Bridges Equipped With Seismic Risk Mitigation Systems, Homam Mohamad Ghazal
Performance Assessment Of Existing Rc Bridges Equipped With Seismic Risk Mitigation Systems, Homam Mohamad Ghazal
Theses
Many bridges built before adopting current design standards may be at risk as they do not meet the latest seismic performance objectives. Bridges are vital infrastructure components required to be serviceable after earthquakes to avoid negative consequences on daily traffic. Previous seismic hazard studies considered the United Arab Emirates an earthquake-prone region subjected to two scenarios: (i) near-field events, and (ii) far-field earthquakes. Therefore, the vulnerability of pre-seismic code bridges in the UAE should be carefully assessed, and retrofit techniques should be proposed to mitigate possible earthquake losses. This study is thus devoted to assessing the seismic vulnerability of a …
The Impact Of Ride-Hail Surge Factors On Taxi Bookings, Sumit Agarwal, Ben Charoenwong, Shih-Fen Cheng, Jussi Keppo
The Impact Of Ride-Hail Surge Factors On Taxi Bookings, Sumit Agarwal, Ben Charoenwong, Shih-Fen Cheng, Jussi Keppo
Research Collection School Of Computing and Information Systems
We study the role of ride-hailing surge factors on the allocative efficiency of taxis by combining a reduced-form estimation with structural analyses using machine-learning-based demand predictions. Where other research study the effect of entry on incumbent taxis, we use higher frequency granular data to study how location-time-specific surge factors affect taxi bookings to bound the effect of customer decisions while accounting for various confounding variables. We find that even in a unique market like Singapore, where incumbent taxi companies have app-based booking systems similar to those from ride-hailing companies like Uber, the estimated upper bound on the cross-platform substitution between …
Hybrid Tabu Search Algorithm For Unrelated Parallel Machine Scheduling In Semiconductor Fabs With Setup Times, Job Release, And Expired Times, Changyu Chen, Madhi Fathi, Marzieh Khakifirooz, Kan Wu
Hybrid Tabu Search Algorithm For Unrelated Parallel Machine Scheduling In Semiconductor Fabs With Setup Times, Job Release, And Expired Times, Changyu Chen, Madhi Fathi, Marzieh Khakifirooz, Kan Wu
Research Collection School Of Computing and Information Systems
This research is motivated by a scheduling problem arising in the ion implantation process of wafer fabrication. The ion implementation scheduling problem is modeled as an unrelated parallel machine scheduling (UPMS) problem with sequence-dependent setup times that are subject to job release time and expiration time of allowing a job to be processed on a specific machine, defined as: R|rj,eij,STsd|Cmax. The objective is first to maximize the number of processed jobs, then minimize the maximum completion time (makespan), and finally minimize the maximum completion times of the non-bottleneck machines. A mixed-integer programming (MIP) model is proposed as a solution approach …
Coordinated Delivery To Shopping Malls With Limited Docking Capacity, Ruidian Song, Hoong Chuin Lau, Xue Luo, Lei Zhao
Coordinated Delivery To Shopping Malls With Limited Docking Capacity, Ruidian Song, Hoong Chuin Lau, Xue Luo, Lei Zhao
Research Collection School Of Computing and Information Systems
Shopping malls are densely located in major cities such as Singapore and Hong Kong. Tenants in these shopping malls generate a large number of freight orders to their contracted logistics service providers, who independently plan their own delivery schedules. These uncoordinated deliveries and limited docking capacity jointly cause congestion at the shopping malls. A delivery coordination platform centrally plans the vehicle routes for the logistics service providers and simultaneously schedules the dock time slots at the shopping malls for the delivery orders. Vehicle routing and dock scheduling decisions need to be made jointly against the backdrop of travel time and …
Efficient Certificateless Multi-Copy Integrity Auditing Scheme Supporting Data Dynamics, Lei Zhou, Anmin Fu, Guomin Yang, Huaqun Wang, Yuqing Zhang
Efficient Certificateless Multi-Copy Integrity Auditing Scheme Supporting Data Dynamics, Lei Zhou, Anmin Fu, Guomin Yang, Huaqun Wang, Yuqing Zhang
Research Collection School Of Computing and Information Systems
To improve data availability and durability, cloud users would like to store multiple copies of their original files at servers. The multi-copy auditing technique is proposed to provide users with the assurance that multiple copies are actually stored in the cloud. However, most multi-replica solutions rely on Public Key Infrastructure (PKI), which entails massive overhead of certificate computation and management. In this article, we propose an efficient multi-copy dynamic integrity auditing scheme by employing certificateless signatures (named MDSS), which gets rid of expensive certificate management overhead and avoids the key escrow problem in identity-based signatures. Specifically, we improve the classic …
Analyzing Offline Social Engagements: An Empirical Study Of Meetup Events Related To Software Development, Abhishek Sharma, Gede Artha Azriadi Prana, Anamika Sawhney, Nachiappan Nagappan, David Lo
Analyzing Offline Social Engagements: An Empirical Study Of Meetup Events Related To Software Development, Abhishek Sharma, Gede Artha Azriadi Prana, Anamika Sawhney, Nachiappan Nagappan, David Lo
Research Collection School Of Computing and Information Systems
Software developers use a variety of social mediachannels and tools in order to keep themselves up to date,collaborate with other developers, and find projects to contributeto. Meetup is one of such social media used by softwaredevelopers to organize community gatherings. We in this work,investigate the dynamics of Meetup groups and events relatedto software development. Our work is different from previouswork as we focus on the actual event and group data that wascollected using Meetup API.In this work, we performed an empirical study of eventsand groups present on Meetup which are related to softwaredevelopment. First, we identified 6,327 Meetup groups related …
Batchlens: A Visualization Approach For Analyzing Batch Jobs In Cloud Systems, Shaolun Ruan, Yong Wang, Hailong Jiang, Weijia Xu, Qiang. Guan
Batchlens: A Visualization Approach For Analyzing Batch Jobs In Cloud Systems, Shaolun Ruan, Yong Wang, Hailong Jiang, Weijia Xu, Qiang. Guan
Research Collection School Of Computing and Information Systems
Cloud systems are becoming increasingly powerful and complex. It is highly challenging to identify anomalous execution behaviors and pinpoint problems by examining the overwhelming intermediate results/states in complex application workflows. Domain scientists urgently need a friendly and functional interface to understand the quality of the computing services and the performance of their applications in real time. To meet these needs, we explore data generated by job schedulers and investigate general performance metrics (e.g., utilization of CPU, memory and disk I/O). Specifically, we propose an interactive visual analytics approach, BatchLens, to provide both providers and users of cloud service with an …
Amplitude And Wavelength Scaling Of Sinusoidal Roughness Effects In Turbulent Channel Flow At Fixed ReΤ, Sparsh Ganju, Sean C. C. Bailey, Christoph Brehm
Amplitude And Wavelength Scaling Of Sinusoidal Roughness Effects In Turbulent Channel Flow At Fixed ReΤ, Sparsh Ganju, Sean C. C. Bailey, Christoph Brehm
Mechanical Engineering Faculty Publications
Direct numerical simulations are performed for incompressible, turbulent channel flow over a smooth wall and different sinusoidal wall roughness configurations at a constant Reτ = 720. Sinusoidal walls are used to study the effects of well-defined geometric features of roughness-amplitude, a, and wavelength, λ, on the flow. The flow in the near-wall region is strongly influenced by both a and λ. Establishing appropriate scaling laws will aid in understanding the effects of roughness and identifying the relevant physical mechanisms. Using inner variables and the roughness function to scale the flow quantities provides support for Townsend’s hypothesis, …
Targeting Hif-2Α In The Tumor Microenvironment: Redefining The Role Of Hif-2Α For Solid Cancer Therapy., Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer
Targeting Hif-2Α In The Tumor Microenvironment: Redefining The Role Of Hif-2Α For Solid Cancer Therapy., Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer
Henry M. Rowan College of Engineering Departmental Research
Inadequate oxygen supply, or hypoxia, is characteristic of the tumor microenvironment and correlates with poor prognosis and therapeutic resistance. Hypoxia leads to the activation of the hypoxia-inducible factor (HIF) signaling pathway and stabilization of the HIF-α subunit, driving tumor progression. The homologous alpha subunits, HIF-1α and HIF-2α, are responsible for mediating the transcription of a multitude of critical proteins that control proliferation, angiogenic signaling, metastasis, and other oncogenic factors, both differentially and sequentially regulating the hypoxic response. Post-translational modifications of HIF play a central role in its behavior as a mediator of transcription, as well as the temporal transition from …
Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D
Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D
Articles
Healthcare systems are under siege globally regarding technology adoption; the recent pandemic has only magnified the issues. Providers and patients alike look to new enabling technologies to establish real-time connectivity and capability for a growing range of remote telehealth solutions. The migration to new technology is not as seamless as clinicians and patients would like since the new workflows pose new responsibilities and barriers to adoption across the telehealth ecosystem. Technology-mediated workflows (integrated software and personal medical devices) are increasingly important in patient-centered healthcare; software-intense systems will become integral in prescribed treatment plans [1]. My research explored the path to …