Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons™

Open Access. Powered by Scholars. Published by Universities.®

2021

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 7141 - 7170 of 9981

Full-Text Articles in Engineering

Exploring How Prize Challenges Complement An Organization's Innovation Efforts, Ademir Vrolijk, Zoe Szajnfarber Feb 2021

Exploring How Prize Challenges Complement An Organization's Innovation Efforts, Ademir Vrolijk, Zoe Szajnfarber

CESUN Conference

prize challenge, open innovation, crowdsourcing, NASA, 3D Printed Habitat Challenge, additive manufacturing


Risk Management Decision Making For Security And Trust In Hardware Supply Chains, Zachary A. Collier, Thomas L. Polmateer, James H. Lambert Feb 2021

Risk Management Decision Making For Security And Trust In Hardware Supply Chains, Zachary A. Collier, Thomas L. Polmateer, James H. Lambert

CESUN Conference

Modern cyber-physical systems are enabled by electronic hardware and embedded systems. The security of these sub-components is a concern during the design and operational phases of cyber-physical system life cycles. Compromised electronics can result in mission-critical failures, unauthorized access, and other severe consequences. As systems become more complex and feature greater connectivity, system owners must make decisions regarding how to mitigate risks and ensure resilience and trust. This paper provides an overview of research efforts related to assessing and managing risks, resilience, and trust with an emphasis on electronic hardware and embedded systems. The research takes a decision-oriented perspective, drawing …


The Challenges And Opportunities Of Teaching Systems Engineering For Large Scale Engineering Systemse, Edward Pines, Dennis Engi Feb 2021

The Challenges And Opportunities Of Teaching Systems Engineering For Large Scale Engineering Systemse, Edward Pines, Dennis Engi

CESUN Conference

In this paper, we discuss a course in large scale systems engineering that was developed as part of a twelve-credit Graduate Certificate in Systems Engineering for part-time and returning students. Our focus was on how to work on big, unmanageable, messy problems. Teaching systems engineering for large-scale engineering systems is challenging for many reasons. One of the main challenges is the breadth of material to be addressed within one or two courses. Other challenges result from how students learn about the transitions from the development of a conceptual framework to systems architecture through engineering design, mathematical analysis and eventual construction …


Propose Of Architecture Design For Early Warning System With Space And Terrestrial Infrastructure, Akihiko Nishino Feb 2021

Propose Of Architecture Design For Early Warning System With Space And Terrestrial Infrastructure, Akihiko Nishino

CESUN Conference

The purpose of this research is to design an architecture of early warning system with Global Navigation Satellite System (GNSS) and terrestrial infrastructure for improving a coverage of disaster information dissemination. In the proposed architecture, segments and information flow are identified in order to introduce an early warning system to target areas where there are no such kinds of public alert distribution. It can be adapted worldwide by combining GNSS satellite and terrestrial infrastructure. At the beginning of disaster, information will be sent from the agency via GNSS to terrestrial infrastructure, widely used such as a siren and a public …


Principles For Determining The Motion Of Blood Through Arteries, Sylvio R. Bistafa Feb 2021

Principles For Determining The Motion Of Blood Through Arteries, Sylvio R. Bistafa

Euleriana

Translation of Principia pro motu sanguinis per arterias determinando (E855). This work of 1775 by L. Euler is considered to be the first mathematical treatment of circulatory physiology and hemodynamics.


A Bibliometric Analysis Of Distributed Incremental Clustering On Images, Ayushi Agrawal, Preeti Mulay, Krithika Iyer, Saloni Sarbhai Feb 2021

A Bibliometric Analysis Of Distributed Incremental Clustering On Images, Ayushi Agrawal, Preeti Mulay, Krithika Iyer, Saloni Sarbhai

Library Philosophy and Practice (e-journal)

Unstructured information is continuously irregular and streaming information from such a sequence is tedious because it lacks labels and accumulates with time. This is possible using Incremental Clustering algorithms that use previously learned information to accommodate new data and avoid retraining. This paper therefore seeks to understand the status of "Distributed Incremental Clustering" on images with text and numerical values, its limitations, scope, and other details to devise a better algorithm in future. To further enhance the analysis, we have also included methodology, which can be used to perform clustering on images or documents based on its content.


Novel Guidewire Design And Coating For Continuous Delivery Of Adenosine During Interventional Procedures., Mervyn B Forman, Erik Brewer, Zachary R Brown, Elizabeth V Menshikova, Anthony M. Lowman, Edwin K Jackson Feb 2021

Novel Guidewire Design And Coating For Continuous Delivery Of Adenosine During Interventional Procedures., Mervyn B Forman, Erik Brewer, Zachary R Brown, Elizabeth V Menshikova, Anthony M. Lowman, Edwin K Jackson

Henry M. Rowan College of Engineering Departmental Research

Background: The "no-reflow phenomenon" compromises percutaneous coronary intervention outcomes. There is an unmet need for a device that prevents no-reflow phenomenon. Our goal was to develop a guidewire platform comprising a nondisruptive hydrophilic coating that allows continuous delivery of adenosine throughout a percutaneous coronary intervention. Methods and Results: We developed a guidewire with spaced coils to increase surface area for drug loading. Guidewires were plasma treated to attach hydroxyl groups to metal surfaces, and a methoxy-polyethylene glycol-silanol primer layer was covalently linked to hydroxyl groups. Using polyvinyl alcohol, polyvinyl pyrrolidone, and polyvinyl acetate, a drug layer containing jet-milled adenosine was …


Removal Of Pharmaceutical Residues From Water And Wastewater Using Dielectric Barrier Discharge Methods—A Review, Emile S. Massima Mouele, Jimoh O. Tijani, Kassim O. Badmus, Omoniyi Pereao, Omotola Babajide, Cheng Zhang, Tao Shao, Eduard Sosnin, Victor Tarasenko, Ojo O. Fatoba, Katri Laatikainen, Leslie F. Petrik Feb 2021

Removal Of Pharmaceutical Residues From Water And Wastewater Using Dielectric Barrier Discharge Methods—A Review, Emile S. Massima Mouele, Jimoh O. Tijani, Kassim O. Badmus, Omoniyi Pereao, Omotola Babajide, Cheng Zhang, Tao Shao, Eduard Sosnin, Victor Tarasenko, Ojo O. Fatoba, Katri Laatikainen, Leslie F. Petrik

Mining Engineering Faculty Research & Creative Works

Persistent pharmaceutical pollutants (PPPs) have been identified as potential endocrine disruptors that mimic growth hormones when consumed at nanogram per liter to microgram per liter concentrations. Their occurrence in potable water remains a great threat to human health. Different conventional technologies developed for their removal from wastewater have failed to achieve complete mineralization. Advanced oxidation technologies such as dielectric barrier discharges (DBDs) based on free radical mechanisms have been identified to completely decompose PPPs. Due to the existence of pharmaceuticals as mixtures in wastewater and the recalcitrance of their degradation intermediate by-products, no single advanced oxidation technology has been able …


College Of Engineering News, Georgia Southern University Feb 2021

College Of Engineering News, Georgia Southern University

College of Engineering & Computing: News & Publications (2010-2023)

  • Graduate Lands Dream Job at Tesla


Characterization Of The Strain-Rate–Dependent Mechanical Response Of Single Cell–Cell Junctions, Amir Monemian Esfahani, Jordan Rosenbohm, Bahareh Tajvidi Safa, Nickolay V. Lavrik, Grayson Minnick, Quan Zhou, Fang Kong, Xiaowei Jin, Eunju Kim, Ying Liu, Yongfeng Lu, Jung Yul Lim, James K. Wahl Iii, Ming Dao, Changjin Huang, Ruiguo Yang Feb 2021

Characterization Of The Strain-Rate–Dependent Mechanical Response Of Single Cell–Cell Junctions, Amir Monemian Esfahani, Jordan Rosenbohm, Bahareh Tajvidi Safa, Nickolay V. Lavrik, Grayson Minnick, Quan Zhou, Fang Kong, Xiaowei Jin, Eunju Kim, Ying Liu, Yongfeng Lu, Jung Yul Lim, James K. Wahl Iii, Ming Dao, Changjin Huang, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Cell–cell adhesions are often subjected to mechanical strains of different rates and magnitudes in normal tissue function. However, the rate-dependent mechanical behavior of individual cell– cell adhesions has not been fully characterized due to the lack of proper experimental techniques and therefore remains elusive. This is particularly true under large strain conditions, which may potentially lead to cell–cell adhesion dissociation and ultimately tissue fracture. In this study, we designed and fabricated a single-cell adhesion micro tensile tester (SCAμTT) using twophoton polymerization and performed displacement-controlled tensile tests of individual pairs of adherent epithelial cells with a mature cell–cell adhesion. Straining the …


Research Of Focl Parameters In The Range Of Positive Temperatures, Dilmurod Davronbekov, Zafar Khakimov Feb 2021

Research Of Focl Parameters In The Range Of Positive Temperatures, Dilmurod Davronbekov, Zafar Khakimov

Bulletin of TUIT: Management and Communication Technologies

This article studies the parameters of fiber-optic communication lines (FOCL) in the temperature range. For research, a climatic unit has been developed that allows a wide temperature range for testing (from -90°C to + 90°C) and an experimental complex for investigating the stability of optical parameters of a fiber-optic cable with temperature changes in the range from + 18°C to + 76°C. A technology of sequential switching of optical fibers of a fiber-optic cable by means of welding is proposed, thanks to which the constructive problem of placing a long optical fiber in a limited volume of a heat chamber …


The Concept Of Constructing Set-Theoretic Models Of Structures Of Intelligent Multi-Axis Mechatronic Robot Modules, Nazarov Khayriddin Nuritdinovich, Matyokubov Nurbek Rrustamovich, Temurbek Omonboyevich Rakhimov, Pulatov Rustambek Alisher Ugli Feb 2021

The Concept Of Constructing Set-Theoretic Models Of Structures Of Intelligent Multi-Axis Mechatronic Robot Modules, Nazarov Khayriddin Nuritdinovich, Matyokubov Nurbek Rrustamovich, Temurbek Omonboyevich Rakhimov, Pulatov Rustambek Alisher Ugli

Bulletin of TUIT: Management and Communication Technologies

The article discusses the features and areas of application of multi-axis electromagnetic mechatronic modules in modules of mechatronic and robotic systems that allow not only to increase productivity and improve the quality of manufactured products, but also by replacing heavy, monotonous and sometimes associated with a risk to human health, manual labor with a machine to release a person for creative constructive work. The generalized structure of a multi-axis mechatronic module is presented; multiple theoretical models of construction principles for the study of electromagnetic mechatronic modules of robots and robotic systems are constructed. In this case, the main attention is …


International Journal Of Electrical And Computer Engineering, Fred Lacy Feb 2021

International Journal Of Electrical And Computer Engineering, Fred Lacy

Faculty Publications

A superconductor has the ability to conduct electricity perfectly and exclude magnetic fields from its interior. In order to understand electromagnetic characteristics of superconductors, their material properties need to be examined. To facilitate this understanding, a theoretical model based on concepts of electromagnetics is presented to explain the electrical and magnetic properties of superconductors. The permittivity response is the key aspect of the model and it describes the electrical resistance response and why it vanishes at the material’s critical temperature. The model also explains the behavior of magnetic fields and why they cannot exist inside superconducting materials. The theoretical concepts …


What Tesla’S $1.5 Billion Bet On Bitcoin Means For Crypto Legitimacy, Singapore Management University Feb 2021

What Tesla’S $1.5 Billion Bet On Bitcoin Means For Crypto Legitimacy, Singapore Management University

Perspectives@SMU

Some significant issues need to be resolved before Tesla can accept Bitcoin as a legitimate method of payment, says UNSW Business School's Mark Humphery-Jenner


Kinematic And Kinetic Changes After Total Hip Arthroplasty During Sit-To-Stand Transfers: Systematic Review, Junsig Wang, Safeer F. Siddicky, Michael P. Dohm, C. Lowry Barnes, Erin M. Mannen Feb 2021

Kinematic And Kinetic Changes After Total Hip Arthroplasty During Sit-To-Stand Transfers: Systematic Review, Junsig Wang, Safeer F. Siddicky, Michael P. Dohm, C. Lowry Barnes, Erin M. Mannen

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Background: Total hip arthroplasty (THA) is a common and effective surgical procedure that allows patients with hip osteoarthritis to restore functional ability and relieve pain. Sit-to-stand transfers are common demanding tasks during activities of daily living and are performed more than 50 times per day. The purpose of this systematic review is to obtain a comprehensive understanding of biomechanical changes during sit-to-stand transfers after THA.

Methods: Relevant articles were selected through MEDLINE, Scopus, Embase, and Web of Science. Articles were included if they met the following inclusion criteria: 1) participants underwent total hip arthroplasty without restriction on the arthroplasty design, …


Resilient Florida Buildings: Alternative Fuel Options For Maintaining Power During Outages, Brochure, Florida Solar Energy Center, Colleen Mccann Kettles Feb 2021

Resilient Florida Buildings: Alternative Fuel Options For Maintaining Power During Outages, Brochure, Florida Solar Energy Center, Colleen Mccann Kettles

FSEC Energy Research Center®

Electricity outages impact buildings as well as the fueling infrastructure that delivers energy resources for power generation and transportation. A fueling infrastructure with minimal downtime during power outages is needed to increase the resiliency of buildings and the economy. This brochure describes alternative fuels to consider for a buildings resiliency plan. This material is based upon work supported by the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy (EERE) under the Energy Technology Development Program Award Number DE-EE0008880. FSEC Art#: BLDG-89 Updated: 05/20/2021


Transdermal Uptake Of Benzophenone-3 From Clothing: Comparison Of Human Participant Results To Model Predictions, Azin Eftekhari, Jonathan T. Hill, Glenn C. Morrison Feb 2021

Transdermal Uptake Of Benzophenone-3 From Clothing: Comparison Of Human Participant Results To Model Predictions, Azin Eftekhari, Jonathan T. Hill, Glenn C. Morrison

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Background: Models of transdermal uptake of chemicals from clothing have been developed but not compared with recent human subject experiments. In a well-characterized experiment, participants wore t-shirts pre-dosed with benzophenone-3 (BP-3) and BP-3 and a metabolite were monitored in urine voids. Objective: Compare a dynamic model of transdermal uptake from clothing to results of the human subject experiment. Methods: The model simulating dynamic transdermal uptake from clothing was coupled with direct measurements of the gas phase concentration of benzophenone-3 (BP-3) near the surface of clothing to simulate the conditions of the human subject experiment. Results: The base-case model results were …


The Bridge Newsletter Spring 2021, Missouri University Of Science And Technology Feb 2021

The Bridge Newsletter Spring 2021, Missouri University Of Science And Technology

The Bridge Newsletter

-Researchers investigate improved bridge repair after collisions
-White initiated as 132nd honor member of Chi Epsilon
-Bereyso named New Face of Civil Engineering by ASCE
-150-year Celebration of Civil Engineering


Quantitative Set-Based Design To Inform Design Teams, Eric Specking, Nicholas Shallcross, Gregory S. Parnell, Edward Pohl Feb 2021

Quantitative Set-Based Design To Inform Design Teams, Eric Specking, Nicholas Shallcross, Gregory S. Parnell, Edward Pohl

Industrial Engineering Faculty Publications and Presentations

System designers, analysts, and engineers use various techniques to develop complex systems. A traditional design approach, point-based design (PBD), uses system decomposition and modeling, simulation, optimization, and analysis to find and compare discrete design alternatives. Set-based design (SBD) is a concurrent engineering technique that compares a large number of design alternatives grouped into sets. The existing SBD literature discusses the qualitative team-based characteristics of SBD, but lacks insights into how to quantitatively perform SBD in a team environment. This paper proposes a qualitative SBD conceptual framework for system design, proposes a team-based, quantitative SBD approach for early system design and …


Investigating The Impacts Of Crash Prediction Models On Quantifying Safety Effectiveness Of Adaptive Signal Control Systems, Weimin Jin, Mashrur Chowdhury, Sakib Mahmud Khan, Patrick Gerard Feb 2021

Investigating The Impacts Of Crash Prediction Models On Quantifying Safety Effectiveness Of Adaptive Signal Control Systems, Weimin Jin, Mashrur Chowdhury, Sakib Mahmud Khan, Patrick Gerard

Publications

Introduction: Adaptive Signal Control System (ASCS) can improve both operational and safety benefits at signalized corridors. Methods: This paper develops a series of models accounting for model forms and possible predictors and implements these models in Empirical Bayes (EB) and Fully Bayesian (FB) frameworks for ASCS safety evaluation studies. Different models are validated in terms of the ability to reduce the potential bias and variance of prediction and improve the safety effectiveness estimation accuracy using real-world crash data from non-ASCS sites. This paper then develops the safety effectiveness of ASCS at six different corridors with a total of 65 signalized …


Parking Recommender System Privacy Preservation Through Anonymization And Differential Privacy, Yasir Saleem Shaikh, Mubashir Husain Rehmani, Noel Crespi, Roberto Minerva Feb 2021

Parking Recommender System Privacy Preservation Through Anonymization And Differential Privacy, Yasir Saleem Shaikh, Mubashir Husain Rehmani, Noel Crespi, Roberto Minerva

Publications

Recent advancements in the Internet of Things (IoT) have enabled the development of smart parking systems that use services of third-party parking recommender system to provide recommendations of personalized parking spot to users based on their past experience. However, the indiscriminate sharing of users’ data with an untrusted (or semitrusted) parking recommender system may breach the privacy because users’ behavior and mobility patterns could be inferred by analyzing their past history. Therefore, in this article, we present two solutions that preserve privacy of users in parking recommender systems while analyzing the past parking history using k-anonymity (anonymization) and differential privacy …


Adaptive Signal System Safety Impacts Final Report, Mashrur Chowdhury, Weiman Jin, M. Sabbir Salek, Sakib Mahmud Khan, Katherine Brunk, Patrick Gerard, Nathan Huynh, Mohammad Torkjazi Feb 2021

Adaptive Signal System Safety Impacts Final Report, Mashrur Chowdhury, Weiman Jin, M. Sabbir Salek, Sakib Mahmud Khan, Katherine Brunk, Patrick Gerard, Nathan Huynh, Mohammad Torkjazi

Publications

The research team conducted a literature review and a nation-wide survey at the beginning of the research. The literature review revealed that Adaptive Signal Control System (ASCS) was effective in reducing crashes in some studies, while in other studies, the crash reduction due to ASCS was not statistically significant. Twenty-eight states participated in the nation-wide survey and helped the research team identify corridor characteristics, such as the design speed and Annual Average Daily Traffic (AADT) of an ASCS corridor, which would allow for the best operational and safety outcomes. Then, to determine the safety effects of ASCS, the research team …


Discrete Element Modeling Of Hydrogel Extrusion, Rohit Boddu Feb 2021

Discrete Element Modeling Of Hydrogel Extrusion, Rohit Boddu

Theses and Dissertations

Hydrogels are widely used in extrusion bioprinting as bioinks. Understanding how the hydrogel microstructure affects the bioprinting process aids researchers in predicting the behavior of biological components. Current experimental tools are unable to measure internal forces and microstructure variations during the bioprinting process. In this work, discrete element modeling was used to study the internal interactions and the elastic deformation of the molecular chains within hydrogel networks during the extrusion process. Two-dimensional models of hydrogel extrusions were created in Particle Flow Code (PFC; Itasca Co., Minneapolis, MN). For our model's calibration, hydrogel compression testing was used in which a cluster …


A High-Temperature-Resistant Inorganic Matrix For Concrete Structures Enhanced By Fiber-Reinforced Polymer, Jing Zhu, Wenzhong Zheng, Lili Xie, Lesley Sneed Feb 2021

A High-Temperature-Resistant Inorganic Matrix For Concrete Structures Enhanced By Fiber-Reinforced Polymer, Jing Zhu, Wenzhong Zheng, Lili Xie, Lesley Sneed

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This paper probed deep into a high-temperature resistant inorganic matrix: alkali-activated slag cement (AASC), which is a kind of cementitious material prepared by alkali-activator and pozzolanic or latent hydraulic material. Firstly, the mix ratio of the AASC was optimized to improve the wettability and mechanical properties. Then, the effects of the adhesive matrix and the type of fiber-reinforced polymer (FRP) were observed through FRP-to-concrete bond tests on 93 specimens. The test results, coupled with anchorage analysis, indicate that the AASC has comparable reinforcing effects as those of organic epoxy matrix; the anchorage length of FRP sheets has a significant influence …


Evaluation Of Orange Pavement Striping For Use In Work Zones, Erin Lammers-Staats, William Staats, Ken Agent Feb 2021

Evaluation Of Orange Pavement Striping For Use In Work Zones, Erin Lammers-Staats, William Staats, Ken Agent

Kentucky Transportation Center Research Report

Interstate widening projects are commonplace in Kentucky, and safety is of primary concern within the project work zone. Past experience with long work zones revealed two critical safety issues: driver confusion due to unclear pavement markings and a lack of continuous work zone signage for motorists indicating they are still within a work zone. This concern is heightened in transition and taper areas. Highly visible markings in an alternative color other than standard yellow or white might better distinguish the proper travel path for motorists and prevent drivers from returning to normal driving behavior and speeds once they get through …


Fiscal Year 2019 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack Feb 2021

Fiscal Year 2019 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack

Kentucky Transportation Center Research Report

The Federal Highway Administration (FHWA) requires state transportation agencies to submit a biennial report on local highway finances. The purpose of these reports is to provide FHWA with the data it needs to capture the financing of highway activities at the local level. Based on this information, it can identify trends in revenue, expenditures, investments, and program development, and in turn make decisions about future investments. The report, FHWA-536, asks agencies to report on four areas of local highway finance: 1) disposition of highway-user revenues; 2) revenues used for roads and streets identified by source and funding type; 3) road …


Ship Detection And Tracking In Inland Waterways Using Improved Yolov3 And Deep Sort, Yang Jie, Lilianasimwe Leonidas, Farhan Mumtaz, Munsif Ali Feb 2021

Ship Detection And Tracking In Inland Waterways Using Improved Yolov3 And Deep Sort, Yang Jie, Lilianasimwe Leonidas, Farhan Mumtaz, Munsif Ali

Electrical and Computer Engineering Faculty Research & Creative Works

Ship detection and tracking is an important task in video surveillance in inland waterways. However, ships in inland navigation are faced with accidents such as collisions. For collision avoidance, we should strengthen the monitoring of navigation and the robustness of the entire system. Hence, this paper presents ship detection and tracking of ships using the improved You Only Look Once version 3 (YOLOv3) detection algorithm and Deep Simple Online and Real-time Tracking (Deep SORT) tracking algorithm. Three improvements are made to the YOLOv3 target detection algorithm. Firstly, the Kmeans clustering algorithm is used to optimize the initial value of the …


Modeling And Analysis Of Microstrip Annular Ring Antenna With Capacitive Coupling Matching Network, Yan Li, Sheng Sun, Lijun Jiang, Buning Tian Feb 2021

Modeling And Analysis Of Microstrip Annular Ring Antenna With Capacitive Coupling Matching Network, Yan Li, Sheng Sun, Lijun Jiang, Buning Tian

Electrical and Computer Engineering Faculty Research & Creative Works

In this manuscript, microstrip annular ring antenna with capacitive coupling matching network is modeled and analyzed with equivalent circuit model and cavity model, which is simple and accurate for this structure. The proposed approach not only demonstrates physics lying behind the engineering design but also will be a good guideline for the microstrip annular ring antenna design. A prototype working UHF RFID band (902-928 MHz) is designed. Overall dimension of the proposed antenna is about 0.5λ0 x 0.5λ0 x 0.055λ0, and the realized gain is larger than 5 dB with axial ratio is smaller than 3 dB. The measured results …


Bone Cement As A Local Chemotherapeutic Drug Delivery Carrier In Orthopedic Oncology: A Review, Sunjeev S. Phull, Alireza Rahimnejad Yazdi, Michelle Ghert, Mark R. Towler Feb 2021

Bone Cement As A Local Chemotherapeutic Drug Delivery Carrier In Orthopedic Oncology: A Review, Sunjeev S. Phull, Alireza Rahimnejad Yazdi, Michelle Ghert, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Metastatic bone lesions are common among patients with advanced cancers. While chemotherapy and radiotherapy may be prescribed immediately after diagnosis, the majority of severe metastatic bone lesions are treated by reconstructive surgery, which, in some cases, is followed by postoperative radiotherapy or chemotherapy. However, despite recent advancements in orthopedic surgery, patients undergoing reconstruction still have the risk of developing severe complications such as tumor recurrence and reconstruction failure. This has led to the introduction and evaluation of poly (methyl methacrylate) and inorganic bone cements as local carriers for chemotherapeutic drugs (usually, antineoplastic drugs (ANPDs)). The present work is a critical …


In Vitro Evaluation Of Novel Titania-Containing Borate Bioactive Glass Scaffolds, Romina Shafaghi, Omar Rodriguez, Anthony W. Wren, Loraine Chiu, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler Feb 2021

In Vitro Evaluation Of Novel Titania-Containing Borate Bioactive Glass Scaffolds, Romina Shafaghi, Omar Rodriguez, Anthony W. Wren, Loraine Chiu, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Titanium-containing borate bioactive glass scaffolds (0, 5, 15, and 20 mol %, identified as BRT0, BRT1, BRT3, and BRT4) with a microstructure similar to that of human trabecular bone were prepared and evaluated in vitro for potential bone loss applications in revision total knee arthroplasty (rTKA). Methyl thiazolyl tetrazolium (MTT) cell viability assays of scaffold ion release extracts revealed that BRT0 scaffolds (0 mol % titanium) inhibited cell proliferation and activity at day 14. At day 30, all scaffold extracts decreased cell proliferation and activity significantly. However, live/dead cell assay results demonstrated that degradation products from all the scaffolds had …