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Articles 721 - 750 of 7238
Full-Text Articles in Engineering
Asymptotically Optimal Algorithm For Checking Whether A Given Vector Is A Solution To A Given Interval-Quantifier Linear System, Vladik Kreinovich
Asymptotically Optimal Algorithm For Checking Whether A Given Vector Is A Solution To A Given Interval-Quantifier Linear System, Vladik Kreinovich
Departmental Technical Reports (CS)
In many practical situations, we have a linear dependence between different quantities. In such situations, we often need to solve the corresponding systems of linear equations. Often, we know the parameters of these equations with interval uncertainty. In this case, depending on the practical problem, we have different notions of a solution. For example, if we determine parameters from observations, we are interested in all the unknowns which satisfy the given system of linear equations for some possible values of the parameters. If we design a system so that it does not exceed given tolerance bounds, then we need to …
Is The World Itself Fuzzy? Physical Arguments For -- And Unexpected Computational Consequences Of -- Zadeh's Vision, Vladik Kreinovich, Olga Kosheleva
Is The World Itself Fuzzy? Physical Arguments For -- And Unexpected Computational Consequences Of -- Zadeh's Vision, Vladik Kreinovich, Olga Kosheleva
Departmental Technical Reports (CS)
Fuzzy methodology has been invented to describe imprecise ("fuzzy") human statements about the world, statements that use imprecise words from natural language like "small" or "large". Usual applications of fuzzy techniques assume that the world itself is ``crisp'', that there are exact equations describing the world, and fuzziness of our statements is caused by the incompleteness of our knowledge. But what if the world itself is fuzzy? What if there is no perfect system of equations describing the physical world -- in the sense that no matter what system of equations we try, there will always be cases when this …
Workspace Analysis Of A Linear Delta Robot: Calculating The Inscribed Radius, Michael Louis Pauly
Workspace Analysis Of A Linear Delta Robot: Calculating The Inscribed Radius, Michael Louis Pauly
Graduate Theses - Mechanical Engineering
One of the most important traits of a robotic manipulator is its work envelope, the space in which the robot can position its end effector. Parallel manipulators, while generally faster, are restricted by smaller work envelopes [1]. As such, understanding the parameters defining a physical robot’s work envelope is essential to the optimal design, selection, and use of robotic parallel manipulators. A Linear Delta Robot (LDR) is a type of parallel manipulator in which three prismatic joints move separate arms which connect to a single triangular end plate [2]. In this study, general inverse kinematics were derived for a linear …
Path Flow Estimator For Planning Applications In Small Communities, Seungkyu Rya, Anthony Chen, H. Michael Zhang, Will Recker
Path Flow Estimator For Planning Applications In Small Communities, Seungkyu Rya, Anthony Chen, H. Michael Zhang, Will Recker
Graduate Student Publications
This paper presents an alternative planning framework to model and forecast network traffic for planning applications in small communities, where limited resources debilitate the development and applications of the conventional four-step travel demand forecasting model. The core idea is to use the path flow estimator (PFE) to estimate current and forecast future traffic demand while taking into account of various field and planning data as modeling constraints. Specifically, two versions of PFE are developed: a base year PFE for estimating the current network traffic conditions using field data and planning data, if available, and a future year PFE for predicting …
Simulation Of A Rising Sun Magnetron Employing A Faceted Cathode With A Continuous Current Source, Sulmer Fernandez-Gutierrez, Jim Browning, Ming-Chieh Lin, David N. Smithe, Jack Watrous
Simulation Of A Rising Sun Magnetron Employing A Faceted Cathode With A Continuous Current Source, Sulmer Fernandez-Gutierrez, Jim Browning, Ming-Chieh Lin, David N. Smithe, Jack Watrous
Electrical and Computer Engineering Faculty Publications and Presentations
It has been proposed that gated field emitters could be used in place of conventional thermionic cathodes to control the current injection in a magnetron, both temporally and spatially. Since gated field emitters have to be fabricated on flat surfaces, a faceted cathode would be used to implement this approach. A 2D ten cavity, rising sun magnetron has been modeled using the particle-in-cell code VORPAL. Cylindrical, five-sided, and ten-sided faceted cathodes were modeled to study the variation of magnetron operation due to the cathode shape. This work shows the results of the device performance employing three different cathode geometries with …
Design Studies Of Swept Wind Turbine Blades, Scott M. Larwood, C. P. Van Dam, Daniel Schow
Design Studies Of Swept Wind Turbine Blades, Scott M. Larwood, C. P. Van Dam, Daniel Schow
All Faculty Articles - School of Engineering and Computer Science
The growth of wind energy is sustained by innovation that lowers the cost of energy. One recent innovation is the swept blade, which deflects in operation and lowers loads. With sweep, a design rotor diameter can increase, capturing more power, with the loads remaining within limits. This concept has been demonstrated in a U.S. program and is in commercial production. This paper describes a parametric study of swept blade design parameters for a 750 kW machine. The amount of tip sweep had the largest effect on the energy production and blade loads; other parameters had less impact. The authors then …
Poster: Protecting Against Data Exfiltration Insider Attacks Through Application Programs, Asmaa Mohamed Sallama, Elisa Bertino
Poster: Protecting Against Data Exfiltration Insider Attacks Through Application Programs, Asmaa Mohamed Sallama, Elisa Bertino
Cyber Center Publications
In this paper, we describe a system that distinguishes be- tween legitimate and malicious database transactions per- formed by application programs. Our system is particularly useful for protecting against code-modification attacks performed by insiders who have access to and can change the programs' source code to make them execute different queries than those they are expected to execute. Our system works with any type of DBMS and requires minimum modification to application programs.
Tsu Faculty Publication Database, David Owerbach
Tsu Faculty Publication Database, David Owerbach
Office of Research Institutional Research and Scholarship
No abstract provided.
Cubic Spline Interpolation By Solving A Recurrence Equation Instead Of A Tridiagonal Matrix, Peter Revesz
Cubic Spline Interpolation By Solving A Recurrence Equation Instead Of A Tridiagonal Matrix, Peter Revesz
School of Computing: Conference and Workshop Papers
The cubic spline interpolation method is proba- bly the most widely-used polynomial interpolation method for functions of one variable. However, the cubic spline method requires solving a tridiagonal matrix-vector equation with an O(n) computational time complexity where n is the number of data measurements. Even an O(n) time complexity may be too much in some time-ciritical applications, such as continuously estimating and updating the flight paths of moving objects. This paper shows that under certain boundary conditions the tridiagonal matrix solving step of the cubic spline method could be entirely eliminated and instead the coefficients of the unknown cubic polynomials …
Predicting Solar Irradiance Using Time Series Neural Networks, Ahmad Alzahrani, Jonathan W. Kimball, Cihan H. Dagli
Predicting Solar Irradiance Using Time Series Neural Networks, Ahmad Alzahrani, Jonathan W. Kimball, Cihan H. Dagli
Electrical and Computer Engineering Faculty Research & Creative Works
Increasing the accuracy of prediction improves the performance of photovoltaic systems and alleviates the effects of intermittence on the systems stability. A Nonlinear Autoregressive Network with Exogenous Inputs (NARX) approach was applied to the Vichy-Rolla National Airport's photovoltaic station. The proposed model uses several inputs (e.g. time, day of the year, sky cover, pressure, and wind speed) to predict hourly solar irradiance. Data obtained from the National Solar Radiation Database (NSRDB) was used to conduct simulation experiments. These simulations validate the use of the proposed model for short-term predictions. Results show that the NARX neural network notably outperformed the other …
Calderón Preconditioned Pmchwt Equations For Analyzing Penetrable Objects In Layered Medium, Yongpin P. Chen, Lijun Jiang, Sheng Sun, Weng Cho Chew, Jun Hu
Calderón Preconditioned Pmchwt Equations For Analyzing Penetrable Objects In Layered Medium, Yongpin P. Chen, Lijun Jiang, Sheng Sun, Weng Cho Chew, Jun Hu
Electrical and Computer Engineering Faculty Research & Creative Works
We study Calderón preconditioners for analyzing electromagnetic scattering by penetrable objects in a layered medium. To account for the scattering effects of the multilayered background, the layered medium Green's function is adopted in the Poggio-Miller-Chang-Harrington-Wu-Tsai (PMCHWT) method. However, similar to the free-space case, the spectrum of the resulting equation is undesirable. This leads to a slow convergence of an iterative solver, especially when the geometry is densely meshed. To improve the convergence, a highly effective preconditioner is proposed. Different from its free-space counterpart, the preconditioning operator is constructed based on the Calderón identities for inhomogeneous medium. To reduce the relatively …
Fano Resonances Realized In Thz Metamaterials Composed Of Continuous Metallic Wires And Split Ring Resonators, Z. Li, S. Cakmakyapan, B. Butun, C. Daskalaki, S. Tzortzakis, Xiaodong Yang, E. Ozbay
Fano Resonances Realized In Thz Metamaterials Composed Of Continuous Metallic Wires And Split Ring Resonators, Z. Li, S. Cakmakyapan, B. Butun, C. Daskalaki, S. Tzortzakis, Xiaodong Yang, E. Ozbay
Mechanical and Aerospace Engineering Faculty Research & Creative Works
No abstract provided.
Modeling Of Thermal And Mechanical Behavior Of Zrb₂-Sic Ceramic After High Temperature Oxidation, Jun Wei, Lokeswarappa R. Dharani, K. Chandrashekhara, Greg Hilmas, William Fahrenholtz
Modeling Of Thermal And Mechanical Behavior Of Zrb₂-Sic Ceramic After High Temperature Oxidation, Jun Wei, Lokeswarappa R. Dharani, K. Chandrashekhara, Greg Hilmas, William Fahrenholtz
Mechanical and Aerospace Engineering Faculty Research & Creative Works
No abstract provided.
Runtime Self-Calibrated Temperature-Stress Cosensor For 3-D Integrated Circuits, Chun Zhang, Dian Ma, Changzhi Li, Yiyu Shi
Runtime Self-Calibrated Temperature-Stress Cosensor For 3-D Integrated Circuits, Chun Zhang, Dian Ma, Changzhi Li, Yiyu Shi
Electrical and Computer Engineering Faculty Research & Creative Works
On-chip temperature and stress sensors are important for runtime system management techniques tackling thermomechanical reliability issues in 3-D integrated circuits (ICs). However, traditional temperature and stress sensor designs require large calibration overhead to improve accuracy, which incurs significant cost for massive production. To address the challenge, in this paper, we propose a novel temperature-stress cosensor design for 3-D ICs. By exploring the inherent reciprocity of temperature and stress mechanisms, it achieves runtime self-calibration such that no dedicated calibration effort is needed. Simulation results show that the cosensor achieves 0.26 C and 0.43 MPa accuracy on average in temperature and stress …
Conducting Scaffolds For Liver Tissue Engineering, Armin Tahmasbi Rad, Naushad Ali, Hari Shankar R. Kotturi, Mostafa Yazdimamaghani, Jim Smay, Daryoosh Vashaee, Lobat Tayebi
Conducting Scaffolds For Liver Tissue Engineering, Armin Tahmasbi Rad, Naushad Ali, Hari Shankar R. Kotturi, Mostafa Yazdimamaghani, Jim Smay, Daryoosh Vashaee, Lobat Tayebi
Chemical and Biochemical Engineering Faculty Research & Creative Works
It is known that there is a correlation between a cell membrane potential and the proliferation of the cell. The high proliferation capacity of liver cells can also be attributed to its specific cell membrane potential as liver cell is recognized as one of the most depolarized of all differentiated cells. We hypothesized that this phenomenon can be emphasized by growing liver cells in conducting scaffolds that can increase the electrical communication among the cells. In this article, using tissue engineering techniques, we grew hepatocyte cells in scaffolds with various compositions. It was found that the scaffolds containing conducting polymer …
Solid Waste As Renewable Source Of Energy: Current And Future Possibility In Libya, Tarek A. Hamad, Abdulhakim A. Agll, Yousif M. Hamad, John W. Sheffield
Solid Waste As Renewable Source Of Energy: Current And Future Possibility In Libya, Tarek A. Hamad, Abdulhakim A. Agll, Yousif M. Hamad, John W. Sheffield
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Solid waste holds the greatest potential as biomass source in Libya. The rapid expansion of industry has led to increased urbanization and growing population. These factors have dramatically increased the amount of MSW (municipal solid waste) generated in Libya. However, issues related to environmentally sound MSW management - including waste decrease and clearance - have not been addressed sufficiently. This study presents an overview on solid waste that can be used as a source of bioenergy in Libya including MSW, ISW (industrial solid waste), and HSW (health care wastes) as biomass sources. The management of solid waste and valorization is …
Study Of Energy Recovery And Power Generation From Alternative Energy Source, Abdulhakim Amer A. Agll, Yousif M. Hamad, Tarek A. Hamad, John W. Sheffield
Study Of Energy Recovery And Power Generation From Alternative Energy Source, Abdulhakim Amer A. Agll, Yousif M. Hamad, Tarek A. Hamad, John W. Sheffield
Mechanical and Aerospace Engineering Faculty Research & Creative Works
The energy requirement pattern of world is growing up and developing technology. The available sources, while exhausting and not friendly to the environment, are highly used. Looking at partial supply and different options of environment problems associated with usage, renewable energy sources are getting attention. MSW (Municipal solid waste) composition data had been collected from 1997 to 2009, in Benghazi Libya, to evaluate the waste enthalpy. An incinerator with capacity of 47,250 kg/h was confirmed to burn all the quantity of waste generated by the city through the next 15 years. Initial study was performed to investigate energy flow and …
Inland Waterway Operational Model & Simulation Along The Ohio River, Doug Kreis, Roy E. Sturgill, Brian K. Howell, Christopher W. Van Dyke, D. Stephen Voss
Inland Waterway Operational Model & Simulation Along The Ohio River, Doug Kreis, Roy E. Sturgill, Brian K. Howell, Christopher W. Van Dyke, D. Stephen Voss
Kentucky Transportation Center Research Report
The inland waterway system of the U.S. is a vital network for transporting key goods and commodities from the point of production to manufacturers and consumers. Shipping materials via the inland waterways is arguably the most economical and environmentally friendly option (compared to hauling freight by trains or railways). Despite the advantages the inland waterways enjoys over competing modes, key infrastructure – such as locks and dams, which help to control water levels on a number of rivers and make navigation possible – is declining. Limited funds have been allocated to make the necessary repairs to lock and dam facilities. …
Manufacturing Of Transparent Composites Using Vacuum Infusion Process, V. G.K. Menta, R. R. Vuppalapati, K. Chandrashekhara, Thomas P. Schuman
Manufacturing Of Transparent Composites Using Vacuum Infusion Process, V. G.K. Menta, R. R. Vuppalapati, K. Chandrashekhara, Thomas P. Schuman
Chemistry Faculty Research & Creative Works
A novel optically transparent glass fiber reinforced polymer matrix composite has been developed by infusing a clear epoxy resin system of matching refractive index into a conventional E-glass fabric preform. Transparent composites are manufactured using a low cost, environmentally friendly vacuum infusion process. Physical and mechanical tests have been conducted. Transparent composites manufactured using the modified vacuum infusion process had a fiber volume fraction of 40%. Tensile strength and tensile modulus of these composites were 374.9 MPa and 31.74 GPa respectively. The results indicate that the transparent composites possess good physical and mechanical properties. These transparent composites form a good …
Audit Template For Inland Port Sustainability, Doug Kreis, Sarah Mccormack, Christopher Van Dyke, Bryan Gibson
Audit Template For Inland Port Sustainability, Doug Kreis, Sarah Mccormack, Christopher Van Dyke, Bryan Gibson
Kentucky Transportation Center Research Report
This report serves as an assessment of port sustainability and its potential applications for the inland river ports of Kentucky and the surrounding region. The report discusses and defines sustainability, both generally as it relates to business and industry and specifically as it relates to the port industry. Given the unique nature of the inland port industry, the report reviews lessons learned from 11 port site visits conducted by Kentucky Transportation Center in 2012, primarily at major U.S. coastal ports but also representative inland ports. KTC’s analysis identifies the sustainability challenges facing various domestic and international ports, and what policy …
Inland Waterways Funding Mechanisms Synthesis, Doug Kreis, Bryan Gibson, Christopher W. Van Dyke, Candice Y. Wallace, Sarah M. Mccormack
Inland Waterways Funding Mechanisms Synthesis, Doug Kreis, Bryan Gibson, Christopher W. Van Dyke, Candice Y. Wallace, Sarah M. Mccormack
Kentucky Transportation Center Research Report
The inland waterway system is a vital part of the nation’s multi-modal freight network. Although less visible than other modes, inland waterways allow shippers to transport bulk commodities in a relatively cheap and environmentally-friendly method. To ensure this transportation mode remains a feasible option and accommodates growth, it must continue to be safe, efficient, and functional. This synthesis provides comprehensive perspective on the financial prospects of the inland waterways system. It analyzes current funding levels, along with proposed funding changes and reforms.
Financial support for the inland waterways system comes from the Inland Waterways Trust Fund (IWTF). Historical data gathered …
Biphilic Nanoporous Surfaces Enabled Exceptional Drag Reduction And Capillary Evaporation Enhancement, Xianming Dai, Fanghao Yang, Ronggui Yang, Xinyu Huang, William A. Rigdon, Xiaodong Li, Chen Li
Biphilic Nanoporous Surfaces Enabled Exceptional Drag Reduction And Capillary Evaporation Enhancement, Xianming Dai, Fanghao Yang, Ronggui Yang, Xinyu Huang, William A. Rigdon, Xiaodong Li, Chen Li
Faculty Publications
Simultaneously achieving drag reduction and capillary evaporation enhancement is highly desired but challenging because of the trade-off between two distinct hydrophobic and hydrophilic wettabilities. Here, we report a strategy to synthesize nanoscale biphilic surfaces to endow exceptional drag reduction through creating a unique slip boundary condition and fast capillary wetting by inducing nanoscopic hydrophilic areas. The biphilic nanoporous surfaces are synthesized by decorating hydrophilic functional groups on hydrophobic pristine multiwalled carbon nanotubes. We demonstrate that the carbon nanotube-enabled biphilic nanoporous surfaces lead to a 63.1% reduction of the friction coefficient, a 61.7% wetting speed improvement, and up to 158.6% enhancement …
Shaping The Axial-Ratio Footprint Of Crossed-Dipole Antennas, Adam Narbudowicz, Max Ammann, Janusz Przewocki
Shaping The Axial-Ratio Footprint Of Crossed-Dipole Antennas, Adam Narbudowicz, Max Ammann, Janusz Przewocki
Conference papers
A method is proposed to adaptively change the axial-ratio beam of simple circularly-polarized antennas. It is shown, that by varying the phase shift between two orthogonal elements the axial-ratio beam shape can be dynamically adjusted. This allows control of the direction of minimum axial-ratio and the ability to increase or decrease the beamwidth in one of two planes. The method is intended for satellite navigation systems: it can improve the rejection of reflected signals in varying propagation conditions (e.g. urban canyons), while using simple and low-cost circularly-polarized antennas.
Can Protected Bike Lanes Help Close The Gender Gap In Cycling? Lessons From Five Cities, Jennifer Dill, Tara Goddard, Christopher Monsere, Nathan Mcneil
Can Protected Bike Lanes Help Close The Gender Gap In Cycling? Lessons From Five Cities, Jennifer Dill, Tara Goddard, Christopher Monsere, Nathan Mcneil
Urban Studies and Planning Faculty Publications and Presentations
Even in areas with increased levels of bicycling, there remains a significant “gender gap” in bicycling in the United States, in contrast to many other countries with high rates of bicycling. The primary objective of this paper was to explore whether protected bike lanes could help reduce the gender gap. To do so, the authors used survey data from a comprehensive evaluation of protected bike lanes in five large U.S. cities (Austin, TX, Chicago, IL, Portland, OR, San Francisco, CA, and Washington, DC) that included survey responses of 1,111 intercepted bicyclists and 2,283 residents. Both men and women overwhelmingly felt …
Growth And Properties Of Carbon Microcoils And Nanocoils, Muneaki Hikita, Robyn Bradford, Khalid Lafdi
Growth And Properties Of Carbon Microcoils And Nanocoils, Muneaki Hikita, Robyn Bradford, Khalid Lafdi
Chemical and Materials Engineering Faculty Publications
Various types of coiled carbon filaments have been synthesized using chemical vapor deposition and other methods. These carbon filaments exhibit unique electrical and mechanical properties due to their versatile shapes and structures. To form coiled shapes, different types of catalyst compositions and reactive gases have been explored. Generally, coiled carbon filaments are classified by coil diameter and shape (e.g., microcoil and nanocoil). In this review, coiled carbon filaments are classified into three growth mechanism categories:
(1) bidirectional double helical growth;
(2) bidirectional twisted growth; and
(3) tip single helical or twisted growth.
Next, their synthesis methods and hypothetical growth mechanisms …
The Icon Horn Loudspeaker, Vincent Phan
The Icon Horn Loudspeaker, Vincent Phan
Mechanical Engineering
A horn loudspeaker in layperson terms is essentially taking a megaphone and integrating it into a standard speaker. Similar to a cheerleader yelling into a megaphone, the horn loudspeaker will amplify the sound from the speaker with no additional power needed. Using standard speaker horn theory, the geometry of the “megaphone” can be engineered to tune the acoustic performance tailored to loudness and/or specific acoustics frequencies. The horn contours are similar to traditional orchestra instruments such as the French horn, trumpet, and tuba. The iconic beauty of a horn married with the quantitative engineering theory creates an aesthetic yet functional …
A Cfd Investigation Of The Hydrodynamic Characteristics Of Fluid Flow Through An Impeller And Multi-Objective Design Optimization Of A Centrifugal Pump, Mohammed Khammat Sagban
A Cfd Investigation Of The Hydrodynamic Characteristics Of Fluid Flow Through An Impeller And Multi-Objective Design Optimization Of A Centrifugal Pump, Mohammed Khammat Sagban
Doctoral Dissertations and Master's Theses
In this thesis, the first part is conducting an investigation of the hydrodynamic characteristics (pressure and velocity) of fluid flow (water) through an impeller of a centrifugal pump. To illustrate a one-dimensional model is used to identify an impeller of a GDM 10 x 12 HD centrifugal pump using Vista CPD design and BladeGen tool. A three-dimensional model is then built with a commercial software package ANSYS Blade Modeler. The structured mesh of the impeller blade is obtained by using TurboGrid system. The volute of the centrifugal pump is built in ANSYS geometry, and an unstructured mesh is accomplished by …
A Continuous/Discontinuous Fe Method For The 3d Incompressible Flow Equations, Nikolaos Kyriazis
A Continuous/Discontinuous Fe Method For The 3d Incompressible Flow Equations, Nikolaos Kyriazis
Doctoral Dissertations and Master's Theses
A projection scheme for the numerical solution of the incompressible Navier-Strokes equation is presented. Finite element discontinuous Galerkin (dG) discretization for the velocity in the momentum equations is employed. The incompressibility constraint is enforced by numerically solving the Poisson equation for pressure using a continuous Galerkin (cG) discretization. The main advantage of the method is that is does not require the velocity and pressure approximation spaces to satisfy the usual inf-sup condition, thus equal order finite element approximations for both velocity and pressure can be used. Furthermore, by using cG discretization for the Poisson equation, no auxiliary equations are needed …
Direct Numerical Simulations Of Non-Premixed Ethylene–Air Flames: Local Flame Extinction Criterion, Vivien R. Lecoustre, Paul G. Grias, Somesh P. Roy, Zhaoyu Luo, Dan C. Haworth, Hong G. Im, Tianfeng F. Lui, Arnaud Trouvé
Direct Numerical Simulations Of Non-Premixed Ethylene–Air Flames: Local Flame Extinction Criterion, Vivien R. Lecoustre, Paul G. Grias, Somesh P. Roy, Zhaoyu Luo, Dan C. Haworth, Hong G. Im, Tianfeng F. Lui, Arnaud Trouvé
Mechanical Engineering Faculty Research and Publications
Direct Numerical Simulations (DNS) of ethylene/air diffusion flame extinctions in decaying two-dimensional turbulence were performed. A Damköhler-number-based flame extinction criterion as provided by classical large activation energy asymptotic (AEA) theory is assessed for its validity in predicting flame extinction and compared to one based on Chemical Explosive Mode Analysis (CEMA) of the detailed chemistry. The DNS code solves compressible flow conservation equations using high order finite difference and explicit time integration schemes. The ethylene/air chemistry is simulated with a reduced mechanism that is generated based on the directed relation graph (DRG) based methods along with stiffness removal. The numerical configuration …
Slow Release Of Ions From Internalized Silver Nanoparticles Modifies The Epidermal Growth Factor Signaling Response, Kristen K. Comfort, Elizabeth I. Maurer, Saber M. Hussain
Slow Release Of Ions From Internalized Silver Nanoparticles Modifies The Epidermal Growth Factor Signaling Response, Kristen K. Comfort, Elizabeth I. Maurer, Saber M. Hussain
Chemical and Materials Engineering Faculty Publications
Due to their distinctive physiochemical properties, including a robust antibacterial activity and plasmonic capability, hundreds of consumer and medical products contain colloidal silver nanoparticles (AgNPs). However, even at sub-toxic dosages, AgNPs are able to disrupt cell functionality, through a yet unknown mechanism. Moreover, internalized AgNPs have the potential to prolong this disruption, even after the removal of excess particles. In the present study, we evaluated the impact, mechanism of action, and continual effects of 50 nm AgNP exposure on epidermal growth factor (EGF) signal transduction within a human keratinocyte (HaCaT) cell line. After AgNP expose, EGF signaling was initially obstructed …