Engineering Commons^™

Application Of Drum-Buffer-Rope Methodology In Scheduling Of Healthcare System, Arefeh Mohammadi, Emmanuel S. Eneyo

Durham School of Architectural Engineering and Construction: Faculty Publications

Theory of constraints (TOC) is a management philosophy that seeks to increase throughput (efficiency or performance) of the system by identifying those processes that are constraining the system bottlenecks. There have been very few profound studies of TOC in health care systems. In order to fill this gap, this study was conducted to determine how healthcare systems are utilizing components of TOC to schedule operations and what results are being obtained. This is done by using a patient flow model for a radiotherapy section of a hospital. The drum-buffer-rope (DBR) was used as the methodology for scheduling this flow. Successful …

Teaching Sustainable Design Using Bim And Project-Based Energy Simulations, Zhigang Shen, Wayne Jensen, Tim Wentz, Bruce Fischer

Durham School of Architectural Engineering and Construction: Faculty Publications

The cross-disciplinary nature of energy-efficient building design has created many challenges for architecture, engineering and construction instructors. One of the technical challenges in teaching sustainable building design is enabling students to quantitatively understand how different building designs affect a building’s energy performance. Concept based instructional methods fall short in evaluating the impact of different design choices on a buildings’ energy consumption. Building Information Modeling (BIM) with energy performance software provides a feasible tool to evaluate building design parameters. One notable advantage of this tool is its ability to couple 3D visualization of the structure with energy performance analysis without requiring …

Alignment And Composition Of Laminin-Polycaprolactone Nanofiber Blends Enhance Peripheral Nerve Regeneration, Rebekah A. Neal, Sunil S. Tholpady, Patricia L. Foley, Nathan Swami, Roy C. Ogle, Edward A. Botchwey

School of Medical Diagnostics & Translational Sciences Publications

Peripheral nerve transection occurs commonly in traumatic injury, causing deficits distal to the injury site. Conduits for repair currently on the market are hollow tubes; however, they often fail due to slow regeneration over long gaps. To facilitate increased regeneration speed and functional recovery, the ideal conduit should provide biochemically relevant signals and physical guidance cues, thus playing an active role in regeneration. To that end, laminin and lamininpolycaprolactone (PCL) blend nanofibers were fabricated to mimic peripheral nerve basement membrane. In vitro assays established 10% (wt) laminin content is sufficient to retain neurite-promoting effects of laminin. In addition, modified collector …

Enhanced Killing Effect Of Nanosecond Pulse Electric Fields On Panc1 And Jurkat Cell Lines In The Presence Of Tween 80, Gaurav Basu, Bhargava Subhash Kalluri, Ahmet Can Sabuncu, Christopher J. Osgood, Michael W. Stacey

Bioelectrics Publications

We investigated the effects of nanosecond pulse electric fields (nsPEFs) on Jurkat and PANC1 cells, which are human carcinoma cell lines, in the presence of Tween 80 (T80) at a concentration of 0.18% and demonstarted an enhanced killing effect. We used two biological assays to determine cell viability after exposing cells to nsPEFs in the presence of T80 and observed a significant increase in the killing effect of nsPEFs. We did not see a toxic effect of T80 when cells were exposed to surfactant alone. However, we saw a synergistic effect when cells exposed to T80 were combined with the …

Probing Nanoparticle Interactions In Cell Culture Media, Ahmet C. Sabuncu, Janna Grubbs, Shizhi Qian, Tarek M. Abdel-Fattah, Michael W. Stacey, Ali Beskok

Bioelectrics Publications

Nanoparticle research is often performed in vitro with little emphasis on the potential role of cell culture medium. In this study, gold nanoparticle interactions with cell culture medium and two cancer cell lines (human T-cell leukemia Jurkat and human pancreatic carcinoma PANC1) were investigated. Gold nanoparticles of 10, 25, 50, and 100 nm in diameter at fixed mass concentration were tested. Size distributions and zeta potentials of gold nanoparticles suspended in deionized (DI) water and Dulbecco's Modified Eagle's Media (DMEM) supplemented with fetal calf serum (FCS) were measured using dynamic light scattering (DLS) technique. In DI water, particle size distributions …

Oxidative Effects Of Nanosecond Pulsed Electric Field Exposure In Cells And Cell-Free Media, Olga N. Pakhomova, Vera A. Khorokhorina, Angela M. Bowman, Raminta Rodaitė-Riševičienė, Gintautas Saulis, Shu Xiao, Andrei G. Pakhomov

Bioelectrics Publications

Nanosecond pulsed electric field (nsPEF) is a novel modality for permeabilization of membranous structures and intracellular delivery of xenobiotics. We hypothesized that oxidative effects of nsPEF could be a separate primary mechanism responsible for bioeffects. ROS production in cultured cells and media exposed to 300-ns PEF (1–13 kV/cm) was assessed by oxidation of 2′, 7′-dichlorodihydrofluoresein (H₂DCF), dihidroethidium (DHE), or Amplex Red. When a suspension of H₂DCF-loaded cells was subjected to nsPEF, the yield of fluorescent 2′,7′dichlorofluorescein (DCF) increased proportionally to the pulse number and cell density. DCF emission increased with time after exposure in nsPEF-sensitive Jurkat …

The Use Of An In Vitro 3d Melanoma Model To Predict In Vivo Plasmid Transfection Using Electroporation, Benadette Marrero, Richard Heller

Bioelectrics Publications

A large-scale in vitro 3D tumor model was generated to evaluate gene delivery procedures in vivo. This 3D tumor model consists of a "tissue-like" spheroid that provides a micro-environment supportive of melanoma proliferation, allowing cells to behave similarly to cells in vivo. This functional spheroid measures approximately 1 cm in diameter and can be used to effectively evaluate plasmid transfection when testing various electroporation (EP) electrode applicators. In this study, we identified EP conditions that efficiently transfect green fluorescent protein (GFP) and interleukin 15 (IL-15) plasmids into tumor cells residing in the 3D construct. We found that plasmids …

Macro And Microfluidic Flows For Skeletal Regenerative Medicine, Brandon D. Riehl, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

Fluid flow has a great potential as a cell stimulatory tool for skeletal regenerative medicine, because fluid flow-induced bone cell mechanotransduction in vivo plays a critical role in maintaining healthy bone homeostasis. Applications of fluid flow for skeletal regenerative medicine are reviewed at macro and microscale. Macroflow in two dimensions (2D), in which flow velocity varies along the normal direction to the flow, has explored molecular mechanisms of bone forming cell mechanotransduction responsible for flow-regulated differentiation, mineralized matrix deposition, and stem cell osteogenesis. Though 2D flow set-ups are useful for mechanistic studies due to easiness in in situ and post-flow …

Shear-Horizontal Vibration Modes Of An Oblate Elliptical Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, John A. Kosinski

Department of Mechanical and Materials Engineering: Faculty Publications

We study shear-horizontal free vibrations of an elastic cylinder with an oblate elliptical cross section and a traction-free surface. Exact vibration modes and frequencies are obtained. The results show the existence of thickness-shear and thickness-twist modes. The energy-trapping behavior of these modes is examined. Trapped modes are found wherein the vibration energy is largely confined to the central portion of the cross section and little vibration energy is found at the edges. It is also shown that face-shear modes are not allowed in such a cylinder. The results are useful for the understanding of the energy trapping phenomenon in contoured …

A Review Of National Msw Generation Assessments In The United States, David J. Tonjes, Krista L. Greene

Technology & Society Faculty Publications

Municipal solid waste (MSW) is generated in very large quantities (probably, between 200 and 400 million tonnes per year) in the United States (US). MSW is generated at millions of places and there is no one precise, general definition for MSW that is generally applied, despite US Environmental Protection Agency efforts. As an element of both commerce and politics, reporting may be framed towards particular ends. Therefore, the two best known assessments of the quantity of US MSW production differ by approximately 50%. The assessors understand some of the reasons for the differences, but our analysis suggests that there are …

Kentucky Water Resources Research Institute Annual Technical Report Fy 2011, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The FY2011 Annual Technical Report for Kentucky consolidates reporting requirements for the Section 104(b) base grant award into a single document that includes; 1) a synopsis of each research project that was conducted during the period, 2) citations for related publications, reports, and presentations, 3) a description of information transfer activities, 4) a summary of student support during the reporting period, and 5) notable awards and achievements during the year.

Project 2011KY166B (Sewage to fertilizer: a proposed solution to water pollution) was not initiated because the principal investigator (Dr. Rebecca Evans Kelley) resigned from the Department of Biological Sciences at …

Global Homotopy Continuation And Stability Analysis: Optimal Application To Chemical Engineering Design, David Anthony Harney

Doctoral Dissertations

"The design of chemical engineering process equipment routinely necessitates the solution of large systems of non-linear equations. The processing speed of standard desktop computers have allowed for equation-oriented process simulators to become commercially viable. For a fully equation-oriented simulator to be competitive with standard iterative solvers, a robust and reliable non-linear equation solver is required and standard Newton methods fail to provide the necessary reliability.

Homotopy continuation methods have been proposed as a way to greatly expand the domain of convergence of the process simulator's equation solving algorithm. This research expands upon existing homotopy continuation algorithms, investigates bounding algorithms, corrector …

Investigation Of Drillstring Vibration Reduction Tools, Mohammed Fayez Al Dushaishi

Masters Theses

"Drilling related problems such as drillstring vibration is an important cause of premature failure of drillstring components and drilling inefficiency. The vibration of drillstring interferes with measurement collected while drilling. In severe cases, drillstring vibration will lead to wellbore instability that will result in an increase in the operation cost. In the late 1980's, a lot of studies and techniques were developed to mitigate drillstring vibration and downhole vibration measurements were introduced to the industry in two forms; real time measurements and memory devices measurements

A study of drillstring vibration of three different wells located in the Norwegian North Sea …

Multiple-Input Multiple-Output System On A Spinning Vehicle With Unknown Channel State Information, Aditya Muralidhar

Masters Theses

"This thesis work presents the investigations into the performance of a multiple-input multiple-output (MIMO) system with its transmitters on a spinning vehicle and no available channel state information (CSI) at the transmitter or the receiver. The linear least squares approach is used to estimate the channel and the estimation error is measured. The spinning is simulated based on a sample radiation pattern of a patch antenna. The antenna gains at different angles are obtained from this pattern and are used to model spinning. Spinning gives rise to a periodic component in the channel which can be estimated based on the …

Simulation Of Heat/Mass Transfer Of A Three-Layer Impingement/Effusion Cooling System, Brandon Smith

Electronic Theses and Dissertations

Cooling techniques for high density electrical components and electronic devices have been studied heavily in recent years. The advancements in the electrical/electronic industry have required methods of high heat flux removal. Many of the current electrical components and electronic devices produce a range of heat fluxes from 20 W/cm2 – 100 W/cm2 . While parallel flow cooling systems have been used in the past, jet impingement is now more desirable for its potential to have a heat transfer coefficient 3-5 times greater than that of parallel flow at the same flow rate. Problems do arise when the jet impingement is …

Re, Os, Al And Mg Boron Rich Ceramic Compounds For Structural Application, Zhilin Xie

Electronic Theses and Dissertations

Hard and ultra-incompressible materials are of great interest due to their important applications in industry. A common route to design hard materials is combining transition metals with light and small covalent elements. Light elements such as carbon, oxygen, nitrogen and boron have been considered as good candidates. This study includes the synthesis of ReB2, OsB2 and another higher boride AlMgB14. Most of the techniques used for ReB2 synthesis reported 1:2.5 Re to B ratio because of the loss of the B during high temperature synthesis. However, as a result of B excess, the amorphous boron, located along the grain boundaries …

Enhancing Spectrum Utilization In Dynamic Cognitive Radio Systems, Dusadee Treeumnuk

Electrical & Computer Engineering Theses & Dissertations

Cognitive radio (CR) is regarded as a viable solution to enabling flexible use of the frequency spectrum in future generations of wireless systems by allowing unlicensed secondary users (SU) to access licensed spectrum under the specific condition that no harmful interference be caused to the licensed primary users (PU) of the spectrum. In practical scenarios, the knowledge of PU activity is unknown to CRs and radio environments are mostly imperfect due to various issues such as noise uncertainty and multipath fadings. Therefore, important functionalities of CR systems are to efficiently detect availability of radio spectrum as well as to avoid …

Flying In The Dark: Managing The Risks, Dale Wilson

All Faculty Scholarship for the College of Education and Professional Studies

No abstract provided.

Engaging The Imagination Of Young People To Increase Technical Literacy, Isabel Huff, Glenn W. Ellis, Lucy Mcauliffe, Sonia K. Ellis, Beth Mcginnis-Cavanaugh

Engineering: Faculty Publications

This paper examines the use of cognitive tools in designing an educational website that helps middle school learners improve their technological literacy. The Talk to Me website consists of a young adult novel, online activities that expand on concepts introduced in the novel, and a blog written by college engineering students about their experiences attending college and taking engineering courses. Talk to Me is designed using Imaginative Education, a learning theory developed by Kieran Egan that outlines learners' different phases of development as their level of understanding and linguistic ability becomes more sophisticated. Beta testing occurred in 2010 with a …

Trapping Phosphorus In Runoff With A Phosphorus Removal Structure, Chad J. Penn, Joshua M. Mcgrath, Elliott Rounds, Garey A. Fox, Derek M. Heeren

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Reduction of phosphorus (P) inputs to surface waters may decrease eutrophication. Some researchers have proposed fi ltering dissolved P in runoff with P-sorptive byproducts in structures placed in hydrologically active areas with high soil P concentrations. Th e objectives of this study were to construct and monitor a P removal structure in a suburban watershed and test the ability of empirically developed fl ow-through equations to predict structure performance. Steel slag was used as the P sorption material in the P removal structure. Water samples were collected before and after the structure using automatic samples and analyzed for total dissolved …

The Use Of Electrical Resistivity Tomography (Ert) To Delineate Water-Filled Vugs Near A Bridge Foundation, Jeremiah Chukwunonso Obi

Masters Theses

"A structural support was needed to strengthen the load-bearing capacity of an unnamed bridge foundation in Laclede County in South-Central Missouri due to increasing traffic volume and age of the bridge. This area is characterized by karstic features such as losing streams, underground caves and sinkholes. During the construction of a drilled shaft for the substructure, a few feet north of the north footing of the pier, voids were noted beneath a roughly 2 foot thick cap of dolomite rock. Because of this, there were concerns about the integrity of the rock beneath the existing bridge foundation. Consequently, subsurface investigation …

Forecasting Natural Gas Consumption In İstanbul Using Neural Networks And Multivariate Time Series Methods, Ömer Fahretti̇n Demi̇rel, Seli̇m Zai̇m, Ahmet Çalişkan, Pinar Özuyar

Turkish Journal of Electrical Engineering and Computer Sciences

The fast changes and developments in the world's economy have substantially increased energy consumption. Consequently, energy planning has become more critical and important. Forecasting is one of the main tools utilized in energy planning. Recently developed computational techniques such as genetic algorithms have led to easily produced and accurate forecasts. In this paper, a natural gas consumption forecasting methodology is developed and implemented with state-of-the-art techniques. We show that our forecasts are quite close to real consumption values. Accurate forecasting of natural gas consumption is extremely critical as the majority of purchasing agreements made are based on predictions. As a …

Negative Effective Mass Density Of Acoustic Metamaterial Using Dual-Resonator Spring-Mass Model, Kwek Tze Tan, H. H. Huang, C. T. Sun

Mechanical Engineering Faculty Research

In this paper, we propose an acoustic metamaterial with a microstructure consisting of two internal resonators. The performance of this dual-resonator metamaterial is compared to the original singleresonator metamaterial. Analytical findings show that the dual-resonator metamaterial exhibits its negative effective mass density over a larger frequency spectrum, particularly at two distinctively asymptotic regions. The wave propagation phenomenon in the metamaterial is investigated using finite element simulation. Computational results reveal that the dual-resonator metamaterial is capable of attenuating wave propagation in a larger operating frequency. Practical applications like vibration control and blast mitigation are demonstrated and discussed.

Validation Of Delamination Reduction Trend For Stitched Composites Using Quasi-Static Indentation Test, Kwek Tze Tan, N. Watanabe, A. Yoshimura, Y. Iwahori

Mechanical Engineering Faculty Research

A novel empirical-based Delamination Reduction Trend (DRT) for stitched composites has been recently proposed. The DRT is capable of predicting the effective reduction in impact induced delamination area due to the influence of stitching. DRT simply relates two parameters: normalized delamination area and stitch fibre volume fraction, to characterize the effectiveness of stitching in impact damage suppression. This paper seeks to validate the DRT by using quasi-static indentation (QSI) test, which is considered analogous to low velocity impact test, due to similar structural response. Results from QSI test show good agreement with DRT. Furthermore, limitations in DRT have been established.

Process Completing Sequences For Resource Allocation Systems With Synchronization, Song Foh Chew, Shengyong Wang

Mechanical Engineering Faculty Research

This paper considers the problem of establishing live resource allocation in workflows with synchronization stages. Establishing live resource allocation in this class of systems is challenging since deciding whether a given level of resource capacities is sufficient to complete a single process is NP-complete. In this paper, we develop two necessary conditions and one sufficient condition that provide quickly computable tests for the existence of process completing sequences. The necessary conditions are based on the sequence of completions of � subprocesses that merge together at a synchronization. Although the worst case complexity is O(2�), we expect the number of subprocesses …

Creating A State-Wide Transfer Program For Engineering Technology And Technology Management Studies, Gregory Arbuckle, Mark Doggett

SEAS Faculty Publications

The primary purpose of the Western Kentucky Pipeline for 2+2+2 Engineering Technology and Technology Management (ET/TM) students program is to significantly increase degree production and workforce preparation in central and western Kentucky through the construction of a long-term sustainable, reproducible model bridging program of cooperation between Western Kentucky University (WKU), Murray State University (MSU) and the Kentucky Community and Technical College System (KCTCS). The program will significantly increase industrial and technology education opportunities, technology enrollment and two and four-year degree completion. Additionally, this project supports the Kentucky Council on Postsecondary Education’s (CPE) goal to double the overall number of undergraduate …

Perceptions And Rankings Of Technology Management Competencies, Mark Doggett, Pam Mcgee, Sophia Scott

SEAS Faculty Publications

According to Thamhain (2005) the “Management of technology is the art and science of creating value by using technology together with other resources of an organization” (p. 6). A technology manager should have some minimum level of technical knowledge, applied abilities in systems design, application, products or processes, and skills in one or more contextual areas (ITEA, 2000/2002). Technology managers must have certain competencies that are agreed-upon or measurable, preferably both. At the university level, technology management programs are distinctly different from engineering or engineering technology programs (i.e., mechanical, electrical, civil, etc.). A required management curriculum is what distinguishes ATMAE …

Energy Recovery In Passenger Cars, Alberto A. Boretti

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The turbocharged direct injection stoichiometric spark ignition gasoline engine has less than diesel full load brake engine thermal efficiencies and much larger than diesel penalties in brake engine thermal efficiencies reducing the load. This engine has, however, a much better power density, and therefore may operate at much higher brake mean effective pressure (BMEP) values over driving cycles thus reducing the fuel economy penalty of the vehicle. This engine also has the advantage of the very well developed three-way catalytic (TWC) converter after treatment to meet future emission regulations. Replacement of fossil gasoline with renewable gasoline-like fuels has major advantages. …

Impact Of Rotated Aisles On Travel Distance In Manufacturing Facilities, Dale Masel, Samantha Hedges

12th IMHRC Proceedings (Gardanne, France – 2012)

To design a facility, expected flows between the resources is one of the most important input. Flows are usually calculated given some statistics of previous periods or from the expected demand and the process required. However, in a refurbishing and recycling facility, flows are very fluctuating and not trivial to predict. The quantity produced by such facility not only depends on the demand but also on the supplies which are returned products under guaranty or discarded products after their end-of-use. The uncertainty and the variability on these supplies are often higher than the one on the demand which makes it …

Simulation-Based Performance Improvement Of A Defense Logistics Warehouse, Banu Y. Ekren, Gerald W. Evans, Sunderesh S. Heragu, John S. Usher

12th IMHRC Proceedings (Gardanne, France – 2012)

Warehouses play a critical role in supply chains. They serve as a vital link between manufacturers and customers. In this study, we investigate performance of the largest warehouse (Eastern Distribution Center - EDC) of the Defense Logistics Agency (DLA) located in New Cumberland, PA and propose a near optimum design for the receiving area of the warehouse to improve its performance. First, we develop a simulation model of the system. Second, we interface an optimization model with the simulation in order to optimize the number of people working at the induction stations. In the optimization model, our goal is to …