Engineering Commons^™

Rabies Virus-Like Particles Expressed In Hek293 Cells, Diego Fontana, Ricardo Kratje, Marina Etcheverrigaray, Claudio Prieto

Vaccine Technology IV

No abstract provided.

Expectation Of China's Contribution To World Vaccine Development And Supplies: Status, Strategy And International Approach, Li Shi

Vaccine Technology IV

No abstract provided.

A Convenient Synthesis Of 2,6-Dichlorohomonicotinic Acid, Chase Buchanan, Richard W. Fitch

Symposium 2012

In our synthetic efforts toward the alkaloid phantasmidine, we required a convenient source of the title compound. Herein, we describe a short synthesis of 2,6-dichlorohomonicotinic acid by direct allylation of 2,6-dichloropyridine with LDA/allyl chloride, followed by permanganate oxidation of the side chain [figure1]. Yields for the allylation are high, while permanganate oxidation required more adjustment. Successful conditions require the modest acidification of the mixture with acetic acid and cleanup by acid base workup. No chromatography is needed.

Convenient Parallel Synthesis Of Alkyl- And Aryl-S-Tert-Butyl Thiothers, Rebecca Norcross, Jessica Stanfield, Richard W. Fitch

Symposium 2012

While preparing novel cysteine derivatives as oxidation catalysts, we needed S-tert-butylcysteine. We also examined acid-promoted tert-butylation of thiols using tert-butanol as reagent and solvent. While cysteine and aminoethanethiol work well using tBuOH in 4M HCl, other thiols fail in the aqueous environment and aerobic conditions. We examined a variety of aliphatic and aromatic thiols in tBuOH with H2SO4 catalysis and found that argon sparging and the use of 1 eq of acid led to good yields in a parallel format.

Process Understanding Approach For A Late-Stage Recombinant Protein Vaccine Produced In Saccharomyces Cerevisiae, Jose Manuel Otero, Brian Mickus, Amanda Schallop, Brian Doyle, Nedim Altaras

Vaccine Technology IV

No abstract provided.

Challenges In Development Of An Anti-Idiotypic Cancer Vaccine, Adolfo Castillo

Vaccine Technology IV

No abstract provided.

The Role Of Public-Private Partnerships In Advancing Vaccine Technologies And Improving Vaccine Effectiveness And Delivery For Developing Countries, Ray Cummings

Vaccine Technology IV

No abstract provided.

Challenges In Batch Production Of Malaria Vaccines, Nicolas Havelange

Vaccine Technology IV

No abstract provided.

Establishing Human Vaccine Manufacturing In Southern Africa, Morena Makhoana

Vaccine Technology IV

No abstract provided.

Rational Design Of A Fully Synthetic Nanoparticle-Based Vaccine For Smoking Cessatio, Takashi Kishimoto

Vaccine Technology IV

No abstract provided.

Recombinant Vlp Based Human Vaccines For Emerging Markets, Qinjian Zhao

Vaccine Technology IV

No abstract provided.

111 Years Producing Immunobiologicals: New Challenges, Jorge Kalil

Vaccine Technology IV

No abstract provided.

Development Of A Vaccine Against Clostridium Difficile Infection (Cdi): Design, Purification, And Biological Activities Of The Recombinant Toxin 1 Antigens, Jerzy Karczewski

Vaccine Technology IV

No abstract provided.

Estimating Land Surface Temperature Using A Thermal Sharpening Technique, Yitong Jiang, Qihao Weng

Symposium 2012

No abstract provided.

Recombinant Influenza Vaccine, Manon Cox

Vaccine Technology IV

No abstract provided.

Glasses For Radiotherapy, Delbert E. Day

Materials Science and Engineering Faculty Research & Creative Works

No abstract provided.

Near Surface Hydrometeorology For Sustainable Water Management, V. Sridhar, W. T. A. Jaksa

Civil Engineering Faculty Publications and Presentations

Due to strong interactions between the land and atmosphere and the resulting feedbacks as altered by the anthropogenic changes, it is critical to quantify the surface fluxes and boundary layer properties that has direct implications on the regional evolution of hydrometeorology. This study evaluates the impact of irrigation using the Weather Research and Forecasting (WRF) numerical weather prediction (NWP) model in the Snake River Basin in Idaho. Our simulation extends for the period in the growing season and compares the control and irrigation runs to assess the irrigation induced cooling on the surface energy balance. Understanding this near surface cooling …

Approaches To Control Nitrate Pollution In The San Joaquin Watershed, Misgana K. Muleta, Stephen Clayton

Civil and Environmental Engineering

No abstract provided.

Evaluating Alternative Hydraulic Solutions To Limit Nutrient Contamination Of An Aquifer In Southern California, Jake M. Perry, Misgana K. Muleta

Civil and Environmental Engineering

Many small communities depend on groundwater sources for drinking water and they often use septic tanks for wastewater treatment and disposal. Nitrate and other pollutants leaking from poorly designed septic tank systems can percolate to the aquifers and alter quality of the groundwater. This study describes a groundwater model developed using Visual MODFLOW for an aquifer that is used as a water supply source for the communities of Beaumont and Cherry Valley, CA. The aquifer has been contaminated by nitrates leaking from septic tank systems. The model will assist in clarifying the extent of interactions between nitrate pollutants, percolation from …

A Formal Bayesian Approach For Uncertainty Analysis Of A Watershed Model, Misgana K. Muleta

Civil and Environmental Engineering

Uncertainty analysis (UA) has received substantial attention in water resources during the last decade. Bayesian approaches are often preferred for UA. This study describes a formal Bayesian approach for the assessment of parameter uncertainty and predictive uncertainty using a spatially distributed hydrologic model and will demonstrate its application using data from a well monitored experimental watershed. A Markov-Chain Monte Carlo (MCMC) scheme has been used to sample posterior parameter distributions. A formal, flexible likelihood function that explicitly accounts for heteroscedasticity, temporal correlation and non-normality of simulation residuals has been used to describe closeness of the simulated and observed streamflow. Performance …

Uncertainty Analysis And Calibration Of Swmm Using A Formal, Bayesian Methodology, Misgana K. Muleta

Civil and Environmental Engineering

Importance of uncertainty analysis (UA) to estimate the degree of reliability associated with model predictions is being understood. Consequently, literature that describes various Bayesian methods for the assessment of parameter and model predictive uncertainty has been steadily rising. Applications dealing with urban stormwater management are, however, very limited. This study demonstrates successful application of a formal Bayesian methodology for UA of the U.S. EPA Stormwater Management Model (SWMM), a widely used urban stormwater management model, and illustrates the methodology using a highly urbanized watershed in southern California. DREAM(ZS), a recently developed effective and efficient sampling algorithm, and a generalized, formal …

Multiple Structure Alignment With Mstali, Paul Shealy, Homayoun Valafar

Faculty Publications

Background

Multiple structure alignments have received increasing attention in recent years as an alternative to multiple sequence alignments. Although multiple structure alignment algorithms can potentially be applied to a number of problems, they have primarily been used for protein core identification. A method that is capable of solving a variety of problems using structure comparison is still absent. Here we introduce a program msTALI for aligning multiple protein structures. Our algorithm uses several informative features to guide its alignments: torsion angles, backbone C^α atom positions, secondary structure, residue type, surface accessibility, and properties of nearby atoms. The algorithm allows …

Numerical Modeling Of Lifting Flows In The Presence Of A Free Surface, Leonardo R. Carmona Vasquez

LSU New Orleans Theses and Dissertations

This thesis work started as an attempt to create a computational tool to model hydrodynamics problems involving lifting flows. The method employed to solve the problem is potential flow theory.

Despite the fast evolution of computers and the latest developments in Navier-Stokes solvers, such as the Ranse methods; potential flow theory offers the possibility to create or use existing computational tools, which allow us modeling hydrodynamics problems in a simpler manner. Navier-Stokes solver can be very expensive from the computational point of view, and require a high level of expertise in order to achieve reliable models.

Based on the above, …

Improved Operational Limits For Offshore Pipelay Vessels, Daniel Rey Givan

LSU New Orleans Theses and Dissertations

Subsea pipelines are used extensively throughout the world’s oceans to transport oil and gas from offshore facilities to land, often hundreds of miles. These pipelines range in diameter from three to sixty inches and are installed in deeper depths every year, currently as deep as 2,900 meters. Pipeline construction and installation costs are a large percentage of offshore projects and thus, methods toward reducing costs is an imperative objective. With pipeline installation projects taking place in harsher environments, vessel operability is vital. This work presents an improved method for determining limiting criteria for pipelay operations to more effectively plan and …

The Interacting Multiple Models Algorithm With State-Dependent Value Assignment, Rastin Rastgoufard

LSU New Orleans Theses and Dissertations

The value of a state is a measure of its worth, so that, for example, waypoints have high value and regions inside of obstacles have very small value. We propose two methods of incorporating world information as state-dependent modifications to the interacting multiple models (IMM) algorithm, and then we use a game's player-controlled trajectories as ground truths to compare the normal IMM algorithm to versions with our proposed modifications. The two methods involve modifying the model probabilities in the update step and modifying the transition probability matrix in the mixing step based on the assigned values of different target states. …

Pattern Recognition Of Power System Voltage Stability Using Statistical And Algorithmic Methods, Varun Togiti

LSU New Orleans Theses and Dissertations

In recent years, power demands around the world and particularly in North America increased rapidly due to increase in customer’s demand, while the development in transmission system is rather slow. This stresses the present transmission system and voltage stability becomes an important issue in this regard. Pattern recognition in conjunction with voltage stability analysis could be an effective tool to solve this problem

In this thesis, a methodology to detect the voltage stability ahead of time is presented. Dynamic simulation software PSS/E is used to simulate voltage stable and unstable cases, these cases are used to train and test the …

An Investigation Of Mist/Air Film Cooling With Application To Gas Turbine Airfoils, Lei Zhao

LSU New Orleans Theses and Dissertations

Film cooling is a cooling technique widely used in high-performance gas turbines

to protect turbine airfoils from being damaged by hot flue gases. Film injection holes are

placed in the body of the airfoil to allow coolant to pass from the internal cavity to the

external surface. The ejection of coolant gas results in a layer or “film” of coolant gas

flowing along the external surface of the airfoil.

In this study, a new cooling scheme, mist/air film cooling is proposed and

investigated through experiments. Small amount of tiny water droplets with an average

diameter about 7 μm (mist) is …

Active Response Of Polymer Materials From External Stimuli – Solvents And Light; Grafting Reactions On Perovskite Layers, Jianxia Zhang

LSU New Orleans Theses and Dissertations

The active response of a series of polymeric materials was investigated. Both solvent activated and light activated thin films and wire systems show dynamic behaviors when exposed to different stimuli.

Solvent mediated fluxional behavior of polymer thin films involved extensive, rapid curling both on infusion and evaporation of good solvents. These films can be either lab-fabricated ones or commercial ones, and the curling behavior can be as fast as seconds. Conditions including polymer materials, chosen solvents, and film geometry can affect the behavior.

Methods that allowed for the creation and retention of distorted wire structures were also developed; the asymmetric …

Fusing Dependent Decisions For Hypothesis Testing With Heterogeneous Sensors, Satish Giridhar Iyengar, Ruixin Niu, Pramod Varshney

Electrical Engineering and Computer Science - All Scholarship

In this paper, we consider a binary decentralized detection problem where the local sensor observations are quantized before their transmission to the fusion center. Sensor observations, and hence their quantized versions, may be heterogeneous as well as statistically dependent. A composite binary hypothesis testing problem is formulated, and a copula-based generalized likelihood ratio test (GLRT) based fusion rule is derived given that the local sensors are uniform multi-level quantizers. An alternative computationally efficient fusion rule is also designed which involves injecting a deliberate random disturbance to the local sensor decisions before fusion. Although the introduction of external noise causes a …

High Temperature Mechanical Properties Of Zirconium Diboride, L.J. Vandeperre, J. Wang, F. Giuliani

Ultra-High Temperature Ceramics: Materials For Extreme Environmental Applications II

No abstract provided.