Engineering Commons^™

Ultrasonic Assisted Layer-By-Layer Assembly For Stable Nanocolloids Of Curcumin And Paclitaxel, Zhiguo Zheng

Doctoral Dissertations

Researchers have been trying to fight cancer with synthesis of new bioactive compounds but many of these novel drugs have low solubility in water and it is difficult to deliver them into a patient's body. One way of solving this particular problem is to use nanoscale drug delivery systems. In this dissertation, we describe using an ultrasonic assisted layer-by-layer encapsulation process to prepare anti-cancer drugs with 50∼200 nm particle size with designed coating to achieve sustained release and target delivery.

Two methods for systematic manufacture of low solubility anti-cancer drug nanoparticles were proposed: I) Top-down approach to breakdown larger drug …

De Novo Gene Synthesis By Rapid Polymerase Chain Assembly Coupled With Immunoaffinity Purification: A Novel Process And Workstation, Joel R. Termaat

Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research

The de novo synthesis of genes is emerging as a powerful tool in biotechnology. The ability to synthesize genes of any desired sequence opens the door to seemingly unlimited research possibilities. Major advances have been made recently in de novo gene synthesis, with Polymerase Chain Assembly (PCA) routinely used to construct functional sequences from short single-stranded oligonucleotides. However, current PCA techniques are lacking in speed and fidelity. Additionally, substantial undesired reactants/products are present in the final reaction. A novel process and accompanying workstation has been developed that incorporates rapid PCA synthesis coupled with subsequent affinity purification of the synthesis mixture. …

Enhancement Of Historical Printed Document Images By Combining Total Variation Regularization And Non-Local Means Filtering, Laurence Likforman-Sulem, Jérôme Darbon, Elisa H. Barney Smith

Electrical and Computer Engineering Faculty Publications and Presentations

This paper proposes a novel method for document enhancement which combines two recent powerful noise-reduction steps. The first step is based on the total variation framework. It flattens background grey-levels and produces an intermediate image where background noise is considerably reduced. This image is used as a mask to produce an image with a cleaner background while keeping character details. The second step is applied to the cleaner image and consists of a filter based on non-local means: character edges are smoothed by searching for similar patch images in pixel neighborhoods. The document images to be enhanced are real historical …

Neural Network Prediction Of Ultimate Compression After Impact Loads In Graphite-Epoxy Coupons From Ultrasonic C-Scan Images, Nikolas L. Geiselman

Master's Theses - Daytona Beach

The purpose of this project was to investigate how accurately an artificial neural network could predict the ultimate compressive loads of impact damaged 24-ply graphite-epoxy coupons from ultrasonic C-scan images. The 24-ply graphite-epoxy coupons were manufactured with bidirectional preimpregnated tape and cut into 21 coupons, 4 inches by 6 inches each. The coupons were impacted at known impact energies of 10, 12, 14, 16, 18, and 20 Joules in order to create barely visible impact damage (BVID). The coupons were then scanned with an ultrasonic C-scan system to create an image of the damaged area. Each coupon was then compressed …

Development Of Multidisciplinary Design Optimization Process For A Large Scale Hybrid Composite Wind Turbine Blade, Jin Woo Lee

Master's Theses - Daytona Beach

Development of a multidisciplinary design optimization (MDO) of a large scale hybrid composite wind turbine blade is performed. Multiple objectives are considered in the MDO process to maximize annual energy production and lifetime profit, minimize weight and power production rate. A wind turbine blade is divided into regions and the layup sequences for each region are considered as design variables. The scale of wind turbine blade is also considered to find the optimum size of a wind turbine blade. Applied loads due to extreme wind conditions for rotor rotation and rotor stop condition are considered for finite element analysis (FEA) …

The Effect Of Maternal Diet On Fetal Development, Catherine Wilcox

Renée Crown University Honors Thesis Projects - All

Using mice as a model system, this study aimed to compare the effect of a high fat diet (HFD), high sugar diet (HSD) and a control diet (CD) on fetal growth and development at the time of birth (post-natal day 0 or PND 0), post-natal day 7 (PND 7) and post-natal day 14 (PND 14). Published literature has documented the effects of a negative in-utero environment on fetal development, but currently there is limited research regarding the continued effects on development after birth. Mouse pups were harvested and then imaged in 3-D using a high-resolution micro-computed tomography (micro-CT) system. Total …

Section Abstracts: Aeronautical And Aerospace Sciences

Virginia Journal of Science

Abstracts of the Aeronautical and Aerospace Sciences Section for the 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond, Virginia.

Impulse, Dana Hess, Kyle Johnson, Eric Landwehr, Cindy Rickeman

Impulse (Jerome J. Lohr College of Engineering Publication)

College:
[Page] 2 Dealing with budget cuts: Dean Lewis Brown explains why the College needed to cut programs and people.
[Page] 6 Father, daughter, and Uncle Sam: Associate Dean Richard Reid and senior math student Lindsey Reid share the same address, but their experiences in Iraq were as different as 2003 and 2010.
[Page] 8 The choice of more top scholars: More of state’s top students are applying here. In 2009, scholarships were offered to forty students with thirty or better ACT scores; thirty-four of them accepted the offer.
[Page] 10 Rising female enrollment: Female enrollment at the College has …

Cottonwood Riparian Site Selection On The Cheyenne River Sioux Reservation, Julie A. Thorstenson, Diane Rickerl, Janet H. Gritzner

Great Plains Research: A Journal of Natural and Social Sciences (through 2013)

The construction of the Oahe Dam on the Missouri River eliminated thousands of acres ofriparian and floodplain lands on the Cheyenne River Sioux Reservation in South Dakota. Restoration is needed to replace wildlife habitat. This study focused on site selection for native cottonwood (Populus deltoides Bartr. Ex Marsh. ssp. Monilifers (Ait.) Eckenwalde) restoration to help mitigate this loss. Geographic information systems technologies were used to develop a suitability model for cottonwood restoration. Tribal lands were extracted from a digital dataset oflandownership. Those touched by or included in a 46 m border of the Moreau River were candidate sites. Of …

Review Of A Dry Oasis: Institutional Adaptation To Climate On The Canadian Plains. Edited By Gregory P. Marchildon., Siân Mooney

Great Plains Research: A Journal of Natural and Social Sciences (through 2013)

A Dry Oasis examines past and potential future climate challenges on the Canadian Plains. The book provides extensive discussion, data, and analysis of challenges related to water supply and management within the South Saskatchewan River Basin (SSRB). Past challenges, experiences, and institutional responses are described and used to frame possible future adaptation pathways under expected future climate change. The book provides an excellent grounding in the historical settlement and development of the SSRB, paying particular attention to the ways that the economy, society, and institutions have adapted in response to climatic variability.

Review Of Gasoline, Diesel, And Ethanol Biofuels From Grasses And Plants. By Ram B. Gupta And Ayhan Demirbas., Adam Liska

Great Plains Research: A Journal of Natural and Social Sciences (through 2013)

A new book on the production of biofuels by Gupta and Demirbas provides technical insight into the conversion processes that could provide a range of domestic fuels from plant materials to substitute for foreign oil. It focuses primarily on conversion processes for production of cellulosic ethanol, Fischer-Tropsch diesel, pyrolysis bio-oil, and hydrothermal biocrude from biomass resources, as well as "first-generation" grain ethanol and biodiesel from vegetable oil. In addition to a detailed summary of these chemical processes, the book provides a briefer treatment of related matters such as biofuel policy, economics, and environmental issues. The book does discuss the limitations …

Estimation Of Land Surface Evapotranspiration With A Satellite Remote Sensing Procedure, Ayse Kilic, Ian Ratcliffe, Pariskhit Ranade, Kenneth Hubbard, Ramesh K. Singh, Babuarao Kamble, Jeppe Kjaersgaard

Great Plains Research: A Journal of Natural and Social Sciences (through 2013)

There are various methods available for estimating magnitude and trends of evapotranspiration. Bowen ratio energy balance system and eddy correlation techniques offer powerful alternatives for measuring land surface evapotranspiration. In spite of the elegance, high accuracy, and theoretical attractions of these techniques for measuring evapotranspiration, their practical use over large areas can be limited due to the number of sites needed and the related expense. Application of evapotranspiration mapping from satellite measurements can overcome the limitations. The objective of this study was to utilize the METRIC^TM (Mapping Evapotranspiration at High Resolution using Internalized Calibration) model in Great Plains environmental …

Do Invasive Riparian Woody Plants Affect Hydrology And Ecosystem Processes?, Julie Huddle, Tala Awada, Derrel Martin, Xinhua Zhou, Sue Ellen Pegg, Scott Josiah

Great Plains Research: A Journal of Natural and Social Sciences (through 2013)

© 2011 Copyright by the Center for Greot Plains Studies, University of Nebraska-Lincoln

Full Dispersion Versus Debye Model Evaluation Of Lattice Thermal Conductivity With A Landauer Approach, Changwook Jeong, Supriyo Datta, Mark S. Lundstrom

Birck and NCN Publications

Using a full dispersion description of phonons, the thermal conductivities of bulk Si and Bi(2)Te(3) are evaluated using a Landauer approach and related to the conventional approach based on the Boltzmann transport equation. A procedure to extract a well-defined average phonon mean-free-path from the measured thermal conductivity and given phonon-dispersion is presented. The extracted mean-free-path has strong physical significance and differs greatly from simple estimates. The use of simplified dispersion models for phonons is discussed, and it is shown that two different Debye temperatures must be used to treat the specific heat and thermal conductivity (analogous to the two different …

Electronic Structure, Vibrational Spectrum, And Thermal Properties Of Yttrium Nitride: A First-Principles Study, Bivas Saha, Timothy D. Sands, Umesh V. Waghmare

Birck and NCN Publications

Yttrium nitride (YN) is a promising semiconductor for use in metal/semiconductor superlattices for thermoelectric applications. We determine its electronic structure, vibrational spectrum, and thermal properties using first-principles density functional theory (DFT) based simulations with a generalized gradient approximation (GGA) of the exchange correlation energy. We employ GGA+U and GW approximations in our calculations to (a) improve the accuracy of the calculation of bandgaps and (b) determine specific features of its electronic structure relevant to transport properties, such as transverse (m(t)*) and longitudinal (m(1)*) conduction band effective mass. To evaluate consequences of forming alloys of YN with other materials to its …

Hydrostatic Pressure Testing Of A Square-Cross Section Stainless Steel Propellant Tank Manufactured Using Selective Laser Sintering, Spencer Fuller

Master's Theses - Daytona Beach

The purpose of this study was to determine if parts manufactured using metal selective laser sintering (SLS) exhibit the same isotropic material properties as conventionally made metal parts. This was accomplished by performing a hydrostatic pressure test (HPT) of a metal SLS manufactured propellant tank, constructed for a nano-satellite of the cubesat class. Strain measurements from twelve strain gage locations on the propellant tank were recorded. A finite element analysis (FEA) model, which assumes isotropic material properties, was generated and a FEA analysis was ran at several pressure loads. The tanks strain data at the corresponding pressure loads from the …

Advanced Thermal Models For Improved Design Of Counter Flow Microchannel Heat Exchangers, Bobby Mathew

Doctoral Dissertations

Theoretical models of counter flow microchannel heat exchangers subjected to scaling and secondary effects are developed in this dissertation. The scaling effects studied include axial heat conduction and viscous dissipation, while the secondary effects considered in this dissertation is that of external heat transfer via heat flux and temperature. The theoretical models developed are one-dimensional and consist primarily of ordinary governing equations that describe the axial variation of hot and cold fluid. For the case of axial heat conduction, the axial variation of wall temperature is also modeled. The models are dependent on various factors, such as Reynolds number, Prandtl …

The Solvent Effectiveness On Extraction Process Of Seaweed Pigment, Warkoyo Warkoyo, Elfi Anis Saati

Makara Journal of Technology

Eucheuma cottonii seaweed is a species of seaweed cultured in Indonesian waters, because its cultivation is relatively easy and inexpensive. It has a wide variety of colors from green to yellow green, gray, red and brown, indicating photosynthetic pigments, such as chlorophyll and carotenoids. An important factor in the effectiveness of pigment extraction is the choice of solvent. The correct type of solvent in the extraction method of specific natural materials is important so that a pigment with optimum quality that is also benefical to the society can be produced. The target of this research is to obtain a high …

A Modeling And Simulation Framework For Electrokinetic Nanoparticle Treatment, James Phillips

Doctoral Dissertations

The focus of this research is to model and provide a simulation framework for the packing of differently sized spheres within a hard boundary. The novel contributions of this dissertation are the cylinders of influence (COI) method and sectoring method implementations. The impetus for this research stems from modeling electrokinetic nanoparticle (EN) treatment, which packs concrete pores with differently sized nanoparticles. We show an improved speed of the simulation compared to previously published results of EN treatment simulation while obtaining similar porosity reduction results. We mainly focused on readily, commercially available particle sizes of 2 nm and 20 nm particles, …

Semi-Deterministic Single Interaction Mimo Channel Model, Arghavan Emami-Forooshani, Sima Noghanian

Electrical Engineering Faculty Publications

In this chapter a mathematical model to characterize wireless communication channel is developed which falls into semi-deterministic channel models. This model is based on electromagnetic scattering and reflecting and fundamental physics however it has been kept simple through appropriate assumptions.

Section Abstracts: Biomedical And General Engineering

Virginia Journal of Science

Abstracts of the Biomedical and General Engineering Section for the 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond VA.

Improved Analytical Analysis Of A Pressurized Water Reactor Secondary Loop, Megan J. Holba

All Capstone Projects

In the nuclear industry, the addition of poly-acrylic acid (PAA) as a dispersant to the secondary cooling loop in pressurized water reactors (PWRs) has been found beneficial in keeping the corroded Fe in solution. The purpose of this study is to measure the effectiveness of the addition of PAA to Braidwood Nuclear Power Station and other plants, to show the benefits of PAA implementation and to evaluate the current method for Fe detection. The current analytical method for the X-Ray Fluorescence Detector has an upper detection limit of 5,000 μg Fe, however, the results frequently exceed the upper limit. In …

Effect Of Slide Gate And Embr On The Transport Of Inclusions And Bubbles In Slab Continuous Casting Strands, Yufeng Wang, Anping Dong, Lifeng Zhang

Materials Science and Engineering Faculty Research & Creative Works

This study is to investigate the effect of electromagnetic brake (EMBr) on fluid flow and particle motion in steel slab continuous casting strands. the effect of slide gate moving on fluid flow pattern was discussed. a strong swirl and asymmetrical flow at the outports and, subsequently, inside the slab mold, was induced by slide gate. the application of EMBr would be a remedy to the swirl flow in the casting mold. Flow pattern has great influence on the trajectories of injected bubbles and nonmetallic inclusions. More bubbles tend to release from the top surface near the wide face opposite to …

Leaching Of Potential Hazardous Elements Of Coal Cleaning Rejects, Luis F.O. Silva, Maria Izquierdo, Xavier Querol, Robert B. Finkelman, Marcos L.S. Oliveira, Marcus Wollenschlager, Mark R. Towler, Rafael Pérez-López, Felipe Macias

Chemical and Biochemical Engineering Faculty Research & Creative Works

The geochemical characteristics of coal cleaning rejects (CCR) in Santa Catarina State, Brazil, were investigated. Around 3.5 million ton/ year of coal waste are dumped in Santa Catarina State. Coal beneficiation by froth flotation results in large amounts of CCR composed of coaly and mineral matter, the latter characterized by the occurrence of sulphide minerals and a broad array of leachable elements. The total and leachable contents of more than 60 elements were analyzed. Atmospheric exposure promotes sulphide oxidation that releases substantial sulphate loads as well as Ca²⁺, K⁺, Mg²⁺, Cl- and Al^{3+ …}

Guidance, Navigation And Control Of A Fly-By-Wire Transport Category Airship Designed For Hover Cargo Delivery, Harshad H. Lalan

Master's Theses - Daytona Beach

The purpose of this thesis is to develop fly-by-wire pilot controls for a transport category airship propelled with six thrust vectoring engines, and to develop control laws to maintain position, heading, and attitude during hover and cargo operations. Owing to the large body area, most airships require that they be pointed into the wind to maintain their position. This research aims at controlling an airship attitude and position during hover cargo delivery, irrespective of the wind direction.

Control laws were developed for two primary modes of the airship: Flight (High Speed Mode) and Hover (Cargo Delivery Mode). Different sets of …

Hemocompatibility Of Silicon-Based Substrates For Biomedical Implant Applications, Lingyan Liu

Chemical, Biomolecular, and Corrosion Engineering Faculty Research

Silicon membranes with highly uniform nanopore sizes fabricated using microelectromechanical systems (MEMS) technology allow for the development of miniaturized implants such as those needed for renal replacement therapies. However, the blood compatibility of silicon has thus far been an unresolved issue in the use of these substrates in implantable biomedical devices. We report the results of hemocompatibility studies using bare silicon, polysilicon, and modified silicon substrates. The surface modifications tested have been shown to reduce protein and/or platelet adhesion, thus potentially improving biocompatibility of silicon. Hemocompatibility was evaluated under four categories—coagulation (thrombin–antithrombin complex, TAT generation), complement activation (complement protein, C3a …

Binary And Core-Shell Nanoparticle Dispersed Liquid Crystal Cells For Metamaterial Applications, George Nehmetallah, Rola Aylo, Partha P. Banerjee

Electrical and Computer Engineering Faculty Publications

We theoretically explored the feasibility of a tunable metamaterial using binary as well as core-shell nanoparticle dispersed liquid crystal cells in the infrared and optical regimes. Owing to the spatial variation of the permittivity of the liquid crystal host upon the application of a bias voltage, the host was decomposed into a layered medium and the effective refractive index recalculated for each layer due to the distribution of polaritonic and plasmonic nanoparticles.

The scattering, extinction, and absorption of such a nanoparticle dispersed liquid crystal cell were also found. Depending on the applied voltage bias across the liquid crystal host, the …

Parametric Study Of Gear Rattle And The Effect Of Flexible Enclosures On Gearbox Vibratory Responses, Joshuah Thomas Racine

Masters Theses

Gearbox noise emitted from vehicles has become of particular importance to manufacturers due to the significant reduction of engine and masking noises in most modem designs. The reduction of gearbox rattle was the subject of this research using Romax Designer. Both drive and neutral loading conditions were considered for a parametric study of the influence of altering input torque fluctuation, backlash between gears, component rigidities and driveline inertia. Next, an external enclosure was added, where its effect was studied by altering the wall thickness, material properties and fixed boundary positions. Finally, results obtained from Romax Designer for a physical gearbox …

Measured Performance Of A 1.72 Kw Rooftop Grid Connected Photovoltaic System In Ireland, Lacour Ayompe, Aidan Duffy, Sarah Mccormack, Michael Conlon

Articles

This paper presents results obtained from monitoring a 1.72 kWp photovoltaic system installed on a flat roof of a 12 m high building in Dublin, Ireland (latitude 53.4 N and longitude 6.3 E). The system was monitored between November 2008 and October 2009 and all the electricity generated was fed into the low voltage supply to the building. Monthly average daily and annual performance parameters of the PV system evaluated include: final yield, reference yield, array yield, system losses, array capture losses, cell temperature losses, PV module efficiency, system efficiency, inverter efficiency, performance ratio and capacity factor. The maximum solar …

Stochastic Hybrid Embodied Co2-Eq Analysis: An Application To The Irish Apartment Building Sector, Adolf Acquaye, Aidan Duffy, Biswajit Basu

Articles

Although embodiedCO2-eq analysis has seen recent developments as evident in the establishment of the ISO14040 and 14044 LCA standards, it is recognized that due to weaknesses in gathering data on product-related emissions,embodiedCO2-eq values are probabilistic. This paper presents a stochastic analysis of hybrid embodied CO2-eq in buildings to account for this weakness in traditional methods and, by way of example, applies it to an Irish construction-sector case study. Using seven apartment buildings, 70,000 results are simulated with Monte Carlo analysis and used to derive probabilistic and cumulative embodied CO2-eq intensity distributions for apartment buildings in Ireland. A Wakeby distribution with …