Engineering Commons^™

Quantitative Fluorescence Imaging Using A Paired Agent Approach For Improving Surgical Decision Making, Sanjana Pannem

Dartmouth College Ph.D Dissertations

Surgical resection remains to be the cornerstone of treatment for most solid tumors, where the primary objective is to remove all visible and microscopic disease. However, the extent of tumor resection is inherently limited by the surgeon’s ability to distinguish tumor from normal tissue, intraoperatively. As a result, positive surgical margins (PSM), where residual tumor remains after surgery, are a common occurrence and are associated with increased recurrence, need for adjuvant therapies, dismal patient outcomes, and high healthcare costs.

Fluorescence guided surgery (FGS) has emerged as a promising technique to enhance intraoperative visualization of tumors and may help reduce the …

Picc-Pal: A Support Band For Independent Picc Line Use, Kylie Luker

Honors Theses

This project presents the design and evaluation of PICC-PAL, a wearable assistive device intended to improve independence and usability for patients managing peripherally inserted central catheters (PICC lines) at home. Current at-home PICC line management often requires help due to the fine motor skills needed to connect and secure tubing. This increases reliance on caregivers and introduces potential risks such as infection and dislodgement. Through stakeholder analysis, prior art evaluation, and iterative prototyping, a device was developed to stabilize the PICC line lumen and enable one-handed connection of medical tubing. Throughout the project, multiple design concepts were explored, with the …

Study Of Complex Biological Systems Through Ai-Empowered Metabolomic Analysis And Modeling, Runyu Zhao

McKelvey School of Engineering Graduate Student Theses & Dissertations

This dissertation establishes an integrated framework that leverages artificial intelligence (AI) and advanced metabolomics to overcome the "complexity bottleneck" in microbial engineering, specifically addressing the global crises of plastic waste and carbon emissions. By framing the research within the complex biosystems for effective bioproduction and bioremediation, this work develops novel strategies to engineer and analyze biological systems for a circular bioeconomy. In the "Build" phase (Chapter 2), the study addresses the instability of synthetic microbial consortia. By utilizing calcium-alginate hydrogel compartmentalization, the research successfully decouples the growth of the phototroph Synechococcus elongatus from its heterotrophic partners (P. putida and Y. …

Inference-Time Scaling For Robust And Adaptive Computational Imaging, Yuyang Hu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Computational imaging has transformed fields such as medical imaging, computational photography, and remote sensing by combining physical measurement models with advanced image reconstruction algorithms. Two major paradigms have driven significant progress: model-based deep learning (MBDL), which integrates learned priors with physics-based data consistency, and generative models, especially diffusion models, which capture complex image distributions and enable posterior sampling for uncertainty quantification. Despite their success, most existing methods still operate under static inference: they rely on fixed pretrained priors, predetermined sampling procedures, and a fixed forward model during reconstruction. This rigidity limits their robustness in the presence of distribution shift, complex …

Individualized Models For Perception And Cognition, Dominic Marticorena

McKelvey School of Engineering Graduate Student Theses & Dissertations

This dissertation develops individualized models of perceptual and cognitive behavior, inferring latent capacities from limited data with sufficient efficiency, precision, and generality for person-level prediction. In perception, a nonparametric Bayesian framework for adaptive psychophysics is extended from audition to vision, producing an estimator that recovers dense individualized contrast sensitivity profiles through variational inference, a generalized kernel, and information-guided stimulus selection. A multitask extension enables simultaneous estimation of multiple psychometric fields by exploiting shared latent structure. Transferring this inferential logic to cognition, where relevant dimensions must be supplied by task design rather than physics, requires new measurement infrastructure. A Minecraft-based platform …

Optimization Of A Point Absorber Wave Energy Converter (Wec), Rutwa Dilipkumar Nagar

Electronic Theses and Dissertations

This study examines the performance and optimization of a point absorber wave energy converter with a partially submerged spherical float. A comprehensive open-source computational framework integrates frequency-domain hydrodynamic analysis with time-domain simulation using Capytaine, BEMIO, and WEC-Sim. Hydrodynamic coefficients such as added mass, radiation damping, and excitation forces are calculated and integrated into the governing equation of motion using the Cummins formulation. A parametric analysis varies the float diameter and geometric configurations across several cases. Hydrodynamic coefficients and response amplitude operators are assessed to analyze system behavior and resonance characteristics. Results indicate consistent trends in normalized added mass, with radiation …

Improving Transfer Portal Decision-Making Through A Microsoft Excel Optimization Model, Peyton Steffes

Honors Projects

The creation of the transfer portal has increased the mobility of collegiate athletes, giving players the autonomy to switch teams throughout their career. As a result, the roster development process has become more complex, as coaches are tasked with the challenge of recruiting from the transfer portal, which involves an extensive decision-making process. Coaches not only have to evaluate a substantial pool of players, but they also must consider the following constraints they are under: scholarship budget, roster spots available, and positional needs. To simplify this decision-making process, this analysis includes the results of a Microsoft Excel data optimization model …

Project Management Practices In Manufacturing: An Analytical Case Study, Margaret Randle, Robert Reynolds

Honors Capstones

Global industries are undergoing significant transitions in organizational models, technological innovation, and non-economic indicators of product quality, including sustainability and operational efficiency. The current workforce needs to not only develop competency of these technical skills, but also an adaptive, system-oriented approach to problem-solving as well. This case study, which highlights a manufacturing company’s project of increasing production efficiency, presents concepts learned through the textbook Project Management: Achieving Competitive Advantage by Jeffrey K. Pinto. The study thoroughly breaks down the full project lifecycle and the integration of systems of people, data, and initiatives in a framework that can be used to …

On Time-Series Analysis By Structured Matrix Decompositions With Applications To Signal Direction-Of-Arrival Estimation, Georgios Ierotheos Orfanidis

Electronic Theses and Dissertations

Modern autonomous systems operating in highly dynamic, non-stationary environments require reliable inference from short, potentially corrupted time-series measurements, where conventional statistical methods relying on large-sample support and stationarity assumptions become fundamentally inapplicable. This dissertation develops a unified, model-free theoretical framework for time-series analysis, with a particular application to signal Direction-of-Arrival (DoA) estimation, grounded in structured matrix decompositions under both the L2-norm and L1-norm formulations.

We first approach the problem from a conventional viewpoint by carrying out standard matrix analysis directly on Hankel-structured representations of time-series data. In this context, we demonstrate that L1-norm decompositions of Hankel matrices offer strong resistance …

Computer Vision And Deep Learning-Based Decision Support System Using Eye Motion Tracking For Nystagmus Detection, Kowshik Balasubramanian

Electronic Theses and Dissertations

This thesis presents the design, implementation, and experimental validation of an artificial intelligence (AI)-driven system for detecting and quantifying nystagmus an involuntary, rhythmic oscillation of the eyes intended as a portable, low-cost complement to conventional Videonystagmography (VNG). The complete pipeline integrates six algorithmic stages: face landmark detection, contrast enhancement, background-aware pixel thresholding, grid-based vertical column filtering, connected-component cluster analysis, and centroid computation, operating in real time on standard smartphone video to extract a sub-pixel normalized iris position time-series without any specialized eye-tracking hardware or infrared illumination. The system supports diagnostic decision-making, highlighting its promise for incorporation into telemedicine settings. The …

Influence Of Web Thickness And Concrete Cover On The Fire Resistance Of Aashto Type Iv Prestressed Concrete Bridge Girders, Fnu Nidhi

Electronic Theses and Dissertations

Bridge fires caused by vehicle accidents, fuel tanker explosions and storage of combustible material beneath highway structures have led to severe structural damage and catastrophic collapse of prestressed concrete bridges. Critical structural collapse due to fire incidents such as I-85 prestressed concrete bridge girder collapse in Atlanta, 2017 and I-95 steel plate girder bridge partial collapse in Philadelphia, 2023 demonstrated the vulnerability of girders when exposed to extreme hydrocarbon fire temperatures exceeding 1000°C within few minutes. These events highlight the urgent need to better understand the thermal and structural behavior of bridge girders and explore design modifications that can enhance …

Passenger Autonomy In Airport Systems: Integrating Accessibility, Spatial Design, And Technology To Improve Operational Efficiency, John Michael Schmitz

Honors Projects

Airports are among the most complex operational environments in modern transportation, requiring the coordination of passenger movement, security processes, and infrastructure under significant time constraints. Although there have been many advancements in aviation, most passengers continue to experience high levels of stress and confusion while trying to navigate airport terminals. This paper argues that operational efficiency in airport systems is achieved by increasing  passenger autonomy through the utilization of accessible design, spatial legibility, and new emerging technologies. This paper takes note of some foundational theories that drove urban design and cognitive psychology, including Lynch’s concept of imageability, Passini’s theory of …

Extraction And Interpretation Of Eeg Features For Diagnosis And Severity Prediction Of Ad And Ftd Using Deep Learning, Tuan Vo

Electronic Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by progressive cognitive decline and memory impairment. Frontotemporal dementia (FTD), the second most prevalent form, primarily affects the frontal and temporal lobes and often leads to changes in personality, behavior, and language. Due to overlapping clinical symptoms, FTD is frequently misdiagnosed as AD. Electroencephalography (EEG) offers a portable, non-invasive, and cost-effective method for studying brain activity; however, its diagnostic utility for differentiating dementia subtypes is limited by signal complexity and noise. In this dissertation, I propose an EEG-based feature extraction framework that leverages deep learning to identify …

Sdn Controller For Distributed Quantum Computing, Firas Selmi

Masters Theses

Quantum networks promise transformative capabilities for computation [1], but current hardware remains limited; state-of-the-art quantum processors still operate with only a few hundred qubits [2], far below the scale required for practical applications. This limitation motivates the use of Distributed Quantum Computing (DQC), where computation is performed across multiple interconnected nodes. However, efficient DQC requires global network awareness and orchestration, a role analogous to Software-Defined Networking (SDN) in classical systems. In this work, we investigate the impact of SDN-inspired control logic on quantum networks by executing a scaled distributed implementation of Shor’s algorithm to factor N = 15 over a …

Analysis Toolkit For Potential Lunar Landing Zones, Jacobo Matallana

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science and Engineering Morehead State University in partial fulfillment of the requirements for the Degree Master of Science by Jacobo Matallana on April 24, 2026.

Experimental Investigation Of Mode-Ii Interlaminar Fatigue Damage In Stitched And Unstitched End-Notched Flexure Carbon Fiber Composites, Madelyn Sloan Berry

Honors Theses

Composite materials are increasingly used in aerospace structures due to their high strength-to-weight ratio, but their susceptibility to interlaminar fatigue damage remains a critical concern, particularly under mode-II shear loading. This study investigates the fatigue behavior of stitched and unstitched quasi-isotropic carbon fiber composite specimens made of SAERTEX Class-75 non-crimp fabrics and Hexcel 1078-1 epoxy via vacuum assisted resin transfer molding. Global fatigue behavior was analyzed using displacement and crack length cycle relationships derived from compliance calibration methods (CCM), while local behavior was examined using digital image correlation (DIC). Unstitched specimens exhibited a single rapid crack growth associated with unstable …

Llm For Clinical Named Entity Recognition: A Study On Rag With Pubmed And Umls, Apoorv Tripathi

Electronic Theses and Dissertations

The first step of biomedical NLP is recognizing clinical named entities, which consist of identifying and categorizing a variety of clinical entities such as diseases, symptoms, genetics, diagnostic tests, procedures, etc. from a body of unstructured clinical text. This study presents a PubMed and UMLS based Retrieval Augmented Generation framework which improves the performance of the Large Language Models to identify clinical entities by providing context. In particular, the framework consists of a two-stage pipeline, where candidate tokens are identified from initial LLM-based classification and refined with retrieved context from either PubMed or UMLS. The proposed framework is assessed across …

Advanced Studies In Characterization Of Pyrolysis Products From Live Vegetation, Mahsa Alizadeh

Theses and Dissertations

Fire is a naturally occurring element in many ecosystems which can have both positive and negative effects. However, in recent years the frequency of the fires and the area they affect has increased. The rapid spread of wildland fires coupled with the limited resources available to forest services to manage wildland fires highlights the urgency for accurate prediction of fire spread. Fire prediction models enable the fire management services to predict the spread of fire and prioritize firefighting efforts more effectively. Understanding reactions and mechanisms occurring during wildland fires improves the fire prediction models. During wildland fires, the biomass covering …

Improving Electrochemical Measurements And Informing Future Reprocessing Of Advanced Nuclear Fuels, J. Marvin Torrie

Theses and Dissertations

This research promotes the application of molten salts through developing analytical tools in electroanalytical studies and in the data analysis of vapor pressure data. The electrochemical community lacks standardized, stable, and repeatable reference electrode designs which threaten the reliability of measured thermophysical properties and repeatability of published studies. This work confirms the application of a saturated reference electrode design for molten chlorides systems that outperforms traditional Ag+/Ag reference electrodes. In the field of thermal physical property measurements, vapor pressure data for chloride salts are diffused throughout the literature, uncertainty quantification is absent or limited, and all previous studies rely on …

A Treatise On Tool Development: The Arthroscope’S Cultural, Technological, And Metascientific Translation, Montgomery F. Waterer

Honors Theses

The arthroscope was a revolutionary development in the fields of medicine, engineering, and ethics. There are many valuable lessons to be learned from the story of its development and translation that are relevant to the future of medicine and society. Beginning with a brief description of the tool’s design, this paper will examine a period within the history of the arthroscope. This window contains multiple innovators and ends with the life and work of Dr. Robert Jackson. In examining the relevant historical facts of its development, this paper will then briefly address the importance of sports medicine in the development …

Opportunistic Breast Cancer Detection With Photon-Counting Ct: A Quantitative Pilot Study Of Reconstruction-Dependent Image Quality, Graham Hannon

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photon-counting computed tomography (PCCT) has emerged as a promising imaging modality with improved spatial resolution and contrast capabilities compared to conventional energy-integrating detector systems. These advantages present an opportunity for opportunistic detection of breast cancer in routine thoracic CT scans that include breast tissue. In this pilot study, we evaluated the feasibility of opportunistic breast cancer detection using clinical PCCT data through quantitative image analysis. Two patients with confirmed breast malignancies and corresponding thoracic PCCT scans were retrospectively analyzed. Dedicated reconstructions were performed with varying convolution kernels, field-of-view sizes, and virtual monoenergetic spectra. Image quality was assessed using signal-to-noise ratio …

Space Degradable Pyrotechnic Fastener, Jonathan Baker

Honors Theses

Space debris has become a critical threat to orbital operations, with over 30,000 tracked objects currently circling Earth. Traditional separation charges used in satellite launches contribute significantly to this problem by generating unpredictable shrapnel that can remain in orbit for decades or centuries. This project proposes the design and development of a spacedegradable explosive bolt that exploits the harsh space environment to accelerate material breakdown after use.

The design utilizes advanced polymer materials selected for their susceptibility to degradation from UV radiation — an environmental factor abundant in Low Earth Orbit (LEO). Our prototype will be engineered to meet industry-standard …

Mason Avenue Culvert, Caden Boynton

Honors Theses

This project addressed the replacement of a culvert crossing Wabascon Creek along North Mason Avenue in Battle Creek, Michigan. Following significant flooding caused by snowmelt in 2023, the existing wooden box culvert—originally constructed in the 1960s—sustained damage when inlet wingwalls detached from the structure, requiring temporary repairs. Design alternatives were developed to provide a durable and reliable replacement, incorporating structural, water resources, transportation, and construction engineering considerations. The design process also addressed environmental sustainability requirements, cost-effectiveness and constructability. Final deliverables included engineering calculations, plans and specifications, a cost estimate and a project schedule to support implementation of a resilient long-term …

Ergonomic And Material Flow Improvements For A Medical Device Assembly Line, Matthew Kobus

Honors Theses

This project evaluated material handling inefficiencies and ergonomic concerns within Stryker’s Neptune medical device assembly line. Two primary issues were identified: lack of a standardized part-location system in the supermarket and excessive operator travel between subassembly and main assembly. These issues resulted in search waste, motion waste, lost production time, and increased ergonomic strain.

To address the labeling issue, a standardized bin labeling system was developed and tested. A time study comparing labeled and unlabeled conditions showed that average retrieval time decreased from approximately 120 seconds to 22 seconds, an 81% reduction. Statistical analysis confirmed that this improvement was significant …

Investigating The Cost And Efficiency Of Two Chemical Pathways To Produce The Plant-Based Coagulants, Taylor Nixon

Honors Theses

Plant-based coagulants are promising sustainable alternatives for water treatment due to their biodegradability, low toxicity, and reduced risk of secondary pollution. Unlike conventional inorganic coagulants, they generate less sludge and avoid secondary contamination in the environment. This project examines two chemical modification strategies for producing cationic cellulose coagulants. The first involves direct amination of cellulose using CHPTAC, while the second employs periodate-oxidized dialdehyde cellulose, which enables reductive amination through reactive aldehyde groups. These approaches are expected to yield materials with differing charges, surface functionalities, and structural properties that may influence coagulation performance. The study evaluates the technical and economic feasibility …

Analyzing Proposed Unmanned Aerial System Regulations And Their Impact On Manned Aircraft Operations, Kordell Irish

Honors Theses

The purpose of the thesis is to investigate the current state of the proposed Part 108 regulations and to find possible solutions to the problems faced by Part 108 implementation, with a focus on the interactions between manned and unmanned aircraft. The thesis covers upcoming changes to federal aviation regulations by the Federal Aviation Administration (FAA) regarding unmanned aircraft systems and their integration into the national airspace system. Currently, most unmanned aircraft systems (UAS) are regulated under Part 107 of the federal aviation regulation. A brief literature review will provide a background and timeline in the lead-up to the Part …

Mild Thermal Treatment Of Lithium-Ion Batteries To Optimize Black Mass Production, Brooke Lillie

Theses and Dissertations

This thesis explains the design of equipment and the experimental procedure for thermal treatment of lithium-ion batteries for the purpose of low-cost materials recycling. Conditions used were between 150 ℃ and 425 ℃, involving different atmospheric conditions and treatment durations. The battery samples were processed through a sieve shaker device. Mass loss during the heat treatment, and separation of the battery through sieving was used to analyze the effect of the treatments on separability of black mass from the batteries. Additionally, internal battery temperature was measured and compared to real average furnace temperature to monitor thermal runaway. Testing showed minimal …

Development Of A Grease Resistant Barrier For Food Industry Applications, Mira Marino

Honors Theses

The objective of this project is to develop a grease-resistant barrier coating for paper-based food packaging and to evaluate the economic feasibility of implementing this coating system at an industrial scale. As demand increases, this project focuses on identifying an optimal pigment and binder combination that enhances barrier performance while maintaining cost-effectiveness. The primary goal was to maximize grease and moisture resistance of coated paper while ensuring the process is economically viable and compatible with existing paper mill operations.

The final plant design consists of one continuous stirred tank reactor (CSTR) and three centrifugal pumps integrated into an existing paper …

Enhancing Lane Detection In Autonomous Vehicles Using Data Augmentation For Adverse Environmental Conditions, Rutvikkumar Dave

Electronic Theses and Dissertations

To make sure that self-driving and connected automobile technologies are safe and work well, it’s really important that they can correctly identify lanes. But lane detection Algorithms typically have a hard time working well when the weather is bad, such when it rains, fogs, or goes too fast. The circumstances cause visual distortions that make existing computer vision systems less reliable, which makes it harder requires autonomous navigation systems to work well. This paper introduces a comprehensive lane detection system that integrates synthetic Weather-informed data augmentation combined with a Weather-aware Temporal Lane Detection Network (WTLDNet) to make it easier for …

Analysis For Predicting Surface Temperature And Combustion Of Heavy-Duty, Pre-Chamber-Enabled, Hydrogen Engines, Tony Spezia

Master's Theses (2009 -)

Hydrogen as an alternative fuel shows great promise to help reduce greenhouse gas emissions from heavy duty engines. However, the challenge for hydrogen engines is that hydrogen has very different combustion properties compared to conventional hydrocarbon fuels. Hydrogen has very high flame speeds, very low ignition energy, and very wide flammability limit. These properties result in hydrogen engines being prone to abnormal combustion. Abnormal combustion makes hydrogen engines difficult to control or can cause catastrophic damage to the engine, so it is important to avoid conditions where abnormal combustion occurs. Hot spots along the combustion chamber walls are often the …