Engineering Commons^™

Development And Evaluation Of A Modeling Platform For Evaluating Immunotherapeutic Efficacy In The Tumor Microenvironment., Dylan Andrew Goodin

Electronic Theses and Dissertations

The tumor microenvironment (TME) represents the complex outcome of numerous tumor, stromal, and immune interactions, and whose composition can significantly affect treatment response. Particularly, immunotherapeutic efficacy is subject to multiple tumor-specific TME interactions that may be difficult to evaluate/predict clinically. Mathematical modelling has been formulated to evaluate specific aspects of the TME, including vasculature, ECM deposition, and immune-tumor interactions. However, the computational challenge of simulating multiple TME interactions has led to sacrificing varying degrees of model generalizability and clinical relevance. This work describes increased computational performance of a 3D continuum model that simulates tumor tissue, ECM, and vasculature using a …

Novel Designs Of Soft Tactile Sensor And Robot Finger Manipulator Based On Optical Fibers., Seokyoung Han

Electronic Theses and Dissertations

Robotic manipulation is one of the main types of automated labor that humans want to achieve in order to free ourselves from mundane and hazardous tasks. The range of realizations could be very broad, from massive industrial robots to highly advanced medical devices for human healthcare. Given the critical nature of these application spaces, they require robust, safe, and most of all versatile designs. In that direction, one of the most interesting topics is the anthropomorphic robotic manipulator. Since it is inspired by human hands’ function and structure, it is able to achieve the aforementioned system requirements. However, the perfect …

Electrokinetic Particle Trapping Performance Of Conductive Nanofiber Mats In Microfluidic Wells., Jacob Hunter West

Electronic Theses and Dissertations

The frequency dependence of electrokinetic particle trapping using large-area (>mm²) conductive carbon nanofiber (CNF) mat electrodes is investigated. The fibers provide nanoscale geometric features for the generation of high electric field gradients, which is necessary for particle trapping via dielectrophoresis (DEP). A device was fabricated with an array of microfluidic wells for repeated experiments; each well included a CNF mat electrode opposing an aluminum electrode. Fluorescent microspheres (1 µm) were trapped at various electric field frequencies between 30 kHz – 1 MHz. Digital images of each well were analyzed to quantify particle trapping. DEP trapping by the …

Emergency Vehicle Prioritization In Connected And Autonomous Traffic., Mohamadreza Haghani

Electronic Theses and Dissertations

Reducing the response time of emergency vehicles (EV) is highly important due to the relationship between response time and fatality rate. Emerging technologies can help reduce response time by enhancing EV prioritization. On the other hand, EV prioritization can negatively impact general traffic especially in cross streets of signalized intersections. In this research, three main objectives were followed. Firstly, creation and dissipation of EVP disruption on arterial cross streets was studied to recommend solutions to prevent this disruption. Secondly, lane-changing and stopping behavior of CAVs were studied in EV prioritization to identify the best lane-changing behavior through minimizing delay. Thirdly, …

Rockin’ Rehab: Novel Rocking Chair For Children With Spinal Cord Injury To Enable Trunk Muscle Activation And Detect Muscle Activation Patterns., Johnathan Jay George

Electronic Theses and Dissertations

Introduction: Activity-based locomotor training improves trunk control in children with spinal cord injury (SCI), and there is need for additional activities to allow these children to activate trunk muscles. The purpose of this research was to design, fabricate, and evaluate a rocking chair for children with SCI, and to investigate the activation of muscles during use. Sensorization of the chair to confirm muscle activation is also explored. Methods: Quality Function Deployment (QFD) design methodologies identified and ranked needs and features for the rocking chair. A design was developed and evaluated via finite element analysis. The chair was fabricated and tested …

Multithreaded Applications On The Heterogeneous Research Computing Environment., Sungbo Jung

Electronic Theses and Dissertations

Bioinformatics is a domain that has experienced rapid research growth in recent years, as evidenced by the increasing number of articles in biomedical databases such as PubMed, which adds over a million publications every year. However, this also poses a challenge for researchers who need to find relevant citations for their work. Therefore, developing efficient indexing and searching methods for text data is crucial for Bioinformatics. One key technique for information retrieval is document inversion, which involves creating an inverted index to enable efficient searching through vast collections of text or documents. This Ph.D. research aims to design the research …

Effect Of Swirl Ratio On Simulated Vortech Chamber Vortex Parameters, Samuel Kolar

Civil Engineering Undergraduate Honors Theses

A numerical simulator can use computational fluid dynamics (CFD) to model an experimental tornado-simulating chamber at Texas Tech University (known as VorTECH). Previous studies evaluating this particular CFD model have produced results that compare the touchdown swirl ratio (S_TD), core radius (r_c), maximum tangential velocity at touchdown (V_tmax @ S_TD), and height of the maximum tangential velocity (z_c) reasonably well with experimental data from the VorTECH facility. The effects of swirl ratio beyond S_TD on important vortex parameters including r_c, V_tmax, z …

Release Of Small Molecules From Rubber: Effects Of Materials Properties, Mechanical Loading And Molecular Interactions, Yongcan Du

All Dissertations

Release of small molecules from polymeric materials has wide applications in the delivery systems of active molecules such as drug, fragrance, and semiochemical. Rubber materials are good candidates for the excipients of those systems due to properties such as good flexibility, permeability, and biocompatibility. Factors like material properties, mechanical loading, and molecular interactions may affect the release of small molecules in those systems. Therefore, understanding how those factors affect the release is key to the formulation, design, and evaluation of those systems.

To study the effects of materials properties, vulcanized natural rubber sheets with different crosslink densities, loaded with small …

Transcriptomic Profiling Of Engineered Human Gene Integration In The Mouse Genome Following In Vitro Gene Editing, Ethan Potts, Made Harumi Padmaswari, Christopher Nelson

Biomedical Engineering Undergraduate Honors Theses

Gene replacement is a promising method of therapy for genetic diseases. However, safety and efficacy are areas that need more research. This experiment aims to use RNA sequencing and bioinformatic techniques to provide answers to these questions and provide direction to future studies to develop a gene replacement therapeutic. C2C12 mouse myoblast cells were transfected with a vector containing a CRISPR-Cas9 system and the Human Factor IX (hF9) gene in order to hijack target genes and integrate the hF9 gene. The two target genes, myoglobin (Mb) and creatine kinase (Ckm), were chosen for their high rate of expression and low …

Real-Time Measurements From Wearable Sensors To Enhance Stability On Uneven Terrain, Sophie Copelin

Biomedical Engineering Undergraduate Honors Theses

The presented thesis is a study of sensation associated with inversion/eversion movement about the anterior/posterior axis. The long-term goal is to create a system that provides feedback to a prosthesis user, so their chances of falling is decreased. This feedback system would use wearable sensors to detect certain angles, so that sensory feedback could be provided. The study aimed to determine if Xsens Movella DOT sensors could be used in a system like this, so the accuracy of the Xsens Movella DOT sensors was assessed and the difference in angles that could be determined by them when compared to that …

A Comprehensive Materials Approach To Thermal Management In Fiber Lasers, Bailey Meehan

All Dissertations

Optical fiber-based amplifiers and lasers enable a great many useful devices and conveniences. Unfortunately, however, they can generate considerable heat during operation that drives the need for complex cooling solutions, thus reducing many of the size, weight, and power (SWAP) benefits for which fiber lasers are known. Additionally, at elevated temperatures, thermally-driven phenomena, such as Transverse Mode Instability (TMI), can be induced that limit the power-scaling of fiber lasers. The focus of this Dissertation is to explore novel approaches to thermal management in fiber lasers through judicious materials science and engineering to obviate the aforementioned limitations. Fibers studied in this …

The Development Of A Convenient And Consistent Methodology For Flight Proficiency To Certify Multi-Rotor Uas Pilots For State Departments Of Transportation, Colin Dees

All Dissertations

To fly an unmanned aircraft system (UAS), commonly referred to as a “drone,” the Federal Aviation Administration (FAA) requires pilots to pass a knowledge test. There is no requirement at the state or federal level for drone operators to demonstrate the ability to operate a UAS. The National Institute of Science and Technology (NIST) has created an exam for public and private entities to assess basic UAS flight proficiency. It is the only nationally recognized flight proficiency protocol. NIST does not provide a scoring recommendation and leaves it to the user to determine the minimum criteria to pass. There is …

Female Students’ Sense Of Belonging Influence On Engineering Technology Degree Retention: A Phenomenological Study, Edith Wittenmyer

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this qualitative study is to identify and understand the phenomenon of sense of belonging regarding female students’ lived experiences that may impact retention rates for female students in engineering technology majors at this particular major midwestern university. Delving deeper into the lived experiences of engineering technology female students is the focus of this research. The study’s outcome may support academic policy changes which will increase retention and graduation of female students in pursuit of engineering technology degrees.

Laser Powder Directed Energy Deposition (Lp-Ded) Inconel 718: Laser Power And Heat Treatment Effect On Microstructure And Mechanical Properties, Dana Victoria Godinez

Open Access Theses & Dissertations

This study examines the microstructure and mechanical properties (tensile, hardness, and fatigue endurance) of laser powder-directed energy deposition (LP-DED) printed specimens with varying deposition parameters. Five samples with power inputs ranging from 350 to 2620W, all of similar thicknesses, were evaluated to enable a direct comparison. The varying specimens were heat treated, including stress relief, hot isostatic pressing, solution, and two-step aging. The resulting microstructures and their corresponding hardness values were compared at each heat treatment stage. The fully heat-treated specimens' tensile properties and fatigue life were also examined and compared. Key findings of this study indicate that complete heat …

Development Of A Digital Engineering Testing Framework For Cubesat Applications, Javier Alberto Martell

Open Access Theses & Dissertations

Digital Engineering (DE) is playing an important and expanded role in todayâ??s industry. As engineering systems become more and more complex with each new iteration, the need for a more efficient and agile methodology for project management and development is needed. The SleeperSat-1 (SPST-1) is a Modular Open System Architecture (MOSA) type of small satellite being developed by the UTEP Aerospace Center. The SPST-1 will mostly use digital engineering tools for its lifecycle research and development. CubeSats require rigorous environmental testing not only to ensure the success of the mission, but also to ensure the safety of the crew, space …

Microwave Emission Model Parameter Tuning For Surface Soil Moisture Retrieval Using Uav-Mounted Dual Polarization L-Band Radiometer, Santiago Hoyos Echeverri

Open Access Theses & Dissertations

Surface soil moisture retrieval from L-band brightness temperature has been developed for the past decades due to multiple beneficial characteristics of 1-2 GHz frequency bands for remote sensing of the environment. Numerous microwave emission models have been proposed for tower and satellite-based operations with successful retrieval of surface soil moisture and vegetation water content. As a result of the development of cost-effective and low-mass microwave L-band radiometers such as the Portable L-band Radiometer (PoLRa), surface soil moisture surveying traditionally developed by satellite missions SMOS and SMAP can now be developed at local scales, bringing these operations to commercial small unmanned …

Reduction Of The Length Of Stay At The Emergency Department Of The Audie L. Murphy Hospital, Arwa Al Shikrian

Theses

We implemented the DMAIC framework (Define, Measure, Analyze, Improve, and Control) and Lean Six Sigma methods to reduce the length of stay (LOS) in the Emergency Department (ED) at Audie L. Murphy VA Hospital, a crucial issue affecting operational efficiency and patient care quality. This project was conducted in conjunction with an internship at the Hospital; our efforts were an integral part of a Green Belt project being conducted by Mr. Roarke Verkaik-Bushby, Hospital Administration Service, to

whom this author reported.

We employed quantitative research design, meticulously observing, measuring, and analyzing ED processes. We tracked patient flow, identified bottlenecks, and …

Rasc-Al Large Scale Lunar Crater Prospector, Austin Arnold, Coleman Alvarez, Mark Suberu

Senior Design Project For Engineers

The purpose of this project is to design a conceptual layout of a lunar rover capable of exploring craters at the lunar south pole. The rover should be autonomous and capable of self-sustainment for at least one year in extreme cold and darkness. While determining the location and accessibility of water ice and other volatiles within the crater. This document will contain all information related to the team's conceptual design. Including research, component selection, electrical design, and mechanical design.

Lunar Rascals Video: https://www.youtube.com/watch?v=MdcjzVMtzaI

A Comprehensive Analysis Of Training Induced Heat-Related Injuries At Fort Moore, Anthony Beger

Data Science Undergraduate Honors Theses

Heat related injuries are a significant problem for the United States Armed Forces. There were over 11,000 confirmed cases of heat-related illnesses that were diagnosed at more than 230 military installations from 2018-2022. These injuries are primarily due to hyperthermia (i.e., abnormally high body temperature) resulting from extreme environmental temperatures, high humidity, medications, or excessive physical work or exercise. Fort Moore has the most heat related injuries of any installation in the U.S. Department of Defense since it is home to one of the largest U. S. Army training posts with most training involving intensive outdoor activity in high heat …

Comparing North American Professional Sports League Season Formats Using Monte Carlo Simulation, Lathan Gregg

Industrial Engineering Undergraduate Honors Theses

Each NFL, NBA, and MLB season consists of a regular season, in which teams play a set number of scheduled games and a playoff, in which qualifying teams compete for a championship. At the conclusion of each season, teams are ranked based on their performance throughout the season. This study aims to investigate the ability of each league's season format to accurately rank teams using Monte Carlo simulation. Matches between two teams are simulated by using the team’s assigned strength ranks to calculate a winning probability for each team. The winning probabilities are simulated with different skill values, dictating how …

Using Convolutional Neural Networks For Autonomous Drone Navigation, Joshua Jowers

Industrial Engineering Undergraduate Honors Theses

Unmanned Aerial Vehicles (UAVs), more commonly known as drones, serve various purposes, notably in military applications. Consequently, there arises a need for navigation methods impervious to intercepted signals [1]. Previous research has explored numerous solutions, including machine learning. This paper delves into a specific machine learning approach employing a Convolutional Neural Network (CNN) to discern image locations [2]. It elucidates the conversion of a CNN model between two machine learning libraries and presents results from multiple experiments examining parameters and factors influencing the approach's efficacy. These experiments encompass testing different data sources, image quantities, and processing pipelines to gauge their …

Detection Of Hypoxia Via Rgb Imaging, Nathania Nischal

Biomedical Engineering Undergraduate Honors Theses

Colorectal cancer is a common form of cancer, and is heavily researched in murine models. Colonoscopies are often performed in clinical settings to assess the health of the colon, as well as locate and assess the severity of tumors in a non-invasive way. As the quality of the images is dependent on the colonic environment and the light available, it is important to ensure the accuracy of the images via a normalization algorithm. The RGB images procured from these colonoscopies have great potential as a diagnostic tool for physicians, as varying scales of discoloration is common in hypoxic tissue. While …

Dorsal Root Ganglia Neurite Outgrowth Following Traumatic Spinal Cord Injury Repair: A Review, Adrienne Vaughan

Biomedical Engineering Undergraduate Honors Theses

Traumatic spinal cord injury (tSCI) can cause partial sensorimotor deficiency or total dysfunction, rendering patients unable to perform necessary tasks and dramatically decreasing their quality of life. tSCI is a very prevalent issue. In the United States alone, there are approximately 54 new cases of SCI per one million people each year, or 18,000 new cases annually. tSCI creates a lesion gap filled with axon-inhibiting fibrotic scar tissue. Comprehensive functional recovery following traumatic spinal cord injury (tSCI) requires axonal regeneration across wound site lesions. Dorsal root ganglia (DRG) neurite outgrowth is often evaluated in PNI therapeutic research since it can …

Suppressing Reactive Oxygen Species Via Application Of Antioxidant Supramolecular Polymers, Zacchaeus Wallace

Honors Theses

Cardiovascular diseases along with various other disease conditions are characterized by an upregulation in reactive oxygen species (ROS), which can overwhelm homeostatic processes in the body, resulting in cellular apoptosis and severe oxidative damage. The lack of clinically approved treatments to regulate or alleviate this elevated ROS presence underscores the need for novel therapeutic strategies. While antioxidants promote cell rescue through ROS scavenging, their clinical translation is impeded by insufficient bioavailable concentrations at the source of injury. The opportunity to apply antioxidant supramolecular polymers of peptide amphiphiles (PAs) is an exciting prospect of research to combat corresponding issues. For this …

Computational Predictions Of Heart Failure Drug Effects On Cardiac Fibrosis, Aaron Gardner

Chemical Engineering Undergraduate Honors Theses

The extracellular matrix is a complex system surrounding cells that is crucial to all of the cardiovascular system’s functions. Fibrosis is an excessive accumulation (scarring) of the extracellular matrix. Fibrosis is typically a negative event, and the scarring must be reduced in the heart in order to maintain its functionality. Due to this, simulations are run using the software “Netflux” in order to determine the effects of different heart failure drugs on cardiac fibrosis. The drugs that were simulated were an ACE Inhibitor, BAR Beta Blocker, ARB Blocker, and Entresto. These drugs were simulated over 50 hours at three different …

Optimization Of Collagen And Cell Concentrations For Engineered Tissues, Avery Fiser

Chemical Engineering Undergraduate Honors Theses

Improvements regarding the drug discovery process are necessary due to less than 1% of drugs making it from the initial discovery phase to patient treatment in clinics. One method of enhancing this process involves improving the relevance and dependability of in vitro testbeds utilized during pre-clinical testing. Improvement along these factors can provide a more relevant view for eventual drug behavior in patients. This additional relevance can allow for a reduced timeline in drug development for improving patient care. A consistent and morphologically sound baseline engineered tissue is vital to the creation of successful experimental models. Parameters such as cell …

Modeling Vibration Stiffness: An Analytical Extension Of Hertzian Theory For Angular Contact Bearings With A Thin Viscoelastic Coating, Davis R. Burton

Honors Theses

This thesis considers the novel angular contact rolling-element bearings proposed by NASA’s Glenn Research Center, which are coated with a thin solid lubricant that exhibits viscoelastic behavior. Current analytical models for the dynamic stiffness matrix of angular contact bearings, critical for vibration analysis, lack the ability to model the effects of a solid coating, as well as the time dependencies inherent in viscoelastic theory. The author first presents an overview of the stiffness matrix derivation, followed by a treatment of the underlying Hertzian contact theory. An analytical extension of this theory is proposed which accounts for a thin elastic layer …

Rapid Response Satellite Launcher, Nathan Jones, Joey Cosentino, Jayson Layton, Afek Adar

Senior Design Project For Engineers

Air launch to orbit is a new style or spacecraft where rockets are attached to a large aircraft and released at cruising altitude to then ignite and launch into space. Companies such as Virgin Orbit are using it as a cheap and efficient way to move satellite payloads into lower or upper Earth orbit. These styles of launchers can be designed to be much smaller than ground-launched spacecraft, reducing cost and weight of the launcher in comparison. With many private companies coming into the space and satellite industry, the design and manufacturing of these launchers have become a focus within …

Encapsulated 2d Materials And The Potential For 1d Electrical Contacts, Sarah Wittenburg

Physics Undergraduate Honors Theses

The utilization of two-dimensional materials and heterostructures, particularly graphene and hexagonal boron nitride, have garnered significant attention in the realm of nanoelectronics due to their unique properties and versatile functionalities. This study focuses on the synthesis and fabrication processes of monolayer graphene encapsulated between layers of hBN, aiming to explore the potential of these heterostructures for various electronic applications. The encapsulation of graphene within hBN layers not only enhances device performance but also shields graphene from environmental contaminants, ensuring long-term stability. Experimental techniques, including mechanical exfoliation and stamp-assisted transfer, are employed to construct three-layer stacks comprising hBN-graphene-hBN. The fabrication process …

Comprehensive Current Flow Modeling And Circuit Parameter Analysis For A Brushed Dc Motor Regenerative Braking System, Caleb Nathaniel Bondy

Legacy Theses & Dissertations (2009 - 2024)

The literature surrounding regenerative braking systems deals heavily with control system analysis and less to do with the electrical analysis of the circuitry itself. This thesis develops a step-by-step current flow model for a single-phase brushed DC motor regenerative braking system using the RL unit step-response equation as a starting point. This model and the equations derived from it will be analyzed to see what limitations arise from the circuitry on the overall performance of the system, such as non-ideal resistances, switching delays, and affects from current draw of accessory circuitry. The efficiency will be calculated in the context of …