Engineering Commons^™

Production Of Porous Alginate Substrates Via Membrane Emulsification For Pharmaceutical Applications, Genesis D. Correa-Rivera, David A. Acevedo, Zoltan K. Nagy

The Summer Undergraduate Research Fellowship (SURF) Symposium

The Food and Drug Administration (FDA) released in 2013 a report that established the pharmaceuticals current good manufacturing practices for the 21^st century. This report encourages the creation of new technology in the pharmaceutical industry. Therefore, this research aims to develop a reliable method to produce porous polymers particles to be used in a novel continuous crystallization in porous substrate. The aim of the current work is to create porous polymer microspheres with uniform particle size distribution using a commercially available membrane emulsification system. In the present study, the emulsification was made using a dispersed phase composed of miglyol …

Gdd(Growth Degree Day) Module For Vinsense Visual Analytics System, Pradeep K. Lam, David Ebert , Phd, Jiawei Zhang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Limited resources and increasing costs require vineyards to develop optimized methods of planting, growing, and harvesting crops in order to ensure max yield and stay competitive in the marketplace. Data from sensors planted within the soil paired with weather reports and observation data from farmers could help develop competitive farming strategies. While automatic computation models are usually a black box that cannot explain how the input data are transformed into output, the farmers require an approach that allows them to interactively manipulate and supervise the computation process. The VinSense project was developed for this purpose. In this paper, we focus …

Effect Of Conveying And Distributive Mixing Elements On Breakage Phenomenon In Twin Screw Granulation, Jiayu Li, Shankali U Pradhan, Carl Wassgren

The Summer Undergraduate Research Fellowship (SURF) Symposium

Twin screw wet granulation (TSG) is gaining more attention and becoming an important process in the pharmaceutical industry. The process is widely implemented because of its flexibility, short residence time, and small equipment footprint. Past studies have shown that screw elements can have a significant impact on the performance of the TSG process. In addition, these studies identified that breakage of wet mass is a significant step in the process. Currently there is no literature that focuses on the effect of each screw element on the breakage process. In this work, experiments have been designed to isolate the breakage process …

Exploring How Haptics Contributes To Immersion In Virtual Reality, Dimcho Zhelyazkov Karakashev, Hong Z. Tan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Virtual Reality (VR) has been around for more than fifty years but the technology hasn’t reached practical usability until very recently. With the current head-mounted display (HMD) technology and an abundance of investment in VR startups, we have finally reached at the point where it is possible to simulate complex virtual environments that feel immersive. A major problem with virtual reality is that everything looks real but you can not touch and feel virtual objects. We are focusing on developing a device that will allow users to feel what they touch in VR. We developed a hand-held interface and an …

Investigation Of Aluminum Foams And Graphite Fillers For Improving The Thermal Conductivity Of Paraffin Wax-Based Phase Change Materials, Javieradrian Ruiz, Amy Marconnet, Yash Ganatra, John Howarter, Alex Bruce

The Summer Undergraduate Research Fellowship (SURF) Symposium

Passive thermal management with phase change materials (PCMs) has become the one of the most promising methods to cool cell phone processors due to the relatively simple implementation and profound impact on processor temperatures. Enhancing the thermal properties of conventional PCMs, mainly thermal conductivity and latent heat storage, allows for an overall improved thermal management system. This study aims to improve the thermal conductivity of paraffin wax (a typical commercial PCM) by the introduction of an expanded graphite (EG) filler to form a paraffin wax composite, and then infiltration of the EG/paraffin composite into an aluminum foam matrix. The thermal …

Leveraging Smart Infusion Pump Data For Workflow, Patient Care And Usability Improvement In Human Factors, Yan Ni Ding, Denny Yu, Poching Delaurentis, Kang-Yu Hsu, Joon Hong Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Infusion pumps are medical devices that deliver fluids like medication, and nutrients in a precise, timely, and controlled manner that is critical to patient care. It is widely used in clinical settings especially in hospitals, nursing homes and sometimes at home. Smart infusion pumps technology are supposed to be reduce nurses’ workload, but due to the recurring number of alarms which disrupt the workflow of the infusion process, most nurses prefer to use the traditional infusion pumps or work-around the safety features of the smart pumps. Thus, the aim of this research is to leverage Smart Infusion Pump data to …

Impact Of Microscope, Loupes, And Video Displays On Microsurgeons’ Risk For Musculoskeletal Injuries, Yiyu Shi, Denny Yu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microsurgery is commonly performed with operating microscopes or loupes to repair traumatic injuries, damage from cancer surgery, etc.; however, the prolonged, awkward, and constrained postures from using these equipment puts microsurgeons at risk for musculoskeletal pain and injuries. An alternative heads-up displays may improve surgeons’ ergonomics by allowing microsurgeons to perform the procedure in a more comfortable and ergonomic position. The study compares the effect of microscope, loupes and video displays on postures during microsurgical targeting task. This study incorporated three steps to contrast displays. Firstly, 12 participants wearing six reflective markers completed a surgery simulation using all three displays, …

How User's Visualization Literacy Relates To Their Cognitive Traits, Jiming Yang, Sukwon Lee, Ji Soo Yi

The Summer Undergraduate Research Fellowship (SURF) Symposium

Researchers in the field of Information Visualization have suggested that users’ cognitive abilities would likely to affect their understanding of data visualizations and deeper exploration in the visualizations. However, the evidence is still scant to link between user’s visualization literacy and their cognitive traits. Thus, the research goal of this study is to explore how user’s visualization literacy and their cognitive traits are related. In particular, we focused on two cognitive traits: numeracy and need-for-cognition. In order to achieve the goal, first, we measured visualization literacy, numeracy, and need-for-cognition using existing instruments with 46 Amazon Mechanical Turk workers, and the …

Modeling Of Ion/Target Interactions In Plasma Facing Components Of Fusion Reactor, Nicole Neto Godry Farias, Tatyana Sizyuk, Ahmed Hassanein

The Summer Undergraduate Research Fellowship (SURF) Symposium

Nuclear fusion is a promising source of clean energy that can be one of the key future suppliers of the world’s increasing power demand. One of today’s main challenges faced by scientists and engineers regarding nuclear reactors is to design plasma-facing components (PFCs) that can withstand extreme conditions of temperature, pressure, and ions/particles irradiation. Material evolution and damage of PFCs are strongly related to the bombardment and diffusion processes of ions resulting from fusion fuel, i.e., deuterium and tritium and reaction products, i.e., helium. However, work is still needed in order to understand fuel diffusion in the presence of helium …

Rapid Grain Boundary Mobility At Ambient Temperatures, Jarrod M. Lund, R Adam Bilodeau, Rebecca K. Kramer

The Summer Undergraduate Research Fellowship (SURF) Symposium

Understanding and measuring the influence of grain boundaries (planar defects in the crystalline structure of materials) and their motion has become a dominant aspect in materials research, with applications in additive manufacturing, fatigue prevention, and material modeling. However, modeling grain boundaries and grain boundary mobility (GBM) is difficult due to the high temperatures or external stresses, imaging solutions compatible with the material system, and long time-scales required to create measurable experimental results. In this paper, we introduce a novel material system that allows for easy and fast visualization of GBM. A drop of liquid metal eutectic gallium indium (eGaIn) placed …

Fabrication And Evaluation Of Magnetic Micro Actuators For Implantable Self-Clearing Glaucoma Drainage Devices, Haritha Ramadorai, Hyunsu Park, Hyowon Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

According to the World Health Organization, glaucoma is the second leading cause of blindness in the world. It currently affects more than 2.7 million people in the United States alone and over 79.6 million people worldwide are estimated to be inflicted by this debilitating disease by 2020. Glaucoma patients are often characterized with elevated intraocular pressure (IOP) and are treated with implantation of glaucoma drainage devices (GDD) to maintain optimum IOP. Although initially effective at delaying glaucoma progression, contemporary GDD often lead to numerous complications and only 50% of implanted devices remain functional after 5 years. Biofouling is seen to …

Bone Tissue Engineering: Scalability And Optimization Of Densified Collagen-Fibril Bone Graft Substitute Materials, John G. Nicholas, Lauren E. Watkins, Sherry L. Voytik-Harbin

The Summer Undergraduate Research Fellowship (SURF) Symposium

Over 240 million people missing teeth worldwide experience lingering problems such as difficulty speaking and eating, undesirable aesthetics, and resorption of bone supporting neighboring teeth. The gold standard of treatment utilizes grafts to attach a function-restoring implant to supporting bone. Current graft materials suffer from problems including autologous donor site morbidity, long resorption time, incomplete integration with the maxillae or mandible, and structural weakness. Patient-specific, cellularized bone grafts may be a solution to these issues by accelerating and improving the quality of regenerated bone. Recently, encapsulation of mesenchymal stem cells within self-assembling type I collagen oligomer matrices has been shown …

Experimental Testing And Validation Of P-Band Bi-Static Remote Sensing Of Soil Moisture In 137-138mhz Range, Xiangyu Qu, Yao-Cheng Lin, James L. Garrison

The Summer Undergraduate Research Fellowship (SURF) Symposium

Remote sensing using readily available communication signal transmitted by ORBCOMM satellites at very high frequency (VHF) range (137-138MHz) is a promising method for detecting the root zone soil moisture content. The radio wave reflectivity of soil is strongly correlated to soil moisture content. Therefore, if we were able to measure the reflectivity, we might be able to estimate the soil moisture content. In this preliminary study, we analyze direct signal data from the satellites to investigate and verify communication channels in frequency range of interest and their characteristics (bandwidth, pattern, etc.). The analysis of direct signal data is also used …

Strength Of Reinforced Concrete Beams With High-Strength Steel, Brian C. Rogers, Aishwarya Puranam, Santiago Pujol

The Summer Undergraduate Research Fellowship (SURF) Symposium

Structures are commonly made of reinforced concrete, which is a composite material made of concrete and steel reinforcement. Using high-strength steel, with yield stress larger than 100 ksi, could help reduce the quantity of steel required in structural members, thus reducing costs and improving constructability. The hypothesis being tested is that smaller quantities of high-strength steel reinforcement (HSSR) can be used in place of conventional steel in reinforced concrete beams while maintaining similar strength and deformation at failure. Two reinforced concrete beams with two different types of longitudinal steel reinforcement were constructed. The beams were 18 in. wide, 30 in. …

Performance Of Tf-Vls Grown Inp Photovoltaic Cells, Junyan Shi, Yubo Sun, Peter Bermel

The Summer Undergraduate Research Fellowship (SURF) Symposium

A grand challenge of photovoltaics (PV) is to find materials offering a promising combination of low costs and high efficiencies. While III-V material-based PV cells have set many world records, often their cost is much greater than other commercial cells. To help address this gap, thin-film vapor-liquid-solid (TF-VLS) grown Indium Phosphide (InP) PV cells have recently been developed, which both eliminate a key source of high costs and offer a direct bandgap of 1.34eV with potential to approach maximum theoretical efficiencies. However, the unanticipated phenomenon of open circuit voltage (V_oc) degradation has prevented TF-VLS grown InP PV cells …

Metamodels Of Residual Stress Buildup For Machining Process Modeling, Stuart B. Mccrorie, Michael Sangid

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the process of machining materials, stresses, called residual stresses, accumulate in the workpiece being machined that remain after the process is completed. These residual stresses can affect the properties of the material or cause part distortion, and it is important that they be calculated to prevent complications from arising due to the residual stresses. However, these calculations can be incredibly computationally intensive, and thus other methods are needed to predict the residual stresses in materials for quick decision-making during machining. By using metamodels - a method of representing data where few data points exist - we can achieve an …

Effect Of Particle Concentration And Ac Electric Field Strength On Particle Trapping In Rapid Electrokinetic Patterning (Rep), Sixuan Li, Avanish Mishra, Steve Wereley

The Summer Undergraduate Research Fellowship (SURF) Symposium

Rapid Electrokinetic Patterning (REP) is an optoelectric technique for trapping and translating micro- and nanoparticles non-invasively. It uses a combination of laser-induced AC electrothermal flow and particle-electrode interactions in the presence of a uniform AC electric field. The trapping is governed by laser power, electric field strength, AC frequency and dielectric properties of the particle and the medium. A REP trap has an AC frequency, termed critical frequency, above which particles cannot be trapped. It is expected to be dependent on dielectric properties of the particle and the medium. However, we propose that the particle concentration and AC field strength …

Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure is a leading cause of death in the United States, and cardiac thrombus, a common morbidity associated with heart failure, significantly increases a patient’s risk of embolic events. The objective of this project is to characterize left-ventricular (LV) thrombus development using high frequency ultrasound imaging in a murine model. C57BL/6J wild-type mice (n=6) were injected intraperitoneally with iron dextran five times a week for six weeks to increase oxidative stress in the heart. Granulocyte-colony stimulating factor (G-CSF) was subcutaneously injected daily during the second week to initiate stem cell migration and stimulate endothelial cell activation, thus increasing the …

Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Soccer is a unique sport in which athletes use their heads as tools for gameplay, which may ultimately cause cumulative traumatic brain injuries. Due to rising popularity of soccer in the United States alongside the increased occurrence of CTE and mTBI in other contact sports, there is a growing concern over how to keep the repetitive forces caused by heading, as low as possible. Different variables that can affect the peak force felt when heading a soccer ball can be simulated and compared with in-game data, however, this has never been properly tested before. In the present study two size …

Role Of Sumoylation In Mitochondrial Division In Tetrahymena Thermophila, Ramya Modi, James Forney

The Summer Undergraduate Research Fellowship (SURF) Symposium

SUMOylation is a post translation modification that involves the addition of a small protein called SUMO, Small Ubiquitin-like MOdifier to a target protein. It is an important mechanism for the regulation of gene expression, the maintenance of genomic stability and in modifying nuclear proteins. More recently evidence has emerged for its importance in regulating mitochondrial fission and fusion in mammalian cells. This study evaluates the parameters for optimal staining of Tetrahymena thermophila mitochondria using two different dyes and then examines different cell lines with defects in the SUMOylation pathway. The first staining method uses Mitotracker Green, a vital stain that …

Increasing Maize Tolerance To Drought And Flood With Seed Coating Treatments, Jacob E. Bennett, Achint Sanghi, R. P. Kingsly Ambrose

The Summer Undergraduate Research Fellowship (SURF) Symposium

The lack of irrigation in regions prone to drought, and flooding due to high rainfall or lack of drainage affects seed viability and the subsequent germination and crop establishment. Seed treatment in the form of coatings shows promise as an effective method to preserve the viability of corn (Zea mays) seeds in drought and flood conditions. Chemical formulations may help improve the seed corn vigor under these stressed conditions. This study examined the efficacy of β-aminobutyric acid [BABA] and N-isopropylacrylamide [NIPA] in inducing drought resistance, as well as the ability of lanolin and linseed oil to provide flood …

Brain Inspired Enhanced Learning Mechanism Based On Spike Timing Dependent Plasticity (Stdp) For Efficient Pattern Recognition In Spiking Neural Networks, Sourjya Roy, Gopalakrishnan Srinivasan, Vijay Raghunathan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Artificial neural networks, that try to mimic the brain, are a very active area of research today. Such networks can potentially solve difficult problems such as image recognition, video analytics, lot more energy efficiently than when implemented in standard von-Neumann computing machines. New algorithms for neural computing with high bio-fidelity are being developed today to solve hard machine learning problems. In this work, we used a spiking network model, and implemented a self-learning technique using a Spike Timing Dependent Plasticity (STDP) algorithm, that closely mimics the neural activity of the brain. The basic STDP algorithm modulates the synaptic weights interconnecting …

Large Scale Monolithic Solar Panel Simulation - A Study On Partial Shading Degradation, Suhas V. Baddela, Xingshu Sun, Muhammad A. Alam

The Summer Undergraduate Research Fellowship (SURF) Symposium

Shadow-induced degradation is a major concern for both power output and long-term reliability in solar cells. Apart from the obvious fact that shading reduces the amount of solar irradiance available to solar panels, it may lead to formation of hot spots, where solar cells are forced to reverse breakdown with localized heating, and potentially, permanent damage. To get a better understanding of shadow-induced degradation, we develop an electro-thermal coupled simulator that can self-consistently solve the electrical and thermal distributions of solar panel under arbitrary shading conditions. The simulation framework consists of two part: a) compact models that can describe the …

Mechanical Investigation Of Phase-Transforming Cellular And Origami Materials, John M. Cleveland, David Restrepo, Yunlan Zhang, Pablo Zavattieri, Nilesh Mankame

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cellular materials, such as honeycombs and metallic foams, have attracted much attention due to their exceptional ability to absorb and diffuse mechanical energy. These materials have a wide range of applications, such as improving vehicle crash safety and helmet impact resistance. However, many of these materials are rendered unusable after one application. Phase-transforming cellular materials (PXCMs) utilize a reversible bistable mechanism to facilitate energy absorption from one-dimensional impacts and loads. These mechanisms have the added benefit over other cell structures of reusability. In this study, various PXCM designs are discussed and examined to determine their energy absorption capabilities.

Three different …

High Strain Rate Experiments Of Energetic Material Binder, Roberto Rangel Mendoza, Michael Harr, Weinong Chen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Energetic materials, in particular HMX, is widely used in many applications as polymer bonded explosives (PBX) and rocket propellant. However, when damaged, HMX is known to be an unstable substance which renders it a hazardous material and in some cases unreliable. Finding critical mechanical conditions at high rates that render various forms of energetic materials as unreliable would be vital to understand the effects that vibrations and compression forces have on energetic materials. A better understanding would enable the ability to develop improvements in the manufacturing of PBX and rocker propellant. The method utilized to evaluate the mechanical properties of …

Effects Of Internal Egr On Modern Diesel Engines Internal Equipped With Vva At Idle, Erik R. Santini, Dheeraj B. Gosala, Gregory M. Shaver

The Summer Undergraduate Research Fellowship (SURF) Symposium

Vehicle emissions regulations are continuing to grow more challenging requiring near-zero levels of pollutant emissions. Nitric oxide (NOx) emissions are heavily regulated with the emission limit expected to become 1/10^th of its present limit by 2021. In order to meet the new regulations, improvements in both the engine and the exhaust aftertreatment system are required. Exhaust gas recirculation (EGR) is used to reduce the NOx produced by the engine while the aftertreatment system converts most of the engine-out emissions to safer gases before releasing them to the atmosphere. One of the main challenges with the aftertreatment system is that …

Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa

The Summer Undergraduate Research Fellowship (SURF) Symposium

Development of high throughput assays is a crucial step in developing more efficient techniques that aid in many important areas of research today such as drug development or identification of protein structure function relationships. Integration of high throughput assays into more research efforts could drastically decrease the time and cost it takes for a new drug to hit the market. Protein Kinase A (PKA) is an extensively studied protein as it is highly upregulated in cancer and is a hot spot for drug targeting. In this work, azide-tagged PKA is covalently attached to magnetic beads using azide-alkyne cycloaddition, a well-known …

Cartilage Engineering: Optimization Of Media For Chondrogenic Differentiation In Vitro, Evan Surma, Sherry L. Harbin, Hongji Zhang, Stacy Halum

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lower back pain from intervertebral disc injury affects around 84% of the population at some point in their life, which at its worst may cause total immobilization. This pain can only be temporarily relieved by spinal fusion or intervertebral disc replacement; however, both of these cause loss of natural motion in patients by removing damaged fibrocartilage discs. While these techniques help mitigate pain briefly, no permanent solution exists currently to both relieve pain and preserve natural motion. My work may be a solution by eventually providing patient-specific implants that resemble native tissue in the regeneration process that could be absorbed …

Characterization Of Suspension Polymerized Polyacrylamide And Poly(Sodium Acrylate-Acrylamide) Copolymer And Their Size Influence On The Properties Of Concrete, Cole R. Davis, Kendra A. Erk, Stacey L. Kelly

The Summer Undergraduate Research Fellowship (SURF) Symposium

Shrinkage leading to cracking and mechanical instability is a major problem for concrete due to the loss of water during the curing process. However, through the addition of Superabsorbent Polymer (SAP) hydrogels, shrinkage can be prevented, increasing the strength of concrete. Characterization of suspension polymerized polyacrylamide (PAM) poly(sodium acrylate-polyacrylamide) (PANa-PAM) copolymer microsphere sizes, morphology and swelling behavior was conducted before adding them to concrete. Size was determined using microscopy paired with ImageJ analysis. Coulter Counter size characterization was also used to determine the particle size distribution. Swelling behavior was determined using the tea bag method as well as size analysis …

Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term …