Engineering Commons^™

Effect Of Nanoparticle Size, Support, And Potassium Dopant On Ruthenium Activity For Levulinic Acid (La) Hydrogenation To Γ-Valerolactone (Gvl), Shuo Cao

Theses and Dissertations

The purpose of this thesis is to study the effect of nano-particle size, support and potassium dopant on ruthenium activity on the levulinic acid (LA) hydrogenation to ã-valeroactone (GVL).In hydrogenation reaction, H2 as the gas phase reactant reacts with the metal atoms at the surface of particle size, thus a high level of metal dispersion is critical to maximize the amount of atoms on the surface. This reaction has been widely investigated by varied metal supported catalysts and proved that Ru is the most active metal for it. However, most of researchers only focused on the reaction pathway, rather than …

The Anti-Angiogenic Effects Of Sparstolonin B, Henry Rhodes Bateman

Theses and Dissertations

Sparstolonin B (SsnB) is a novel bioreactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has demonstrated anti-inflammatory properties, inhibiting Toll-like receptor mediated inflammation in isolated macrophages and in mice. Angiogenesis, the process of new capillary formation from existing blood vessels, is dysregulated in many pathological disorders, including atherosclerosis, diabetic retinopathy, and tumor growth. The goal of the project was to investigate the anti-angiogenic effects of SsnB.

The first part of the project utilized in vitro functional assays to study how SsnB affected endothelial cells. SsnB inhibited endothelial cell tube …

Impact Of Physical Activity In The Prevention Of Colorectal Cancer, Sarah Ashley Barnes

Theses and Dissertations

This review evaluates the current understanding of research on the impact of physical activity in the prevention of colorectal cancer. Current biological mechanisms implicated in physical activity and colorectal cancer risk reduction are blood glucose regulation, insulin sensitivity, leptin and adiponectin profiles, inflammation as well as secreted protein acidic and rich in cysteine (SPARC), an exercise induced myokine. Recent literature indicates that 30-60 minutes of moderate to vigorous activity a day is effective against colorectal cancer development, and there is convincing evidence of aerobic exercise as differently beneficial in recruiting mechanisms identified as preventative against colorectal cancer. This article provides …

Resveratrol Attenuates The Development Of Trans-Aortic Constriction (Tac) Induced Heart Failure In Mice, Prakash Kumar Gupta

Theses and Dissertations

Heart failure (HF) still remains the leading cause of morbidity and mortality and imposes severe global affliction and enormous cost on the healthcare system. Although current pharmacological therapies have shown to slow down the progression of HF, but seems to have reached their limits in improving overall patient prognosis. Thus, an immediate call for novel alternate therapies are needed which act independently as well as in conjunction with current treatment modality. Studies were performed in the well-established transverse aortic constriction (TAC) model of chronic pressure overload (PO) in mice. In the first series of studies, Male C57BL6 mice (26-28 g) …

Mass Spectrometry And Tandem Mass Spectrometry Characterization Of Protein Patterns, Protein Markers And Whole Proteomes For Pathogenic Bacteria, Jennifer Intelicato-Young

Theses and Dissertations

There have been many recent reviews published on MALDI-TOF MS (matrix assisted laser desorption/ionization time-of-flight) MS (mass spectrometry) for identification of bacteria particularly with relevance to clinical microbiology. MALDI-TOF MS is now a mature technique for bacterial identification with great promise. The purpose of this review is to put into perspective MALDI-TOF MS and other widely used mass spectrometry methods for characterization of proteins. MALDI-TOF MS is used for rapid determination of a mass pattern of proteins for bacterial characterization; these proteins

are generally not identified. Alternatively, after gel separation, MALDI TOF-TOF MSMS (tandem mass spectrometry) or on-line LC-ESI MS-MS …

Fault Location In Power Networks Using Synchronized Phasor Measurements, Cuong Nguyen

Theses and Dissertations

Faults in electric power systems can lead to cascading power outages which cause tremendous loss to the economy and affect people’s lives. Technical reports of recent blackout events in the United States pointed out the lack of situational awareness as one of the main causes of widespread outages. Time synchronized phasor measurement is recommended as a technology that can improve the monitoring of power system condition. By knowing exactly where a fault occurs, necessary actions can be taken in a timely manner and thus, damage caused by that fault can be limited. In this thesis, first, a method for precise …

Quasinovo: Algorithms For De Novo Peptide Sequencing, James Paul Cleveland

Theses and Dissertations

High-throughput proteomics analysis involves the rapid identification and characterization of large sets of proteins in complex biological samples. Tandem mass spectrometry (MS/MS) has become the leading approach for the experimental identification of proteins. Accurate analysis of the data produced is a computationally challenging process that relies on a complex understanding of molecular dynamics, signal processing, and pattern classification. In this work we address these modeling and classification problems, and introduce an additional data-driven evolutionary information source into the analysis pipeline.

The particular problem being solved is peptide sequencing via MS/MS. The objective in solving this problem is to decipher the …

The Study Of Alternate, Solid-Phase Fluorinating Agents For Use In Reactive Gas Recycle Of Used Nuclear Fuel, Dillon Inabinett

Theses and Dissertations

Surrogate oxides of the Used Nuclear Fuel (UNF) matrix were fluorinated using alternate, solid-phase fluorinating agents XeF2 and NH4HF2 to form volatile and non-volatile compounds and demonstrate the possibility of a chemical and thermal separations. A matrix of experiments was conducted at the milligram quantity scale using a Shimadzu DTG-60 TG/DTA installed at SRNL (Savannah River National Laboratory) for testing of all non-radioactive samples and a Netzsch STA 409 TGA installed in the laboratory at USC (University of South Carolina) for testing of all radioactive samples. The fluorination and subsequent volatilization potentials were analyzed by mixing excess fluorinating agent with …

Selection And Clustering For Disease Associated Genetic Variants, Yubo Zou

Theses and Dissertations

Epigenetics is the study of chemical reactions, which are orchestrated for the development and maintenance of an organism. Genetic or epigenetic variants (GEVs) encompass different types of genetic measures, such as Deoxyribonucleic acid (DNA) methylation at different CpG sites, expression level of genes, or single nucleotide polymorphisms (SNPs). With the development of technology, huge amount of genetic and epigenetic information is produced. However, the rich information potentially brings in challenges in data analyses. Thus it is necessary to reduce the dimension of data to improve efficiency. In my dissertation, I will focus on two directions of dimension reduction: variable selection …

Computational Analysis And Prediction Of Genome-Wide Protein Targeting Signals And Localization, Jhih-Rong Lin

Theses and Dissertations

Computational prediction of protein subcellular localization can greatly help to elucidate its functions. Despite the existence of dozens of protein localization prediction algorithms, the prediction accuracy and coverage are still low. Several ensemble algorithms have been proposed to improve the prediction performance, which usually include as many as 10 or more individual localization algorithms. However, their performance is still limited by the running complexity and redundancy among individual prediction algorithms. In the first part of the dissertation, we propose a novel method for rational design of minimalist ensemble algorithms for practical genome-wide protein subcellular localization prediction. The algorithm is based …

Role Of Microrna-155 In A Mouse Model Of Colon Cancer., Claire Mitchell Midyette

Theses and Dissertations

Colorectal cancer remains the third most common malignancy and the fourth most common cause of cancer mortality worldwide. Dysregulated miRNA levels are associated with several types of malignancies and may serve as important biomarkers and/or therapeutic targets in colorectal cancer. We examined the role of miRNA-155 on tumorigenesis and associated symptoms using a well-characterized mouse model of colorectal cancer. C57BL/6 wild-type mice and miRNA-155-/- mice (n=7-13 group) were given a single injection of AOM (10mg/Kg) followed by 3 cycles of DSS (2% in the water for 1 week followed by 2 weeks of plain water). A C57BL/6 wild-type group that …

Investigation Of Start Domain Proteins In Human Luteinized Cells And Cos-1 Cells, Bo Shi

Theses and Dissertations

After the luteinizing hormone surge of the menstrual cycle, the ovarian follicular granulosa and theca cells terminally differentiate to form the luteal cells of the corpus luteum. During this process known as luteinization, granulosa cells begin to synthesize large quantities of progesterone, a hormone essential for pregnancy. The rate limiting step for the de novo synthesis of pregnenolone (the precursor to progesterone) is the transport of cholesterol from the outer to the inner mitochondrial membrane, a process mediated by STARD1. STARD1 contains a C-terminal lipid binding domain holding one molecule of cholesterol, and an N-terminal domain targeting STARD1 to the …

Improving Robustness And Scalability Of Available Ner Systems, Amber Mckenzie

Theses and Dissertations

The focus of this research is to study and develop techniques to adapt existing NER resources to serve the needs of a broad range of organizations without expert NLP manpower. My methods emphasize usability, robustness and scalability of existing NER systems to ensure maximum functionality to a broad range of organizations. Usability is facilitated by ensuring that the methodologies are compatible with any available open-source NER tagger or data set, thus allowing organizations to choose resources that are easy to deploy and maintain and fit their requirements. One way of making use of available tagged data would be to aggregate …

A Method For Evaluating Power Generation Concepts Considering The Optimal Concept Of Operations, Tianlei Zhang

Theses and Dissertations

When trying to select an appropriate power generation plant for a micro-grid power distribution system like an electric ship, designers must consider both the physical characteristics (e.g., weight, volume, power ratings) and performance characteristics (e.g., fuel consumption, quality of service) of all the design alternatives. Comparing the design alternatives in terms of the physical characteristics is relatively straightforward, but in terms of performance characteristics each design alternative has to be evaluated within its own optimal performance points to make a fair comparison. However, at present no effective method or software tools exist to enable this evaluation at the earliest design …

Graphene-Supported Metal Nanoparticles For Applications In Heterogeneous Catalysis, Hany Elazab

Theses and Dissertations

Due to its unique properties and high surface area, Graphene has become a good candidate as an effective solid support for metal catalysts. The Nobel Prize in Physics for 2010 was awarded to Andre Geim and Konstantin Novoselov "for groundbreaking experiments regarding the two-dimensional material graphene". Microwave-assisted synthesis of various metallic nanostructured materials was investigated for CO oxidation applications. These metallic nanostructured materials were used to convert CO to CO2 as an effective approach for carbon monoxide elimination due to its harmful effect on health and environment. In particular, this dissertation is focusing on palladium as a transition metal that …

Fabrication And Characterization Of Compact High Resolution Radiation Detectors Based On 4h-Sic N-Type Epilayer And Cdznte, Kelvin Juvenal Zavalla Mendoza

Theses and Dissertations

The need of room-temperature, compact, and high resolution radiation detectors has opened the path for the development of new materials with suitable properties. Silicon carbide (SiC) and CdZnTe (CZT) are semiconductor materials with wide band gap that can operate efficiently at room temperatures (RT) and above. CZT has a high average atomic number (Z) which offers a high photoelectric absorption coefficient for x-/gamma rays. SiC allows high energy heavy ion detection due to its high radiation hardness even at temperatures much higher than room temperatures (RT). This thesis focuses on the fabrication and characterization of semiconductor based radiation detectors for …

Experimental Study On Piping Failure Of Earthen Levee And Dams, Yusuf Ahmed Sharif

Theses and Dissertations

Piping in an earthen levee, one of the main causes of failure, is a complex phenomenon. Most of the available research on piping failure has been on non-cohesive sandy soils. Jet Erosion Test and Hole Erosion Test have been conducted to study piping failure in an indirect manner. However, no general purpose formula is presently available to describe the erosion process due to complex erosion characteristics of cohesive soils in earthen levees.

Experimental investigations in a flume to understand the piping erosion process in an earthen levee are conducted in this research. One of the sidewalls and the bottom of …

Electrokinetic Mixing And Separation In Microfluidic Systems, Fang Yang

Theses and Dissertations

Electrokinetics involves the study of liquid or particle motion under the action of an electric field; it includes electroosmosis, electrophoresis, dielectrophoresis, and electrowetting, etc. The applications of electrokinetics in the development of microfluidic devices have been widely attractive in the past decade. Electrokinetic devices generally require no external mechanical moving parts and can be made portable by replacing the power supply by small battery. Therefore, electrokinetic based microfluidic systems can serve as a viable tool in creating a lab-on-a-chip (LOC) for use in biological and chemical assays. Here we present our works of electrokenitic based mixing and separation in microfluidics …

Application Of Computational Fluid Dynamics Methods To Improve Thermal Hydraulic Code Analysis, Dennis Shannon Sentell, Jr.

Theses and Dissertations

A computational fluid dynamics code is used to model the primary natural circulation loop of a proposed small modular reactor for comparison to experimental data and best-estimate thermal-hydraulic code results. Recent advances in computational fluid dynamics code modeling capabilities make them attractive alternatives to the current conservative approach of coupled best-estimate thermal hydraulic codes and uncertainty evaluations. The results from a computational fluid dynamics analysis are benchmarked against the experimental test results of a 1:3 length, 1:254 volume, full pressure and full temperature scale small modular reactor during steady-state power operations and during a depressurization transient. A comparative evaluation of …

Electromagnetic Modeling Of Gan Varactor Microwave Switches, Yi-Hsuan Yang

Theses and Dissertations

Microwave switches are important components which have been widely used in many microwave systems, such as electronic products, satellites communications, antennas, and radars etc. Traditionally, microwave switches are fabricated using pin diodes or MEMS, Si MOSFETs or GaAs HEMTs. These devices, due to the material limitations are suffering from a low breakdown voltage and are unable to handle high power. III-Nitride based varactor microwave switches provide opportunities for high power microwave devices, due to highly conducting 2D electron gas in the channel and high breakdown electric field.

Designing microwave switches typically involves modeling and simulation using tools such as MATLAB, …

Removal Of Synthetic Organic Compounds And Nom By Single-Walled Carbon Nanotubes-Ultrafiltration And Forward Osmosis Membrane System, Jiyong Heo

Theses and Dissertations

This overall theme of this dissertation is to investigate the potential engineered application of low pressure membranes incorporated with single-walled carbon nanotubes (SWNTs) and forward osmosis (FO) membrane systems for the removal of synthetic organic compounds (SOCs) and natural organic matter (NOM) from drinking water sources. The focus is on the use of SWNTs-ultrafiltration (UF) and FO membrane systems to facilitate the removal of these compounds and potential applications of these membrane system designs for reducing the energy demands and membrane fouling in environmental water filtration process and seawater desalination. The SWNTs-UF results indicate that SOCs transport is influenced by …

Advanced Fuels Modeling: Evaluating The Steady-State Performance Of Carbide Fuel In Helium-Cooled Reactors Using Frapcon 3.4, Luke H. Hallman

Theses and Dissertations

Uranium carbide (UC) has long been considered a potential alternative to uranium dioxide (UO2) fuel, especially in the context of Gen IV gas-cooled reactors. It has shown promise because of its high uranium density, good irradiation stability, and especially high thermal conductivity. Despite its many benefits, UC is known to swell at a rate twice that of UO2. However, the swelling phenomenon is not well understood, and we are limited to a weak empirical understanding of the swelling mechanism.

One suggested cladding for UC is silicon carbide (SiC), a ceramic that demonstrates a number of desirable properties. Among them are …

Fault Aware Soft Restart Of An Islanded Microgrid Using An Inverter Coupled Energy Storage System, Asif Anwar

Theses and Dissertations

This research developed a method for autonomous operation of an inverter-coupled energy storage system for safe islanding- re-energization - and reconnection of the facility-island or microgrid to the utility / distribution circuit in a seamless manner in the event of a fault. This enables the energy storage system to function as an autonomous source within the utility power distribution system without the need to re-engineer the existing protection coordination in the distribution system. Fault detection based on voltage measurements from the inverter terminals are used to detect a fault and isolate the energy storage-powered facility with negligible power feed into …

Application Of Agent-Based Approaches To Enhance Container Terminal Operations, Omor Sharif Abul Bashar Mohammad

Theses and Dissertations

Queuing at marine terminal gates has long been identified as a source of emissions and high drayage costs due to the large number of trucks idling. The first study in this dissertation addresses queuing of trucks at marine terminal gates and presents a novel agent-based framework where the drayage companies can minimize congestion by using the provided real-time gate queuing information. The problem was tackled based on the approach of El Farol Bar problem from game theory. Our proposed model can be used as a means of managing demand for the marine terminals, assuming that drayage firms will adjust their …

Asymmetric Hydrogenation Of Α, Β-Unsaturated Carboxylic Acid Over Chiral-Modified Palladium Catalyst, Shuai Tan

Theses and Dissertations

The production of optically pure chemicals through enantioselective catalytic reaction plays a key role a variety of industrials (e.g., pharmaceutical, agrochemical). Among several established methods, chiral-modified supported transition metal catalyst has been addressed attentions since past decades due to an environmental concern. Asymmetric hydrogenation of α, β-unsaturated carboxylic acid over Pd catalyst is of particular interest in this area. Nevertheless, the spectroscopic aspect, as well as the kinetic mechanism of such reaction system are still not clearly understood and require further study. In this work, a model catalytic reaction has been investigated from both spectroscopic and kinetic view. To be …

Linking Obesity To Colorectal Cancer: Recent Insights Into Plausible Biological Mechanisms, Catherine Guffey

Theses and Dissertations

Obesity has emerged as a leading environmental risk factor for the development of CRC. However, the mechanisms underlying this relationship have not yet been fully explained. Recent literature has focused on 1) inflammatory processes, 2) adipokines, and 3) estrogen. Obesity-enhanced inflammation is largely orchestrated by increases in adipose tissue macrophages leading to the secretion of TNF-alpha, MCP-1, and IL-6, all of which are linked to CRC. Adiponectin is decreased with obesity and has been reported to be negatively associated with CRC, while leptin, which is increased, is positively associated with the disease. Estrogen has been shown to influence CRC, although …

Characterization Of Two Ods Alloys: 18cr Ods And 9cr Ods, Julianne Kay Goddard

Theses and Dissertations

ODS alloys, or oxide dispersion strengthened alloys, are made from elemental or pre-alloyed metal powders mechanically alloyed with oxide powders in a high-energy attributor mill, and then consolidated by either hot isostatic pressing or hot extrusion causing the production of nanometer scale oxide and carbide particles within the alloy matrix; crystalline properties such as creep strength, ductility, corrosion resistance, tensile strength, swelling resistance, and resistance to embrittlement are all observed to be improved by the presence of nanoparticles in the matrix. The presented research uses various methods to observe and characterize the microstructural and microchemical properties of two experimental ODS …

Accuracy, Cost And Performance Trade-Offs For Streaming Set-Wise Floating Point Accumulation On Fpgas, Krishna Kumar Nagar

Theses and Dissertations

The set-wise summation operation is perhaps one of the most fundamental and widely used operations in scientific applications. In these applications, maintaining the accuracy of the summation is also important as floating point operations have inherent errors associated with them. Designing floating-point accumulators presents a unique set of challenges: double-precision addition is usually deeply pipelined and without special micro-architectural or data scheduling techniques, the data hazard that exists. There have been several efforts to design floating point accumulators and accurate summation architecture using different algorithms on FPGAs but these problems have been dealt with separately. In this dissertation, we present …

Microencapsulation Of A Connexin-43 Mimetic Peptide As A Novel Wound Healing Agent In An Ocular Injury Model, Keith Brian Moore

Theses and Dissertations

Corneal transplantation and related surgical procedures are areas of tissue replacement which have seen promising advances. Currently, cornea transplants are one of the most common surgical procedures, with approximately 40,000 occurring each year in the United States. Still, problems exist with a 20% rejection rate, post surgical infections, and the need for a constant supply of donors. The ability to safely and quickly heal and regenerate corneal epithelia fills an area of advancement in regenerative medicine, with implications reaching beyond the scope of vision therapies toward healing of a wide range of tissues and wounds. In vivo corneal wounds were …

Theoretical Investigation Of The Water-Gas Shift Reaction At The Three Phase Boundary Of Ceria Supported Platinum Metal Clusters, Sara Aranifard

Theses and Dissertations

The Water-Gas Shift (WGS: CO+H2O→CO2+H2) reaction is a key step in hydrogen fuel processing for mobile fuel cell applications. Since the reaction is equilibrium-limited and exothermic, high conversions are favored by low temperatures. However, conventional low-temperature shift catalysts are not active enough. Reducible oxide supported small noble metal clusters have shown excellent activity as low temperature WGS catalysts and it is generally believed that these catalysts are bifunctional. In other words, the reaction occurs at the three-phase boundary (TPB) of the noble metal, the reducible oxide, and the gas phase. The small noble metal cluster adsorbs/activates the CO molecules and …