Engineering Commons^™

Effects Of Cell-Cell Signaling On Mesenchymal Stem Cell Mechanosensing And Adaptation To Dynamic Material, Matthew E. Lowe

Theses and Dissertations

The goal of this research is to identify the role of engineered cell-cell signals on how cells sense material properties. Mesenchymal stem cells (MSCs) are adult cells whose behavior is regulated by matrix mechanosensing, which is characterized by stiffness-dependent changes in cell shape and the nuclear localization of mechano-transducer proteins including YAP (Yes-associated Protein). MSC area and nuclear YAP translocation increase with increasing stiffness, and although low levels of N-cadherin-based cell-cell signaling reduce this effect, two fundamental questions remain: (1) do engineered cell-cell signals at higher concentrations further reduce matrix mechanosensing, and (2) does N-cadherin signaling affect MSC adaptation to …

A Broad Spectrum Defense Against Adversarial Examples, Sean Mcguire

Theses and Dissertations

Machine learning models are increasingly employed in making critical decisions across a wide array of applications. As our dependence on these models increases, it is vital to recognize their vulnerability to malicious attacks from determined adversaries. In response to these adversarial attacks, new defensive mechanisms have been developed to ensure the security of machine learning models and the accuracy of the decisions they make. However, many of these mechanisms are reactionary, designed to defend specific models against a known specific attack or family of attacks. This reactionary approach does not generalize to future "yet to be developed" attacks. In this …

Improving Ideation Of User Actions Using A Novel Ideation Method, Thomas L. Ashworth

Theses and Dissertations

During early stages of the design process, ideation methods are used to generate a set of potential solutions based on a particular need. Solutions to design problems generally require both technology and user actions (or tactics) of some sort, although solution ideas may omit explicit mention of either technology or tactics. Previous research suggests that an explicit consideration of tactics in early-stage ideation enables design teams to improve the quantity, quality, variety, and novelty of their idea sets. In this paper, a novel ideation method known as the Random Prompts method is presented, and its performance is evaluated against a …

Finite Fatigue Life Prediction Of Additively Manufactured Aircraft Engine Turbine Blade With Respect To Internal Defect Size And Location, Daniel G. Miller

Theses and Dissertations

Current fatigue life modeling techniques with respect to defects emphasize the dependence on the defect size with respect to fatigue life, but does not account for the effects of where a defect might be located. This research outlines a process to include defect location into the model analysis for a more precise prediction of the number of cycles to failure and where the finial failure could occur within a component. The focus is on a turbine blade structure using IN718 subjected to a pure vibratory load. The basic model predicts component life using a stress map from the frequency analysis …

Mechanical Properties And Tension-Tension Fatigue Behavior Of A Novel Additively Manufactured Polymer Matrix Composite At Room And Elevated Temperature, Grayson M. Harber

Theses and Dissertations

The tension-tension fatigue behavior of a novel additively manufactured AM carbon fiber reinforced polymer matrix composite was studied. This novel material system consists of T1100 carbon fibers, and a UV photocured resin developed by Continuous Composites and Sartomer. Tensile properties and tension-tension fatigue were investigated for the 090 fiber orientation as well as for the ±45 fiber orientation. Specimens with 0/90 fiber orientation were tested at ambient laboratory temperature 23 °C and at elevated temperature 150 °C, while the specimens with the ±45 fiber orientation were tested only at ambient laboratory temperature. Tension-tension fatigue testing was carried out with a …

Retention Prediction And Policy Optimization For United States Air Force Personnel Management, Joseph C. Hoecherl

Theses and Dissertations

Effective personnel management policies in the United States Air Force (USAF) require methods to predict the number of personnel who will remain in the USAF as well as to replenish personnel with different skillsets over time as they depart. To improve retention predictions, we develop and test traditional random forest models and feedforward neural networks as well as partially autoregressive forms of both, outperforming the benchmark on a test dataset by 62.8% and 34.8% for the neural network and the partially autoregressive neural network, respectively. We formulate the workforce replenishment problem as a Markov decision process for active duty enlisted …

High Power Microwave Operational Exposure Detection Using Thermoacoustic Wave Generation In Lossy Dielectric Polymers, James J. Frey

Theses and Dissertations

A feasibility analysis for the use of microwave-induced thermoacoustic (TA) wave generation in lossy dielectric media to detect pulsed high power microwave directed energy weapons in force health protection applications was conducted based on a series of empirical and computational investigations. A potential target volume material, carbon-loaded polytetrafluoroethylene, was identified for further study based on anticipated complex dielectric properties, with laboratory measurements of select electromagnetic (EM), thermal, and elastic material properties of relevance to the TA effect conducted to determine parameter values. A planar geometry TA-based signal chain model using thin film piezoelectric sensors was developed for both finite element …

Value Focused Thinking Analysis Of C-Band Australia Radar Operations, Samuel Ray Grothman

Theses and Dissertations

The radars used for Space Domain Awareness (SDA) are inherently all-weather, day/night sensors capable of around the clock operations. Despite this fact, some radars are operated for fewer than their maximum operating capabilities. The decision-making process for selecting the operating hours of a sensor has historically been based on only a few factors or just one. This research uses the techniques in Value Focused Thinking to develop an evaluation process to score possible alternatives and find the alternative with the most value for the decision maker. By investigating the value that is added by operating an SDA radar, it is …

Enabling Rapid Chemical Analysis Of Plutonium Alloys Via Machine Learning-Enhanced Atomic Spectroscopy Techniques, Ashwin P. Rao

Theses and Dissertations

Analytical atomic spectroscopy methods have the potential to provide solutions for rapid, high fidelity chemical analysis of plutonium alloys. Implementing these methods with advanced analytical techniques can help reduce the chemical analysis time needed for plutonium pit production, directly enabling the 80 pit-per-year by 2030 manufacturing goal outlined in the 2018 Nuclear Posture Review. Two commercial, handheld elemental analyzers were validated for potential in situ analysis of Pu. A handheld XRF device was able to detect gallium in a Pu surrogate matrix with a detection limit of 0.002 wt% and a mean error of 8%. A handheld LIBS device was …

Analyzing Microarchitectural Residue In Various Privilege Strata To Identify Computing Tasks, Tor J. Langehaug

Theses and Dissertations

Modern multi-tasking computer systems run numerous applications simultaneously. These applications must share hardware resources including the Central Processing Unit (CPU) and memory while maximizing each application’s performance. Tasks executing in this shared environment leave residue which should not reveal information. This dissertation applies machine learning and statistical analysis to evaluate task residue as footprints which can be correlated to identify tasks. The concept of privilege strata, drawn from an analogy with physical geology, organizes the investigation into the User, Operating System, and Hardware privilege strata. In the User Stratum, an adversary perspective is taken to build an interrogator program that …

Cost-Benefit Analysis Of The Saudi Land Bridge Project, Faris J. Alotaibi

Theses and Dissertations

Projects are the backbone of economic thrive of nations, especially infrastructure projects. It’s counted as the base layer of allowing economic trade between beneficiaries. Railway projects have always been a huge element in increasing trade operations between Saudi Arabia and the rest of the world, by providing an efficient and environmentally friendly way that is capable of hauling large loads of exports all the way to the seaports and from there to the rest of the world. The Saudi land bridge project will cost about $11 billion and will provide a new link between the existent railway in the eastern …

Orbit Determination With Event-Based Cameras To Improve Space Domain Awareness, Conor M. Wisentaner

Theses and Dissertations

The objective of this research is to assess the utility of a COTS EBC for SDA applications by evaluating its ability to produce data for orbit updates of resident space objects. Unlike traditional frame-based imaging sensors, the pixels on an EBC activate independently when a change in brightness is detected to produce a continuous data flow on a per pixel basis. This unique functionality provides much higher temporal resolution than traditional frame-based sensors, such that an EBC can generate far more data points from a single observation than a frame-based sensor. However, current COTS EBCs have less spatial resolution than …

A Methodological Framework For Parametric Combat Analysis, Dustin L. Hayhurst Sr.

Theses and Dissertations

This work presents a taxonomic structure for understanding the tension between certain factors of stability for game-theoretic outcomes such as Nash optimality, Pareto optimality, and balance optimality and then applies such game-theoretic concepts to the advancement of strategic thought on spacepower. This work successfully adapts and applies combat modeling theory to the evaluation of cislunar space conflict. This work provides evidence that the reliability characteristics of small spacecraft share similarities to the reliability characteristics of large spacecraft. Using these novel foundational concepts, this dissertation develops and presents a parametric methodological framework capable of analyzing the efficacy of heterogeneous force compositions …

Multichannel Blind Deconvolution Of Circularly Polarized Imagery, Patrick B. Cunningham

Theses and Dissertations

Current methods can be used to recreate an expected Stokes polarization vector from measured light for characterization purposes. However, this only applies to three of the Stokes parameters, that is, the linear polarization components. Circular polarization is not currently being utilized for object characterization because the mathematical complexity is greater than for that of linear polarization. This research will analyze a way to expand existing algorithms to include circular polarization and enable the complete reconstruction of the Stokes vector from the measured light into a blind deconvolution algorithm for Stokes estimation and image reconstruction.

Additive Manufacturing Of Molybdenum For High Temperature Structural Applications, Megan L. Bustin

Theses and Dissertations

This research considered additive manufactured (AM) molybdenum (Mo) and the effect of three variables on microstructure, mechanical properties, and the relationship between the two. Test temperature, laser speed, and shield gas or build atmosphere were varied, and samples tested and analyzed using a three-point bending test, chemical composition, and optical and scanning electron microscopy. The relationship among variables and results using a Design of Experiments was limited compared to the inclusion of every tested sample. Most effects were expected: samples tested at room temperature were brittle without statistical significance; increasing laser speed resulted in decreased ductility and strain, smaller grain …

Evaluating Performance Competencies In The Royal Saudi Air Force Engineering Directorate And Squadrons, Faisal A. Al Dawood

Theses and Dissertations

The effectiveness of tasks performed by the directorate of aeronautical engineering and squadrons in RSAF directly impacts flight safety, which in turn influences the organization either positively or negatively. Therefore, improving engineers' competencies will improve the overall performance of the organization. The study refined and reconstructed a model, namely a T-shape competency model, to assess the engineers' competencies which revealed some management and competency-related deficiencies and concluded with managerial recommendations.

Development Of A Security-Focused Multi-Channel Communication Protocol And Associated Quality Of Secure Service (Qoss) Metrics, Paul M. Simon

Theses and Dissertations

The threat of eavesdropping, and the challenge of recognizing and correcting for corrupted or suppressed information in communication systems is a consistent challenge. Effectively managing protection mechanisms requires an ability to accurately gauge the likelihood or severity of a threat, and adapt the security features available in a system to mitigate the threat. This research focuses on the design and development of a security-focused communication protocol at the session-layer based on a re-prioritized communication architecture model and associated metrics. From a probabilistic model that considers data leakage and data corruption as surrogates for breaches of confidentiality and integrity, a set …

Root-Cause Analysis Of Rsaf Maintenance-Related Flight Safety Mishaps, Heaf H. Alqahtani

Theses and Dissertations

Poor maintenance is a major factor in many aviation mishaps. This is due to the fact that some maintenance activities are carried out improperly or overlooked as a result of human error. It is important to acknowledge that maintenance mistakes are a visible sign of deeper organizational issues. Therefore, adequate solutions to maintenance issues must consider organizational influences. Despite efforts to reduce the accident rate within the Royal Saudi Air Force (RSAF), the RSAF suffers from an increasing trend in mishaps attributed to maintenance. Therefore, safety data was analyzed to examine trends. Additionally, the Human Factors Analysis and Classification System …

A Case Study Of The Efficacy Of Model-Based Requests For Information, Kyle J. Arruda

Theses and Dissertations

The Department of Defense (DoD) has encouraged the transition to digital engineering, yet there are limited guides for how to transition and there is limited data to show where an organization like a program office can reap the most benefit from the transition. To identify areas where potential benefits may be realized, this thesis compares two Requests for Information (RFIs), one document-based and one model-based, from generation to response. A survey was developed and administered to 7 members of a single program office to grade the RFI responses. The survey was based on the 43 benefit categories identified in the …

A Deep Learning Approach For Airport Runway Identification From Satellite Imagery, Mahmut Gemici

Theses and Dissertations

The United States lacks a comprehensive national database of private Prior Permission Required (PPR) airports. The primary reason such a database does not exist is that there are no federal regulatory obligations for these facilities to have their information re-evaluated or updated by the Federal Aviation Administration (FAA) or the local state Department of Transportation (DOT) once the data has been entered into the system. The often outdated and incorrect information about landing sites presents a serious risk factor in aviation safety. In this thesis, we present a machine learning approach for detecting airport landing sites from Google Earth satellite …

The Role Of Small Gtpases In Regulating Blood-Brain Barrier Mechanotransduction, Brandon Jude Deore

Theses and Dissertations

Fluid shear stress is an important mediator of vascular permeability, yet the molecular mechanisms underlying the effect of shear on the blood-brain barrier (BBB) have yet to be clarified in cerebral vasculature despite its importance for brain homeostasis.. Neurological symptoms including the formation of microclots, stroke, and other neurological pathologies associated with changes in cerebral blood flow are hallmarks of BBB dysfunction. The in vitro model used in this dissertation is compatible with real-time measurement of barrier function using a transendothelial electrical resistance as well as immunocytochemistry and dextran permeability assays. These experiments reveal that there is a threshold level …

Bioengineered Scaffolds To Induce Alignment And Promote Axon Regeneration Following Spinal Cord Injury, Kiet Anh Tran

Theses and Dissertations

Scaffolds delivered to injured spinal cords to stimulate axon connectivity often act as a bridge to stimulate regeneration at the injured area, but current approaches lack the permissiveness, topology and mechanics to mimic host tissue properties. This dissertation focuses on bioengineering scaffolds through the means of altering topology in injectables and tuning mechanics in 3D-printed constructs as potential therapies for spinal cord injury repair. A self-assembling peptide scaffold, RADA-16I, is used due to its established permissiveness to axon growth and ability to support vascularization. Immunohistochemistry assays verify that vascularized peptide scaffolds promote axon infiltration, attenuate inflammation and reduce astrogliosis. Furthermore, …

Assessing Readiness For Implementation Of Prognostics And Health Management In Small And Medium Enterprises, Sara C. Fuller

Theses and Dissertations

Prognostics and Health Management (PHM) refers to using robust sensing, monitoring, and control to detect, assess, and track system health degradation and failure modes, allowing for enhanced management and operational decisions. The need for PHM within a manufacturing facility has increased due to a variety of reasons, such as the increasing complexity of manufacturing equipment.

A lack of readiness for digital implementations is linked to failure. The literature highlights certain barriers and enablers that can signal whether a technology implementation will be successful, such as management and maintenance employees’ desire to change the existing process, an understanding and willingness to …

A Spatial Long-Term Trend Analysis Of Estimated Chlorophyll-A Concentrations In Utah Lake Using Earth Observation Data, Kaylee Brook Tanner

Theses and Dissertations

We analyzed chlorophyll-a (chl-a) concentrations in shallow, turbid Utah Lake using Landsat data from 1984 to 2021. Utah Lake is ~40 km by 21 km, has a surface area of ~390 km2, an average depth of ~3 m, and loses ~50% of inflow to evaporation. This limits spatial mixing, allowing us to evaluate impacts to smaller lake regions. We evaluated long-term trends at the pixel level and for areas related to boundary conditions. We created 17 study areas based on differences in shoreline development and nutrient inflows. We expected impacted areas to exhibit increasing chl-a trends, as population growth and …

Experimental Study On Co2-Sensitive Polyacrylamide As Potential In-Situ Sealing Agent For Co2 Leakage Pathways In Geological Storage Sites, Iris Laihmen Quan Lopez

Theses and Dissertations

As the world pushes for ‘greener’ technologies and carbon neutrality, efforts have focused on creating novel ways to mitigate humankind’s carbon footprint. Carbon capture and storage (CCS) has become a prevalent technique that has proven to be an effective long-term method to safely relocate excess carbon dioxide (CO₂) into subsurface formations. However, CCS is a newer technique which requires constant monitoring due to potential leakage pathways present in CO₂ storage sites; therefore, a preventive approach to seal leakage pathways is recommended. This dissertation explores the potential of CO₂-sensitive polyacrylamide (CO₂-SPAM) as a novel …

Novel 3d Bench Top Model For Vascular Calcification Research, Ursla-Marie K. Offiah

Theses and Dissertations

Cardiovascular disease is the leading cause of non-communicable disease in the whole world killing 17 million people in 2012. Among the many vascular diseases is vascular calcification (VC) which is the mineral build up in the walls of blood vessels. Medial calcification is the plaque buildup in the medial layer of the blood vesicle that is characterized by arterial stiffness and high blood pressure. Current calcification research involves two dimensional (2D) lab methods such as flat petri dishes to investigate the mechanism that causes and inhibits vascular calcification. Research has shown that the use of three-dimensional (3D) models can be …

An Investigation Into The Velocity-Dependence Of The Coefficient Of Friction Between Concrete And Maraging Steel, Trace A. Duncan

Theses and Dissertations

This work investigates the velocity-dependent coefficient of friction between concrete and 300 Maraging steel over short displacements. A modified torsional Hopkinson bar is utilized for rotating thin-walled steel rings in contact with a concrete disk under static precompression. Rotational velocity is varied between tests to determine the velocity dependence of the friction coefficient. Normal force is varied between certain tests to determine the pressure dependence of the friction coefficient between the concrete and steel. Three different types of concrete are tested to deduce any composition effect on the friction coefficient. Dry and greased conditions’ impact on the friction coefficient are …

Experiments To Mitigate Flow Recirculation In A Closed Anechoic Chamber Using Mesh Screens As Turbulence Suppressors, Tori Kay Wolverton

Theses and Dissertations

The desire to gather acoustic data of a propeller in simulated hover without environmental effects is met with the challenge of recirculating flow in a closed anechoic chamber. Flow recirculation in an anechoic chamber is not ideal because the effects of it being ingested by the rotor cause unsteady loadings on the propeller. This unsteady loading causes vortex noise from the turbulence introduced by the recirculation of the flow. The aim is to study the acoustic signature of a propeller separate from external factors and engine noise. Two different propellers with three different screen combinations were tested in a closed …

Ferrous Alloy Manufacturing For The Martian Surface Through In-Situ Resource Utilization With Ionic Liquids Harvested Iron And Bosch Process Carbon, Blake C. Stewart

Theses and Dissertations

As research continues for the habitation of the Lunar and Martian surfaces, the need for materials for construction of structural parts, mechanical components, and tools remains as a major milestone. The use of in-situ resource utilization (ISRU) techniques is critical due to the financial, physical, and logistical burdens of sending supplies beyond low-Earth orbit. The Bosch process is currently in development as a life support system at the National Aeronautics and Space Administration’s (NASA) Marshall Space Flight Center (MSFC) to regenerate oxygen (O2) from metabolic carbon dioxide (CO2) with the byproduct of elemental carbon (C). The Bosch process presents a …

A Biomechanical Approach To Prevent Falls In Ergonomic Settings, Sachini Kodithuwakku Arachchige

Theses and Dissertations

Introduction: Fall-related injuries are exceptionally prevalent in occupational settings. While endangering the workers’ health, falls cause poor productivity and increased economic burden in the workplace. Hence, identifying these threats and training workers to achieve proper postural control is crucial. Purpose: Study 1: To investigate the ankle joint kinematics in unexpected and expected trip responses during single-tasking (ST), dual-tasking (DT), and triple-tasking (TT), before and after a physically fatiguing exercise. Study 2: To investigate the impact of virtual heights, DT, and training on static postural stability and cognitive processing. Methods: Study 1: Twenty collegiate volunteers (10 males and females, one left …