Engineering Commons^™

Cellular Response Of Metallic Materials And Microstructure Entropy Guided Understanding Of Strength In Biomedical Austenitic Stainless Steels, Na Gong

Open Access Theses & Dissertations

Austenitic stainless steels and cobalt-chrome alloys are used to fabricate biomedical devices with good mechanical strength, excellent wear and corrosion resistance. Cellular activity of Zr-modified Co-Cr-Mo alloys and osteoblast functions on Cu-containing and Cu-free austenitic stainless steel were studied. Experiments on the influence of Zr addition to Co-Cr-Mo alloys and Cu-containing austenitic stainless steel clearly demonstrated that cell adhesion, proliferation and cell-substrate interactions were favorably modulated in the presence of Zr and Cu. Additionally, stronger vinculin focal adhesion contact and signals associated with actin stress fibers together with extracellular matrix protein, fibronectin, were observed. Furthermore, comparative studies on the effect …

Development Of A Cold Gas Propulsion System For A 1u Cube Satellite, Norma Alicia Perea

Open Access Theses & Dissertations

In efforts to further the development test capabilities of nanosatellites on earth, NASA White Sands Test Facility (WSTF) is developing a Magnetic Levitation Table (MLT) for ground testing of nanosatellites. Testing of the table requires dedicated test articles that employ space-like systems, but those that can be used in the confines of a small lab testing area. In collaboration with WSTF, the University of Texas at El Paso (UTEP) Center for Aerospace Exploration Technology Research (cSETR) is developing an 1U cold gas propulsion cube-satellite demonstrator (CGD) to test capabilities of the levitation table. A 1U cube satellite was designed with …

A Comprehensive And Modular Robotic Control Framework For Model-Less Control Law Development Using Reinforcement Learning For Soft Robotics, Charles Sullivan

Open Access Theses & Dissertations

Soft robotics is a growing field in robotics research. Heavily inspired by biological systems, these robots are made of softer, non-linear, materials such as elastomers and are actuated using several novel methods, from fluidic actuation channels to shape changing materials such as electro-active polymers. Highly non-linear materials make modeling difficult, and sensors are still an area of active research. These issues have rendered typical control and modeling techniques often inadequate for soft robotics. Reinforcement learning is a branch of machine learning that focuses on model-less control by mapping states to actions that maximize a specific reward signal. Reinforcement learning has …

Bio-Inspired Method For Close-Proximity Operations On A Near-Earth Asteroid, Rene Alberto Valenzuela Najera

Open Access Theses & Dissertations

Space maneuvers in the vicinity of small celestial bodies and achieving a soft landing over the surface of small celestial bodies are essential movements to advance the status of exploration, collection of geographical data, measurement of physical properties among other on-orbit tasks. Before a spacecraft reaches hovering position over an asteroid in order to perform orbital tasks, close-proximity operations must be done. Since the movements of the spaceships depend on the acceleration forces provided by the thrusters and external disturbances forces, the correct planning of execution of the close-up trajectories on the celestial body orbit and trajectory to land on …

Synthesis And Characterization Of Material Systems For 3d Printed Smart Structures, Hilda Fontes

Open Access Theses & Dissertations

The silica hollow spheres have demonstrated excellent results in multiple applications such as light-weight composites, and optical applications as a glass coating. This material also exhibits excellent thermal, shock impact, and hydrophilic properties extremely useful for industrial applications. However, a controllable size of the particle is desired to further increase the number of applications of the silica hollow spheres.

This Thesis aims a method to fabricate silica hollow spheres in a single step with a controlled diameter size. A study was developed to demonstrate the particle size change when adjusting the molecular weight of the medium by using different alcohol …

Early Detection Of Asthma Via Enhanced Resolution Of Small Airways Using Ultra-Low Frequency Impulse Oscillometry, Christopher M. Aguilar

Open Access Theses & Dissertations

Examination of lung function for diagnosis and monitoring of diseases such as chronic obstructive pulmonary disease (COPD) and asthma can be performed with a variety of pulmonary function testing (PFT) techniques. The most commonly prescribed of these procedures are spirometry and whole-body plethysmography. However, these active participation tests depend on forced breathing maneuvers, may be physically exhausting, might not produce enough information, and are susceptible to being subject-dependent. In contrast, passive PFT approaches such as the forced oscillation technique (FOT) and the impulse oscillometry system (IOS) are increasingly being utilized for measuring lung mechanics because they require only minimal participation, …

Fabrication, Development, And Characterization Of Hipco Swcnt - Alginate Hydrogel Composites For Cellular Product Applications, Fabian Armando Alvarez-Primo

Open Access Theses & Dissertations

In this study, we designed, synthesized, and characterized ultrahigh purity single-walled carbon nanotube (SWCNT)-alginate hydrogel composites. Among the parameters of importance in the formation of an alginate-based hydrogel composite with single-walled carbon nanotubes, are their varying degrees of purity, their particulate agglomeration and their dose-dependent correlation to cell viability, all of which have an impact on the resultant compositeâ??s efficiency and effectiveness towards biomedical applications. To promote their homogenous dispersion by preventing agglomeration of the SWCNT, at first, we used three different surfactants-sodium dodecyl sulfate (SDS-anionic), cetyltrimethylammonium bromide (CTAB-cationic), and Pluronic F108 (nonionic). After experimentation and corroboration through evidence obtained …

Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla

Open Access Theses & Dissertations

All the new chemical entities/drug molecules intended for therapeutic use must be administered using an appropriate delivery system/dosage form to achieve maximum bioavailability. However, designing a drug delivery system is complex as several factors such as lipophilicity, molecular mass, crystallinity, ionic charge, polymorphic forms and hydrogen bonding) affect the solubility and permeability of these molecules. Biopharmaceutics drug classification system (BCS) categorizes the existing drugs into four classes based on the aqueous solubility and membrane permeability and it is reported that >70% of the drugs are poorly soluble and belong to BCS class II and BCS class IV. Several physical, chemical …

Supercritical Processed Decellularized Extracellualr Matrix As Regeneration Therapeutics Applying 3d Printing, Seungwon Chung

Open Access Theses & Dissertations

Extracellular matrix has been broadly applied and show great promise in medical applications and tissue engineering. Product of extracellular matrix (ECM) should be treated with decellularization and purification process. Supercritical carbon dioxide treatment is of particular interest for purifying ECM because of its medically available and rapid speed of process. However, it is not fully researched in treatment of biomaterials for tissue engineering. Therefore, we investigated optimal conditions of supercritical carbon dioxide processing in different extracting parameters from porcine adipose tissue. The 3-day, dual treatment including enzymatic decellularization and supercritical fluid extraction of pork adipose tissue were performed. Two types …

3d Printed Alginate-Based Zinc Oxide Nanoparticle Scaffolds For Wound Healing, Carol Cleetus

Open Access Theses & Dissertations

Effective treatment of chronic wounds is essential for the prevention of infection and scar tissue formation, requiring a novel approach to address the limitations of existing options. This study utilizes Calcium Chloride (CaCl2) crosslinked alginate, a common biomaterial widely used in wound dressing, and UV activated Zinc Oxide (ZnO) nanoparticles (NPs) for their potential hydroxyl radical mediated antibacterial applications. ZnO NPs were synthesized by combustion method from Zinc Nitrate Hexahydrate and Sucrose. Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) characterization were used to verify composition and NP size. Terephthalic Acid, used as a fluorescent probe, confirmed the generation of …

Remediation And Prevention Of Harmful Algae Blooms (Habs) In Ascarate Lake At El Paso, Texas, Elizabeth Herrera Ortega

Open Access Theses & Dissertations

Ascarate park in El Paso, Texas is an example of an urban ecosystem in the middle of a growing city. It is the largest public-use recreational park in El Paso county and it includes a 48-acre Ascarate lake. The purpose of this study was to prevent harmful algae growth in Ascarate lake using phytoremediation by analyzing different water quality parameters. We installed artificial islands on west cove of the lake with African iris plants to determine the feasibility of remediation to prevent algae blooms in Ascarate lake. Water samples were collected at different points close and away from the islands …

Rpas: An Enhanced Finite Element Code For The Mechanistic Analysis Of Rigid Pavements, Nancy Aguirre

Open Access Theses & Dissertations

Significant amount of research has been conducted to improve the design of rigid pavements through the development of mechanistic analysis tools capable of accurately modeling the performance of such pavements. The use of the finite element (FE) method as a comprehensive tool for modeling the responses of rigid pavements has been limited in the past because of the complexity of calculations in modeling nonlinear behaviors, which are difficult to describe mathematically and computationally. Researchers from The University of Texas at El Paso developed NYSLAB, an FE modeling tool, for the analysis of rigid pavements subjected to traffic and environmental loading …

Evaluating Flow Features For Network Application Classification, Carlos Alcantara

Open Access Theses & Dissertations

Communication networks provide the foundational services on which our modern economy depends. These services include data storage and transfer, video and voice telephony, gaming, multimedia streaming, remote invocation, and the world wide web. Communication networks are large-scale distributed systems composed of heterogeneous equipment. As a result of scale and heterogeneity, communication networks are cumbersome to manage (e.g., configure, assess performance, detect faults) by human operators. With the emergence of easily accessible network data and machine learning algorithms, there is a great opportunity to move network management towards increasing automation. Network management automation will allow for a reduced likelihood of human …

A Survey Of The Current State Of The Practice In Bridging The Gap Between Engineering Ontologies And Modeling Profiles For Engineering Applications, John Artus

Open Access Theses & Dissertations

Model-Based Systems Engineering holds the promise of enhancing systems engineering tasks and product quality through better, more efficient exchange of data across tools, personnel, and departments, a higher quality of analysis resulting from greater access to cross-discipline data, better coordination between engineering activities and those of program management, and many other benefits. Yet, there is still no standardized method for achieving commonality of architecture vocabulary across projects, across, companies, across industries such that entities operating in the same domain produce products that speak the same technical language. Some specialized domains, such as the Department of Defense (DoD), have developed Architecture …

Assessment Of Hydraulic And Structural Behavior Of Inundated Pavements, Mojtaba Asadi

Open Access Theses & Dissertations

Severe flooding events have increasingly inundated the transportation infrastructure, including road networks, across the world and the Unites States. Such extreme events induce significant ingress of water into the pavement layers, which in turn leads to structural defects due to the reduction of the shear strength and resilient moduli of the soil layers, asphalt stripping in flexible pavements, pumping effect in rigid pavements, migration of fines into drainable layers, and swelling of expansive soils. Consequently, premature pavement failure may take place that can impose unforeseen maintenance/rehabilitation costs to highway agencies. Although some experimental research studies have been conducted to assess …

Structure-Property-Performance Evaluation Of Refractory Metal Incorporated Gallium Oxide Thin Films For Extreme Environment Applications, Anil Krishna Battu

Open Access Theses & Dissertations

An approach is presented to design refractory-metal (RM) incorporated Ga2O3-based materials with controlled structural, mechanical, and optical properties. A model system based on molybdenum (Mo) doped Ga2O3 (GMO) has been considered to elucidate the combined effect of RM-doping and processing parameters on the properties and oxygen sensor performance of GWO nanomaterials. The molybdenum (Mo) content in Ga2O3 was varied from 0 to 11 at% in the sputter-deposited Ga-Mo-O films. Molybdenum was found to significantly affect the structure and optical properties. While low Mo content (≤4 at%) results in the formation of single-phase (β-Ga2O3), higher Mo content results in amorphization. Chemically …

Low Weight Design Of A Pressure-Fed System For A Small Payload Launch Vehicle, Lucero Buendia

Open Access Theses & Dissertations

Carbon fiber reinforced polymer (CFRP) composites have become of great interests to aerospace industries because of their low-cost, lightweight and their tailorable mechanical properties. In aerospace structures, for example, heavy metals have been used in cryogenic fuel and oxidizer tanks for over 50 years. However, weight savings can be substantial if materials such as composites are used instead. From Delta IV heavy-lift launch vehicle it is known that cryogenic composite tanks can save approximately up to 30% of weight in fuel and oxidizer tanks. Although there is a wealth of studies in the mechanical behavior of composites at room temperature, …

The Effect Of K2co3 Concentration In Kerosene Emulsions On Spray Droplet Sizes For A Magnetohydrodynamic Power Generator, Alejandra Castellano

Open Access Theses & Dissertations

Potassium carbonate (K2CO3) is an effective seeding material to introduce potassium vapor in oxy-fuel combustion to create a conductive plasma. Injecting potassium carbonate before combustion promotes particle volatilization and improves the generation of potassium vapor. This can be achieved by emulsifying a potassium carbonate solution with kerosene. Several studies have investigated creating stable emulsions with kerosene with water by using differing surfactants. However, the effects of using varying concentrations of K2CO3 dissolved in deionized water have not been fully explored. Based on methods of creating successful emulsions, the development of a successful mixture comprised of kerosene and K2CO3 solution is …

Regulation Of Schlafen 11 Expression, Christian Waldemar Corona Ayala

Open Access Theses & Dissertations

Schlafen 11 (SLFN11) is a member a family of proteins that can be found in mammals. Members of this family are involved in important functions. SLFN11 in particular has been identified as a restriction factor for several evolutionarily disparate viruses such as HIV-1 and Flaviviruses and to play an important role in DNA repair, sensitizing cells to chemotherapy. Despite its relevance SLFN11 remains largely uncharacterized. The aim of this research was to achieve a more comprehensive understanding the regulation mechanism of SLFN 11 expression. Before our research, it was only known that type I interferon (IFN) regulates SLFN11 levels. However, …

To Or Through The Skin: A Rational Design Of Transdermal Drug Delivery, Isaac Giovanni Deaguero

Open Access Theses & Dissertations

The skin is the largest organ in the body and plays many crucial roles through diverse functions ranging from protection, temperature regulation, energy storage via fat deposits, and is used to communicate with our surroundings. Various methods have been attempted to deliver drugs to target areas of the skin in effective dosages by a variety of means with limited success. Recently, advances in transdermal drug delivery have offered avenues previously unattainable through conventional means. Some of these new delivery methods have been reviewed, explored and offer promising results with the potential to carve a new avenue in the way therapeutic …

Development And Characterization Of Perovskite Solar Cells For Tandem Device Configuration, Angel Moiseis De La Rosa

Open Access Theses & Dissertations

Photovoltaic devices based on perovskite materials are constantly progressing towards more applicability in large-area panels. In order for perovskite-based photovoltaics to reach reliable and stable commercialization, common issues with the use of perovskite still need to be resolved, including the need to identify fabrication processes that can yield optimal material parameters for better photovoltaic performance. Defining an optimal fabrication process requires that researchers and manufacturers alike come to an agreement regarding perovskite characteristics that result from device operation and material processing. This work focuses on characterizing physical, electrical, and electronic properties of a FAxCs1-xPb(IyBr1-y)3 perovskite, and how some of these …

Structural Analysis Of Deformed Caprock Associated With A Salt Shoulder At Gypsum Valley Salt Wall, Paradox Basin, Colorado, Hanah Draper

Open Access Theses & Dissertations

This study documents the style and distribution of deformation present in Triassic-age gypsic and carbonate caprock associated with the Gypsum Valley Salt Wall Salt Shoulder in the Paradox Basin, Colorado in order to determine the mechanism and timing of deformation. Mapping of gypsic and carbonate capstone facies shows that the caprock layering that was generated during formation has been deformed by large-and-small-scale folding and faulting, brecciation, and boudinage. Deformation within the caprock resulted in widely variable orientations along the length of the salt shoulder, that also varies locally in intensity of deformation and with proximity to the passively rising diapir …

Thermoanalytical Studies On The Decomposition Of Energetic Ionic Liquids, Alan Esparza

Open Access Theses & Dissertations

Hydrazine has been extensively used as a propellant for space applications for more than half a century. However, its hazardous characteristics cause high storage and handling costs. For this reason, the search for alternatives, the so-called “green monopropellants,” is of great interest. Most green monopropellants are mixtures of an oxidizer and a fuel, and several ionic liquids (ILs) have been proposed for this application. Among them, hydroxylammonium nitrate (HAN) and 2-hydroxylethylhydrazinium nitrate (HEHN) are promising oxidizer and fuel, respectively. The objective of the present work was to clarify the decomposition kinetics of both HAN and HEHN, using thermogravimetric analysis (TGA), …

Extracting Mechanical Properties Of Compacted Geomaterials Using Intelligent Compaction Technology, Aria Fathi

Open Access Theses & Dissertations

The primary tool currently used for quality management of earthwork and unbound aggregates is the nuclear density gauge (NDG) to ensure appropriate density and moisture content. Measurement of moisture content and dry density, even though quite practical and straightforward, does not directly tie the construction quality with the mechanistic-empirical design processes where stress and modulus are employed. With the recent popularity of the mechanistic pavement design procedures, research efforts have been undertaken to understand and develop procedures for implementing modulus-based quality control (QC) procedures of compacted geomaterials. These procedures involve the use of in-situ nondestructive testing (NDT) devices that estimate …

Independent And Simultaneous Control Of Electromagnetic Wave Properties In Self-Collimating Photonic Crystals Using Spatial Variance, Jesus Javier Gutierrez

Open Access Theses & Dissertations

Photonic crystals are engineered periodic structures that provide great control over electromagnetic waves. One of these mechanisms is self-collimation, in which the electromagnetic wave travels through the photonic crystal along an axis of the lattice without diffracting or spreading. This mechanism of self-collimation is a dispersion phenomenon, which is dependent on the unit cell's physical and geometrical characteristics. An algorithm for generating spatially variant lattices (SVL) was developed that can change geometrical properties in photonic crystals as a function of position, like unit cell orientation, fill fraction, symmetry, and others in a manner that is smooth, continuous, and virtually free …

A Cellulose-Based Biological Sensor For The Quantitative Determination Of Glucose And Glycated Hemoglobin (Hba1c), Gilberto Henao-Pabon

Open Access Theses & Dissertations

ABSTRACT

Importance: Diabetes is a common world-wide disease characterized by insulin resistance and as result there is an increased risk of cardiovascular disease and other metabolic abnormalities, that contribute to irreversible end-organ damage. The cause of diabetes is multifactorial and includes genetic, inflammatory and environmental factors plus lifestyle issues. Because in diabetes there are high levels of glucose and glycated hemoglobin, these molecules are used in clinical settings for the acute and chronic management of diabetic patients.

Objectives: a. To design and build an electrochemical biological sensor using the enzyme Glucose Oxidase (GOX) to detect glucose in biological fluids.

b. …

The Study Of The Mouse Schlafen Family Members As Mediators Of Antiviral Activity, Julia Fernanda Hernandez

Open Access Theses & Dissertations

The Schlafen family of proteins was first characterized in 1988, and since then evidence of their relevance in different physiological and pathological situations have been accumulating although at a slow pace. Hence, the biological roles of these proteins remain ill-defined. The expression of these proteins is positively regulated by type 1 interferons, constituting a component of the innate immune response. Functions of these proteins vary from regulation of cell proliferation to restriction of viral infections. Recent studies have implicated SLFN11 and SLFN13 as inhibitors of HIV-1 infection2-4. The mechanism of action of SLFN11 resides in its capacity to regulate the …

Laser Diagnostics Of Compressible And High-Intensity Premixed Methane-Air Combustion Inside A Backward Facing Step Combustor Using High- Repetition Rate Ch-Plif And Piv, Md. Amzad Hossain

Open Access Theses & Dissertations

A novel high repetition rate (10 kHz) planar laser-induced fluorescence (PLIF) diagnostic technique was used for the flame front study. Premixed methane-air combustion was studied at different flow turbulence conditions (Re = 15000, 30000 and 64000; 12CFM, 25CFM and 50 CFM; 10m/s, 20 m/s and 40 m/s) and fuel loading (Փ =0.6 to 1.2). The study used an optically accessible backward-facing step high-speed combustor. Methane-air mixture was supplied to the combustor at atmospheric pressure and standard room temperature (T =25°C). CX-CH PLIF was used to detect the actual flame front structures. The flame dynamics were then correlated to the flow …

An Accelerated Creep Testing Program For Nickel Based Superalloys, Robert M. Mach

Open Access Theses & Dissertations

In order to improve the energy production within the United States, new materials are developed with the goal of increased functionality. These materials are required to perform at extreme pressures and temperatures (up to and beyond 200MPa and 650â??) as well as be sustainable beyond 105 hours. Before developing these materials into components for power generation, mechanical testing is required to better understand the behavior of these materials at various loads and temperatures. The longest of these tests is the conventional creep test which is a real time test that can beyond 105 hours depending on service conditions. Hundreds of …

Development Of The Payload System And Obc Microcontroller Coding For A Cubic Satellite Performing An Additive Self-Repair Experiment In Space, Eduardo Macias-Zugasti

Open Access Theses & Dissertations

Additive manufacturing, which is also known as three-dimensional printing, in space is one of the most promising technologies advancing current capabilities for in-orbit space manufacturing and assembly. Additive manufacturing contributes to the reduction of cost per kilogram and number of launches, thus facilitating extraterrestrial colonization and deep-space exploration. The state of the art includes advancing efforts inside the International Space Station (ISS). However, the ISS is a controlled environment and, to the best of our knowledge, no spacecraft or satellite has performed additive manufacturing tasks in the extreme environment of outer space. In this work a 1U CubeSat named Orbital …