Engineering Commons^™

Synthesis Of Polyethylene Glycol-Based Hydrogels And Silver/Gold Nanostructures For Biomedical Applications, Isabelle Ishimwe Niyonshuti

Graduate Theses and Dissertations

This work focuses on the synthesis of biocompatible polyethylene glycol (PEG)-based hydrogels, silver nanoparticles (AgNPs), and silver-gold nanocages (Ag-AuNCs) for biomedical applications. The dissertation includes two parts with Part I on the work of PEG-based hydrogel for wound healing applications and Part II on the work of Ag/Au nanostructures for antimicrobial applications. Part I studies PEG-based hydrogel for the delivery of fibroblast growth factors (FGFs) for wound healing applications, aiming to overcome the challenge of designing hydrogels capable of the sustained release of bioactive FGFs. This research develops new biocompatible anionic injectable hydrogel formulations based on Poly (Oligo Ethylene Glycol …

A Double-Sided Stack Low-Inductance Wire-Bondless Sic Power Module With A Ceramic Interposer, Si Huang

Graduate Theses and Dissertations

The objective of this dissertation research is to develop a novel three-dimensional (3-D) wire bondless power module package for silicon carbide (SiC) power devices to achieve a low parasitic inductance and an improved thermal performance. A half-bridge module consisting of 900-V SiC MOSFETs is realized to minimize stray parasitic inductance as well as to provide both vertical and horizontal cooling paths to maximize heat dissipation. The proposed 3-D power module package was designed, simulated, fabricated and tested. In this module, low temperature co-fired ceramic (LTCC) substrate with vias is utilized as an interposer of which both top and bottom sides …

Multifunctional Programmable Self-Assembled Nanoparticles In Nanomedicine, Yoshie Sakamaki

Graduate Theses and Dissertations

Developing methodologies to control the architecture of nanoparticles (NPs) at the atomic level prevents their inhomogeneity and leads to a variety of expected functions. Rationally designed nanoparticles can either be programmed or crystallized structures into pre-determined structures achieving tunable particle pore size and physiochemistry. In this dissertation, two broad classes of multifunctional nanoparticles are developed, metal-organic frameworks and DNA-NP aggregates.

Metal-organic frameworks are a novel class of highly porous crystalline materials built from organic linkers and metal cluster-based secondary building units. However, applications in bioremediation have not been developed very well especially in applications regarding drug delivery systems (DDS). The …

Preliminary Development Of The Dialysis-Membrane-Based Passive Biocide Delivery System For Spacecraft Water Recovery Units, Rogelio Elias Garcia Fernandez

Graduate Theses and Dissertations

The purpose of this investigation is to explore the capabilities of a dialysis-membrane-based system for the in-line dosing of silver ions to treated water in spacecraft water recovery units. The spacecraft environmental control and life support system community (ECLSS) are interested in adopting silver ions as a biocide in future spacecraft water recovery processes since silver ions are effective biocide at concentrations that humans can safely consume. The system has been designed following the configuration of the Water Processor Assembly (WPA) aboard the International Space Station. In this configuration, silver ions have to be added at the last step in …

Recombinant Production And Purification Of Green Fluorescent Protein (Gfp)-Fused Metal Binding Protein For Palladium Nanoparticle Synthesis, Shadrach Ibinola

Graduate Theses and Dissertations

In lieu of chemical and physical methods, biologically guided synthesis is increasingly used as a cost-effective medium for the fabrication of nanoparticles (NP). Recently, a palladium metal binding sequence Pd4 (TSNAVHPTLRHL) has been demonstrated to be instrumental in the production of palladium (Pd) nanoparticles. Although, by eliminating the additional cost of purification of the protein, the crude lysate of E. coli containing Pd specific protein has been proven to be a viable cost-effective means for the synthesis of Pd NP, studies have not be done to ascertain the comparative catalytic activity of nanoparticles synthesized from both clarified lysate and pure …

Automated Flight Controller Adaptive Compensation For Actuator Failures In Transport Type Aircraft, Daniel James Fresella

Graduate Theses and Dissertations

Aircraft operate over a wide range of conditions including atmospheric, weight, and center ofgravity changes. This presents a substantial challenge to automatic control system designers. When these operating conditions are merged with a partial or full control surface failure, automatic flight control is near impossible with conventional controllers. Additionally, when pilots experience control failure emergencies during flight, workload and fatigue increase drastically. The continued research of automatic flight control systems that can seamlessly adapt to unmodelled failures will enable a new generation of robust aircraft control. In this paper a 9th order 6 degree of freedom aircraft model is used …

Investigation Of Iron-Nickel Films Based Catalysts: Controlling Hydrogen Evolution Reaction (Her) Through An Electrode-Electrolyte Engineering Approach, Sergio Ivan Perez Bakovic

Graduate Theses and Dissertations

Electrochemical energy conversion technologies need to be economically viable in order to be adopted. Earth-abundant transition metals (i.e., Fe, Co, and Ni) have attracted attention due to their high availability, low cost, and catalytic characteristics that are in many cases found in and exploited by nature. Herein, we synthesize FexNi100-xOy electrocatalyst films and study how the electrocatalyst-electrolyte interactions alter the hydrogen evolution reaction (HER).In this work, FexNi100-xOy films were synthesized to study the composition, chemical state, and morphology. Characterization results provided a well-established electrocatalyst film platform to then proceed with electrochemical evaluations. The effects of the electrode composition and electrochemically …

Statistical Modeling, Learning And Computing For Stochastic Dynamics Of Complex Systems, Mohammadmahdi Hajiha

Graduate Theses and Dissertations

With the recent advances in sensor technology, it is much easier to collect and store streams of system operational and environmental (SOE) data. These data can be used as input to model the underlying behavior of complex engineered systems and phenomenons if appropriate algorithms with well-defined assumptions are developed. This dissertation is comprised of the research work to show the applicability of SOE data when fed into proposed tailored algorithms. The first purposes of these algorithms are to estimate and analyze the reliability of a system as elaborated in Chapter 2. This chapter provides the derivation of closed-form expressions that …

Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello

Graduate Theses and Dissertations

Resistance to therapy in cancer is a major cause of poor prognosis in patients. Tumor hypoxia plays an active role in mediating treatment resistance and has been linked to metastases and metastatic potential in cancer. Our research focused on three objectives: i) To understand metabolic effects of chronic and intermittent hypoxia in murine breast cancer cells and its affiliation with metastatic potential ii) To identify the metabolic changes associated with radiation therapy in a panel of radiosensitive and radioresistant human head and neck cancer cells and iii) to monitor the changes in cell metabolism associated with gain of treatment resistance. …

Material Detection With Thermal Imaging And Computer Vision: Potentials And Limitations, Jared Poe

Graduate Theses and Dissertations

The goal of my masters thesis research is to develop an affordable and mobile infraredbased environmental sensoring system for the control of a servo motor based on material identification. While this sensing could be oriented towards different applications, my thesis is particularly interested in material detection due to the wide range of possible applications in mechanical engineering. Material detection using a thermal mobile camera could be used in manufacturing, recycling or autonomous robotics. For my research, the application that will be focused on is using this material detection to control a servo motor by identifying and sending control inputs based …

Frequency Effect On Peak Pressure Coefficients Using The Narrowband Synthesis Random Flow Generator (Nsrfg) Method, Zayuris Del Carmen Atencio Mojica

Graduate Theses and Dissertations

The collapse of the Tacoma Narrows Bridge in Washington state in 1940 due to high wind forces gave structural engineers notice of the importance of understanding the behavior of wind forces on infrastructure. Wind forces play an important role in the design of buildings and other structures. ASCE 7-16 is the manual used for the design of these buildings and other structures throughout the country. These design criteria have been approved based on research projects involving experimental procedures. For the design of wind loads, ASCE 7-16 uses criteria based on wind tunnel (WT) tests. However, since the development of computing …

Computational Frameworks For Multi-Robot Cooperative 3d Printing And Planning, Laxmi Prasad Poudel

Graduate Theses and Dissertations

This dissertation proposes a novel cooperative 3D printing (C3DP) approach for multi-robot additive manufacturing (AM) and presents scheduling and planning strategies that enable multi-robot cooperation in the manufacturing environment. C3DP is the first step towards achieving the overarching goal of swarm manufacturing (SM). SM is a paradigm for distributed manufacturing that envisions networks of micro-factories, each of which employs thousands of mobile robots that can manufacture different products on demand. SM breaks down the complicated supply chain used to deliver a product from a large production facility from one part of the world to another. Instead, it establishes a network …

Tribological Studies Of Thick Polytetrafluoroethylene Coatings Enhanced By Polydopamine And Nanoparticles, Sujan Kumar Ghosh

Graduate Theses and Dissertations

Polytetrafluoroethylene (PTFE) is a popular low friction solid lubricant with high chemical and thermal stability. Thick PTFE coatings have the potential for many tribological applications, such as replacing Tin-based Babbitt materials in journal bearings. However, the weak bonding strength to the substrate and the high wear rate of PTFE coatings are current limiting factors. The lack of understanding of their tribological properties and wear mechanisms in oil-lubricated conditions and how coating thickness affects the tribological performance further hindered the use of PTFE coatings. In this dissertation, polydopamine (PDA), a bio-inspired adhesive, is used as an underlayer for or as a …

Applications Of Masw And Mhvsr Techniques For Infrastructure Evaluation With A Focus On The Effects Of Different Transformation Techniques And Near-Field Effects On Derived Dispersion Data, Salman Rahimi

Graduate Theses and Dissertations

This dissertation is aimed at understanding two aspects of active surface wave methods to improve the accuracy and reliability of this method. These include (1) the performance of four common wavefield transformation methods for the multichannel analysis of surface wave (MASW) data processing and (2) near-field effects. Toward this end, extensive field measurements were conducted considering different factors affecting these two topics. The MASW and microtremor horizontal to vertical spectral ratio (MHVSR) were then employed to examine their efficiency for infrastructure health monitoring.

Regarding the performance of the four common transformation techniques, it was observed that for sites with a …

Development Of Novel Battery Materials For Lithium-Ion Batteries And Beyond, Jiyu Cai

Graduate Theses and Dissertations

As fossil fuels are depleting and causing environmental issues, it becomes imperative to widely implement renewable energies (e.g., solar and wind power). In this context, electrical energy storage (EES) systems are essential to accommodate the intermittent supply and uneven distribution of renewable energies. To this end, high-energy-density EES devices are highly demanded, such as rechargeable batteries. This dissertation presents my efforts in developing novel battery materials for lithium-ion batteries (LIBs), sodium-ion batteries (SIBs), and solidstate lithium batteries (SSLBs). These efforts include electrochemical evaluations of battery materials, surface modifications of electrodes via atomic layer deposition (ALD), and advanced characterizations of batteries …

Phase-Field Modeling Of The Polymer Membrane Formation Process For Micro- And Ultra-Filtration, Michael Rosario Cervellere

Graduate Theses and Dissertations

Porous polymer membrane filters are widely used in separation and filtration process. Micro- and ultra-filtration membranes are commonly used in biopharmaceutical applications such as filtering viruses and separating proteins from a carrier solution. The formation of these membrane filters via phase inversion is a complex and interconnected process where varying casting conditions can have a wide variety of effects on the final membrane morphol- ogy. Tailoring membrane filters for specific performance characteristics is a tedious and time consuming process. The time and length scales of membrane formation make it extremely difficult to experimentally observe membrane formation. Modeling the membrane formation …

Data-Driven Methods To Address Truck Parking Shortages For Long-Haul Commercial Truck Drivers, Sharif Mahmud

Graduate Theses and Dissertations

Truck parking is a critical concern for both the trucking industry and the truck drivers. Long-haul commercial truck drivers rely on safe and adequate parking to support interstate commerce, which has become a challenge due to parking shortages. The recent electronic logging device (ELD) mandate, forcing a strict compliance to hours of service (HOS) regulations, are leading to higher demand for parking. A number of federal, regional, and local studies reveal that truck activity will increase and truck parking demand will outpace parking supply in the coming years. Such parking shortages likely disrupt freight flows and pose risks to truck …

Mitigating Calcium Oxychloride Damage In Cementitious Paste And Concrete Utilizing Supplementary Cementitious Materials, Casey Jones

Graduate Theses and Dissertations

It is understood among engineers in the United States (U.S.) that improvement is needed throughout the transportation infrastructure. In the 2021 Infrastructure Report Card produced by the American Society of Civil Engineers, the roadways of this nation merit a D. This leaves room for improvement in order to provide durable pavements throughout this nation. Areas with significant winter weather may have exacerbated effects in decreased roadway longevity due to freezing/thawing cycles and the use of chemical deicers to mitigate gelid roadway conditions. Much research focuses on surface scaling and reinforcement corrosion using these materials; however, joint deterioration, due to chemical …

Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu

Graduate Theses and Dissertations

The focus of regeneration therapy for traumatic brain injuries and Alzheimer's disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple individual factors and study them individually to gain a better understanding of the mechanics between the neuronal cell and ECM, which will aid in the design of in vitro experimental studies.

This study develops …

Deployment Policies To Reliably Maintain And Maximize Expected Coverage In A Wireless Sensor Network, Nicholas T. Boardman

Graduate Theses and Dissertations

The long-term operation of a wireless sensor network (WSN) requires the deployment of new sensors over time to restore any loss in network coverage and communication ability resulting from sensor failures. Over the course of several deployment actions it is important to consider the cost of maintaining the WSN in addition to any desired performance measures such as coverage, connectivity, or reliability. The resulting problem formulation is approached first through a time-based deployment model in which the network is restored to a fixed size at periodic time intervals. The network destruction spectrum (D-spectrum) has been introduced to estimate reliability and …

Optimization Of Vaccine Supply Chains In Low- And Middle-Income Countries Utilizing Drones, Maximilian Kolter

Graduate Theses and Dissertations

Despite tremendous efforts from governments and humanitarian organizations, millions of children in low- and low-middle-income countries (LICs and LMICs) are still excluded from the benefits of immunization. The vaccine distribution in LICs and LMICs is challenging for several reasons, such as limited cold chain capacities, vaccine wastage, uncertain demand, and lack of access to immunization services. A promising avenue to address these issues is the utilization of drones for vaccine delivery. Drones can fly at high speed on direct paths and could enable on-demand deliveries to mitigate limited storage capacities. Further, their independence of road networks could allow them reaching …

Grid Strength Assessment Trough Q-V Modal Analysis And Maximum Loadability Of A Wind-Dominated Power System Using P-Q Regions, Pierre Obed Dorile

Graduate Theses and Dissertations

Climate change is a menace to the existence of the world and policymakers are trying totackle this phenomenon by deploying large-scale wind farms into their grids. Among them, wind energy shows a promising future to substitute the traditional power plants. However, the deployment of these wind farms into the grid is not a panacea that does not pose any challenges to the grid operators. Keeping the power system voltage stable while considering the strength of the transmission grid is among the major challenges facing by the transmission system operators. Amid normal operation and fault conditions, wind farms should help the …

Electrochemical Deposition In Energy Storage Devices, Witness Atutala Martin

Graduate Theses and Dissertations

Metals, whether in a solid or soluble ion form, are a vital part of any electrochemical storage system. More so, Li metal is widely considered as the ideal anode because of its low density and low electrochemical potential (-3.04 V vs. the standard hydrogen electrode – SHE). However, just like most metals, it does not plate or strip evenly during cycling which can lead to cycling performance issues, short cycling lifespans, and even safety concerns brought about by dendrites that can cause internal short-circuiting within cells. This research focused on investigating the electroplating of metals in both aqueous and non-aqueous …

Signal Processing And Data Analysis For Real-Time Intermodal Freight Classification Through A Multimodal Sensor System., Enrique J. Sanchez Headley

Graduate Theses and Dissertations

Identifying freight patterns in transit is a common need among commercial and municipal entities. For example, the allocation of resources among Departments of Transportation is often predicated on an understanding of freight patterns along major highways. There exist multiple sensor systems to detect and count vehicles at areas of interest. Many of these sensors are limited in their ability to detect more specific features of vehicles in traffic or are unable to perform well in adverse weather conditions. Despite this limitation, to date there is little comparative analysis among Laser Imaging and Detection and Ranging (LIDAR) sensors for freight detection …

Scheduling Allocation And Inventory Replenishment Problems Under Uncertainty: Applications In Managing Electric Vehicle And Drone Battery Swap Stations, Amin Asadi

Graduate Theses and Dissertations

In this dissertation, motivated by electric vehicle (EV) and drone application growth, we propose novel optimization problems and solution techniques for managing the operations at EV and drone battery swap stations. In Chapter 2, we introduce a novel class of stochastic scheduling allocation and inventory replenishment problems (SAIRP), which determines the recharging, discharging, and replacement decisions at a swap station over time to maximize the expected total profit. We use Markov Decision Process (MDP) to model SAIRPs facing uncertain demands, varying costs, and battery degradation. Considering battery degradation is crucial as it relaxes the assumption that charging/discharging batteries do not …

High Temperature Degradation In Gan-Based Hall Effect Sensors, Alexis Anne Krone

Graduate Theses and Dissertations

This research focuses on understanding the effects of accelerated aging through temperature and environment on novel gallium nitride-based Hall effect magnetic field sensors and determining device reliability under electric vehicle operating conditions. The device reliability was modeled using accelerated aging for the temperatures of 200 °C, 350 °C, 450 °C, and 600 °C under various time steps unique to each temperature and either air, which is identical to operating circumstances, or argon, which would model the hermetic packaging environment. Using a high temperature furnace and oven, devices underwent high temperature storage tests at a chosen temperature and time step. Afterwards, …

A Computational Study Of Radiation Damage In Bilayer Silicon-Gold Structures, Cameron Hopper

Graduate Theses and Dissertations

Irradiation from sources such as nuclear reactors bombard materials with neutrons and heavy ions. The primary consequence of this irradiation is the displacement of atoms from their atomic structure. As the structure becomes damaged, the mechanical properties can change. Eventually, this can result in a failure due to embrittlement. This type of damage is hard to detect and can result in sudden, unexpected failure. Therefore, focusing on managing the consequences of irradiation has been a heavily researched topic. To manage irradiation, the focus is primarily to manage the voids and interstitials that appear during irradiation. Grain boundaries and amorphous regions …

Nanomaterial-Based Biosensors For Detection Of Salmonella Typhimurium And Avian Influenza Virus H5n1 In Poultry, Xinge Xi

Graduate Theses and Dissertations

This research focused on developing biosensing method and biosensing device for rapid detection of pathogens in poultry: Salmonella Typhimurium and avian influenza virus H5N1. The first part of the dissertation reports an original research on the development of a portable biosensing device for Salmonella detection. The device was designed and constructed based on a previously developed optical biosensing method, using immuno-magnetic nanoparticles to specifically capture target bacteria, and immuno-quantum dot beads to label the target bacteria for fluorescence detection. All the actions of sample mixing, magnetic separation, and fluorescence detection were controlled automatically in a disposable microfluidic chip in the …

Promoting Diversity In Academic Research Communities Through Multivariate Expert Recommendation, Omar Salman

Graduate Theses and Dissertations

Expert recommendation is the process of identifying individuals who have the appropriate knowledge and skills to achieve a specific task. It has been widely used in the educational environment mainly in the hiring process, paper-reviewer assignment, and assembling conference program committees. In this research, we highlight the problem of diversity and fair representation of underrepresented groups in expertise recommendation, factors that current expertise recommendation systems rarely consider. We introduce a novel way to model experts in academia by considering demographic attributes in addition to skills. We use the h-index score to quantify skills for a researcher and we identify five …

Privacy-Preserving Cloud-Assisted Data Analytics, Wei Bao

Graduate Theses and Dissertations

Nowadays industries are collecting a massive and exponentially growing amount of data that can be utilized to extract useful insights for improving various aspects of our life. Data analytics (e.g., via the use of machine learning) has been extensively applied to make important decisions in various real world applications. However, it is challenging for resource-limited clients to analyze their data in an efficient way when its scale is large. Additionally, the data resources are increasingly distributed among different owners. Nonetheless, users' data may contain private information that needs to be protected.

Cloud computing has become more and more popular in …