Engineering Commons^™

Refinement And Automation Using Algorithmic Control Of Breathforce, A Respiratory Training System For Patients With Spinal Cord Injuries., Anna Goestenkors

Electronic Theses and Dissertations

Spinal cord injuries (SCI) can lead to impaired respiratory and cardiovascular function and a general decrease in lung compliance. This can complicate breathing as well as impair the ability to sigh, cough, and clear secretions, leading to increased risk of respiratory infections. Respiratory training has been shown to combat these effects. BreathForce is under active development to create a user-centric inspiratory-expiratory device that is an affordable option for at-home training. This study reports on the refinement of valve design and automation incorporated into BreathForce to enhance and enforce clinical practices and processes as part of the respiratory training protocol used …

Electrical Characterization Of Phytoplankton Suspensions Using Impedance Spectroscopy., Margaret R Jett

Electronic Theses and Dissertations

Phytoplankton are closely monitored because of their important environmental role, and the impacts they have on their local ecosystems. Some phytoplankton respond to stress by producing lipids, which can be harvested for biofuels and other chemicals. Microfluidic devices have been important in improving the portability and throughput of phytoplankton characterization methods, increasing their potential for in situ use. This study utilized a small sample of phytoplankton suspended in a stagnant medium and measured the impedance response using a lab-on-chip and impedance analyzer. The individual cell characteristics were derived from the impedance response of the group. The goal was to characterize …

Development And Evaluation Of A Body Weight Support Treadmill For Use With Locomotor Training On Pediatric Spinal Cord Injury Patients., Winston T Rauch

Electronic Theses and Dissertations

The consequences of spinal cord injury (SCI) are devastating regardless of the age of a patient. When the injury occurs in children five years old or younger, however, the impact is magnified due to the inevitable development of scoliosis (96%) and hip dysplasia (57%) (Schottler et al., 2012). To reduce occurrence of these complications and improve the quality of life for these patients, specialized activity-based therapies such as locomotor training (LT) are being increasingly used to improve overall trunk control and muscle activity in the lower extremities (Harkema et al., 2012; Howland et al., 2014). The aim of this therapy …

Room Temperature Alkali Treatment Of Rice Straw For Enhanced Enzymatic Hydrolysis., Seth Mains

Electronic Theses and Dissertations

Due to the pollution of fossil fuels due to greenhouse emissions, researchers continue to search for alternative methods that allow for the clean production of energy, fuels, and polymer fibers. A method currently under investigation is the use of lignocellulosic biomass as a solution to current problems with energy and polymer fiber production. Through the process of pretreatment, possibilities for lignocellulosic biomass expand due to improved accessibility of the cellulose and hemicellulose which can be broken down via enzymatic hydrolysis into C5 and C6 sugars such as xylose and glucose. This study investigated the fermentation of the rice straw into …

Conversion Of Multicellds Digital Snapshots To Isa-Tab Format., Corey P. Chitwood

Electronic Theses and Dissertations

The MultiCellular Data Standard (MultiCellDS) is an interdisciplinary effort to create a data standard for sharing multicellular experimental, simulation, and clinical data. The ultimate goal of the overall project is to allow for data sharing that will lead to better analyses and simulations for multicellular biology and predictive medicine in association with the PhysiCell, a software that allows for simulations of large numbers of cells in 3D tissues. Digital cell lines are files that contain a standardized representation of a biological cell line and include phenotypic parameters as well as microenvironmental conditions for use in simulations. A Digital Cell Line …

Wetting And Drying Dynamics For Tio2 With Pbs Quantum Dots., Kelly M. Lee

Electronic Theses and Dissertations

Initial solar cells utilized silicon and alloys for their economic viability. Photoelectrochemical photovoltaic cells were discovered with technological advancement which increased solar efficiency and further improved economic feasibility leading to quantum dot sensitized solar cells. Lead sulfide quantum dots and titanium dioxide were studied for wetting and drying effects. Zeta potential, pH values, SEM, and optical microscopes quantified or observed the colloidal suspension and dried sample behavior. Combined mixtures of lead sulfide and titania were dried at 3.6 pH and 12.56 pH values. This due to the observed zeta potential isoelectric point of titania, and behavior showed increased stability occurring …

The Study Of Copper Corrosion Mechanisms Using Electrochemical Experimental Techniques., Evan Grimm

Electronic Theses and Dissertations

The purpose of this study was to discover and thoroughly explain the corrosion mechanisms of copper in saltwater, tap water and deionized water, and to apply these methods and findings when testing the corrosion mechanisms of other materials. The experimental procedure consisted of measuring the open circuit potential, electrochemical impedance spectroscopy, linear sweep voltammetry, and Tafel analysis.

The copper was found to corrode at a greater rate in saltwater, followed by tap water then deionized water, with a larger difference between saltwater and tap water than between tap water and deionized water. Each reaction was found to be both kinetically …

Machine Learning Models For Lodi Indices., Lucas A. Bruns

Electronic Theses and Dissertations

Two indices published monthly by the Logistics and Distribution Institute (LoDI) predict changes in logistics and distribution activity levels nationally and regionally and are useful for organizations when planning projects and expenses. This research validates the current linear regression model, updates the index conversion method, and introduces machine learning models.

New source data are introduced to the models to validate the current linear regression model and a comparative analysis verifies that the current source data are robust. A rolling average is used for index conversion in place of a fixed reference month to reflect recent changes in employment levels.

Three …

Modified Electrode Surfaces With Hydrogen Evolution Reaction Catalysts Derived From Electropolymerized Complexes With Redox Active Ligands., Amanda Mae Arts

Electronic Theses and Dissertations

The demand for energy is growing exponentially, and to keep up with these demands new technologies for renewable energy have received increased attention. Hydrogen is one of the most promising energy sources for the future and plays a vital role in water electrolysis and fuel cells, as the hydrogen evolution reaction (HER) is the main step in the water splitting process. To increase the reaction rate and improve efficiency for the water electrolysis, catalysts are used to minimize the overpotential.

Most of the current electrocatalysts for HER are heterogeneous in nature and are dominated by platinum and other precious metals …

Develop A Multi-Functional Green Pervious Concrete (Mgpc) Pavement With Polycyclic Aromatic Hydrocarbons (Pahs) Removal Function., Hong Shang

Electronic Theses and Dissertations

Stormwater runoff induced Polycyclic Aromatic Hydrocarbons (PAHs) contaminant increasingly imperils the groundwater quality and the sustainable development of human society due to the potential carcinogenic risks. Pavement can be considered as the first line of defense for contaminant removal of the stormwater runoff. New construction materials with stormwater runoff quantity and quality control are in urgent demand for updating the existing pavement system. An innovative material called Multi-functional Green Pervious Concrete (MGPC) was developed in the department of Civil and Environmental Engineering at University of Louisville. This material uses organoclay as the amendment to enhance the PAHs removal capacity of …

Using An Inventory Of Unstable Slopes To Prioritize Probabilistic Rockfall Modeling And Acid Base Accounting In Great Smoky Mountains National Park, Thomas A. O'Shea

Electronic Theses and Dissertations

An inventory of unstable slopes along transportation corridors and performance modeling are important components of geotechnical asset management in Great Smoky Mountains National Park (GRSM). Hazards and risk were assessed for 285 unstable slopes along 151 miles of roadway. A multi-criteria model was created to select fourteen sites for two-dimensional probabilistic rockfall simulations and Acid Base Accounting (ABA) tests. Simulations indicate that rock material would likely enter the roadway at all fourteen sites. ABA test results indicate that influence of significant acid-producing potential is generally confined to slaty rocks of the Anakeesta Formation and graphitic schist of the Wehutty Formation. …

Bilateral Ground Reaction Force Jumping Asymmetry And Performance, Keith Painter

Electronic Theses and Dissertations

The prevalence of asymmetry in performance research has increased in recent years with mixed results. Much of the performance research has focused on unilateral jumping activities attempting to show relationships to other performance variables. However, bilateral ground reaction forces (bGRF) from jumps are more frequently assessed in athlete monitoring programs and the asymmetry from those jumps could be a simple addition to data already being collected. Research into bGRF asymmetries is lacking and no studies have addressed longitudinal changes. Additionally, research into the relationship of asymmetries to performance have infrequently used athletes. For these reasons, this dissertation will focus on …

Machine Learning Applied To Colloidal Properties Of Perfluorocarbon Nanoemulsions For Imaging In Ards/Ali, Marco Hosfeld

Electronic Theses and Dissertations

Acute Respiratory distress Syndrome (ARDS) and Acute Lung Injury (ALI) are inflammatory lung pathologies consisting of non-hydrostatic pulmonary edema leading to hypoxia and impaired gas exchange in the lungs. ARDS/ALI is both difficult to study and treat as it is not in itself a specific pathology but rather a syndrome consisting of many pathologies that vary case by case. It is, however, consistently characterized by an explosive acute inflammatory response in the lung parenchyma leading to hypoxia. Although time has seen to an increase in the understanding of ARDS/ALI, the mortality rate remains in the range of 30-50%. For these …

Detecting A Heterogenous Sample Of Pigmented Melanoma Cell Lines Using Photoacoustic Flow Cytometry, Margaret Cappellano

Electronic Theses and Dissertations

Metastatic melanoma is the deadliest form of skin cancer, which is in part, attributed to its rapid aggression and lack of response to typical treatment methods. There are far too often cases where a lymph node biopsy does not detect the severity of the cancer, which in turn causes a lack of diagnosis until a mass can be visually detected on a scan, such as a PET, CT, or MRI. Once visible on a scan, the cancer is too progressive for successful treatment. To avoid this, we investigated how a blood sample can be used to negate a missed diagnosis, …

Diagnosis Of Melanoma Disease State From Patient Blood Samples Using Photoacoustic Flow Cytometry, Jacob Salvatore

Electronic Theses and Dissertations

Approximately 1 in 50 Americans develop melanoma in their lifetime. Early detection of melanoma is pivotal to the survival of the patient, with a 99% survival rate for 5 or more years after an early diagnosis. Metastasis, or the spread of cancer, increases the chances of cancerous growth in other parts of the body. In this study, we propose the use of photoacoustic flow cytometry as a diagnostic of patient disease state, by closely monitoring the amount of circulating melanoma cells (CMCs) in a patient’s blood before and after chemotherapy treatments. Using this patient data, we were able to make …

Characterizing The Dormancy And Repair Of A Circumneutral Passive Remediation System Receiving Iron And Sulfate-Rich Amd, Garrett Struble

Electronic Theses and Dissertations

The Wingfield Pines remediation system is a ~20-acre circumneutral, gravity-fed system constructed in 2009 to passively remediate Fe from an ~2000 gallon/minute effluent. In 2017, a fracture to the system’s underground cavern caused the AMD effluent to bypass the system, flowing directly into Chartiers Creek and leaving the system decommissioned between 2017-2019. Soil slurry and water samples were collected in the weeks prior to the system’s reinstalment in September 2019 through January 2020 in order to determine the effect of the repair on remediation efficiency and microbial community composition. This study acted as the first to describe the temporary decommissioning …

Computational Frameworks For Microrna Functional Analysis Of Inter-Kingdom And Indirect Targeting., Mohammed Sayed

Electronic Theses and Dissertations

Genes are DNA sequences that encode the information needed to synthesize molecules necessary for the function of the cell. Some genes are called protein-coding genes because they have the code required to manufacture proteins. The expression of a certain gene means its product (protein) is produced. Although some genes are not protein-coding, they regulate the gene expression of other protein-coding genes. Of these, microRNAs (miRNAs) are small RNA molecules that inhibit the expression of other genes by binding to their mRNA transcripts. miRNAs have been shown to be linked to several biological processes like development and diseases like cancer. Recently, …

Urban Arterial Lane Flow Distribution: A Before And After Traffic Microsimulation Analysis On The Effect Of Implementing New Route Markings And Signage., Larry Michael Summers

Electronic Theses and Dissertations

Urban arterials may not effectively utilize available lanes to move vehicles efficiently as drivers try to establish position along the corridor. This study evaluates lane flow distribution before and after implementing new route markings and overhead signs to utilize existing lanes better. A cellphone-based traffic data service called StreetLight gathered the traffic data used to establish the VISSIM model parameters for simulating current and projected conditions. This study shows that the lane assignment signage and route markers affected the lane flow distribution in the simulation. The simulation indicated the existing condition had average queue lengths of 320.6 meters, average travel …

Machine Learning Approaches For Lung Cancer Diagnosis., Ahmed Mahmoud Ahmed Shaffie

Electronic Theses and Dissertations

The enormity of changes and development in the field of medical imaging technology is hard to fathom, as it does not just represent the technique and process of constructing visual representations of the body from inside for medical analysis and to reveal the internal structure of different organs under the skin, but also it provides a noninvasive way for diagnosis of various disease and suggest an efficient ways to treat them. While data surrounding all of our lives are stored and collected to be ready for analysis by data scientists, medical images are considered a rich source that could provide …

Thermo-Hydro-Mechanical Characterization Of Ottawa Sand And Kaolin Clay Through Experimental Models., Mohammad Joshaghani

Electronic Theses and Dissertations

Recent advances in energy geotechnics and increased utilization of ground source heat pump systems (e.g., geothermal boreholes and energy y piles) and energy geo-structures require improving the understanding of the thermo-hydro-mechanical behavior of soil. Energy geo-structures consist of above-ground facilities, buried structures, and the soil surrounding the buried structure. A buried structure transfers the energy between the ground and above-ground facilities. Energy transfer between above-ground facilities and the soil will cause temperature changes in soil and this will affect soil hydro-mechanical properties. The changes in soil temperature can also significantly alter the soil-structure interaction and its mechanical strength. Soil temperature …

Restaurant Style Prediction Using Word2vec And Support Vector Machine., Saleh Abdullah Almohaimeed

Electronic Theses and Dissertations

Natural Language Processing represents a quantum leap for governance and industries. It enables them to have an insight into hidden patterns and information within their data. In this thesis, we have worked on an important field in Natural Language Processing, which is Text Classification. Our goal is to help restaurant owners to find which dishes customers like more. To do that we have used a dataset from Yelp.com that has 150,000 restaurant reviews, then count the most frequent dishes mentioned. However, this way is not effective except if these reviews are categorized into different restaurants-styles. For this reason, we have …

Design For Metal Fused Filament Fabrication (Dfmf3) Of Ti-6al-4v Alloy., Mohammad Qasim Shaikh

Electronic Theses and Dissertations

Additive manufacturing (AM) offers unmatchable freedom of design with the ability to manufacture parts from a wide range of materials. The technology of producing three-dimensional parts by adding material layer-by-layer has become relevant in several areas for numerous industries not only for building visual and functional prototypes but also for small and medium series production. Among others, while metal AM technologies have been established as production method, their adoption has been limited by expensive equipment, anisotropy in part properties and safety concerns related to working with loose reactive metal powder. To address this challenge, the dissertation aims at developing the …

Adaptive Control And Parameter-Dependent Anti-Windup Compensation For Inertia Varying Quadcopters., Benjamin Edwards Farber

Electronic Theses and Dissertations

A novel parameter-dependent anti-windup compensator is developed to improve the performance of a saturation constrained model reference adaptive controller. The combined control structure solves the input saturation and stability problem for inertia varying quadcopters. The control synthesis follows the conventional two-step anti-windup design paradigm where a nominal controller is designed without consideration of the input saturation, and the anti-windup compensator is designed to minimize deviations from nominal performance caused by saturated inputs. To account for varying inertia of the quadcopter during package retrieval/delivery routines, the inertia parameters of the vehicle/package are estimated with an online recursive system identification technique, and …

Evaluation Of Conventional Energy Conservation Strategies And Active Thermal Insulation Wall System And Economic Analyses., Li Liu

Electronic Theses and Dissertations

For the past few decades, the importance and the technology of building energy conservation is increasing. In support of this research into energy efficiency, the Department of Energy has developed simulation models of sixteen buildings representing most commercial buildings in the US. In this research, four of these sixteen prototype models were used in energy conservation analyses variety of energy conservation strategies in the seven US Climate Zones. To estimate the effectiveness of several common energy conservation measures on yearly building energy use, holistic analyses were conducted using software that accounts for the interactions of the building systems, occupants and …

A Spatial Analysis Of Supply-Demand Of Public Transportation In Jefferson County, Kentucky., Nastaran Abdoli

Electronic Theses and Dissertations

Public transportation is important as it serves individuals, especially the transit-dependent population, by providing a basic mobility service to these people and all others who rely on public transportation. This research utilized estimating public transportation demand and supply to analyze the spatial patterns of public transportation in Jefferson County, Kentucky. The study focuses on the transit-dependent population, and it considers indicators of age, poverty status, vehicle ownership, and foreign-born population with less than five years residency in the United States. This study conducted a public transit supply-demand analysis to identify areas with imbalanced supply and demand in Jefferson County at …

Optimization With Interval Data: New Problems, Algorithms, And Applications., Mohsen Mohammadi Dehcheshmeh

Electronic Theses and Dissertations

The parameters of real-world optimization problems are often uncertain due to the failure of exact estimation of data entries. Throughout the years, several approaches have been developed to cope with uncertainty in the input parameters of optimization problems, such as robust optimization, stochastic optimization, fuzzy programming, parametric programming, and interval optimization. Each of these approaches tackles the uncertainty in the input data with different assumptions on the source of uncertainty and imposes different requirements on the returned solutions. In this dissertation, the approach we take is that of interval optimization, and more specifically, interval linear programming. The two main problems …

Multi-Style Explainable Matrix Factorization Techniques For Recommender Systems., Olurotimi Nugbepo Seton

Electronic Theses and Dissertations

Black-box recommender system models are machine learning models that generate personalized recommendations without explaining how the recommendations were generated to the user or giving them a way to correct wrong assumptions made about them by the model. However, compared to white-box models, which are transparent and scrutable, black-box models are generally more accurate. Recent research has shown that accuracy alone is not sufficient for user satisfaction. One such black-box model is Matrix Factorization, a State of the Art recommendation technique that is widely used due to its ability to deal with sparse data sets and to produce accurate recommendations. Recent …

Isomotive Dielectrophoresis For Enhanced Analyses Of Cell Subpopulations., Mohamed Zakarya Rashed

Electronic Theses and Dissertations

As the relentless dream of creating a true lab-on-a-chip device is closer to realization than ever before, which will be enabled through efficient and reliable sample characterization systems. Dielectrophoresis (DEP) is a term used to describe the motion of dielectric particles/ cells, by means of a non-uniform electric field (AC or DC). Cells of different dielectric properties (i.e., size, interior properties, and membrane properties) will act differently under the influence of dielectrophoretic force. Therefore, DEP can be used as a powerful, robust, and flexible tool for cellular manipulation, separation, characterization, and patterning. However, most recent DEP applications focus on …

Development And Applications Of In-Vitro And In-Silico Models Of The Cardiovascular System To Study The Effects Of Mechanical Circulatory Support., Moustafa Meki

Electronic Theses and Dissertations

Cardiovascular diseases (CVDs) are the leading cause of mortality globally. With ongoing interest in CVDs treatment, preclinical models for drug/therapeutic development that allow for fast iterative research are needed. Owing to the inherent complexity of the cardiovascular system, current in-vitro models of the cardiovascular system fail to replicate many of the physiological aspects of the cardiovascular system. In this dissertation, the main concern is with heart failure (HF). In advanced HF, patients may receive Left Ventricular Assist Devices (LVADs) as a bridge to transplant or destination therapy. However, LVADs have many limitations, including inability to adapt to varying tissue demand …

Mapping Three Dimensional Interactions Between Biomolecules And Electric Fields., Joseph Patrick Brian P.E.

Electronic Theses and Dissertations

Electroporation is a technique that induces the formation of open pores in cell membranes by the application of an electric field. Electroporation is widely practiced in research and clinical work for transfection of genetic sequences and drug molecule transport through the membrane barrier. However, a full theoretical explanation of the molecular mechanisms and thermodynamics responsible for pore formation, structure, and longevity does not yet exist. Advances in molecular dynamics simulations have enabled theoretical studies of electroporation with previously unobtainable fidelity spanning biologically relevant timescales. All-atom simulations utilizing the recently developed method of computational electrophysiology demonstrate that pore size correlates to …