Engineering Commons^™

Bioactivity/Cytotoxicity Of Micro-/Nano-Materials And Novel Development Of Fiber-Optic Probes For Single Cell Monitoring, Qingbo Yang

Doctoral Dissertations

"Manufactured nano-/micro-materials (MNMs) have been widely used and their interactions with niche biological environment are highly concerned for both of their biohazardous and bioactive effects, whereas no available comprehensive evaluations or regulations have been provided yet. This dissertation thus focuses on three major aspects: 1) fundamental toxicity understandings of a typical MNMs (zinc oxide nanoparticles), 2) bioactivity evaluations of representative bioactive MNMs, and 3) development of novel micro-probes for high spatial resolution monitoring. Firstly, the NP's concentration, irradiation, hydrodynamic size, and the localized pH, ionic strength, NP zeta-potential as well as dissolved oxygen levels were found correlated with the production …

Adaptive Consensus Based Formation Control Of Unmanned Vehicles, Haci Mehmet Guzey

Doctoral Dissertations

"Over the past decade, the control research community has given significant attention to formation control of multiple unmanned vehicles due to a variety of commercial and defense applications. Consensus-based formation control is considered to be more robust and reliable when compared to other formation control methods due to scalability and inherent properties that enable the formation to continue even if one of the vehicles experiences a failure. In contrast to existing methods on formation control where the dynamics of the vehicles are neglected, this dissertation in the form of four papers presents consensus-based formation control of unmanned vehicles-both ground and …

Applications Of Simulation And Optimization Techniques In Optimizing Room And Pillar Mining Systems, Angelina Konadu Anani

Doctoral Dissertations

"The goal of this research was to apply simulation and optimization techniques in solving mine design and production sequencing problems in room and pillar mines (R&P). The specific objectives were to: (1) apply Discrete Event Simulation (DES) to determine the optimal width of coal R&P panels under specific mining conditions; (2) investigate if the shuttle car fleet size used to mine a particular panel width is optimal in different segments of the panel; (3) test the hypothesis that binary integer linear programming (BILP) can be used to account for mining risk in R&P long range mine production sequencing; and (4) …

Design, Fabrication, Operation And Aspen Simulation Of Oil Shale Pyrolysis And Biomass Gasification Process Using A Moving Bed Downdraft Reactor, Hassan Golpour

Doctoral Dissertations

"Energy is the major facilitator of the modern life. Every developed and developing economy requires access to advanced sources of energy to support its growth and prosperity. Declining worldwide crude oil reserves and increasing energy needs has focused attention on developing existing unconventional fossil fuels like oil shale and renewable resources such as biomass. Sustainable, renewable and reliable resources of domestically produced biomass comparing to wind and solar energy is a sensible motivation to establish a small-scale power plant using biomass as feed to supply electricity demand and heat for rural development. The work in Paper I focuses on the …

Role Of The Dewetting Mechanism On Moisture Damage In Asphalt Pavements, Nibert Elijah Saltibus

Doctoral Dissertations

Moisture damage is a major form of pavement distress that causes state and federal highways to undergo high maintenance cost (Bhasin, 2006). According to Hicks et al., (2003), in a survey conducted by the Colorado Department of Transportation, mainly including US agencies (1 Canadian Province), 82% of these agencies required the use of anti-strip treatment (additives) to avert moisture damage. Additionally, 87% of these agencies test for moisture susceptibility. Despite extensive research performed on the moisture damage mechanisms in flexible pavements, it has been a challenge to obtain one single test that can comprehensively quantify the damage and to also …

Gold Nanoparticle Enhancements In Electroporation Mediated Dna And Rna Therapeutics, Shuyan Huang

Doctoral Dissertations

Nonviral gene delivery methods have been explored as the replacement of viral systems for their low toxicity and immunogenicity. However, they have yet to reach levels competitive to their viral counterparts. Electroporation figured prominently as an effective nonviral gene delivery approach for its balance on the transfection efficiency and cell viability, no restrictions of probe or cell type, and operation simplicity. The commercial electroporation systems have been widely adopted in the past two decades but still carry drawbacks associated with the high applied electric voltage, unsatisfied delivery efficiency, and/or low cell viability. What we did was to improve electroporation performance …

A Non-Invasive Fluorescence-Based Oxygen Sensor And Platform For Studying Cell Responses To Metabolic Agents In Real-Time, Koutilya Reddy Buchapudi

Doctoral Dissertations

A fluorescence-based sensor in a transverse flow/stop measurement platform has been developed to determine real-time changes in oxygen consumption rates for cell metabolic studies. The oxygen sensitive fluorophore platinum octaethylporphyrin was embedded in a cellulose acetate matrix and affixed to a fiber optic bundle, which provided for transmission of the excitation and emission wavelengths of the film. The fiber optic bundle was sealed in a sensor head that can be used in standard 24-well plates common to research labs. The utility of the sensor and sensing platform were determined by measuring the changes in oxygen consumption rates of Candida albicans …

Diamond Mems Biosensors: Development And Applications, Wenli Zhang

Doctoral Dissertations

This research focuses on the development a dielectrophoresis-enhanced microfluidic impedance biosensor (DEP-e-MIB) to enable fast response, real-time, label-free, and highly sensitive sensor for bacterial detection in clinical sample. The proposed design consists of application of dielectrophoresis (DEP) across a microfluidic channel to one of the impedance spectroscopy electrodes in order to improve the existent bacterial detection limits with impedance spectroscopy. In order to realize such a design, choice of electrode material with a wide electrochemical potential window for water is very important. Conventional electrode material, such as gold, are typically insulated for the application of DEP, and they fail when …

Nanoformulation For Anticancer Drug Delivery: Enhanced Pharmacokinetics And Circulation, Gaurav Parekh

Doctoral Dissertations

In this study, we have explored the application of the Layer-by-Layer (LbL) assembly technique for improving injectable drug delivery systems of low soluble anticancer drugs (e.g. Camptothecin (CPT), Paclitaxel (PTX) or Doxorubicin (DOX)). For this study, a polyelectrolyte shell encapsulates different types of drug nanocores (e.g. soft core, nanomicelle or solid lipid nanocores).The low soluble drugs tend to crystallize and precipitate in an aqueous medium. This is the reason they cannot be injected and may have low concentrations and low circulation time in the blood. Even though these drugs when present in the cancer microenvironment have high anti-tumor inhibition, the …

Intrusion Detection System Of Industrial Control Networks Using Network Telemetry, Stanislav Ponomarev

Doctoral Dissertations

Industrial Control Systems (ICSs) are designed, implemented, and deployed in most major spheres of production, business, and entertainment. ICSs are commonly split into two subsystems - Programmable Logic Controllers (PLCs) and Supervisory Control And Data Acquisition (SCADA) systems - to achieve high safety, allow engineers to observe states of an ICS, and perform various configuration updates. Before wide adoption of the Internet, ICSs used "air-gap" security measures, where the ICS network was isolated from other networks, including the Internet, by a physical disconnect [1]. This level of security allowed ICS protocol designers to concentrate on the availability and safety of …

Nanoenhanced Additive Manufacturing: Additive Introduction Onto Halloysite Nanotubes And Into 3d Printing Filament For Tailored Material Characteristics, James Connor Nicholson

Doctoral Dissertations

With the rapid advancement of additive manufacturing technologies in recent years on both the microscale and the macroscale, research must be done to test the limits of currently available technologies. On the microscale, halloysite nanotubes have proven to be a viable platform for reinforcement of polymers and time release of loaded chemicals, as well as a substrate material for the deposition of nanoparticles. The range of materials are limited due to polarity conflicts, and often lead to wet chemical processes that use more toxic alternatives. Three-dimensional (3D) printing and macroscale additive manufacturing techniques can be used to generate custom structures, …

Functional Clay Nanotubes And Composites, Yafei Zhao

Doctoral Dissertations

Tubular nanomaterials and their composites have been extensively studied in recent years in the fields of physics, chemistry, biology, and biomedicine. Carbon nanotube is the most commonly studied tubular nanomaterial; however, toxicity and high cost make it less attractive in industry and thus restricts its applications. Halloysite nanotubes, which are available in abundance in the United States as well as in other countries around the world, is a low-cost, unique and versatile aluminosilicate mineral with a chemical formula of Al4Si4O10(OH)8·nH2O. Basically, the halloysite tube diameter is around 50 nm and the length varies with different locations ranging from 0.4-1.5 μm. …

Creep And Shrinkage Behavior Of Fly Ash Based Geopolymer Concrete, Md Rashedul Islam

Doctoral Dissertations

The manuscript presented herein is based on the investigation of the short and long term properties of fly ash based geopolymer concrete (GPC) and their link to fly ash characteristics. Fly ash (FA) exhibits a significantly different particle morphology, which impacts the mechanical properties of the resulting GPC and typically contains impurities that fluctuate from one FA source to another. A key contribution of this research work is the capturing of the variability posed by the FA stockpile with a wide range of physical, chemical, and crystallographic characteristics as a source material to select the GPC mix design. In the …

Electrochemical Fatigue Crack Treatment, Konstantin Dolgan

Doctoral Dissertations

Fatigue is responsible for at least 50% of all mechanical and 90% of all metallic failures. Fatigue cracks often start at stress concentrations, and without timely and appropriate remediation, tend to exhibit relatively fast propagation that leads to property damage and sometimes serious accidents.

The objective of this research was to develop a new method of fatigue crack treatment in steel structures and estimate its efficiency and limitations. The method was based on placing fatigue cracks under compression by depositing nickel onto the surfaces of the cracks. The proposed method was applied to ASTM E399 compact-tension specimens machined from ASTM …

The Relative Effect Of Charge Dimensions On Elastic Vibration Attenuation And Blast-Induced Seismic Energy Concepts, Nathan Thomas Rouse

Doctoral Dissertations

"This dissertation focuses on expanding the blasting industry's current understanding of the effect of charge geometry on blast vibration attenuation. The work includes a multiple regression analysis of a sample population of signature hole blast vibration data. The regression analysis is used to identify the relative effect of the variables that affect blast vibrations at various distances from the charge. The study suggests that the most common vibration models used in the blasting industry do not use all of the statistically significant variables. Therefore, the models neglect to fully describe the relationship between the significant variables and the blast vibration. …

Models Predicting The Performance Of Ic Component Or Pcb Channel During Electromagnetic Interference, Chunchun Sui

Doctoral Dissertations

"This dissertation is composed of three papers, which cover the prediction of the characteristics of jitter due to crosstalk and due to simultaneous switching noise, and covers susceptibility of delay locked loop (DLL) to electromagnetic interference.

In the first paper, an improved tail-fit de-convolution method is proposed for characterizing the impact of deterministic jitter in the presence of random jitter. A Wiener filter de-convolution method is also presented for extracting the characteristics of crosstalk induced jitter from measurements of total jitter made when the crosstalk sources were and were not present. The proposed techniques are shown to work well both …

Particle Gel Propagation And Blocking Behavior Through High Permeability Streaks And Fractures, Abdulmohsin Imqam

Doctoral Dissertations

Water channeling, one of the primary reservoir conformance problems, is caused by reservoir heterogeneities that lead to the development of high-permeability streaks and fractures. These streaks and fractures prevent large amounts of oil from being recovered. The ultimate objective of this research was to provide comprehensive insight into designing better particle gel treatments intended for use in large openings, including open fractures, high permeability streaks, and conduits to increase oil recovery and reduce water production.

An intensive laboratory study was conducted to better understand the injection and placement mechanisms of millimeter and micron size preformed particle gels (PPGs) through thief …

Stability Design Criteria And Volt Var Control For Distribution System With Single Phase Solid State Transformers, Darshit Girishchandra Shah

Doctoral Dissertations

Due to recent advancements in semiconductor technology, power electronic converters for high voltage, high power, and high frequency applications will soon be commercially available. Conventional single phase distribution transformers are replaced by solid state transformers (SST) in a distribution test system to investigate their interactive dynamics. Under certain circumstances, instabilities due to harmonic resonance are observed. A design criterion for solid state transformer during no load conditions has been proposed in order to avoid instability using an impedance-based analysis. Stability assessment is also extended to include the impact of distribution system voltages and system wide impedance analysis. It is shown …

Non-Invasive Imaging And Assessment Of Pavements, Adel Mohamed Elkrry

Doctoral Dissertations

"Eight electrical resistivity tomography (ERT) and multi-channel analysis of surface wave (MASW) case studies are presented. The objective is to assess the condition of pavement, base, native soil, and rock all the way down to the top of the bedrock. Each segment of road way is approximately 1000 ft. long. The cases include US 63 north of Rolla, US 54 in Camden County, Rte. 179 in Jefferson City, HWY AT in Franklin County, I-55 in Pemiscot County, I-55 in Perry County, HWY U in Dent County, I-35 in Daviess County. In addition, there are only three types of pavement in …

Impact Of Thorium Based Molten Salt Reactor On The Closure Of The Nuclear Fuel Cycle, Safwan Qasim Mohammad Jaradat

Doctoral Dissertations

"Molten salt reactor (MSR) is one of six reactors selected by the Generation IV International Forum (GIF). The liquid fluoride thorium reactor (LFTR) is a MSR concept based on thorium fuel cycle. LFTR uses liquid fluoride salts as a nuclear fuel. It uses ²³²Th and ²³³U as the fertile and fissile materials, respectively. Fluoride salt of these nuclides is dissolved in a mixed carrier salt of lithium and beryllium (FLiBe). The objective of this research was to complete feasibility studies of a small commercial thermal LFTR. The focus was on neutronic calculations in order to prescribe core design …

Improving Practices In Nanomedicine Through Near Real-Time Pharmacokinetic Analysis, Isidro B. Magana

Doctoral Dissertations

More than a decade into the development of gold nanoparticles, with multiple clinical trials underway, ongoing pre-clinical research continues towards better understanding in vivo interactions. The goal is treatment optimization through improved best practices. In an effort to collect information for healthcare providers enabling informed decisions in a relevant time frame, instrumentation for real-time plasma concentration (multi-wavelength photoplethysmography) and protocols for rapid elemental analysis (energy dispersive X-Ray fluorescence) of biopsied tumor tissue have been developed in a murine model. An initial analysis, designed to demonstrate the robust nature and utility of the techniques, revealed that area under the bioavailability curve …

Local Alternative Sources For Cogeneration Combined Heat And Power System, Abdulhakim Amer Agll

Doctoral Dissertations

"Global demand for energy continues to grow while countries around the globe race to reduce their reliance on fossil fuels and greenhouse gas emissions by implementing policy measures and advancing technology. Sustainability has become an important issue in transportation and infrastructure development projects. While several agencies are trying to incorporate a range of sustainability measures in their goals and missions, only a few planning agencies have been able to implement these policies and they are far from perfect. The low rate of success in implementing sustainable policies is primarily due to incomplete understanding of the system and the interaction between …

Containment Materials For Thin-Strip Casting Of Steel, Abhishek Kumar

Doctoral Dissertations

"The focus of this research was to investigate the corrosion behavior of BN-based and ZrO₂-C refractories by molten steel. These refractories are used as side-dam and core-nozzle in the thin-strip casting of steel. The improvement and development of these refractory components will increase the process efficiency by prolonging the refractory service life.

The first part of this study focused on interaction of BN-ZrO₂-SiC side-dams with steel-inclusion system in a laboratory setup under argon gas environment. It was observed that corrosion of this ceramic was severe in contact with steel compared to slag/inclusion.

The second part of …

Application Of Unified Invariants For Cyber Physical Systems In Smart Grids, Tamal Paul

Doctoral Dissertations

Cyber-Physical Systems (CPS) are complex engineered systems which consist of physical components with an underlying cyber network. The three main components of a cyber-physical System are: physical system, networking and communications element and a distributed cyber system. The primary challenge for cyber-physical systems is to understand what happens when various sub-systems, which have been developed in an isolated environment, are integrated. CPS studies need to ensure sub-systems that had been designed in isolation to meet certain specifications, when combined, do not cause the overall system to fail. The crux of cyber-physical research is thus to find a common platform to …

Microstructure And Geotechnical Properties Of St. Peter Sandstone In Clayton, Iowa, Amir Hossein Bagherieh

Doctoral Dissertations

"The St. Peter Sandstone is significantly different from the minerals and rocks which have been studied extensively in mining. It is brittle and characterized by an unusually high friction angle. On the other hand it is friable, and it is nearly cohesionless. The scarcity of the ground control techniques for this particular mining environment has created many difficulties for mine operators. This research aims to establish a fundamental understanding of the basic mechanical and strength properties of the St. Peter Sandstone for engineering design and scientific research. The specific objectives are 1) characterizing the strength of the St. Peter Sandstone, …

On The Deployment Of On-Chip Noise Sensors, Tao Wang

Doctoral Dissertations

"The relentless technology scaling has led to significantly reduced noise margin and complicated functionalities. As such, design time techniques per se are less likely to ensure power integrity, resulting in runtime voltage emergencies. To alleviate the issue, recently several works have shed light on the possibilities of dynamic noise management systems. Most of these works rely on on-chip noise sensors to accurately capture voltage emergencies. However, they all assume that the placement of the sensors is given. It remains an open problem in the literature how to optimally place a given number of noise sensors for best voltage emergency detection. …

Detection And Recognition Of R/F Devices Based On Their Unintended Electromagnetic Emissions Using Stochastic And Computational Intelligence Methods, Shikhar Prasad Acharya

Doctoral Dissertations

"Radio Frequency (RF) devices produce some amount of Unintended Electromagnetic Emissions (UEEs). UEEs are generally unique to a device and can be thought of as a signature of the device. This property of uniqueness of UEEs can be used to detect and identify the device producing the emission. The problem with UEEs is that they are very low in power and are often buried deep inside the noise band which makes them difficult to detect. There are two types of UEE detection methods. The first one is called stimulated detection method where the UEEs of a device are enhanced using …

Investigation Of Effect Of Process Parameters On Multilayer Builds By Direct Metal Deposition, Tarak Amine

Doctoral Dissertations

"Multilayer direct laser deposition (DLD) is a fabrication process through which parts are fabricated by creating a molten pool into which metal powder is injected as. During fabrication, complex thermal activity occurs in different regions of the build; for example, newly deposited layers will reheat previously deposited layers. The objective of this study was to provide insight into the thermal activity that occurs during the DLD process. This work focused on the effect of the deposition parameters of deposited layers on the microstructure and mechanical properties of the previously deposited layers. Varying the parameters was shown to produce different effects …

On The Design And Analysis Of Compliant Mechanisms Using The Pseudo-Rigid-Body Model Concept, Sushrut Gangadhar Bapat

Doctoral Dissertations

"The pseudo-rigid-body model (PRBM) concept, developed for the analysis and design of large-deflection flexible members, has proved over time to be a simple, efficient and accurate tool for the synthesis, analysis and design of compliant mechanisms. This dissertation investigates a variety of compliant mechanism analysis and design problems using the PRBM concept and assists in further advancement of the implementation of the PRBMs. The dissertation begins with the development of a PRBM for a fixed-guided compliant beam with one inflection point in the deformed state. This research investigation advances the concept of characteristic deflection domain to a new synthesis framework …

An Integrated Study For Hybrid Composite Beam (Hcb) Structures, Mohamed Abdelkhalik Aboelseoud

Doctoral Dissertations

"The hybrid composite beam (HCB) consists of a self consolidating concrete (SCC) arch that is tied at the end by galvanized strands. The tied arch is encapsulated by a glass fiber reinforced polymer (GFRP) shell. A limited number of researches have studied the essential design methodologies and long-term performance of the HCB. The research presented in this dissertation aimed to more fundamentally understand the structural behavior of this new beam and evaluate its durability. This research study was conducted through four phases. A full-scale bridge load testing was conducted on a single-web HCB bridge during the first phase. The first …