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Articles 2221 - 2250 of 3180

Full-Text Articles in Engineering

Solid-State Devices For Detection Of Dna, Protein Biomarkers And Cells, Waseem Asghar Jan 2012

Solid-State Devices For Detection Of Dna, Protein Biomarkers And Cells, Waseem Asghar

Electrical Engineering Dissertations - Archive

Nanobiotechnology and BioMEMS have had tremendous impact on biosensing in the areas of cancer cell detection and therapeutics, disease diagnostics, proteomics and DNA analysis. Diseases are expressed on all levels including DNA, protein, cell and tissue. Therefore it is very critical to develop biosensors at each level. The power of the nanotechnology lies in the fact that we can fabricate devices on all scales from micro to nano. This dissertation focuses on four areas: 1) Development of nanopore sensors for DNA analysis; 2) Development of micropore sensors for early detection of circulating tumor cells (CTCs) from whole blood; 3) Synthesis …

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Precision And Mobility Analysis For Microrobot Design And Control, Muhammed Rasid Pac Jan 2012

Precision And Mobility Analysis For Microrobot Design And Control, Muhammed Rasid Pac

Electrical Engineering Dissertations - Archive

The emerging field of microrobotics extends from manipulation of nanostructures to 3D assembly of micromachines, and to control of motile bacteria as manipulation tools. Microrobots are not necessarily small themselves but the smallest scale in which they operate is measured in micrometers. Microrobots have to be precise, fast, and flexible to be useful as top-down manufacturing tools. As the relative magnitudes of uncertainties and errors with respect to the operational precision of robots grow towards smaller scales, the requirement for better precision increases. Hence, the concepts of precision analysis and precision-based design are important steps in microrobotic system development. In …

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Reducing The Encoding Time For H.264 Baseline Profile Using Parallel Programming Techniques., Tushar Ashok Saxena Jan 2012

Reducing The Encoding Time For H.264 Baseline Profile Using Parallel Programming Techniques., Tushar Ashok Saxena

Electrical Engineering Theses - Archive

This thesis is aimed at reducing the encoding time for a group of pictures (GOP) for h.264 baseline profile on a general purpose CPU. This thesis also aims at drawing a comparison between task based parallelism and data based parallelism. The reduction is achieved by encoding the frames in parallel rather than serially. Task based parallelism is achieved by equally dividing the GOP's in two different threads and running them on the underlying hardware at the same time using Open MP software. Data based parallelism is achieved by finding the hot spots in the software and then parallelizing it using …

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Optimizing A Neural Network Over Size And Iteration Number, Jignesh K. Patel Jan 2012

Optimizing A Neural Network Over Size And Iteration Number, Jignesh K. Patel

Electrical Engineering Theses - Archive

A unique algorithm has been developed for training multilayer perceptron neural networks. First the training algorithm has been used with hidden weight optimization (HWO) and multiple optimal learning factors (MOLF) to get the best performance. In each training iteration, this method first optimally orders the inputs and then optimally orders the hidden basis functions. At the end of each training iteration, the method calculates the validation error versus number of basis function curve in one pass through the validation data. Since, pruning is done at each iteration, we optimize validation error over number of basis functions and number of iterations …

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Fabrication Of Small Diameter Vascular Graft Using Stacked Collagen Films, Sandeep Shah Jan 2012

Fabrication Of Small Diameter Vascular Graft Using Stacked Collagen Films, Sandeep Shah

Bioengineering Theses - Archive

Collagen I have been widely used in the field of vascular tissue engineering. They are characterized better for their interaction at the cellular level but are often limited as vascular graft due to their weak mechanical strength and thrombic property. The crosslinking chemicals or polymers support are used to overcome weak mechanical property. Crosslinking agents tend to have cytotoxic effects while blend with synthetic polymers have mismatch or compliancy issues inside the body. Here in this set of study, we used stacked collagen films and embedded drug delivery system within the film to construct small tubular conduits to meet the …

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Self-Assmbled Lithography-Free Fabrication Of Microchannels And Microfluidics In Polymers, Wintana Tadesse Kahsai Jan 2012

Self-Assmbled Lithography-Free Fabrication Of Microchannels And Microfluidics In Polymers, Wintana Tadesse Kahsai

Bioengineering Theses - Archive

Rapid, reliable and easy to implement approaches are needed for fabrication of circular microchannels in polymeric microfluidics. PDMS has been a choice of material in microfluidics and it is being used as prototype due to its unique property such as flexibility and transparency. Traditional method of fabrication such as photolithography and soft lithography are complicated and time consuming. In this thesis, a non-lithography and bottom-up self-assembled approach is shown. The resulting devices can have uses in many applications such as assays, biosensing, separation of mixtures, micro-mixing and bioreactors. This thesis presents novel approaches of manufacturing self-assembled microchannels in polydimethyleneoxide (PDMS) …

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Effective Construction Schedule Management: Construction Project Monitoring With Project Performance Indicators & The Project Status Report, Christopher Michael Totin Jan 2012

Effective Construction Schedule Management: Construction Project Monitoring With Project Performance Indicators & The Project Status Report, Christopher Michael Totin

Civil Engineering Theses - Archive

A thorough review of construction and engineering literature was conducted to discover and organize current best practices and standards for the purpose of monitoring a construction project. The status of a construction project is a measurement of its progress and performance in terms of time, cost, and scope. Awareness of a construction project's status improves decision-making on the part of owners, engineers, contractors, and other project stakeholders. Project Performance Indicators (PPI) are metrics generated by construction project schedules that define a project's status. Project personnel must monitor critical schedule and cost data, or PPI, in order to maintain control of …

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Investigation Of Co-Pyrolysis Between Sargassum Macroalgae And Polystyrene, Ketwalee Kositkanawuth Jan 2012

Investigation Of Co-Pyrolysis Between Sargassum Macroalgae And Polystyrene, Ketwalee Kositkanawuth

Civil Engineering Dissertations - Archive

Biomass is one source of renewable energy which helps minimize greenhouse gas (GHG) emissions, specifically carbon dioxide (CO2), since biomass utilizes CO2 via photosynthesis. Various conversion processes are applied to utilize energy from biomass, including pyrolysis. Pyrolysis is a thermal route of decomposing biomass at high temperature without the presence of oxygen. The process generates three main products including bio-oil, residue, and non-condensable gases; however, the most promising product is the biomass oil, which is in liquid form and convenient for handle and transport. Numerous studies on pyrolysis of terrestrial biomass reveal that the crude bio-oil cannot be directly used …

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Modeling Leachate Bod And Cod Using Lab-Scale Reactor Landfills And Multiple Linear Regression Analysis, Said Altouqi Jan 2012

Modeling Leachate Bod And Cod Using Lab-Scale Reactor Landfills And Multiple Linear Regression Analysis, Said Altouqi

Civil Engineering Dissertations - Archive

The increasing production of municipal solid waste is a direct consequence of the continuous growth of the world's population and economy. This fact makes protecting the environment against contamination by different kinds of waste a challenging job for engineers and decision makers. Conventional landfilling practices have sometimes failed to protect fresh water resources against leachate contamination as well as the atmosphere against greenhouse gases such as carbon dioxide and methane. Many developed countries have already taken serious steps toward moving to properly engineered, environmental friendly landfills.Landfill leachate contains organic and inorganic pollutants that have been extensively studied in the last …

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Development Of Detailed Computational Flow Model Of High End Server And Validation Using Experimental Methods, Vijayalayan Pandiyan Jan 2012

Development Of Detailed Computational Flow Model Of High End Server And Validation Using Experimental Methods, Vijayalayan Pandiyan

Mechanical and Aerospace Engineering Theses - Archive

The continued development of the microprocessor has led to significant increase in high frequency interconnects and power dissipation. High power devices are pushing the limits of air cooling in data center environments. Data center power consumption continues to grow at a rapid pace. In light of this increasing trend in power consumption, computer systems researchers, application designers, power and cooling engineers, and governmental bodies have all launched research efforts to improve data center energy efficiency [1]. Rack servers tend to be the main perpetrators of wasting energy and represent the largest portion of the IT energy load in a typical …

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Experimental/Computational Analysis Of Active Cooling Of Stacked Device Using Multidimensional Configured Thermoelectric Modules, Vaidehi Bharat Patel Jan 2012

Experimental/Computational Analysis Of Active Cooling Of Stacked Device Using Multidimensional Configured Thermoelectric Modules, Vaidehi Bharat Patel

Mechanical and Aerospace Engineering Theses - Archive

Stacked devices are currently used widely because of their smaller footprint and corresponding ability to accommodate heterogeneous devices such as memory and logic and enable a silicon efficiency greater than 100%. This configuration will results in thermal management challenges due to the torturous heat dissipation path. In addition, the non-uniformity in chip power distribution results in an increased spreading resistance as well as temperature gradient at the device level that can degrade performance and reliability. In this study the Thermoelectric Modules were configured in a multidimensional form surrounding a three dimensional cold core. The corresponding Computational Fluid Dynamics model is …

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Large Scale Finite Element Analysis Using Gpu Parallel Computing, Ashkan Akbariyeh Jan 2012

Large Scale Finite Element Analysis Using Gpu Parallel Computing, Ashkan Akbariyeh

Mechanical and Aerospace Engineering Theses - Archive

In the past years, graphic processing units have become a new abundant parallelcomputing resource on personal computers. In this work parallel computation ofa typical case in nite element analysis for solids has been practiced. The solutionof 3-D linear elastic static problems with 3 degree of freedom is fully implementedutilizing the current GPU technology. Discretization of the problem has been donefor two cases of: Tetrahedral and Hexahedral elements. Acceleration of the solutionhas been realized using SIMT parallel algorithms. Sparse matrix storage formats aswell as matrix-vector operations are investigated for optimum hardware utilization.preconditioned conjugate gradient method has been fully implemented on the …

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Complexity Reduction In H.264 Encoder Using Open Multiprocessing, Tejas Pravin Sathe Jan 2012

Complexity Reduction In H.264 Encoder Using Open Multiprocessing, Tejas Pravin Sathe

Electrical Engineering Theses - Archive

H.264 video standard developed by Joint Video Team has proven dramatic improvements in bit-rate efficiency, compression ratio, video quality and error resilience. But, all this is achieved at the expense of more than four times of the computational complexity due to various new features including quarter-pixel motion estimation with variable block sizes and multiple reference frames, adaptive directional intra-prediction, integer transformation based on discrete cosine transform, alternative entropy coding mode Context-based Adaptive Variable Length Coding (CAVLC) or Context-Based Adaptive Binary Arithmetic Coding (CABAC), in loop de-blocking filter etc. This thesis aims at reducing the encoding time for the video sequence …

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Multi-Variable Model Of A Neural Network Based Weather Forecaster Using 2-Stage Feature Selection, Kunal Chandrakant Vora Jan 2012

Multi-Variable Model Of A Neural Network Based Weather Forecaster Using 2-Stage Feature Selection, Kunal Chandrakant Vora

Electrical Engineering Theses - Archive

This thesis proposes a novel approach for designing a neural network based forecaster that predicts more than one variable at a time. A second order two stage neural network training algorithm is used that employs orthogonal least square for training the output weights. In order to reduce the size of the network and train the forecaster optimally it uses time-domain feature selection and KLT transform based feature selection. The forecaster works well and the feature selection reduces the number of required inputs on the order of 70 %.

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Engineering Characteristics Of Recyled Plastic Pin, Lumber And Bamboo For Soil Slope Stabilization, Faisal Shakib Ahmed Jan 2012

Engineering Characteristics Of Recyled Plastic Pin, Lumber And Bamboo For Soil Slope Stabilization, Faisal Shakib Ahmed

Civil Engineering Theses - Archive

Shallow slope failures are predominant in North Texas and pose a significant maintenance problem. The traditional slope repair and stabilization techniques become expensive in some instances with direct costs associated in maintenance and repair of landslides. A new approach for slope stabilization has been developed using Recycled Plastic Pins ( RPP) to reinforce slope movements. The engineering properties of RPP in compression and bending strength along with environmental considerations dictate the design and repair of slopes using RPP. Two other materials have also been considered as an alternative: (1) Wood lumber and (2) Bamboo. Wood has many advantages as an …

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Development Of A Flexible Pavement Design Procedure Based On The Mechanistic - Empirical Pavement Design Guide: A Case Study, Ali Qays Abdullah Jan 2012

Development Of A Flexible Pavement Design Procedure Based On The Mechanistic - Empirical Pavement Design Guide: A Case Study, Ali Qays Abdullah

Civil Engineering Theses - Archive

This research developed design tables of new flexible pavement structures for New York State Department of Transportation based on the Mechanistic Empirical Design Guide (MEPDG). The design tables were developed using the MEPDG software for Regions 1, 3, and 7 for Upstate part of New York State and for Regions 8, 10, and 11 for the Downstate part of New York State. The MEPDG software was used to run design cases for combinations of: climate conditions, traffic volume, subgrade soil stiffness (Mr) and pavement structures. The conditions that the MEPDG was used to run were: the road structures classified as …

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Geohazard Potential Of Rainfall Induced Slope Failure On Expansive Clay, Jubair Hossain Jan 2012

Geohazard Potential Of Rainfall Induced Slope Failure On Expansive Clay, Jubair Hossain

Civil Engineering Dissertations - Archive

Each year, rain induced slope failures cause significant damages in highway infrastructures and environments, as well as tragic losses of human lives around the world. Rainfall-induced slope failure is a common problem in areas with slope constructed on high plasticity clays. These post failure costs can be significantly reduced if precautions are taken ahead of time. Development of an early hazard warning system based on weather forecast data can help identify potential slopes susceptible to failure due to rainfall. But development of such system will require a better understanding of the in situ behavior of soil due to rainwater infiltration …

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An Evaluation Of Large Diameter Steel Water Pipelines, Tushar Joshi Jan 2012

An Evaluation Of Large Diameter Steel Water Pipelines, Tushar Joshi

Civil Engineering Theses - Archive

Steel water pipelines, as a part of America's underground infrastructure, play a key role in maintaining the quality of life and well-being of communities. Thousands of miles of steel water pipelines make up a huge and complex water transmission system. This complexity generates the necessity for research on underground infrastructure in general and steel pipelines in particular. The objective of this research is to evaluate performance of large diameter (24 in. and larger) steel water pipelines. This research objective was achieved by use of a survey of various North American water utilities to provide details about their inventory. This data …

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Degradation Of Triclosan By Sulfate Radicals Generated By Metal-Mediated Activation Of Oxidants, Prince Albert Nfodzo Jan 2012

Degradation Of Triclosan By Sulfate Radicals Generated By Metal-Mediated Activation Of Oxidants, Prince Albert Nfodzo

Civil Engineering Dissertations - Archive

The presence of persistent and toxic compounds, especially pharmaceuticals and personal care products (PPCPs) in water resources has generated considerable scientific, regulatory, and public interests, requiring the development of cost-effective technologies for the management of PPCPs-contaminated water resources. In particular, triclosan (TCS, 5-chloro-2-(2,4-dichlorophenoxy)phenol), an important antimicrobial agent widely used in many PPCPs, has attracted significant attention due to its potential endocrine disrupting capabilities. In order to address these concerns, advanced oxidation processes (AOPs), resulting in the generation of stronger oxidizing species, typically hydroxyl radicals (HRs) and sulfate radicals (SRs), have been studied and proposed to be effective to degrade a …

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An Improved Model For Predicting Methane Emissions From Landfills Based On Rainfall, Ambient Temperature And Waste Composition, Richa Vijay Karanjekar Jan 2012

An Improved Model For Predicting Methane Emissions From Landfills Based On Rainfall, Ambient Temperature And Waste Composition, Richa Vijay Karanjekar

Civil Engineering Dissertations - Archive

Accurately estimating the emissions of methane (CH4) and carbon dioxide (CO2) in a landfill is important for quantifying its greenhouse gas (GHG) emissions and power generation potential. Previous studies have shown that variation in waste composition, rainfall and ambient temperature of a landfill significantly influences its methane generation potential. Current methane generation models, namely U.S. Environmental Protection Agency's (EPA) Landfill Gas Generation Model (LandGEM) and Intergovernmental Panel on Climate Change's (IPCC) methane generation model, are overly simplified and do not account for the variations in waste composition, rainfall and ambient temperature. The goal of this research was to improve our …

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Development Of A New Device To Evaluate Stabilization Durability Of Expansive Soils By Addressing Wetting/Drying And Leachate Issues, Priya Pravin Lad Jan 2012

Development Of A New Device To Evaluate Stabilization Durability Of Expansive Soils By Addressing Wetting/Drying And Leachate Issues, Priya Pravin Lad

Civil Engineering Theses - Archive

Expansive soils have been known to cause deterioration among all aspects of civil infrastructure for many years primarily due to the presence of clay minerals like Montmorillonite. Replacing these problematic soils is not a viable solution in that it is costly and time consuming.Although many stabilization techniques are available, chemical stabilization has proven to be an important tool in arresting the swell/shrink behavior of expansive soil, which is a major source of distress problems for most infrastructures built on this type of soils. Of the chemical stabilizers available in the market, lime and cement stabilizers are the two most widely …

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Effect Of Additive Morphology & Chemistry On Wear & Friction Of Greases Under Spectrum Loading, Sujay Dilip Bagi Jan 2012

Effect Of Additive Morphology & Chemistry On Wear & Friction Of Greases Under Spectrum Loading, Sujay Dilip Bagi

Material Science and Engineering Theses - Archive

The primary focus of grease development is to minimize friction and improve on wear and load bearing capacity. Traditional method to evaluate wear behavior of grease is based on ASTM D2266 which evaluates the performance of grease at 75°C, 40Kg and 1200 rpm for 1 hour. However, actual applications may require bearings to be subjected to spectrum loading conditions where-in rotations per minute (rpm), load and duration of test are variables. A series of six tests were conducted for all the grease blends; load was treated as the variable in four of the tests while maintaining the frequency constant and …

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Effect Of Ascorbic Acid On Cdte Quantum Dots And Investigation Of Different Chemical Sensors On Cdtehg Quantum Dots, Yamini Chitrala Jan 2012

Effect Of Ascorbic Acid On Cdte Quantum Dots And Investigation Of Different Chemical Sensors On Cdtehg Quantum Dots, Yamini Chitrala

Bioengineering Theses - Archive

The objective of my thesis is to investigate the effect of ascorbic acid on CdTe quantum dots, which is an antioxidant. It was observed that the quantum dots recovered their luminescence intensity after the interaction of the ascorbic acid, where the intensity was quenched by the photosensitizer. The luminescence intensity increased gradually for 0.1mM- 0.5mM concentration of ascorbic acid and remained stable with higher concentrations of the antioxidant. Also, it was observed that under some reaction conditions like pH, temperature and concentration, ascorbic acid had a great influence on its photoluminescence. In the second part of the research project, I …

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Cytotoxicity Evaluation Of Methacrylate-Based Resins For Clinical Endodontics In Vitro, Chul Ahn, Aniket S. Wadajkar, Qiang Zhu, Esteban G. Garza, Lynn A. Opperman, Larry L. Bellinger, Takashi Komabayashi Jan 2012

Cytotoxicity Evaluation Of Methacrylate-Based Resins For Clinical Endodontics In Vitro, Chul Ahn, Aniket S. Wadajkar, Qiang Zhu, Esteban G. Garza, Lynn A. Opperman, Larry L. Bellinger, Takashi Komabayashi

Bioengineering Faculty Publications - Archive

This study examines the cytotoxicity of Super-Bond C&B (SB-C&B), Super-Bond RC Sealer (SB-RC), MetaSEAL (Meta), and AH Plus Sealer (AH+). Freshly mixed and set materials (100 mg) were prepared in vitro and placed in cell culture medium (1 mL) for the working time and for 6 h, respectively. L929 cells seeded into 96-well plates at 5,000 cells/ well were incubated with the eluted medium (200 μL) for 24 h. Cells cultured with medium alone served as the control. Cytotoxicity was evaluated by MTS assay and analyzed with ANOVA. In the freshly mixed group, the average ± SD (%) for cell …

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5 Cm Gap Injury Repair: Growth Factor Support And Functional Analysis In A Rabbit Common Peroneal Nerve Model, Princy K. Prasad Jan 2012

5 Cm Gap Injury Repair: Growth Factor Support And Functional Analysis In A Rabbit Common Peroneal Nerve Model, Princy K. Prasad

Bioengineering Theses - Archive

Nerve conduits have shown to successfully bridge nerve gaps of ≤ 3 cm; however repair of longer, mixed or motor nerve gaps still remains a clinical challenge. In order to study regeneration techniques in clinically relevant long gaps, larger animal models are required. Standardized methods to evaluate functional outcome are necessary to clinically translate experimental treatments. In this study, the capability of the biodegradable and transparent cross-linked doped polyester elastomer (CUPE) to serve as a nerve conduit material in a multiluminal nerve conduit across a 5 cm gap in a rabbit common peroneal nerve model was evaluated. The effect of …

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Near Infrared Quantitative Phase Imaging Of Cellular Manipulation Under Different Physio-Chemical Environments, Bipin Joshi Jan 2012

Near Infrared Quantitative Phase Imaging Of Cellular Manipulation Under Different Physio-Chemical Environments, Bipin Joshi

Bioengineering Theses - Archive

Quantitative phase imaging using Digital Holographic Microscopy (DHM) is emerging as a label-free and wide-field method of characterizing cells with high spatio-temporal resolution. In parallel, silicon based micromechanical and electronic devices are allowing both manipulation (e.g. electrical stimulation, mechanical actuation) as well as characterization (electrical and mechanical) of micro and nano-scopic samples. This has revolutionized development of lab-on-a-chip devices for high throughput analysis of cells and molecules for diagnosis of disease and screening of drug-effects. However, very little progress has been made in optical (e.g. fluorescence, Raman etc) characterization of samples on these silicon-based devices. Especially, wide-field high-resolution optical imaging …

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Detecting Clinical Biomarkers Using Diffusion Tensor Imaging, Tejasvi Gundapuneedi Jan 2012

Detecting Clinical Biomarkers Using Diffusion Tensor Imaging, Tejasvi Gundapuneedi

Bioengineering Theses - Archive

Diffusion tensor imaging (DTI), a modality of MRI that measures water diffusion properties noninvasively, is highly sensitive to subtle structural changes of white matter. It provides a unique and noninvasive method for delineating in-vivo architecture of human brain white matter. Four metrics derived from DTI, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), have been widely used to quantitatively characterize the white matter disruption in mental disorders and degenerative diseases. An atlas-based approach incorporating a digital white matter atlas and registration and skeletonization functions of tract-based spatial statistics (TBSS) has been developed recently. This approach …

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Electrospun Biodegradable Polymeric Membranes For Post-Surgery Anti-Adhesion Applications, Pouriska Kivanany Jan 2012

Electrospun Biodegradable Polymeric Membranes For Post-Surgery Anti-Adhesion Applications, Pouriska Kivanany

Bioengineering Theses - Archive

Abdominal adhesion is a prevalent, troublesome condition occurring after surgical procedures and can cause a variety of side effects such as, abdominal pain with a highly associated cost ($1.3 billion annually for) for expensive surgical removal. Many companies and research groups have studied and developed techniques to prevent adhesion after surgery; however, none have been completely effective or practical for use. Current materials have many drawbacks, such as the inability to degrade, poor surgical handling, and attracting bacteria. Up to 93% of patients receiving abdominal surgeries will develop abdominal adhesions, and a viable treatment option needs to be developed to …

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Involvement Of Mixed Lineage Leukemia And Homeobox Proteins In Dna Damage Recognition And Repair, Somdutta Chakraborty Jan 2012

Involvement Of Mixed Lineage Leukemia And Homeobox Proteins In Dna Damage Recognition And Repair, Somdutta Chakraborty

Bioengineering Theses - Archive

Deoxyribonucleic Acid (DNA) molecules are informational molecules, encoding genetic information which is indispensable in the development and functioning of living organisms. DNA encodes for most proteins essential for all bodily functions and a few of which are known to be involved in the DNA Damage Response/ Repair mechanism. DNA damage recognition and repair is crucial and the cell has an innate mechanism of repairing it. Unrepaired DNA damage leads to genetic mutation or even cancers, which are sustained by further cell division and genetic multiplication. Other researchers have already confirmed the involvement of several proteins and histones like PARP and …

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Evaluation Of Tissue Response From The Regenerative Multielectrode Array (Remi) Implant Using Atf-3 And Cjun, Sarita Bhetawal Jan 2012

Evaluation Of Tissue Response From The Regenerative Multielectrode Array (Remi) Implant Using Atf-3 And Cjun, Sarita Bhetawal

Bioengineering Theses - Archive

Currently available peripheral nerve regenerative interfaces such as the sieve and the micro-channel regenerative electrode, intended to be used for the control and natural feel from advanced robotic prosthetic devices, eventually fail due to nerve damage due to axonopathy. The Regenerative Multi-electrode array (REMI) developed in our lab overcomes this limitation by providing a non-obstructive pathway for regenerating axons. However, it is possible that the mismatch at the electrode-tissue interface may cause axonal injury during limb stretching. In order to determine if micro-motion at the REMI causes neuronal injury I evaluated the nuclear expression of Activating Transcription Factor 3 (ATF-3), …

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