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Articles 1171 - 1200 of 3180

Full-Text Articles in Engineering

Study Of Defect Coalescence In Heterogeneous Material Systems Using Broad Band Dielectric Spectroscopy., Vamsee Vadlamudi, Muthu Ram Prabhu Elenchezhian, Priyanshu Kumar Banerjee, Rassel Raihan, Kenneth Reifsnider Nov 2017

Study Of Defect Coalescence In Heterogeneous Material Systems Using Broad Band Dielectric Spectroscopy., Vamsee Vadlamudi, Muthu Ram Prabhu Elenchezhian, Priyanshu Kumar Banerjee, Rassel Raihan, Kenneth Reifsnider

Institute of Predictive Performance Methodologies (IPPM-UTARI)-Archive

Composite materials are essential for many modern applications, including airplanes and cars, energy conversion and storage devices, medical prosthetics, and civil structures. Detecting the initiation, growth, accumulation, and coalescence of micro-damage in these heterogeneous materials and predicting the onset of component failure using conformal Broadband Dielectric Spectroscopy (BbDS) is a promising area of ongoing research. Recently, the authors have developed the critical path concept and Heterogeneous fracture mechanics concept that depicts the effect of defect nucleation, growth, coalescence, and fracture plane development and correlation of these damage mechanisms to change in dielectric response respectively. Current research applies those concepts to …

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Dual-Drug Containing Core-Shell Nanoparticles For Lung Cancer Therapy, Jyothi Unnikrishna Menon, Aneetta Kuriakose, Roshni Iyer, Elizabeth Hernandez, Leah Gandee, Shanrong Zhang, Masaya Takahashi, Zhang Zhang, Debabrata Saha, Kytai Truong Nguyen Oct 2017

Dual-Drug Containing Core-Shell Nanoparticles For Lung Cancer Therapy, Jyothi Unnikrishna Menon, Aneetta Kuriakose, Roshni Iyer, Elizabeth Hernandez, Leah Gandee, Shanrong Zhang, Masaya Takahashi, Zhang Zhang, Debabrata Saha, Kytai Truong Nguyen

Bioengineering Faculty Publications - Archive

Late-stage diagnosis of lung cancer occurs ~95% of the time due to late manifestation of its symptoms, necessitating rigorous treatment following diagnosis. Existing treatment methods are limited by lack of specificity, systemic toxicity, temporary remission, and radio-resistance in lung cancer cells. In this research, we have developed a folate receptor-targeting multifunctional dual drug-loaded nanoparticle (MDNP) containing a poly(N-isopropylacrylamide)-carboxymethyl chitosan shell and poly lactic-coglycolic acid (PLGA) core for enhancing localized chemo-radiotherapy to effectively treat lung cancers. The formulation provided controlled releases of the encapsulated therapeutic compounds, NU7441 - a potent radiosensitizer, and gemcitabine - an FDA approved chemotherapeutic drug for lung …

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Predicting Adhesive Bond Performance Based On Initial Dielectric Properties, Priyanshu Kumar Banerjee, Muthu Ram Prabhu Elenchezhian, Vamsee Vadlamudi, Rassel Raihan, Kenneth Reifsnider Oct 2017

Predicting Adhesive Bond Performance Based On Initial Dielectric Properties, Priyanshu Kumar Banerjee, Muthu Ram Prabhu Elenchezhian, Vamsee Vadlamudi, Rassel Raihan, Kenneth Reifsnider

Institute of Predictive Performance Methodologies (IPPM-UTARI)-Archive

This paper will focus on an approach to study the mechanical as well as the dielectric properties of an adhesive bond. The dielectric testing is done by using Broadband Dielectric Spectroscopy (BbDS), wherein the dielectric characteristics of the material are analyzed in a wide frequency spectrum. The data obtained by this technique are used to demonstrate the charge transport, the combined dipolar fluctuation, and the effects of polarization occurring between the boundaries of materials. The continuous modifications of the dielectric spectra are due to the changes in the electrical and structural interactions between the particles, shapes, and orientations of the …

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Self-Propulsion Of Leidenfrost Drops Between Non-Parallel Structures, Cheng Luo, Manjarik Mrinal, Xiang Wang Sep 2017

Self-Propulsion Of Leidenfrost Drops Between Non-Parallel Structures, Cheng Luo, Manjarik Mrinal, Xiang Wang

Mechanical and Aerospace Faculty Publications - Archive

In this work, we explored self-propulsion of a Leidenfrost drop between non-parallel structures. A theoretical model was first developed to determine conditions for liquid drops to start moving away from the corner of two non-parallel plates. These conditions were then simplified for the case of a Leidenfrost drop. Furthermore, ejection speeds and travel distances of Leidenfrost drops were derived using a scaling law. Subsequently, the theoretical models were validated by experiments. Finally, three new devices have been developed to manipulate Leidenfrost drops in different ways.

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An Optical Probe For Detecting Chondrocyte Apoptosis In Response To Mechanical Injury, Yihui Huang, Jun Zhou, Amirhossein Hakamivala, Jinglei Wu, Yi Hong, Joseph Borrelli Jr., Liping Tang Sep 2017

An Optical Probe For Detecting Chondrocyte Apoptosis In Response To Mechanical Injury, Yihui Huang, Jun Zhou, Amirhossein Hakamivala, Jinglei Wu, Yi Hong, Joseph Borrelli Jr., Liping Tang

Bioengineering Faculty Publications - Archive

Cartilage injury induced by acute excessive contact stress is common and mostly affects young adult. Although early detection of cartilage injury may prevent serious and lifelong arthritic complications, early detection and treatment is not possible due to the lack of a reliable detection method. Since chondrocyte injury and subsequent cell death are the early signs of cartilage injury, it is likely that cartilage cell apoptosis can be used to predict the extent of injury. To test this hypothesis, a near infrared probe was fabricated to have high affinity to apoptotic cells. In vitro tests show that this apoptosis probe has …

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Conditions For Barrel And Clam-Shell Liquid Drops To Move On Bio-Inspired Conical Wires, Cheng Luo, Xiang Wang Aug 2017

Conditions For Barrel And Clam-Shell Liquid Drops To Move On Bio-Inspired Conical Wires, Cheng Luo, Xiang Wang

Mechanical and Aerospace Faculty Publications - Archive

It has been reported that, in a foggy environment, water drops with either barrel or clam-shell shapes are capable of self-running on conical wire-like structures, such as cactus spines, spider silk, and water striders’ legs. On the other hand, the corresponding moving mechanisms are still not quite understood. For instance, it is unclear under what conditions clam-shell drops would move from the tip towards the root on a conical wire. In this work, based on the balance of forces, we derive conditions for a drop to self-transport towards or away from the root. We find that, although barrel and clam-shell …

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Neuroadaptive Human-Machine Interfaces For Collaborative Robots, Sven Cremer Aug 2017

Neuroadaptive Human-Machine Interfaces For Collaborative Robots, Sven Cremer

Electrical Engineering Dissertations - Archive

With an increasing number of collaborative robots or “co-robots” entering human environments, there is a growing need for safe, intuitive, and efficient (physical) Human-Machine Interfaces. Unlike industrial robots, co-robots operate in cluttered and dynamic working spaces, where accidental collisions are more likely to occur. To minimize interaction forces, co-robots are usually lightweight and compliant. However, this makes the robot dynamics highly nonlinear and therefore difficult to model and control. In addition, the control loop must incorporate feedback from integrated sensors. Future systems under development are covered with force-sensing robot skin comprised of thousands of multi-modal sensors, creating the need for …

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Early Detection Of Metastatic Cancer Using Computational Analysis, Nuzhat Mansur Aug 2017

Early Detection Of Metastatic Cancer Using Computational Analysis, Nuzhat Mansur

Electrical Engineering Dissertations - Archive

Metastasis is the leading cause of cancer related deaths. Early detection of cancer cells can enable early disease diagnosis and stage specific therapeutics. Metastatic cancer cells have abnormal expression of certain proteins. One such protein is Epidermal Growth Factor Receptor (EGFR). Anti-EGFR aptamers have emerged as more effective probe molecules for selectively binding with EGFR compared to antibodies. Capturing cancer cells with aptamer is an emerging and developing technique for cancer cell isolation. Nanotextured substrates inspired by naturally occurring basement membranes are promising platform for triggering unique cell behavior. Along with the biochemical and physical techniques to probe cancer cell …

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Multi-Source Uav-Based Object Classification Using Cnn’S And Data Acquisition System For Robotic Skin, Raghavendra Sriram Margasahayam Subrahamanyam Aug 2017

Multi-Source Uav-Based Object Classification Using Cnn’S And Data Acquisition System For Robotic Skin, Raghavendra Sriram Margasahayam Subrahamanyam

Electrical Engineering Dissertations - Archive

Autonomous robots are intelligent systems capable of performing tasks in the world by themselves, without explicit human control. Examples range from autonomous helicopters to Roomba, the robot vacuum cleaner to robotic manipulators. The numerous sensors onboard gather data related to the desired actions and this poses several challenges and design constraints in terms of computation and hardware design that can prove to be extremely difficult and expensive to avoid. The objective of this research is to study, develop and implement various Intelligent solutions to help solve several real-world problems with respect to multi agent configurations of unmanned systems. We shall …

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Formal Verification Of Dc Distribution Networks, Omar Ali Beg Aug 2017

Formal Verification Of Dc Distribution Networks, Omar Ali Beg

Electrical Engineering Dissertations - Archive

Power electronics-intensive DC distribution networks are emerging as popular alternative to their AC counterparts being more efficient and reliable power delivery platforms. With the recent evolution of control methodology from legacy centralized architecture to distributed control strategy employing communication networks, the DC distribution networks employing such software-based control schemes are evolving into cyber-physical systems. Since there is no central entity to monitor and assess the global cyber scenario, such cyber-physical systems are prone to adversary's cyber attacks. However, cyber attack detection in such cyber-physical DC power systems has not been systematically investigated yet. To fill the gap, this work successfully …

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Nanosilica Based 3d Printed Scaffold Facilitate Osteoblast Mineral Formation, Tugba Cebe Aug 2017

Nanosilica Based 3d Printed Scaffold Facilitate Osteoblast Mineral Formation, Tugba Cebe

Material Science and Engineering Theses - Archive

Bone has the ability to heal fractures so long as the size of the fracture is sufficiently small. If the defect is large or of critical size, a filling material or graft will be needed to help bone union. Among all the available methods to address this medical condition, the common drawback of grafts is that they are limited in supply since a biological site or organism is needed to harvest the biological graft. As a new approach, researchers have been working with bioceramics and biopolymers for their use in bone tissue engineering. In this work, chitosan was modified with …

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Advanced Methods Of Nondestructive Inspection Of Composite Structures Based On Limited Angle X-Ray Computed Tomography, Ekaterina Bostaph Aug 2017

Advanced Methods Of Nondestructive Inspection Of Composite Structures Based On Limited Angle X-Ray Computed Tomography, Ekaterina Bostaph

Mechanical and Aerospace Engineering Dissertations - Archive

This research aimed to study the potential for breaking through object size limitations of current X-ray computed tomography (CT) systems by implementing a limited angle scanning technique. CT stands out among other industrial nondestructive inspection (NDI) methods due to its unique ability to perform 3D volumetric inspection, unmatched micro-focus resolution, and objectivity that allows for automated result interpretation. This work attempts to advance NDI technique to enable microstructural material characterization and structural diagnostics of composite structures, where object sizes often prohibit the application of full 360o CT. Even in situations where the objects can be accommodated within existing micro-CT configuration, …

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Modeling And Measurements Of Thermal Transport In Li-Ion Based Energy Conversion And Storage Devices, Krishna Shah Aug 2017

Modeling And Measurements Of Thermal Transport In Li-Ion Based Energy Conversion And Storage Devices, Krishna Shah

Mechanical and Aerospace Engineering Dissertations - Archive

Heat transfer is of significant importance in energy conversion and storage devices such as Lithium-ion batteries for its safe operation and performance. Li-ion batteries are considered to be the state of the art among the energy storage devices due to their very high energy density and high power density. However, the safety of Li-ion batteries has become a concern in light of recent incidents, where there have been catastrophic events reported due to overheating of large battery packs. It is imperative to fully understand the nature of thermal transport in Li-ion cells. However, this has not been explored in detail …

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Processing Beta-Tricalcium Phosphate And 45s5 Bioglass Mixtures For Osteogenic Bone Tissue Scaffolds, Phillip Zachary James Aug 2017

Processing Beta-Tricalcium Phosphate And 45s5 Bioglass Mixtures For Osteogenic Bone Tissue Scaffolds, Phillip Zachary James

Material Science and Engineering Theses - Archive

A 30% 45S5 Bioglass and 70% -tricalcium phosphate ceramic mixture, which was previously shown to be osteogenic [1], was sintered and the process was investigated as a strengthening mechanism. Samples were sintered for dwell times of 1,2, and 4 hrs at 500°C to avoid crystallization of the 45S5 Bioglass. Two different binders were used, 2% gelatin in deionized water and 2% laponite with 2% oleic acidin deionized water. The mixture was also robocasted as a slurry to evaluate the manufacturing process. Mechanical compression testing shows that the laponite with oleic acid binder acted as a sintering aid leading to a …

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Space Access Systems Design: Synthesis Methodology Development For Conceptual Design Of Future Space Access Systems, Loveneesh Rana Aug 2017

Space Access Systems Design: Synthesis Methodology Development For Conceptual Design Of Future Space Access Systems, Loveneesh Rana

Mechanical and Aerospace Engineering Dissertations - Archive

The early Conceptual Design (CD) of a Space Access System (SAS) is the most abstract, innovative, and technologically challenging phase throughout the entire aerospace product development life-cycle. While it is the most important life-cycle phase which influences around 80 percent of the overall life-cycle-cost, it is also the least understood design phase. The history of space access vehicle design provides numerous examples of projects that failed due to lack of a proper technology-hardware-mission assessment in the CD phase. The present dissertation addresses this crucial phase and develops a prototype best practice solution process to advance the current state of the …

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Micro/Nanoencapsulated Phase Change Materials (Pcms) Toward High Temperature Thermal Energy Storage Applications, Hanfei Zhang Aug 2017

Micro/Nanoencapsulated Phase Change Materials (Pcms) Toward High Temperature Thermal Energy Storage Applications, Hanfei Zhang

Mechanical and Aerospace Engineering Dissertations - Archive

Thermal energy is one of the most important renewable energy sources because of its abundancy. However, despite the long history of people practically trying to harvest thermal energy, the efficiency of thermal energy storage and application to daily life utilization is still a major limitation, especially for high temperature (>300oC) applications. Concentrating solar power (CSP) is one of the very few technologies that have been used commercially to produce electricity from solar thermal energy. Benefiting from the extra latent heat stored during melting/freezing, phase change materials (PCMs) with a high melting point are commonly used in these systems functioning …

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Field-Directed Fabrication Of Hierarchical Structures Toward Electrochemical Applications, Anirudh Balram Aug 2017

Field-Directed Fabrication Of Hierarchical Structures Toward Electrochemical Applications, Anirudh Balram

Mechanical and Aerospace Engineering Dissertations - Archive

The ubiquity of hierarchical structures in nature indicates an inherent advantage to having morphological features comprised of multiple length scales. Such structures help maximize interfacial surface area, allowing for efficient chemical reactions and mass transport despite volumetric constraints. In electrochemical applications such as batteries, supercapacitors, electrolysis, fuel cells, catalysis etc. there is a similar necessity to maximize electrochemically active surface area to facilitate facile charge and mass transport. Inspired by examples in nature, this work seeks to develop scalable fabrication techniques to obtain hierarchically structured high-performance electrodes for electrochemical applications, with a focus on energy applications. Particular emphasis was laid …

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Numerical Investigation Of Stability Characteristics Of A Jet In Counterflow, Siddarth Chintamani Aug 2017

Numerical Investigation Of Stability Characteristics Of A Jet In Counterflow, Siddarth Chintamani

Mechanical and Aerospace Engineering Dissertations - Archive

A jet in counterflow is a configuration in which a jet is issued into an opposing external stream of fluid. Some of the possible applications of this configuration include study of pollutant discharge into body of water, aerodynamic flame holder in after burner, reduction of drag and cooling of bluff body by ejecting a jet of coolant gas into counterflowing stream, thrust vectoring of supersonic jets, sonic boom mitigation. The instability associated with flow reversal which is observed in this configuration of the jet leads to enhanced mixing. However, a detailed understanding of the dynamics and control is needed to …

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Multi-Mesh Reduced-Order Basis Method For Finite Element Analysis, Ashkan Akbariyeh Aug 2017

Multi-Mesh Reduced-Order Basis Method For Finite Element Analysis, Ashkan Akbariyeh

Mechanical and Aerospace Engineering Dissertations - Archive

Reduced order modeling of differential equations parametrized over a parameter space can be used to accelerate optimization and parameter estimation problems. The method of snapshots or reduced order basis is well established among researchers as a tool to build reduced order models of ordinary differential equations. The reduced order basis method has been utilized for numerical solution of parametric PDE problems by researchers in recent years and has many advantages over response surface methods. The application of ROB to finite element analysis has been restricted to using a fixed mesh for snapshots. In this work, a new method is developed …

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Thermal Measurement And Optimization Of Materials And Processes In A Li-Ion Cell, Vivek Vishwakarma Aug 2017

Thermal Measurement And Optimization Of Materials And Processes In A Li-Ion Cell, Vivek Vishwakarma

Mechanical and Aerospace Engineering Dissertations - Archive

Applications of Lithium-ion cells range from consumer electronics to electric cars because of their excellent electrochemical performance and energy density. However, a Li-ion cell also suffers from poor thermal transport characteristics, which reduces performance, causes overheating and thermal runaway. This work contributes towards thermal characterization of key Li-ion battery materials and identifies and improves the rate-limiting, material-level thermal conduction process in a Li-ion cell. Among the various materials within a Li-ion cell, the separator is expected to have the lowest thermal conductivity. In this work, we have carried out first-ever measurements of thermal conductivity and heat capacity of the separator …

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Flexible-Continuum Robot For Bladder Tissue Diagnostics, Samson Abimbola Adejokun Aug 2017

Flexible-Continuum Robot For Bladder Tissue Diagnostics, Samson Abimbola Adejokun

Mechanical and Aerospace Engineering Theses - Archive

The aim of this thesis is to investigate and develop a robotic system capable of a transurethral palpation of any targeted area on the bladder interior wall tissue to determine the biomechanical properties of the tissue considering the urinary tract geometric constraints and to demonstrate the motion kinematics of such robot to achieve a desired robot pose normal to any localized region throughout the bladder workspace. Current technologies have, to varied degree of success, provide approximate, global diagnostics information to bladder tissue elasticity. However, no direct access qualitative methods to measure the bladder tissue properties are known. For this reason, …

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Enhancing Indirect / Direct Evaporative Heat Exchanger In Data Center Cooling By Using Phase Change Material, Ahmed Ali Abuklam Aug 2017

Enhancing Indirect / Direct Evaporative Heat Exchanger In Data Center Cooling By Using Phase Change Material, Ahmed Ali Abuklam

Mechanical and Aerospace Engineering Theses - Archive

Electrical usage in data center continues to grow and recent projection estimate that it contributes 2% in the electricity use in the U.S. One method of controlling the electrical usage during cooling is to reduce or eliminate mechanical cooling; however, using indirect/direct evaporative (IDE) cooling system is starting to be quite popular. IDE has limitations and in this paper we will show how phase change material (PCM) can extend the cooling capacity of IDE. The PCM has been used for temperature control operations. Latent heat storage is one of the most efficient ways of storing thermal energy in PCM. The …

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Cfd Simulation And Design Optimization To Improve Cooling Performance Of Open Compute ‘Big Sur’ Server, Mangesh Mohan Dhadve Aug 2017

Cfd Simulation And Design Optimization To Improve Cooling Performance Of Open Compute ‘Big Sur’ Server, Mangesh Mohan Dhadve

Mechanical and Aerospace Engineering Theses - Archive

In recent years, there have been a phenomenal increase in Artificial Intelligence and Machine Learning that require data collection, mining and using data sets to teach computers certain things to learn, analyze image and speech recognition. Machine Learning tasks require a lot of computing power to carry out numerous calculations. Therefore, most servers are powered by Graphics Processing Units (GPUs) instead of traditional CPUs. GPUs provide more computational throughput per dollar spent than traditional CPUs. Open Compute Servers forum has introduced the state-of-the-art machine learning servers “Big Sur” recently. Big Sur unit consists of 4OU (OpenU) chassis housing eight NVIDIA …

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Analysis Of Composite Structures With Curvature Under Temperature Environment, Muthu Ram Prabhu Elenchezhian Aug 2017

Analysis Of Composite Structures With Curvature Under Temperature Environment, Muthu Ram Prabhu Elenchezhian

Mechanical and Aerospace Engineering Theses - Archive

Composite structures are frequently exposed to environments with change in temperatures during their service life. The thermal behaviours of the laminated composite structures are more pronounced than that of the structures made of isotropic materials. For the structures under thermal environment, extensive studies have been conducted to investigate the induced thermal stresses and deformation of composite laminated plates by linear/non-linear analysis and composite structures by finite element analysis. The main focus of this study is concentrated on development of an analytical method for analyzing composite thin shells and/or moderate curved beam structures under temperature environment. This includes the derivation of …

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Finite Element Analysis On Hybrid Boron-Carbon Composites, Amruta Rupa Nemani Aug 2017

Finite Element Analysis On Hybrid Boron-Carbon Composites, Amruta Rupa Nemani

Mechanical and Aerospace Engineering Theses - Archive

Adaptability to different situations and the ease of combination makes composites one of the most extensively used materials in the engineering industries. One of the ways of managing properties of composites is hybridization of different fibers in one composite. This work merely focuses upon the analysis of effective stiffness of Hybrid materials which is carried out using Finite Element Method. A series of models were experimented in a sequence by imposing various conditions on each of them. Boron and Carbon fibers were used primarily for these experiments because of their better compatibility than other combinations of fibers. Due to the …

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Thermal Modeling Of 3-Dimensionally Stacked Dram Memory, Ratnesh Raj Aug 2017

Thermal Modeling Of 3-Dimensionally Stacked Dram Memory, Ratnesh Raj

Mechanical and Aerospace Engineering Theses - Archive

A large fraction of energy consumed in modern microelectronic devices and systems is taken up by memory access operations, which is expected to cause significant temperature rise. Since memory access operations are very short this is expected to inherently be a transient thermal phenomenon. Despite the critical importance of thermal management in microelectronics, not much work exists on understanding the nature of thermal transport during memory access operations. In this work, a mathematical model to predict the transient temperature rise within a 3D layered memory chip is presented. Most heat-generating memory access processes occur over a short timescale for which …

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Numerical Simulation Of Flow In Fluidic Valves In Rotating Detonation Engines, Nandini Gopalakrishnan Aug 2017

Numerical Simulation Of Flow In Fluidic Valves In Rotating Detonation Engines, Nandini Gopalakrishnan

Mechanical and Aerospace Engineering Theses - Archive

Rotating detonation engines (RDE) have received considerable research attention in recent times for use in propulsion systems. The cycle frequency of operation of an RDE can be as high as 10,000 Hz. Conventional mechanical valves cannot operate at such high frequencies, leading to the need for propellant injectors or valves with no moving parts. A fluidic valve is such a valve and is the focus of this study. The valve consists of an orifice connected to a constant area plenum cavity which operates at constant pressure. The fluidic valve supplies propellants to the detonation tube through the orifice. Hydrogen – …

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Investigation Of Microstructure Effects On Hardness And Oxidation Resistance Of New Generation Ceramic Coatings, Minghui Zhang Aug 2017

Investigation Of Microstructure Effects On Hardness And Oxidation Resistance Of New Generation Ceramic Coatings, Minghui Zhang

Material Science and Engineering Dissertations - Archive

This work was motivated by the demand for a new generation of materials capable for harsh environment applications, and focused on developing a better understanding of the effects of elemental composition and microstructure on the mechanical and thermal properties of coatings. The knowledge gained from this work can be used to design protective coatings with tailored properties for harsh environment applications in the future. High resolution transmission electron microscopy (HRTEM) and electron diffraction have been mainly employed in the microstructure studies of the new generation ceramics, with the assistance of other materials characterization techniques, such as x-ray diffraction (XRD), x-ray …

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Metabolic, Hemodynamic And Electrophysiological Effects Of Transcranial Photobiomodulation (Tpbm) On The Human Brain, Xinlong Wang Aug 2017

Metabolic, Hemodynamic And Electrophysiological Effects Of Transcranial Photobiomodulation (Tpbm) On The Human Brain, Xinlong Wang

Bioengineering Dissertations - Archive

Photobiomodulation (PBM) refers to the use of red-to-near-infrared light to stimulate cellular functions for physiological or clinical benefits. Transcranial photobiomodulation (tPBM) is a noninvasive form of cerebral photobiomodulation that has been observed with various improvements in human cognitive functions. The mechanism of tPBM is assumed to rely on photon absorption by cytochrome c oxidase (CCO), the terminal enzyme in the mitochondrial respiratory chain that catalyzes the reduction of oxygen for energy metabolism. However, few studies have objectively investigated hemodynamic, metabolic and electrophysiological response of the human brain to tPBM. To address this gap, my dissertation research has focused on objective …

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Understanding Key Genetic Mutations And Molecular Alterations On Increasing Migration, Viability, Drug Resistance Of Malignant Brain Tumor In Confinement, Loan Thuy Bui Aug 2017

Understanding Key Genetic Mutations And Molecular Alterations On Increasing Migration, Viability, Drug Resistance Of Malignant Brain Tumor In Confinement, Loan Thuy Bui

Bioengineering Dissertations - Archive

There are more than 120 types of primary brain and central nervous system tumors that affect people of all ages. Glioblastoma multiforme (GBM), for example, is the most frequent type of brain cancers and also among the deadliest of all cancers due to its high invasiveness and resistance to radiation and chemotherapy. Recently, most genetic mutations of malignant brain tumors have been well characterized, but the focus on migrating cancers that directly cause invasion is still in its infancy. We have learned from the literature that most glioma cells infiltrate surrounding brain tissue via by the confined tracks, and fascinated …

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