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Full-Text Articles in Engineering

Feasibility Study: Application Of Steel Sheet-Piles For The Abutment Of Water-Crossing Bridges In Nebraska, Seunghee Kim, Jongwan Eun, Chung R. Song, Chungwook Sim, Hung Phi Van, Basil Abualshar, Ramin Ziaei Tabari May 2023

Feasibility Study: Application Of Steel Sheet-Piles For The Abutment Of Water-Crossing Bridges In Nebraska, Seunghee Kim, Jongwan Eun, Chung R. Song, Chungwook Sim, Hung Phi Van, Basil Abualshar, Ramin Ziaei Tabari

Nebraska Department of Transportation: Research Reports

The overall goal of this study is to investigate the anticipated performance of steel sheet-pile bridge abutments to encourage its wider application to not only new construction but also repair and replacement of existing water-crossing bridges in Nebraska. For this purpose, this study first reviewed several bridge cases with axially loaded sheet pile abutments, as well as previous in-depth studies related to the bearing capacity of sheet piles. Then, this study conducted the large-scale direct shear tests to better understand the interaction between sheet pile and soil. As a result, about four-fifths of the internal friction angle of fill sand …


Point Heat Source Correlation To Microstructural Evolution In Advanced Manufacturing, Mark Anderson May 2023

Point Heat Source Correlation To Microstructural Evolution In Advanced Manufacturing, Mark Anderson

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Although there are different ways that advanced manufacturing can be performed, the use of single-point heat sources has become the standard to control a final product’s properties. It is imperative to understand how the heat source used in the different advanced manufacturing processes affect the microstructure of interest. The intimate relationship between the heat source and microstructure allows for controlling and tailoring a part’s properties. Utilizing different microstructural analysis, the cross-correlation of various point heat sources to developed microstructure was conducted in this dissertation.

Laser powder bed fusion allows for unique print-to-part protocols, but the dynamics of the process makes …


Assessment Of Bridge Pier Response To Fire, Vehicle Impact, And Air Blast, Chen Fang, Qusai Alomari, Daniel G. Linzell May 2023

Assessment Of Bridge Pier Response To Fire, Vehicle Impact, And Air Blast, Chen Fang, Qusai Alomari, Daniel G. Linzell

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Highway bridges exposed to intentional or unintentional fire followed by combined vehicle impact and air blast are at risk of significant damage and, possibly, collapse. Limited studies examining the complex effects of these extreme demands on bridge support elements and parametrizing their response and damage are found in the open literature. Research that is presented is part of an ongoing numerical investigation examining round, multi-column, reinforced concrete (RC), bridge pier behavior subject to multi-hazard scenarios involving fire, vehicle impact, and air blast. Detailed nonlinear finite element analysis models of single columns and multi-column piers supported by a pile foundation system …


Program And Proceedings: Nebraska Academy Of Sciences 1880–2023, 143rd Anniversary Year, One Hundred-Thirty-Third Annual Meeting, April 21, 2023 May 2023

Program And Proceedings: Nebraska Academy Of Sciences 1880–2023, 143rd Anniversary Year, One Hundred-Thirty-Third Annual Meeting, April 21, 2023

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Humans Past and Present

Applied Science and Technology Section

Biology

Biomedical Sciences

Chemistry

Earth Sciences

Environmental Science

Physics

Science Education

2023 Maiben Lecture: Jason Bartz

2023 Friend of Science Award: Ray Ward and Jim Lewis


Modeling And Visualization Of Competing Escalation Dynamics: A Multilayer Multiagent Network Approach, Josh Allen May 2023

Modeling And Visualization Of Competing Escalation Dynamics: A Multilayer Multiagent Network Approach, Josh Allen

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

Recent advances in military technology, such as hypersonic missiles, which can travel at more than five times the speed of sound and descend quickly into the atmosphere, give world nuclear superpowers a new edge. These advances up the game for nuclear superpowers with an extremely rapid, intense burst of military striking capability to secure upfront gains before encountering potentially overwhelming military confrontation. However, this so-called fait accompli has not been systematically studied by the United States in the perspective of the escalation philosophies of nuclear power competitors, or the mathematical modeling and visualization of multi-modal escalation dynamics. This gap may …


Leveraging Aruco Fiducial Marker System For Bridge Displacement Estimation Using Unmanned Aerial Vehicles, Mohamed Aly May 2023

Leveraging Aruco Fiducial Marker System For Bridge Displacement Estimation Using Unmanned Aerial Vehicles, Mohamed Aly

School of Computing: Dissertations, Theses, and Student Research

The use of unmanned aerial vehicles (UAVs) in construction sites has been widely growing for surveying and inspection purposes. Their mobility and agility have enabled engineers to use UAVs in Structural Health Monitoring (SHM) applications to overcome the limitations of traditional approaches that require labor-intensive installation, extended time, and long-term maintenance. One of the critical applications of SHM is measuring bridge deflections during the bridge operation period. Due to the complex remote sites of bridges, remote sensing techniques, such as camera-equipped drones, can facilitate measuring bridge deflections. This work takes a step to build a pipeline using the state-of-the-art computer …


Sim-To-Real Reinforcement Learning Framework For Autonomous Aerial Leaf Sampling, Ashraful Islam May 2023

Sim-To-Real Reinforcement Learning Framework For Autonomous Aerial Leaf Sampling, Ashraful Islam

School of Computing: Dissertations, Theses, and Student Research

Using unmanned aerial systems (UAS) for leaf sampling is contributing to a better understanding of the influence of climate change on plant species, and the dynamics of forest ecology by studying hard-to-reach tree canopies. Currently, multiple skilled operators are required for UAS maneuvering and using the leaf sampling tool. This often limits sampling to only the canopy top or periphery. Sim-to-real reinforcement learning (RL) can be leveraged to tackle challenges in the autonomous operation of aerial leaf sampling in the changing environment of a tree canopy. However, trans- ferring an RL controller that is learned in simulation to real UAS …


Irrigation-As-A-Service For Smallholder Farmers, Ishani Lal May 2023

Irrigation-As-A-Service For Smallholder Farmers, Ishani Lal

Department of Agricultural Economics: Dissertations, Theses, and Student Research

Irrigation is a crucial management practice that can help increase food security among smallholders globally while mitigating climate change impacts. High-efficiency irrigation technologies such as drip kits and sprinkler systems are relatively expensive and smallholder farmers cannot afford them to buffer crop yields against low precipitation. In many developing countries, farmers participate in robust informal markets for renting and sharing of irrigation equipment. Such services may be operated by farmers or via a third party such as irrigation start-ups, water user associations, non-governmental organizations, or even government agencies. These services are referred to collectively as Irrigation-as-a-Service (IaaS).

The objective of …


Engineering Of Microparticle Encapsulated Antioxidant To Mitigate Oxidative Stress In Vitro And In Vivo, Kayla Ney May 2023

Engineering Of Microparticle Encapsulated Antioxidant To Mitigate Oxidative Stress In Vitro And In Vivo, Kayla Ney

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Chronic low back pain (cLBP) is one of the leading causes of years lived with disability in the United States. Current treatments for cLBP have variable results across the patient population, and many patients struggle to find consistent relief. Most current treatments focus on the symptom of pain, not the root cause. In painful degenerated discs, oxidative stress and inflammation function in a vicious cycle and perpetuate degeneration, damage, and pain. Therefore, oxidative stress and inflammation are important targets in addressing the source of pain. This work characterizes an antioxidant, BuOE, encapsulated in a chondroitin sulfate microparticle as a novel …


Innovation For The Air: A Brief History Of Worldwide Aviation, Lauren Plumley May 2023

Innovation For The Air: A Brief History Of Worldwide Aviation, Lauren Plumley

Honors Program: Senior Projects (Public)

The purpose of this report is to present a brief but comprehensive overview of the variety of innovations related to aviation, and to discuss their impact on scientific progress over the course of human history. Relevant discoveries from the fields of physics and aerodynamics, and the numerous technologies built based upon these discoveries, are discussed over a period ranging from ancient times to the twenty-first century. The scope of this report is an overview of the development of powered and unpowered aircraft, including lighter-than-air, heavier-than-air, and aerospace technologies. Aviation developments were generally not limited to one specific country or person, …


Reducing Infiltration And Inflow In Small Collection Systems: Environmental, Economic, And Other Impacts, Andrew Hansen May 2023

Reducing Infiltration And Inflow In Small Collection Systems: Environmental, Economic, And Other Impacts, Andrew Hansen

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Wastewater treatment facilities (WWTFs) and the collection systems (CSs) which feed them provide essential services to society by collecting sewage (aka wastewater), biologically treating it, and minimizing risks to human health as well as the impact of waste on the environment. However, as collection systems age, increasing infiltration and inflow (I/I) from groundwater and stormwater can negatively affect the system. I/I is often mitigated to reduce flow and eliminate other negative impacts to the system.

Ten total case studies, seven mechanical water resource recovery facilities (WRRFs) and three lagoon facilities, were examined for the environmental, economic, and other impacts/benefits from …


Sustainable Revitalization Of Asphalt Pavements: An In-Depth Analysis Of Enhancing The Performance Of Asphalt Binder Through The Application Of Rheological And Molecular Dynamics Simulation Techniques, Muhammad Ahmad May 2023

Sustainable Revitalization Of Asphalt Pavements: An In-Depth Analysis Of Enhancing The Performance Of Asphalt Binder Through The Application Of Rheological And Molecular Dynamics Simulation Techniques, Muhammad Ahmad

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Vegetable-based oils such as corn and soybean oil have triglycerides and fatty acids that allow them to be considered sustainable and effective recycling agents (RAs) for aged asphalt binder. However, there are concerns about their effect on the recycled asphalt binder's long-term performance, moisture damage resistance, and self-healing characteristics restoration. In this study, crude corn oil (CO) and crude soybean oil (SO) were used as RAs to restore the performance of a reclaimed asphalt binder (RAB) extracted from reclaimed asphalt pavement. The binder extracted from RAB was modified with a neat binder PG64-28 and RAs to restore the high-end performance …


Assessing The Performance Of High-Rap Mixtures Incorporating Crude Vegetable Oils And An Antioxidant From Mechanical, Environmental, And Economic Perspectives, Nitish R. Bastola May 2023

Assessing The Performance Of High-Rap Mixtures Incorporating Crude Vegetable Oils And An Antioxidant From Mechanical, Environmental, And Economic Perspectives, Nitish R. Bastola

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Utilization of mixtures with high amounts of reclaimed asphalt pavement (RAP) in the pavement industry is limited because of the adverse effects of aged materials in recycled asphalt materials. To date, numerous approaches have been used to reduce the adversity of RAP in mixtures. One such approach is the use of recycling agents (RAs) from various sources, such as petroleum and bio-oil. However, the current need is to maximize the use of RAP by adopting a sustainable source of RAs. Therefore, this study uses two RAs based on vegetable oils (crude soybean oil and crude corn oil) with high-RAP mixtures …


Design Of A Miniature Robotic Surgery Technology Demonstration Payload For Orbital Spaceflight, Rachael A. Wagner May 2023

Design Of A Miniature Robotic Surgery Technology Demonstration Payload For Orbital Spaceflight, Rachael A. Wagner

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

This thesis describes the design of a technology demonstration payload that will test robotic surgery while aboard a 2024 expedition of the International Space Station (ISS). The payload utilizes a new miniature surgical robot to complete simulated surgical tasks on orbit, both autonomously and while remotely controlled by an Earth-based user. The experiment investigates the effects of microgravity and latency on robotic surgery, with the following goals:

1. Demonstrate the use of a miniature robotic surgical system in microgravity through performing simulated surgical tasks.

2. Quantify the effects of microgravity on robotic surgical techniques including forces, torques, and kinematic accuracy. …


Blood Flow Regulates Atherosclerosis Progression And Regression, Morgan A. Schake May 2023

Blood Flow Regulates Atherosclerosis Progression And Regression, Morgan A. Schake

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Atherosclerosis is the most prevalent pathology of cardiovascular disease with no known cure. Despite the many systemic risk factors for atherosclerosis, plaques do not form randomly in the vasculature. Instead, they form around bifurcations and the inner curvature of highly curving arterial segments that contain so-called disturbed blood flow that is low in magnitude and multidirectional over the cardiac cycle. Conversely, straight, non-bifurcated arterial segments that contain moderate-to-high and unidirectional (i.e., normal) blood flow are protected from plaque development. Thus, blood flow is a key regulator of atherosclerosis that may be able to be leveraged to develop new therapeutics. Towards …


Energy Efficient Integrated Mems Neural Network For Simultaneous Sensing And Computing, Hamed Nikfarjam, Mohammad Megdadi, Mohammad Okour, Siavash Pourkamali, F. M. Alsaleem Apr 2023

Energy Efficient Integrated Mems Neural Network For Simultaneous Sensing And Computing, Hamed Nikfarjam, Mohammad Megdadi, Mohammad Okour, Siavash Pourkamali, F. M. Alsaleem

Durham School of Architectural Engineering and Construction: Faculty Publications

Biological systems seamlessly combine multiple functions in lightweight and energy-efficient structures. Such capability in synthetic structures would be desirable in numerous engineering applications such as aerospace, robotics and wearable devices. Here we report an integrated silicon-based structure configured to sense, perform different classification algorithms, and produce an action signal within the same physical layer. The algorithms are coded in the mechanical responses of the sensing elements of multiple coupled micro-electromechanical systems (MEMS), simultaneously capturing acceleration measurements to produce an actuated signal. This all-in-one structure operates with zero circuitry and low power consumption. As a demonstration, we designed and fabricated a …


Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu Apr 2023

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …


Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu Apr 2023

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …


Multiple Case Study Of Science And Engineering Integration In Secondary School Across Six School Districts, Elizabeth Hasseler, Elizabeth B. Lewis Apr 2023

Multiple Case Study Of Science And Engineering Integration In Secondary School Across Six School Districts, Elizabeth Hasseler, Elizabeth B. Lewis

Department of Teaching, Learning, and Teacher Education: Faculty Publications

A multiple case study was conducted to investigate six districts’ approaches to integrating science and engineering curricula in their secondary education programs. Data collected included classroom observations, interviews with teachers and administrators, college transcripts, professional development, and curriculum, as well as how, and how district personnel supported, and teachers enacted classroom instruction to align with the Next Generation Science Standards (NGSS). Six districts were chosen due to their ranges in their size, urban or rural context, and demographics. There were 25 participants in the study who were either district personnel or secondary teachers. All school districts in the study incorporated …


Considering The Influence Of Coronary Motion On Artery‑Specific Biomechanics Using Fluid–Structure Interaction Simulation, Nicholas A. T. Fogell, Miten Patel, Pan Yang, Roosje M. Ruis, David B. Garcia, Jarka Naser, Fotios Savvopoulos, Clint Davies Taylor, Anouk L. Post, Ryan M. Pedrigi, Ranil De Silva, Rob Krams Apr 2023

Considering The Influence Of Coronary Motion On Artery‑Specific Biomechanics Using Fluid–Structure Interaction Simulation, Nicholas A. T. Fogell, Miten Patel, Pan Yang, Roosje M. Ruis, David B. Garcia, Jarka Naser, Fotios Savvopoulos, Clint Davies Taylor, Anouk L. Post, Ryan M. Pedrigi, Ranil De Silva, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

The endothelium in the coronary arteries is subject to wall shear stress and vessel wall strain, which influences the biology of the arterial wall. This study presents vessel-specific fluid–structure interaction (FSI) models of three coronary arteries, using directly measured experimental geometries and boundary conditions. FSI models are used to provide a more physiologically complete representation of vessel biomechanics, and have been extended to include coronary bending to investigate its effect on shear and strain. FSI both without- and with-bending resulted in significant changes in all computed shear stress metrics compared to CFD (p = 0.0001). Inclusion of bending within …


Science Club, Danielle Gibson, Krista Andersen Apr 2023

Science Club, Danielle Gibson, Krista Andersen

Honors Program: Expanded Learning Clubs

Honors After School program for elementary age children to engage with scientific principles. Students performed hands-on experiments to explore various STEM fields. Each weekly lesson consisted of a different concept to be learned or explored by early elementary aged students.


Reconfigurable Metatiles With Circular Maze-Like Space-Coiling-Based Acoustic Metastructure For Low-To-Mid Frequency Sound Attenuation, Sanjay Kumar, Heow Pueh Lee Apr 2023

Reconfigurable Metatiles With Circular Maze-Like Space-Coiling-Based Acoustic Metastructure For Low-To-Mid Frequency Sound Attenuation, Sanjay Kumar, Heow Pueh Lee

Durham School of Architectural Engineering and Construction: Faculty Publications

This study presents a compact, lightweight, and reconfigurable acoustic metatile for sound mitigation applications. The metatile prototype is designed based on a circular maze-like acoustic metastructure, which utilizes a space-coiling technique for enhanced acoustic performance in low-to-mid frequencies. The proposed labyrinthine acoustic metadisk structure comprises a central hollow front face sheet and two coiling-up backing cavities. Experimental results show that the metadisk has high absorption peaks of 0.81 and 0.75 at 574 and 1436 Hz, respectively, and exhibits high sound transmission loss (STL) values (≥25 dB) in separate wide frequency bands between 100–580 Hz and 820–1600 Hz. Based on the …


A Threshold Helium Leakage Detection Switch With Ultra Low Power Operation, Sulaiman Mohaidat, Fadi M. Alsaleem Apr 2023

A Threshold Helium Leakage Detection Switch With Ultra Low Power Operation, Sulaiman Mohaidat, Fadi M. Alsaleem

Department of Mechanical and Materials Engineering: Faculty Publications

Detecting helium leakage is important in many applications, such as in dry cask nuclear waste storage systems. This work develops a helium detection system based on the relative permittivity (dielectric constant) difference between air and helium. This difference changes the status of an electrostatic microelectromechanical system (MEMS) switch. The switch is a capacitive-based device and requires a very negligible amount of power. Exciting the switch’s electrical resonance enhances the MEMS switch sensitivity to detect low helium concentration. This work simulates two different MEMS switch configurations: a cantilever-based MEMS modeled as a single-degreefreedom model and a clamped-clamped beam MEMS molded using …


Potential Bioavailability Of Representative Pyrogenic Organic Matter Compounds In Comparison To Natural Dissolved Organic Matter Pools, Emily B. Graham, Hyun-Seob Song, Samantha Grieger, Vanessa A. Garayburu-Caruso, James C. Stegen, Kevin D. Bladon, Allison N. Myers-Pigg Apr 2023

Potential Bioavailability Of Representative Pyrogenic Organic Matter Compounds In Comparison To Natural Dissolved Organic Matter Pools, Emily B. Graham, Hyun-Seob Song, Samantha Grieger, Vanessa A. Garayburu-Caruso, James C. Stegen, Kevin D. Bladon, Allison N. Myers-Pigg

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Pyrogenic organic matter (PyOM) from wildfires impacts river corridors globally and is widely regarded as resistant to biological degradation. Though recent work suggests PyOM may be more bioavailable than historically perceived, estimating bioavailability across its chemical spectrum remains elusive. To address this knowledge gap, we assessed potential bioavailability of representative PyOM compounds relative to ubiquitous dissolved organic matter (DOM) with a substrate-explicit model. The range of potential bioavailability of PyOM was greater than natural DOM; however, the predicted thermodynamics, metabolic rates, and carbon use efficiencies (CUEs) overlapped significantly between all OM pools. Compound type (e.g., natural versus PyOM) had approximately …


Deficit Irrigation Management For Irrigated Corn In Nebraska: Economically Viable?, Lia Nogueira, Cory Walters, Emily O'Donnell, E. Wesley F. Peterson, Suat Irmak Apr 2023

Deficit Irrigation Management For Irrigated Corn In Nebraska: Economically Viable?, Lia Nogueira, Cory Walters, Emily O'Donnell, E. Wesley F. Peterson, Suat Irmak

Cornhusker Economics

In this study we determine the economic value of deficit irrigation management using both technological and methodological advancements. The use of soil moisture probes represents the technological improvement. We provide improvements in the methodology as follows. Regarding data, we employ a field-size study, instead of plots, where the irrigation decision is determined by the moisture level in the soil measured through a soil moisture probe. Regarding the understanding of the yield response to water, although we examine the commonly used quadratic function, we improve upon this specification by also examining an alternative response function, the linear response stochastic plateau. Our …


Structural Testing Of Concrete Walls On-Edge With Combined Axial And Out-Of-Plane Loading, Salam Al-Rubaye, Marc Maguire Apr 2023

Structural Testing Of Concrete Walls On-Edge With Combined Axial And Out-Of-Plane Loading, Salam Al-Rubaye, Marc Maguire

Durham School of Architectural Engineering and Construction: Faculty Publications

Full-scale testing of structural components can be time consuming and difficult. The design of full- scale slender concrete walls is highly influenced and controlled by second-order and out-of-plane bending loads. Previous experiments on out-plane bending of slender walls and insulated walls have been performed with bending in the direction of gravity (with or against). Additionally, most of the research considering out-of-plane bending does not include an axial load and suffers from inaccurate results due to not simulating the actual loading and constraining conditions or safety issues. This testing method was developed expressly for the determination of slender wall behavior in …


Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki Apr 2023

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …


Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki Apr 2023

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …


Mitochondrial Complex Iii Bypass Complex I To Induce Ros In Gpr17 Signaling Activation In Gbm, Sana Kari, Jeyalakshmi Kandhavelu, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Meenakshisundaram Kandhavelu Apr 2023

Mitochondrial Complex Iii Bypass Complex I To Induce Ros In Gpr17 Signaling Activation In Gbm, Sana Kari, Jeyalakshmi Kandhavelu, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Meenakshisundaram Kandhavelu

Department of Chemical and Biomolecular Engineering: Faculty Publications

Guanine nucleotide binding protein (G protein) coupled receptor 17 (GPR17) plays crucial role in Glioblastoma multiforme (GBM) cell signaling and is primarily associated with reactive oxidative species (ROS) production and cell death. However, the underlying mechanisms by which GPR17 regulates ROS level and mitochondrial electron transport chain (ETC) complexes are still unknown. Here, we investigate the novel link between the GPR17 receptor and ETC complex I and III in regulating level of intracellular ROS (ROSi) in GBM using pharmacological inhibitors and gene expression profiling. Incubation of 1321N1 GBM cells with ETC I inhibitor and GPR17 agonist decreased the ROS level, …


Crystalline–Amorphous Nanostructures: Microstructure, Property And Modelling, Binqiang Wei, Lin Li, Lin Shao, Jian Wang Apr 2023

Crystalline–Amorphous Nanostructures: Microstructure, Property And Modelling, Binqiang Wei, Lin Li, Lin Shao, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Crystalline metals generally exhibit good deformability but low strength and poor irradiation tolerance. Amorphous materials in general display poor deformability but high strength and good irradiation tolerance. Interestingly, refining characteristic size can enhance the flow strength of crystalline metals and the deformability of amorphous materials. Thus, crystalline–amorphous nanostructures can exhibit an enhanced strength and an improved plastic flow stability. In addition, high-density interfaces can trap radiation-induced defects and accommodate free volume fluctuation. In this article, we review crystalline–amorphous nanocomposites with characteristic microstructures including nanolaminates, core–shell microstructures, and crystalline/amorphous-based dual-phase nanocomposites. The focus is put on synthesis of characteristic microstructures, deformation …