Engineering Commons^™

Synthesis And Characterization Of Poly(Simvastatin) - Incorporated Copolymers And Blends For Bone Regeneration, Theodora Asafo-Adjei

Theses and Dissertations--Biomedical Engineering

Common biodegradable polyesters such as poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) and poly(ε-caprolactone) (PCL) are used as drug delivery vehicles for tissue regenerative applications. However, they are typically bioinert, with drug loading limitations. Polymerizing the active agent or precursor into its respective biodegradable polymer would control drug loading via molar ratios of drug to initiator used for synthesis. Simvastatin was chosen due to its favorable anti-inflammatory, angiogenic, and osteogenic properties. In addition, its lactone ring lends itself to ring-opening polymerization and, consequently, the synthesis of poly(simvastatin) with controlled simvastatin release.

Simvastatin was first polymerized with a 5kDa methyl-terminated poly(ethylene glycol) …

Validation, Optimization, And Image Processing Of Spiral Cine Dense Magnetic Resonance Imaging For The Quantification Of Left And Right Ventricular Mechanics, Gregory J. Wehner

Theses and Dissertations--Biomedical Engineering

Recent evidence suggests that cardiac mechanics (e.g. cardiac strains) are better measures of heart function compared to common clinical metrics like ejection fraction. However, commonly-used parameters of cardiac mechanics remain limited to just a few measurements averaged over the whole left ventricle. We hypothesized that recent advances in cardiac magnetic resonance imaging (MRI) could be extended to provide measures of cardiac mechanics throughout the left and right ventricles (LV and RV, respectively).

Displacement Encoding with Stimulated Echoes (DENSE) is a cardiac MRI technique that has been validated for measuring LV mechanics at a magnetic field strength of 1.5 T but …

The Impact Of Owner Practices And Procedures On Construction Project Safety Performance, Huang Liu

Theses and Dissertations--Civil Engineering

Construction sites are dangerous work environments. One traditional assumption prevails in the construction industry that construction safety should be the sole responsibility of the contractor. However, some safety researchers gradually begin to challenge this assumption. The elementary research in this field try to validate the existence of relationship of the owner’s practices and safety performance, which indicates that the involvements of the owner have a positive impact on improvement of safety performance. Therefore, the owner can and should take a responsibility of the project safety. Some subsequent research focus on collecting and summarizing the best safety practices and procedures of …

Safety-Based Guidelines For Left-Turn Phasing Decisions With Negative Binomial Regression, Kiriakos Amiridis

Theses and Dissertations--Civil Engineering

The efficient and safe movement of traffic at signalized intersections is the primary objective of any signal phasing and timing plan. Accommodation of left turns is more critical due to the higher need for balancing operations and safety. The objective of this study is to develop models to estimate the safety impacts of the use of left-turn phasing schemes. The models are based on data from 200 intersections in urban areas in Kentucky. For each intersection, approaches with a left-turn lane were isolated and considered with their opposing through approach in order to examine the left-turn related crashes. This combination …

Pavement Condition Index And Cost Of Ownership Analysis On Preventative Maintenance Projects In Kentucky, Dominic J. Michels

Theses and Dissertations--Civil Engineering

The Commonwealth of Kentucky has seen increasing use over time of preventative maintenance treatments on its asphalt pavements. Performance of two of the most prevalent treatments employed by the Kentucky Transportation Cabinet (KYTC) – Thin Asphalt Overlay (Thinlay) and Microsurfacing – had yet to be examined in-depth through condition surveys. This thesis describes the data collection process to find the Pavement Condition Index (PCI) of each preventative maintenance site in Kentucky from the last 10 years. With PCI from each site, deterioration curves were generated for each treatment – providing the estimated life extension benefit of each. The analysis then …

Incorporating Travel Time Reliability Into Transportation Network Modeling, Xu Zhang

Theses and Dissertations--Civil Engineering

Travel time reliability is deemed as one of the most important factors affecting travelers’ route choice decisions. However, existing practices mostly consider average travel time only. This dissertation establishes a methodology framework to overcome such limitation.

Semi-standard deviation is first proposed as the measure of reliability to quantify the risk under uncertain conditions on the network. This measure only accounts for travel times that exceed certain pre-specified benchmark, which offers a better behavioral interpretation and theoretical foundation than some currently used measures such as standard deviation and the probability of on-time arrival.

Two path finding models are then developed by …

Analytical Strip Method For Thin Cylindrical Shells, John T. Perkins

Theses and Dissertations--Civil Engineering

The Analytical Strip Method (ASM) for the analysis of thin cylindrical shells is presented in this dissertation. The system of three governing differential equations for the cylindrical shell are reduced to a single eighth order partial differential equation (PDE) in terms of a potential function. The PDE is solved as a single series form of the potential function, from which the displacement and force quantities are determined. The solution is applicable to isotropic, generally orthotropic, and laminated shells. Cylinders may have simply supported edges, clamped edges, free edges, or edges supported by isotropic beams. The cylindrical shell can be stiffened …

Quantitative Analysis Of The Impact Of Craft Labor Availability On Construction Project Performance, Hossein Karimi

Theses and Dissertations--Civil Engineering

A shortage of skilled craft labor in the North American construction industry has been an unfortunate cyclic trend since the late 1980s. This shortage has been reported and discussed frequently by numerous past studies in the context of construction industry. The 2008 U.S. recession was at least one period when the craft shortage temporarily improved, as witnessed by spikes in construction unemployment rates above 20% due to the work slowdowns. However, the current economic recovery period is once again experiencing craft shortages in some sectors of the U.S. construction industry. Although the past literature provides wealth of information about influence …

Segment-Based Reliability Assessment For Water Distribution Networks, Erika Hernandez Hernandez

Theses and Dissertations--Civil Engineering

In recent years, water utilities have placed a greater emphasis on the reliability and resilience of their water distribution networks. This focus has increased due to the continuing aging of such infrastructure and the potential threat of natural or man-made disruptions. As a result, water utilities continue to look for ways to evaluate the resiliency of their systems with a goal of identifying critical elements that need to be reinforced or replaced. The simulation of pipe breaks in water reliability studies is traditionally modeled as the loss of a single pipe element. This assumes that each pipe has an isolation …

3d Body Tracking Using Deep Learning, Qingguo Xu

Theses and Dissertations--Computer Science

This thesis introduces a 3D body tracking system based on neutral networks and 3D geometry, which can robustly estimate body poses and accurate body joints. This system takes RGB-D data as input. Body poses and joints are firstly extracted from color image using deep learning approach. The estimated joints and skeletons are further translated to 3D space by using camera calibration information. This system is running at the rate of 3 4 frames per second. It can be used to any RGB-D sensors, such as Kinect, Intel RealSense [14] or any customized system with color depth calibrated. Comparing to the …

Tunable Nanocomposite Membranes For Water Remediation And Separations, Sebastián Hernández Sierra

Theses and Dissertations--Chemical and Materials Engineering

Nano-structured material fabrication using functionalized membranes with polyelectrolytes is a promising research field for water pollution, catalytic and mining applications. These responsive polymers react to external stimuli like temperature, pH, radiation, ionic strength or chemical composition. Such nanomaterials provide novel hybrid properties and can also be self-supported in addition to the membranes.

Polyelectrolytes (as hydrogels) have pH responsiveness. The hydrogel moieties gain or lose protons based on the pH, displaying swelling properties. These responsive materials can be exploited to synthesize metal nanoparticles in situ using their functional groups, or to immobilize other polyelectrolytes and biomolecules. Due to their properties, these …

Impact Of Climate Change On Extreme Hydrological Events In The Kentucky River Basin, Somsubhra Chattopadhyay

Theses and Dissertations--Biosystems and Agricultural Engineering

Anthropogenic activities including urbanization, rapid industrialization, deforestation and burning of fossil fuels are broadly agreed on as primary causes for ongoing climate change. Scientists agree that climate change over the next century will continue to impact water resources with serious implications including storm surge flooding and a sea level rise projected for North America. To date, the majority of climate change studies conducted across the globe have been for large-sized watersheds; more attention is required to assess the impact of climate change on smaller watersheds, which can help to better frame sustainable water management strategies.

In the first of three …

A Portable Sensor For Measuring Gas Emissions From Dairy Compost Bedded Pack Barns, Katharine Wolf

Theses and Dissertations--Biosystems and Agricultural Engineering

The objective of this study was to develop a gas measurement chamber for the comparison of emissions from different dairy manure storage facilities. Compost bedded pack (CBP) barns are a loose housing system in which cows rest on an intensely managed compost pack. Sawdust is the primary material added to the system, along with manure and urine inputs from the cows, and the pack is stirred one to two times daily. Maintaining a high level of aerobic microbial activity in the pack is critical for cow health. Previous dairy emissions work has not included compost bedded pack barns; it was …

Fractionation And Characterization Of Lignin Streams From Genetically Engineered Switchgrass, Enshi Liu

Theses and Dissertations--Biosystems and Agricultural Engineering

Development of biomass feedstocks with desirable traits for cost-effective conversion is one of the main focus areas in biofuels research. As suggested by techno-economic analyses, the success of a lignocellulose-based biorefinery largely relies on the utilization of lignin to generate value-added products, i.e. fuels and chemicals. The fate of lignin and its structural/compositional changes during pretreatment have received increasing attention; however, the effect of genetic modification on the fractionation, depolymerization and catalytic upgrading of lignin from genetically engineered plants is not well understood. This study aims to fractionate and characterize the lignin streams from a wild-type and two genetically engineered …

Relative Cross Track Error Calculations In Asabe/Iso 12188-2:2012 And Power/Energy Analysis Using A 20 Hp Tractor On A Fully Electric Drivetrain, Joseph D. Rounsaville

Theses and Dissertations--Biosystems and Agricultural Engineering

ASABE/ISO Standard 12188-2 provides test procedures for positioning and guidance systems in agricultural vehicles during straight and level travel. The standard provides excellent descriptions of test procedures, however it does not provide detail on methods to carry out the calculations necessary to calculate relative cross-track error (XTE), which is the primary measurement used to judge accuracy of the system. The standard was used to estimate the guidance accuracy of a relatively low-accuracy vehicle at 1.25 and 0.5 m s^-1. At 1.25 m s^-1, a nearest point calculation overestimated mean XTE by 0.8 cm, or 8.2%. The …

Using The Vehicle Routing Problem (Vrp) To Provide Logistics Solutions In Agriculture, Hasan Seyyedhasani

Theses and Dissertations--Biosystems and Agricultural Engineering

Agricultural producers consider utilizing multiple machines to reduce field completion times for improving effective field capacity. Using a number of smaller machines rather than a single big machine also has benefits such as sustainability via less compaction risk, redundancy in the event of an equipment failure, and more flexibility in machinery management. However, machinery management is complicated due to logistics issues.

In this work, the allocation and ordering of field paths among a number of available machines have been transformed into a solvable Vehicle Routing Problem (VRP). A basic heuristic algorithm (a modified form of the Clarke-Wright algorithm) and a …

Assessment Of Potential Impacts To Subsurface Bodies Of Water Due To Underground Coal Mining, Gabriel Bode-Jimenez

Theses and Dissertations--Mining Engineering

Underground coal mining operations induce ground movements, which may impact overlying hydrogeologic systems. Potential impacts mainly include changes in the hydraulic conductivity of overlying strata, decreasing of the hydraulic head and changes in water flow. The present research quantifies potential hydrogeologic impacts caused by underground mining through modeling of pre- and post-mining hydrogeologic systems.

Three-dimensional conceptual hydrogeologic models were constructed with the Processing Modflow for Windows software package (PMWiN). The models are based on an actual case study, but were simplified in terms of geometry and material properties. Water flow was simulated under changing hydrogeologic properties. A number of scenarios …

Surface Chemisty Study Of Monazite Flotation In Coal Refuse Systems, Wencai Zhang

Theses and Dissertations--Mining Engineering

Rare earth mineral recovery from alternative resources such as coal and coal byproducts is increasingly important to provide an opportunity for economic recovery from U.S. sources. Currently, China produces the majority of the 149,000 tons of rare earth elements used annually worldwide of which the U.S. imports 11% or around 16,000 tons. There are no significant mining operations producing rare earth elements in the U.S. However, there are many U.S. sources containing rare earth minerals such as monazite including heavy mineral sand and phosphate operations. Monazite mineral particles of a few microns have also been detected in Fire Clay seam …

Calculation Of The Edge Effect Offset For High Extraction Coal Panels, Joshua Hescock

Theses and Dissertations--Mining Engineering

The Surface Deformation Prediction System (SDPS) program has been developed as an engineering tool for the prediction of subsidence deformation indices through the implementation of an influence function. SDPS provides reliable predictions of mining induced surface displacements, strains, and tilt for varying surface topography. One of the key aspects in obtaining reliable ground deformation prediction is the determination of the edge effect offset. The value assigned to the edge effect corresponds to a virtual offsetting of boundary lines delineating the extracted panel to allow for roof cantilevering over the mined out area.

The objective of this thesis is to describe …

Fundamental Improvement In The Tribocharging Separation Process For Upgrading Coal, Jinxiang Chen

Theses and Dissertations--Mining Engineering

Triboelectrostatic separation is a physical separation technique that is based on surface electronic property differences among minerals to achieve a separation. Minerals have different surface conductivities and electron affinities. They are charged differently in quantity and/or polarity after a tribocharging process. Particles with different surface charges move discretely under external electric field produce a separation. Electrostatic separation is a dry mineral processing method that does not require any water or chemical reagents. It can greatly simplify the processing circuit and reduce operating cost. Additionally, problems caused by water in conventional wet mineral processing such as water freezing, dewatering, water pollution …

Target Read Operation Of Passive Ultra High Frequency Rfid Tag In A Multiple Tags Environment, Zi Qin Phua

Theses and Dissertations--Mechanical and Aerospace Engineering

Passive ultra-high frequency (UHF) radio frequency Identification (RFID) has emerged as a promising solution for many industrial applications. Passive UHF systems are relatively inexpensive to implement and monitor, as no line of sight is required for the communication. There are several advantages to using a passive RFID system. For example, no internal power source is required to activate the tags, and lower labor costs and efficient multitasking operations are expected in a long term scenario. However, due to factors such as tag-to-tag interference and inaccurate localization, RFID tags that are closely spaced together are difficult to detect and program accurately …

Effect Of Interlayers On Mechanical Properties And Interfacial Stress Transfer Of 2d Layered Graphene-Polymer Nanocompsites, Colton C. Roach

Theses and Dissertations--Mechanical and Aerospace Engineering

Graphene, a monolayer of sp²-hybridized carbon atoms arranged in a two-dimensional (2D) lattice, is one of the most important 2D nanomaterials and has attracted tremendous attentions due to its unique geometric characteristics and exceptional mechanical properties. One of the most promising applications of this 2D nanomaterial is in polymer nanocomposites, in which the ultra-stiff, ultra-thin graphene layers function as reinforcement fillers. However, two significant questions remain to be answered: (1) whether the mechanical behaviors of 2D graphene reinforced nanocomposites can be analyzed by the convention composite theory, which is developed primarily for one-dimensional (1D) fiber-type of fillers, and …

A Physics-Based Approach To Modeling Wildland Fire Spread Through Porous Fuel Beds, Tingting Tang

Theses and Dissertations--Mechanical and Aerospace Engineering

Wildfires are becoming increasingly erratic nowadays at least in part because of climate change. CFD (computational fluid dynamics)-based models with the potential of simulating extreme behaviors are gaining increasing attention as a means to predict such behavior in order to aid firefighting efforts. This dissertation describes a wildfire model based on the current understanding of wildfire physics. The model includes physics of turbulence, inhomogeneous porous fuel beds, heat release, ignition, and firebrands. A discrete dynamical system for flow in porous media is derived and incorporated into the subgrid-scale model for synthetic-velocity large-eddy simulation (LES), and a general porosity-permeability model is …

Experimental Investigation Of Reading Passive Uhf Tags In A Multi-Tag Environment, Yi Zhou

Theses and Dissertations--Mechanical and Aerospace Engineering

Recently, the Internet of things (IoT) has emerged as a promising solution for several industrial applications. One of the key components in IoT is passive radio frequency identification (RFID) tags which do not require a power source for operations. Specifically, ultra-high frequency (UHF) tags are studied in this paper. However, due to factors such as tag-to-tag interference and inaccurate localization, RFID tags that are closely spaced together are difficult to detect and program accurately with unique identifiers. This thesis investigates several factors that affect the ability to encode a specific tag with unique information in the presence of other tags, …

Adaptive Scheduling For Operating Room Management, Honghan Ye

Theses and Dissertations--Mechanical and Aerospace Engineering

The perioperative process in hospitals can be modelled as a 3-stage no-wait flow shop. The utilization of OR units and the average waiting time of patients are related to makespan and total completion time, respectively. However, minimizations of makespan and total completion time are NP-hard and NP-complete. Consequently, achieving good effectiveness and efficiency is a challenge in no-wait flow shop scheduling. The average idle time (AIT) and current and future idle time (CFI) heuristics are proposed to minimize makespan and total completion time, respectively. To improve effectiveness, current idle times and future idle times are taken into consideration …

The Limits & Effects Of Draw On Properties And Morphology Of Pan-Based Precursor And The Resultant Carbon Fibers, Sarah Edrington

Theses and Dissertations--Mechanical and Aerospace Engineering

The process, structure, and property relationship of PAN fiber as a precursor to carbon fiber was studied. The limitations of stable spinning and property improvement associated with hot draw in solution spinning were found and quantified. Conditions were varied to generated precursor fiber up to the limit of draw, from which actual samples were collected for thermal conversion to carbon fiber. Samples of PAN and subsequent carbon fiber were characterized using tensile testing and x-ray analysis. The effects of draw on modulus and break stress, as well as the orientation of the crystalline structure of both parent precursor and resultant …

Forecasting The Workload With A Hybrid Model To Reduce The Inefficiency Cost, Xinwei Pan

Theses and Dissertations--Mechanical and Aerospace Engineering

Time series forecasting and modeling are challenging problems during the past decades, because of its plenty of properties and underlying correlated relationships. As a result, researchers proposed a lot of models to deal with the time series. However, the proposed models such as Autoregressive integrated moving average (ARIMA) and artificial neural networks (ANNs) only describe part of the properties of time series. In this thesis, we introduce a new hybrid model integrated filter structure to improve the prediction accuracy. Case studies with real data from University of Kentucky HealthCare are carried out to examine the superiority of our model. Also, …

Shape Memory Behavior Of Dense And Porous Niti Alloys Fabricated By Selective Laser Melting, Soheil Saedi

Theses and Dissertations--Mechanical and Aerospace Engineering

Selective Laser Melting (SLM) of Additive Manufacturing is an attractive fabrication method that employs CAD data to selectively melt the metal powder layer by layer via a laser beam and produce a 3D part. This method not only opens a new window in overcoming traditional NiTi fabrication problems but also for producing porous or complex shaped structures. The combination of SLM fabrication advantages with the unique properties of NiTi alloys, such as shape memory effect, superelasticity, high ductility, work output, corrosion, biocompatibility, etc. makes SLM NiTi alloys extremely promising for numerous applications.

The SLM process parameters such as laser power, …

Computational Investigation Of Transmural Differences In Left Ventricular Contractility And Hydrogel Injection Treatment For Myocardial Infarction, Hua Wang

Theses and Dissertations--Mechanical and Aerospace Engineering

Heart failure (HF) is one of the leading causes of death and impacts millions of people throughout the world. Recently, injectable hydrogels have been developed as a potential new therapy to treat myocardium infarction (MI). This dissertation is focused on two main topics: 1) to gain a better understanding the transmural contractility in the healthy left ventricle (LV) wall and 2) investigate the efficacy of the hydrogel injection treatment on LV wall stress and function. The results indicate that a non-uniform distribution of myocardial contractility in the LV wall provide a better representation of normal LV function. The other important …

Data-Driven Adaptive Reynolds-Averaged Navier-Stokes K - Ω Models For Turbulent Flow-Field Simulations, Zhiyong Li

Theses and Dissertations--Mechanical and Aerospace Engineering

The data-driven adaptive algorithms are explored as a means of increasing the accuracy of Reynolds-averaged turbulence models. This dissertation presents two new data-driven adaptive computational models for simulating turbulent flow, where partial-but-incomplete measurement data is available. These models automatically adjust (i.e., adapts) the closure coefficients of the Reynolds-averaged Navier-Stokes (RANS) k-ω turbulence equations to improve agreement between the simulated flow and a set of prescribed measurement data.

The first approach is the data-driven adaptive RANS k-ω (D-DARK) model. It is validated with three canonical flow geometries: pipe flow, the backward-facing step, and flow around an airfoil. For all 3 test …