Engineering Commons^™

Synthesis Of Polyethylene Glycol-Based Hydrogels And Silver/Gold Nanostructures For Biomedical Applications, Isabelle Ishimwe Niyonshuti

Graduate Theses and Dissertations

This work focuses on the synthesis of biocompatible polyethylene glycol (PEG)-based hydrogels, silver nanoparticles (AgNPs), and silver-gold nanocages (Ag-AuNCs) for biomedical applications. The dissertation includes two parts with Part I on the work of PEG-based hydrogel for wound healing applications and Part II on the work of Ag/Au nanostructures for antimicrobial applications. Part I studies PEG-based hydrogel for the delivery of fibroblast growth factors (FGFs) for wound healing applications, aiming to overcome the challenge of designing hydrogels capable of the sustained release of bioactive FGFs. This research develops new biocompatible anionic injectable hydrogel formulations based on Poly (Oligo Ethylene Glycol …

Relating The Dongre Workability Test To Cold In-Place Recycled Asphalt Pavements, Gus Williams

Civil Engineering Undergraduate Honors Theses

The Dongre Workability Test (DWT) is a test for determining an asphalt pavement’s relative workability from the stress-strain curve of a sample. While the DWT has seen favorable results with warm mix and hot mix asphalt, Casillas and Braham (2020) attempted to apply this test to cold in-place recycled (CIR) asphalt pavements with limited results. This paper looked at the process of reexamining the DWT method to more favorable results with CIR samples. Phase 1 consisted of defining ten possible metrics from the stress-strain curve and applying them to samples with three different curing conditions. From these preliminary results, the …

Growth Of Pseudomorphic Gesn At Low Pressure With Sn Composition Of 16.7%, Joshua Grant, Grey Abernathy, Oluwatobi Olorunsola, Solomon Opeyemi Ojo, Sylvester Amoah, Emmanuel Wangila, Samir K. Saha, Abbas Sabbar, Wei Du, Murtadha Alher, Bao-Hua Li, Shui-Qing Yu

Physics Faculty Publications and Presentations

Group-IV alloy GeSn holds great promise for the high-performance optoelectronic devices that can be monolithically integrated on Si for near- and mid-infrared applications. Growth of GeSn using chemical vapor deposition technique with various Sn and Ge precursors has been investigated worldwide. To achieve relatively high Sn incorporation, the use of higher pressure and/or higher order Ge hydrides precursors were reported. In this work, we successfully demonstrated the growth of high-quality GeSn with Sn composition of 16.7% at low pressure of 12 Torr. The alloy was grown using the commercially available GeH₄ and SnCl₄ precursors via a chemical vapor …

A Double-Sided Stack Low-Inductance Wire-Bondless Sic Power Module With A Ceramic Interposer, Si Huang

Graduate Theses and Dissertations

The objective of this dissertation research is to develop a novel three-dimensional (3-D) wire bondless power module package for silicon carbide (SiC) power devices to achieve a low parasitic inductance and an improved thermal performance. A half-bridge module consisting of 900-V SiC MOSFETs is realized to minimize stray parasitic inductance as well as to provide both vertical and horizontal cooling paths to maximize heat dissipation. The proposed 3-D power module package was designed, simulated, fabricated and tested. In this module, low temperature co-fired ceramic (LTCC) substrate with vias is utilized as an interposer of which both top and bottom sides …

Multifunctional Programmable Self-Assembled Nanoparticles In Nanomedicine, Yoshie Sakamaki

Graduate Theses and Dissertations

Developing methodologies to control the architecture of nanoparticles (NPs) at the atomic level prevents their inhomogeneity and leads to a variety of expected functions. Rationally designed nanoparticles can either be programmed or crystallized structures into pre-determined structures achieving tunable particle pore size and physiochemistry. In this dissertation, two broad classes of multifunctional nanoparticles are developed, metal-organic frameworks and DNA-NP aggregates.

Metal-organic frameworks are a novel class of highly porous crystalline materials built from organic linkers and metal cluster-based secondary building units. However, applications in bioremediation have not been developed very well especially in applications regarding drug delivery systems (DDS). The …

Preliminary Development Of The Dialysis-Membrane-Based Passive Biocide Delivery System For Spacecraft Water Recovery Units, Rogelio Elias Garcia Fernandez

Graduate Theses and Dissertations

The purpose of this investigation is to explore the capabilities of a dialysis-membrane-based system for the in-line dosing of silver ions to treated water in spacecraft water recovery units. The spacecraft environmental control and life support system community (ECLSS) are interested in adopting silver ions as a biocide in future spacecraft water recovery processes since silver ions are effective biocide at concentrations that humans can safely consume. The system has been designed following the configuration of the Water Processor Assembly (WPA) aboard the International Space Station. In this configuration, silver ions have to be added at the last step in …

Recombinant Production And Purification Of Green Fluorescent Protein (Gfp)-Fused Metal Binding Protein For Palladium Nanoparticle Synthesis, Shadrach Ibinola

Graduate Theses and Dissertations

In lieu of chemical and physical methods, biologically guided synthesis is increasingly used as a cost-effective medium for the fabrication of nanoparticles (NP). Recently, a palladium metal binding sequence Pd4 (TSNAVHPTLRHL) has been demonstrated to be instrumental in the production of palladium (Pd) nanoparticles. Although, by eliminating the additional cost of purification of the protein, the crude lysate of E. coli containing Pd specific protein has been proven to be a viable cost-effective means for the synthesis of Pd NP, studies have not be done to ascertain the comparative catalytic activity of nanoparticles synthesized from both clarified lysate and pure …

Automated Flight Controller Adaptive Compensation For Actuator Failures In Transport Type Aircraft, Daniel James Fresella

Graduate Theses and Dissertations

Aircraft operate over a wide range of conditions including atmospheric, weight, and center ofgravity changes. This presents a substantial challenge to automatic control system designers. When these operating conditions are merged with a partial or full control surface failure, automatic flight control is near impossible with conventional controllers. Additionally, when pilots experience control failure emergencies during flight, workload and fatigue increase drastically. The continued research of automatic flight control systems that can seamlessly adapt to unmodelled failures will enable a new generation of robust aircraft control. In this paper a 9th order 6 degree of freedom aircraft model is used …

Investigation Of Iron-Nickel Films Based Catalysts: Controlling Hydrogen Evolution Reaction (Her) Through An Electrode-Electrolyte Engineering Approach, Sergio Ivan Perez Bakovic

Graduate Theses and Dissertations

Electrochemical energy conversion technologies need to be economically viable in order to be adopted. Earth-abundant transition metals (i.e., Fe, Co, and Ni) have attracted attention due to their high availability, low cost, and catalytic characteristics that are in many cases found in and exploited by nature. Herein, we synthesize FexNi100-xOy electrocatalyst films and study how the electrocatalyst-electrolyte interactions alter the hydrogen evolution reaction (HER).In this work, FexNi100-xOy films were synthesized to study the composition, chemical state, and morphology. Characterization results provided a well-established electrocatalyst film platform to then proceed with electrochemical evaluations. The effects of the electrode composition and electrochemically …

Statistical Modeling, Learning And Computing For Stochastic Dynamics Of Complex Systems, Mohammadmahdi Hajiha

Graduate Theses and Dissertations

With the recent advances in sensor technology, it is much easier to collect and store streams of system operational and environmental (SOE) data. These data can be used as input to model the underlying behavior of complex engineered systems and phenomenons if appropriate algorithms with well-defined assumptions are developed. This dissertation is comprised of the research work to show the applicability of SOE data when fed into proposed tailored algorithms. The first purposes of these algorithms are to estimate and analyze the reliability of a system as elaborated in Chapter 2. This chapter provides the derivation of closed-form expressions that …

Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello

Graduate Theses and Dissertations

Resistance to therapy in cancer is a major cause of poor prognosis in patients. Tumor hypoxia plays an active role in mediating treatment resistance and has been linked to metastases and metastatic potential in cancer. Our research focused on three objectives: i) To understand metabolic effects of chronic and intermittent hypoxia in murine breast cancer cells and its affiliation with metastatic potential ii) To identify the metabolic changes associated with radiation therapy in a panel of radiosensitive and radioresistant human head and neck cancer cells and iii) to monitor the changes in cell metabolism associated with gain of treatment resistance. …

Effect Of Hydrogen Peroxide On Algae And Microcystin In Control And Lake Waters, Tatiana Castillo Hernandez

Biological and Agricultural Engineering Undergraduate Honors Theses

Cyanobacteria are photo-autotrophic organisms with a worldwide distribution, which can result in Harmful Algal Blooms (HABs) producing toxins. One of the most common strains of cyanobacteria is Microcystis, which produces the most abundant cyanotoxin, microcystin. In this study, we analyzed the effect of H₂O₂ on algae and microcystin using both lake and reagent grade water. The first objective was to determine the effect of H₂O₂ on algae and cyanobacteria in lake water that was nutrient enriched. The second objective was to detect the effect of H₂O₂ at oxidizing microcystin in …

Ultra Low-Cycle Fatigue Behavior Comparison Between Additively Manufactured And Rolled 17-4 Ph (Aisi 630) Stainless Steels, David Gonzalez-Nino, Timothy Strasser, Gary S. Prinz

Civil Engineering Faculty Publications and Presentations

This study investigates the mechanical behavior of additively manufactured (AM) 17-4 PH (AISI 630) stainless steels and compares their behavior to traditionally produced wrought counterparts. The goal of this study is to understand the key parameters influencing AM 17-4 PH steel fatigue life under ULCF conditions and to develop simple predictive models for fatigue-life estimation in AM 17-4 steel components. In this study, both AM and traditionally produced (wrought) material samples are fatigue tested under fully reversed (R = −1) strain controlled (2–4% strain) loading and characterized using micro-hardness, x-ray diffraction, and fractography methods. Results indicate decreased fatigue life for …

Third Party Risk Management And Cyber Supply Chain Risk Management, Jerald Garner

Operations Management Presentations

Today’s business environment continues to be a challenge. Businesses whether small, or large leverage third-party vendors to provide critical services like data handling (security, transmitting, and storage), cloud storage/applications, and systems security monitoring.

Each business must ask themselves a few simple questions about one of their most valuable assets “Data”. If or when it leaves your secure working environment:

• How secure is your customer data in transit and storage?
• Do your third-party vendors handle your “critical information”?
  • Provide a secure environment for processing?
  • Comply with a proven Cyber Security Framework?
  • Perform a “Due Diligence” on-boarding step for the Nth vendors …

Thin Safety Margin: The Sefor Super-Prompt-Critical Transient Experiments, Ozark Mountains, Arkansas 1970–1971, Jerry Havens, Collis Geren

Arkansas Scholarly Editions

Thin Safety Margin charts the history of SEFOR, a twenty-megawatt reactor that operated for three years in the rural Ozark Mountains of Arkansas as part of an internationally sponsored program designed to demonstrate the Doppler effect in plutonium-oxide-fueled fast reactors. Authors Jerry Havens and Collis Geren draw upon this history to assess the accidental explosion risk inherent in using fast reactors to reduce the energy industry’s carbon dioxide emissions.

If a sufficiently powerful fast-neutron explosion were to cause the containment of a reactor such as SEFOR’s to fail, the reactor’s radiotoxic plutonium fuel could vaporize and escape into the surrounding …

Settingsorder Article Reprints Open Accessarticle Generation And Characterization Of Human Mesenchymal Stem Cell-Derived Smooth Muscle Cells, Srikanth Sivaraman, Jackson Hedrick, Samia Ismail, Chris Slavin, Raj R. Rao

Biomedical Engineering Faculty Publications and Presentations

Cardiovascular diseases are the leading cause of death worldwide. A completely autologous treatment can be achieved by using elastogenic mesenchymal stem cell (MSC)-derived smooth muscle cells (SMC) at the affected tissue site of vascular diseases such as abdominal aortic aneurysms (AAA). Thus, our work focused on evaluating the efficacy of (a) the combination of various growth factors, (b) different time periods and (c) different MSC lines to determine the treatment combination that generated SMCs that exhibited the greatest elastogenicity among the tested groups using Western blotting and flow cytometry. Additionally, total RNA sequencing was used to confirm that post-differentiation cells …

Generation And Characterization Of Human Mesenchymal Stem Cell-Derived Smooth Muscle Cells, Srikanth Sivaraman, Jackson Hedrick, Samia Ismail, Chris Slavin, Raj R. Rao

Biomedical Engineering Faculty Publications and Presentations

Cardiovascular diseases are the leading cause of death worldwide. A completely autologous treatment can be achieved by using elastogenic mesenchymal stem cell (MSC)-derived smooth muscle cells (SMC) at the affected tissue site of vascular diseases such as abdominal aortic aneurysms (AAA). Thus, our work focused on evaluating the efficacy of (a) the combination of various growth factors, (b) different time periods and (c) different MSC lines to determine the treatment combination that generated SMCs that exhibited the greatest elastogenicity among the tested groups using Western blotting and flow cytometry. Additionally, total RNA sequencing was used to confirm that post-differentiation cells …

Socio-Technical Changes For Sustainable Rice Production: Rice Husk Amendment, Conservation Irrigation, And System Changes, Benjamin R. K. Runkle, Angelia L. Seyfferth, Matthew C. Reid, Matthew A. Limmer, Beatriz Moreno-Garcia, Colby W. Reavis, Jasquelin Pena, Michele L. Reba, M. Arlene A. Adviento-Borbe, Shannon R. M. Pinson, Chris Isbell

Biological and Agricultural Engineering Faculty Publications and Presentations

Rice is a staple food and primary source of calories for much of the world. However, rice can be a dietary source of toxic metal(loid)s to humans, and its cultivation creates atmospheric greenhouse gas emissions and requires high water use. Because rice production consumes a significant amount of natural resources and is a large part of the global agricultural economy, increasing its sustainability could have substantial societal benefits. There are opportunities for more sustainable field production through a combination of silicon (Si) management and conservation irrigation practices. As a Si-rich soil amendment, rice husks can limit arsenic and cadmium uptake, …

Development Of A Cyberinfrastructure For Assessment Of The Lower Rio Grande Valley North And Central Watersheds Characteristics, Linda Navarro, Ahmed Mahmoud, Andrew Ernest, Abdoul Oubeidillah, Jessica Johnstone, Ivan Rene Santos Chavez, Christopher Fuller

Biological and Agricultural Engineering Faculty Publications and Presentations

Lower Laguna Madre (LLM) is designated as an impaired waterway for high concentrations of bacteria and low dissolved oxygen. The main freshwater sources to the LLM flow from the North and Central waterways which are composed of three main waterways: Hidalgo/Willacy Main Drain (HWMD), Raymondville Drain (RVD), and International Boundary & Water Commission North Floodway (IBWCNF) that are not fully characterized. The objective of this study is to perform a watershed characterization to determine the potential pollution sources of each watershed. The watershed characterization was achieved by developing a cyberinfrastructure, and it collects a wide inventory of data to identify …

Hidden In Plain Sight: Why Sustainment Is So Critical To The Circular Supply Chains For Technical Products, Dave Peterson

Operations Management Presentations

• Technical products are typically complex, long-lived and high-cost equipment—such as: aircraft, vehicles, ships, capital equipment/machinery and utilities infrastructure. While many technical products are manufactured via traditional linear supply chains, their useful lives often rely upon sustainment systems incorporating significant aspects of circular supply chains. This webinar takes a closer look at technical products and the critical role of systems sustainment to achieve and fulfill circular supply chains. The key takeaways from this webinar are:
  • The Earth is running out of resources which will have a direct impact upon maintaining/improving our quality of life.
  • The circular economy philosophy has definite relevance …

Cell-Permeable Succinate Increases Mitochondrial Membrane Potential And Glycolysis In Leigh Syndrome Patient Fibroblasts, Ajibola B. Bakare, Raj R. Rao, Shilpa Iyer

Biomedical Engineering Faculty Publications and Presentations

Mitochondrial disorders represent a large group of severe genetic disorders mainly impacting organ systems with high energy requirements. Leigh syndrome (LS) is a classic example of a mitochondrial disorder resulting from pathogenic mutations that disrupt oxidative phosphorylation capacities. Currently, evidence-based therapy directed towards treating LS is sparse. Recently, the cell-permeant substrates responsible for regulating the electron transport chain have gained attention as therapeutic agents for mitochondrial diseases. We explored the therapeutic effects of introducing tricarboxylic acid cycle (TCA) intermediate substrate, succinate, as a cell-permeable prodrug NV118, to alleviate some of the mitochondrial dysfunction in LS. The results suggest that a …

Blood–Brain Barrier Breakdown And Astrocyte Reactivity Evident In The Absence Of Behavioral Changes After Repeated Traumatic Brain Injury, Celeste Dunn, Nasya Sturdivant, Sara Venier, Syed Ali, Jeffery Wolchok, Kartik Balachandran

Biomedical Engineering Faculty Publications and Presentations

Repeated traumatic brain injuries (TBIs) cause debilitating effects. Without understanding the acute effects of repeated TBIs, treatment options to halt further degeneration and damage cannot be developed. This study sought to examine the acute effects of blood–brain barrier (BBB) dysfunction, edema, inflammation and behavioral changes after either a single or double TBI using a C57BL/6 mouse model. We examined the effects of one or two TBIs, of either a mild or moderate severity. Double injuries were spaced 7 days apart, and all analysis was performed 24 h post-injury. To examine edema and inflammation, protein levels of glial fibrillary acidic protein …

Critical Chain – Or Why Wedding Planners Get Ulcers, Greg Hutto

Operations Management Presentations

Planning a wedding is one of the most challenging projects in a young life… So much to do! A respected journal in the project management literature -- Southern Bride -- advises well-off young couples to escape stress and employ a professional wedding planner+. In today's webinar we will contrast two project planning methods in examining one such wedding project -- hastily planned and beset with troubles. We will shed light on the science & art of project management and possibly help our wedding planners (both professional and amateur) avoid stress-induced medical complications. In this webinar, we’ll be spending time with …

An Automated Method To Enrich Consumer Health Vocabularies Using Glove Word Embeddings And An Auxiliary Lexical Resource, Mohammed Ibrahim, Susan Gauch, Omar Salman, Mohammed Alqahtani

Computer Science and Computer Engineering Faculty Publications and Presentations

Background

Clear language makes communication easier between any two parties. A layman may have difficulty communicating with a professional due to not understanding the specialized terms common to the domain. In healthcare, it is rare to find a layman knowledgeable in medical terminology which can lead to poor understanding of their condition and/or treatment. To bridge this gap, several professional vocabularies and ontologies have been created to map laymen medical terms to professional medical terms and vice versa.

Objective

Many of the presented vocabularies are built manually or semi-automatically requiring large investments of time and human effort and consequently the …

Life Cycle Impact Assessment Of Biofuels Derived From Sweet Sorghum In The U.S., Karla G. Morrissey, Greg Thoma, Dora E. Lopez

Chemical Engineering Faculty Publications and Presentations

Background

The objective of this study was to evaluate the environmental impact of the production of a range of liquid biofuels produced from the combination of fermenting sorghum stalk juice (bioethanol) and the pyrolysis/hydrotreatment of residual bagasse (renewable gasoline and diesel). Life cycle impact assessment (LCIA) was performed on a farm-to-wheels system that included: (i) sorghum farming, (ii) juice extraction, (iii) juice fermenting, (iv) bagasse pretreatment, (v) bagasse thermochemical treatment (pyrolysis, hydroprocessing, and steam reforming), and (vi) typical passenger vehicle operation. LCIA results were compared to those of petroleum fuels providing the equivalent functional unit—cumulative kilometers driven by spark ignition …

Vortex-Oriented Ferroelectric Domains In Snte/Pbte Monolayer Lateral Heterostructures, Kai Chang, John W. D. Villanova, Jing-Rong Ji, Souvik Das, Felix Kuster, Salvador Barraza-Lopez, Paolo Sessi, Stuart S. P. Parkin

Physics Faculty Publications and Presentations

Heterostructures formed from interfaces between materials with complementary properties often display unconventional physics. Of especial interest are heterostructures formed with ferroelectric materials. These are mostly formed by combining thin layers in vertical stacks. Here the first in situ molecular beam epitaxial growth and scanning tunneling microscopy characterization of atomically sharp lateral heterostructures between a ferroelectric SnTe monolayer and a paraelectric PbTe monolayer are reported. The bias voltage dependence of the apparent heights of SnTe and PbTe monolayers, which are closely related to the type-II band alignment of the heterostructure, is investigated. Remarkably, it is discovered that the ferroelectric domains in …

Impact Of Long-Term Annealing On Photoluminescence From Ge1-XSnX Alloys, Oluwatobi Olorunsola, Hryhorii Stanchu, Solomon Opeyemi Ojo, Krishna Pandey, Abdulla Said, Joe Margetis, John Tolle, Adrian V. Kuchuk, Yuriy I. Mazur, Gregory J. Salamo, Shui-Qing Yu

Electrical Engineering Faculty Publications and Presentations

We report on the connection between strain, composition, defect density and the photoluminescence observed before and after annealing at 300 °C for GeSn samples with Sn content of 8% to 10%. Results show how the composition and level of strain influenced the separation between the indirect and direct optical transitions, while changes in the level of strain also influenced the density of misfit dislocations and surface roughness. The effect of annealing is observed to lower the level of strain, decreasing the energy separation between the indirect and direct optical transitions, while also simultaneously increasing the density of misfit/threading dislocations and …

Movement Analysis For Neurological And Musculoskeletal Disorders Using Graph Convolutional Neural Network, Ibsa K. Jalata, Thanh-Dat Truong, Jessica L. Allen, Han-Seok Seo, Khoa Luu

Computer Science and Computer Engineering Faculty Publications and Presentations

Using optical motion capture and wearable sensors is a common way to analyze impaired movement in individuals with neurological and musculoskeletal disorders. However, using optical motion sensors and wearable sensors is expensive and often requires highly trained professionals to identify specific impairments. In this work, we proposed a graph convolutional neural network that mimics the intuition of physical therapists to identify patient-specific impairments based on video of a patient. In addition, two modeling approaches are compared: a graph convolutional network applied solely on skeleton input data and a graph convolutional network accompanied with a 1-dimensional convolutional neural network (1D-CNN). Experiments …

Narrow Band Active Contour Attention Model For Medical Segmentation, Ngan Le, Toan Bui, Viet-Khao Vo-Ho, Kashu Yamazaki, Khoa Luu

Computer Science and Computer Engineering Faculty Publications and Presentations

Medical image segmentation is one of the most challenging tasks in medical image analysis and widely developed for many clinical applications. While deep learning-based approaches have achieved impressive performance in semantic segmentation, they are limited to pixel-wise settings with imbalanced-class data problems and weak boundary object segmentation in medical images. In this paper, we tackle those limitations by developing a new two-branch deep network architecture which takes both higher level features and lower level features into account. The first branch extracts higher level feature as region information by a common encoder-decoder network structure such as Unet and FCN, whereas the …

Material Detection With Thermal Imaging And Computer Vision: Potentials And Limitations, Jared Poe

Graduate Theses and Dissertations

The goal of my masters thesis research is to develop an affordable and mobile infraredbased environmental sensoring system for the control of a servo motor based on material identification. While this sensing could be oriented towards different applications, my thesis is particularly interested in material detection due to the wide range of possible applications in mechanical engineering. Material detection using a thermal mobile camera could be used in manufacturing, recycling or autonomous robotics. For my research, the application that will be focused on is using this material detection to control a servo motor by identifying and sending control inputs based …