Engineering Commons^™

Peptoid Morphology Studies And Its Performance In Inhibiting Islet Amyloid Polypeptide, Dongwon Park

Chemical Engineering Undergraduate Honors Theses

Abstract 1

Proteins have various arrays of functions in human bodies. The bio-functions of proteins are depend on their amino acid sequences and folding processes that affect protein structure. While most of proteins fold in their own pathways, some of them misfold and aggregate due to mutations caused by various reasons. These aggregations are believed to be main causes of protein conformation disorders like Alzheimer's disease, Type II diabetes, Huntington's disease, and prion disease. An aggregated form of amyloid beta is considered as a hallmark of Alzheimer's disease. Amyloid beta develops from oligomer into a fibril as the aggregation process …

Particle Image Velocimetry Design & Installation, Zach Ritchie

Mechanical Engineering Undergraduate Honors Theses

This work will mainly focus on the design, construction, and installation of the Particle Image Velocimetry (PIV) system in the Chemical Hazards Research Center wind tunnel. The PIV system utilizes a Class IV (double pulsed) laser, optics to produce a light sheet, timing circuitry, and a high-resolution camera (with buffered output) to measure a system’s velocity (two-dimensional) field by determining the displacement of particles over the time between laser pulses. For maximum mobility and functionality, the PIV system was installed in the center of the tunnel on a moveable cart with the laser and camera mounted to an adjustable support. …

Nanoscale Frictional Properties Of Nickel With One-Dimensional And Two-Dimensional Materials, Timothy K. Schlenger

Mechanical Engineering Undergraduate Honors Theses

When looking at the nanoscale, material interface interactions have been observed to exhibit particularly interesting properties. Our research looks into various combinations of carbyne and graphene atop a nickel block to look into the interface friction properties between them. Both the carbyne and graphene are tested using steered molecular dynamics (SMD) in sheering and peeling directions along the surface of the nickel block. These tests are then analyzed by comparing the magnitude of the acting force versus the displacement of the carbon allotrope sample across the nickel block. It is found that as the width of a carbon allotrope sample …

Time-Of-Flight Based Sonic Speed Measurements For Cold Gas Thruster Development, Brandon W. Kempf

Mechanical Engineering Undergraduate Honors Theses

The purpose of this thesis is to explore an experiment developed for validating the usage of a gaseous solution of water and propylene glycol for cold gas propulsion. The experiment involves a “Time of Flight” method of calculating the speed of sound in the gas and the corresponding specific heat ratio using a copper tube, two MEMS microphones, a piezoelectric speaker, and data-acquisition hardware. The experiment was calibrated using the known thermodynamic properties of air. The accuracy of the experiment was found to be within 0.6% for calculations of the speed of sound in air and within 1.0% of the …

Investigation Of Optical Properties Of Zinc Oxide Photodetector, Tyler Chism

Graduate Theses and Dissertations

UV photodetection devices have many important applications for uses in biological detection, gas sensing, weaponry detection, fire detection, chemical analysis, and many others. Today’s photodetectors often utilize semiconductors such as GaAs to achieve high responsivity and sensitivity. Zinc oxide, unlike many other semiconductors, is cheap, abundant, non-toxic, and easy to grow different morphologies at the micro and nano scale. With the proliferation of these devices also comes the impending need to further study optics and photonics in relation to phononics and plasmonics, and the general principles underlying the interaction of photons with solid state matter and, specifically, semiconductors. For this …

Validation Of A Confocal Light Sheet Microscope Using Push Broom Translation For Biomedical Applications, Joshua Hutcheson

Graduate Theses and Dissertations

There exists a need for research of optical methods capable of image cytometry suitable for point-of-care technology. To propose am optical approach with no moving parts for simplification of mechanical components for the further development of the technology to the poin-of-care, a linear sensor with push broom translation method. Push broom translation is a method of moving objects by the sensor for an extended field of view. A polydimethylsiloxane (PDMS) microfluidic chamber with a syringe pump was used to deliver objects by the sensor. The volumetric rate of the pump was correlated to the integration time of the sensor to …

Genotoxicity Of Graphene In Escherichia Coli, Ananya Sharma

Graduate Theses and Dissertations

Rapid advances in nanotechnology necessitate assessment of the safety of nanomaterials in the resulting products and applications. One key nanomaterial attracting much interest in many areas of science and technology is graphene. Graphene is a one atom thick carbon allotrope arranged in a two-dimensional honeycomb lattice. In addition to being extremely thin, graphene has several extraordinary physical properties such as its exceptional mechanical strength, thermal stability, and high electrical conductivity. Graphene itself is relatively chemically inert and therefore pristine graphene must undergo a process called functionalization, which is combination of chemical and physical treatments that change the properties of graphene, …

Essays In Physicians Preference Items And Inventory Management Within The Healthcare Supply Chain, Mohammad A. Shbool

Graduate Theses and Dissertations

This work is composed of a number of topics in the healthcare area, which are approached separately with appropriate methodologies. The two topics deal with physician preference items via two different approaches. The first one investigates stock keeping unit (SKU) proliferation in healthcare organizations due to physician preference items (PPI). It captures perspectives of physicians and supply chain professionals about this problem through two surveys. The second topic builds a decision-making framework for the PPI selection process that can be used by healthcare organizations to make more objective decisions. A Multi-criteria decision making technique is implemented to illustrate the framework.

Prevention Of Drone Jamming Using Hardware Sandboxing, Joshua Mead

Graduate Theses and Dissertations

In this thesis, we concern ourselves with the security of drone systems under jamming-based attacks. We explore a relatively new concept we previously devised, known as hardware sandboxing, to provide runtime monitoring of boundary signals and isolation through resource virtualization for non-trusted system-on-chip (SoC) components. The focus of this thesis is the synthesis of this design and structure with the anti-jamming, security needs of drone systems. We utilize Field Programmable Gate Array (FPGA) based development and target embedded Linux for our hardware sandbox and drone hardware/software system.

We design and implement our working concept on the Digilent Zybo FPGA, which …

A Tabu Search, Augment-Merge Heuristic To Solve The Stochastic Location Arc Routing Problem, Tiffany L. Yang

Graduate Theses and Dissertations

The location arc routing problem (LARP) is a network optimization problem combining strategic facility location decisions and tactical or operational vehicle routing decisions for customer demand located on arcs of a network. The LARP seeks to locate facilities, or depots, and create vehicle delivery routes to minimize costs. The total cost is comprised of three components: fixed facility locations costs, fixed route creation (or vehicle acquisition) costs, and variable arc traversal costs. The applications of the LARP are varied and often include public services such as mail delivery, garbage collection, and street sweeping. In all of these applications, the magnitude …

Polytetraflouroethylene Thin Coatings For Tribological Applications, Samuel L. Jenkins

Mechanical Engineering Undergraduate Honors Theses

Mechanical components with lower coefficients of friction decrease the amount of energy dissipated by the system due to friction. Coating these components would decrease the coefficients of friction between surfaces without sacrificing the strength of the components. A polytetrafluoroethylene (PTFE) layer adhered through a polydopamine (PDA) layer on a steel substrate will reduce the coefficient of friction on the substrate surface. This paper discusses different methods for attempting to increase the uniformity of the PDA layer as well as decrease the PDA coating time. Methods for increasing uniformity include using a particle disperser instead of a magnet stir rod, changing …

Low-Cost Inkjet Process For 3-D Printing, Christopher T. Schmitt

Mechanical Engineering Undergraduate Honors Theses

This paper presents a low-cost 3-D inkjet process design. Current commercially available 3-D inkjet printers (e.g., Objet Connex) that are capable of multi-material printing are expensive and out-of-reach of most consumers. While fused deposition modeling and other extrusion-based hybrid processes for multi-material printing are becoming available, these techniques are slow and relatively low-resolution. This research attempts to fill the gap by presenting a simple and low-cost solution to bring desktop 3-D inkjet to the community by utilizing components from an Epson inkjet printer. The mechanical system was designed with maximum utilization of the Epson carriage system with the addition of …

Influence Of Hydrogen Concentration And Distribution On Fracture In Nickel, Arturo Sucre Melfi

Mechanical Engineering Undergraduate Honors Theses

Hydrogen embrittlement is a main factor in the premature failure of metals under stress. Using molecular dynamics (MD) simulations, two models were built in order to study how the presence of hydrogen at interstitial positions within the nickel lattice affects how it fractures. The first model was a 3D single crystal nickel sample, while the other was the same nickel model but with different concentrations and locations of hydrogen positioned at or near the crack tip. Two aspects of fracture were studied and compared between the different simulations: the crack tip velocity and dislocation nucleation from the crack tip. Analysis …

Review And Experimental Investigation Of Phase Change Material Use In Buildings, Russell W. Locetta

Mechanical Engineering Undergraduate Honors Theses

This paper presents an overview of phase change materials (PCM) and their properties along with a review of relevant studies conducted in the past several years over phase change materials. An experiment is conducted to examine the differences between external building walls with and without bio-based phase change materials. In addition, the length of time BioPCM requires to completely change phase is examined from the data. Based on the data, the internal wall temperature of a home can be reduced by approximately 2 F. Additionally, a theoretical case study is presented and it is concluded that with the use of …

Droplet Generation At Megahertz Frequencies, John C. Miers

Mechanical Engineering Undergraduate Honors Theses

Droplet formation has been a fascinating subject to scientists for centuries due to its natural beauty and importance to both scientific and industrial applications, such as inkjet printing, reagent deposition, and spray cooling. However, the droplet generation frequency of common drop-on-demand jetting techniques is mostly limited to ~10 kHz. This paper presents an investigation of the possibility of jetting at megahertz frequencies in order to boost the productivity of drop-on-demand material deposition by ~100 times. The focus of this paper is to understand the limitations of generating droplets at a megahertz frequency and to explore possible solutions for overcoming these …

Cloning, Fed-Batch Expression And Purification Of A Novel Anti-Candida Peptide And Development Of A Cleavage Resistant Variant Of Green Fluorescence Protein, Rudra Palash Mukherjee

Graduate Theses and Dissertations

This work illustrates that the intelligent design of a bioprocess for the production of peptides of various length is possible by having a prior knowledge of desired product, cell line, fermentation conditions, and choices for downstream recovery. Cloning, expression, and recovery of a novel 12-mer anti-Candida peptide served as an illustrative case for a proposed Escherichia coli platform. The antifungal peptide, expressed as a fusion to GFPUV during high call density fed-batch, was recovered from cell lysate, concentrated using ion exchange chromatography, and finally cleaved with cyanogen bromide. The platform was capable of producing active peptide capable of arresting the …

Achieving A Better Balance Between Productivity And Performance On Fpgas Through Heterogeneous Extensible Multiprocessor Systems, Abazar Sadeghian

Graduate Theses and Dissertations

Field Programmable Gate Arrays (FPGAs) were first introduced circa 1980, and they held the promise of delivering performance levels associated with customized circuits, but with productivity levels more closely associated with software development. Achieving both performance and productivity objectives has been a long standing challenge problem for the reconfigurable computing community and remains unsolved today. On one hand, Vendor supplied design flows have tended towards achieving the high levels of performance through gate level customization, but at the cost of very low productivity. On the other hand, FPGA densities are following Moore's law and and can now support complete multiprocessor …

Designing Sewn Circuits And Stem Self-Efficacy In Middle School Girls, Kara Kaiser

Graduate Theses and Dissertations

The purpose of this study is to determine if the experience of designing and sewing LilyPad Arduino circuits in crafts projects can increase middle school girls’ STEM self-efficacy. Boys STEM self-efficacy will also be assessed to determine if LilyPad Arduino circuits can also increase boys’ STEM self-efficacy. Researchers have been wondering why there is a male dominance in STEM (science, technology, engineering and mathematics) fields and why some women do not have a particular interest in these subjects. There are several reasons this could happen; stereotypes conveyed to them by parents and/or teachers, they genuinely are not interested in STEM …

Risk Estimation Toward A Natural History Model For Low Grade Glioma Patients, Anh Thi Hoang Pham

Graduate Theses and Dissertations

Glioma is a common type of primary brain tumor that represents 28% of all brain tumors and 80% of malignant tumors. According to a recent study by the Centers for Disease Control and Prevention (CDC), gliomas account for 53%, 35% and 29% of all brain tumors (68%, 74% and 81% of malignant brain tumors) among children (aged 0-14), teenagers (aged 15-19) and young adults, respectively. Gliomas are often diagnosed through radiological imaging and histopathology. There are two main groups of gliomas following World Health Organization’s classification: Low grade gliomas (LGG), or grade I and II gliomas; and high grade gliomas …

Use Of Response Surfaces In The Design Of A Simple Step Stress Accelerated Test Plan, Alexander H. Wong

Graduate Theses and Dissertations

In designing accelerated testing plans, cost is a factor that is missing in much of the literature. This paper explicits considers cost by developing an optimization model with the objective to minimize costs for a simple step stress accelerated test plan. Two methodologies are employed. One is an optimization approach in which an attempt is made to quantify the behavior of a series-parallel hardware system over all stages of testing using a response surface, and then an optimization model is used to determine the settings for stresses and failure mode modifications for all stages of testing prior to the start …

Phase-Field Models For Simulating Physical Vapor Deposition And Microstructure Evolution Of Thin Films, James Stewart Jr.

Graduate Theses and Dissertations

The focus of this research is to develop, implement, and utilize phase-field models to study microstructure evolution in thin films during physical vapor deposition (PVD). There are four main goals to this dissertation. First, a phase-field model is developed to simulate PVD of a single-phase polycrystalline material by coupling previous modeling efforts on deposition of single-phase materials and grain evolution in polycrystalline materials. Second, a phase-field model is developed to simulate PVD of a polymorphic material by coupling previous modeling efforts on PVD of a single-phase material, evolution in multiphase materials, and phase nucleation. Third, a novel free energy functional …

Hardware Trojan Detection Via Golden Reference Library Matching, Lucas Weaver

Graduate Theses and Dissertations

Due to the proliferation of hardware Trojans in third party Intellectual Property (IP) designs, the issue of hardware security has risen to the forefront of computer engineering. Because of the miniscule size yet devastating effects of hardware Trojans, few detection methods have been presented that adequately address this problem facing the hardware industry. One such method with the ability to detect hardware Trojans is Structural Checking. This methodology analyzes a soft IP at the register-transfer level to discover malicious inclusions. An extension of this methodology is presented that expands the list of signal functionalities, termed assets, in addition to introducing …

High Step-Up/Down Transformerless Multilevel Converter For Renewable Energy Applications, Haider Ghazi Mhiesan

Graduate Theses and Dissertations

This thesis focuses on a high step-up/down transformerless dc-dc modular multilevel converter (MMC) that would be applicable to dc power systems. The design achieves high voltage ratios for interfacing renewable energy sources such as photovoltaic and line interactive Uninterruptible Power System (UPS) systems. The circuit topology provides for high step-up/down dc-dc conversion ratios using an MMC approach operating in resonant mode in order to improve overall efficiency. This topology operates to step-up the input voltage with 1:10 or larger conversion ratio. As a bidirectional converter, it also provides step-down capability at the same voltage ratio (10:1 or greater). The MMC …

Control Design Of A Single-Phase Dc/Ac Inverter For Pv Applications, Haoyan Liu

Graduate Theses and Dissertations

This thesis presents controller designs of a 2 kVA single-phase inverter for photovoltaic (PV) applications. The demand for better controller designs is constantly rising as the renewable energy market continues to rapidly grow. Some background research has been done on solar energy, PV inverter configurations, inverter control design, and hardware component selection. Controllers are designed both for stand-alone and grid-connected modes of operation. For stand-alone inverter control, the outer control loop regulates the filter capacitor voltage. Combining the synchronous frame outer control loop with the capacitor current feedback inner control loop, the system can achieve both zero steady-state error and …

Experimental And Computational Studies Of Cortical Neural Network Properties Through Signal Processing, Wesley Patrick Clawson

Graduate Theses and Dissertations

Previous studies, both theoretical and experimental, of network level dynamics in the cerebral cortex show evidence for a statistical phenomenon called criticality; a phenomenon originally studied in the context of phase transitions in physical systems and that is associated with favorable information processing in the context of the brain. The focus of this thesis is to expand upon past results with new experimentation and modeling to show a relationship between criticality and the ability to detect and discriminate sensory input. A line of theoretical work predicts maximal sensory discrimination as a functional benefit of criticality, which can then be characterized …

Correcting Current Imbalances In Three-Phase Four-Wire Distribution Systems, Vinson Joseph Jones

Graduate Theses and Dissertations

The objective of this thesis is to present the theory, design, construction, and testing of a proposed solution to unbalanced current loading on three-phase four-wire systems. The Unbalanced Current Static Compensator is the name of the prototype; herein referred to as the UCSC. The purpose of this prototype is to redistribute current between the three phases of a distribution system. Through this redistribution, negative- and zero-sequence currents are eliminated and a balanced system is seen upstream from the point of installation.

The UCSC consists of three separate single-phase H-bridge inverters that all share the same dc-link capacitor. Each of these …

Design Of An Assistive Technology Adaptive Switch Using An Inertial Measurement Unit, Ethan Storm Williams

Graduate Theses and Dissertations

A new assistive technology switch for people with disabilities was developed utilizing an Inertial Measurement Unit (IMU) as the sensor technology. The hardware can be customized through firmware to provide custom switch activations on a person by person basis. The firmware is customized to recognize specific data features in the IMU data which identify the desired switch activation movement performed by the user. In this way, the switch can be adapted to activate based on the movements of the user. During this research, the generic hardware platform, including the IMU sensor technology and Bluetooth communications, was designed and tested. An …

Minimizing Ethanol Concentration In Organosolv Pretreatment For The Saccharification Of Loblolly Pine, Nelson B. Heringer

Biological and Agricultural Engineering Undergraduate Honors Theses

Organic solvent pretreatment, commonly known as organosolv, is a method used to prepare biomass for enzymatic hydrolysis for the production of biofuels. This method common uses ethanol as the organic solvent. However, this creates an economic issue with the product stream, as ethanol becomes a product and input. This project sought to explore how decreasing the use of ethanol in organosolv pretreatment affected the recoverability of sugars after enzymatic hydrolysis. Loblolly pine (Pinus taeda L.) was pretreated at 170 °C for 60 minutes in 1% dilute sulfuric acid and an ethanol concentration varying from 65% to 35%. Compositional …

Municipal Composting And Organic Waste Diversion: The Case Of Fayetteville, Arkansas, Michael E. Hoppe

Biological and Agricultural Engineering Undergraduate Honors Theses

It is estimated that 40% of food is wasted in the United States; representing $165 billion in wasted resources. A vast majority of that wasted food is ultimately placed in landfills where it decomposes and releases harmful greenhouse gases (GHGs). In fact, food waste alone is responsible for 23% of annual methane emissions for the US. This has a huge impact on global climate change due to the potency of methane as a greenhouse gas. Currently only 5% of the food waste produced is recovered across the nation. Source reduction would be the best solution to reducing this food waste, …

Journal Of The Arkansas Academy Of Science - Volume 70 2016, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.