Engineering Commons^™

Optical Analysis And Fabrication Of Micro And Nanoscale Plasmonically Enhanced Devices, Avery M. Hill

Physics Undergraduate Honors Theses

Plasmonic nanostructures have been shown to act as optical antennas that enhance optical devices due to their ability to focus light below the diffraction limit of light and enhance the intensity of the incident light. This study focuses on computational electromagnetic (CEM) analysis of two devices: 1) GaAs photodetectors with Au interdigital electrodes and 2) Au thin-film microstructures. Experiments showed that the photoresponse of the interdigital photodetectors depend greatly on the electrode gap and the polarization of the incident light. Smaller electrode gap and transverse polarization give rise to a larger photoresponse. It was also shown that the response from …

Immunomodulation Of Breast Cancer Cells For Whole Tumor Vaccination, Kristina G. Maxwell

Biomedical Engineering Undergraduate Honors Theses

Hematogenous metastasis causes 90% of breast cancer-related deaths.Current therapies include chemotherapy and irradiation following surgery. These therapies are very harmful to the human body and do not elicit an anti-tumor immune response. To create a novel therapeutic, an autologous vaccine increasing the immunogenicity of non immunogenic breast cancer cell lines has been proposed.

To create this vaccine, 4T1 mouse mammary breast cancer cells have been selected as the desired cell line to treat. They are non immunogenic and highly invasive. In order to increase their immunogenicity, first projected, was the addition of cytokines to 4T1 cells to increase the expression …

Analysis Of Bridge Deck Sections By Pseudo-Compressibility Method Based On Fdm And Les: Improving Performance Through Implementation Of Parallel Computing, Blandine Therese Mbianda Kemayou

Graduate Theses and Dissertations

The incidence of wind on bridges produces static and dynamic loading that must be adequately addressed when designing bridges. Dynamic loading is the primary concern, as the amplitude of the structures response to the applied loading may be greatly amplified. Ideally, the bridge's properties should be designed to avoid dynamic loading. Previous investigations of wind loading on bridges consisted of measuring forces produced on scaled models of bridges within wind tunnels. However, these wind tunnel tests are costly and time consuming due to cost to fabricate and instrument the bridge cross sections. Recent advancements in computational power of computers allow …

Quantification And Characterization Of Fracture Resistance In Asphalt Concrete Based On R-Curve Method, Shu Yang

Graduate Theses and Dissertations

The application of fracture energy is widely applied in the evaluation of cracking in the laboratory for asphalt concrete. However, this single number does not provide information on the characterization of the initiation and propagation of cracks. The Resistance Curve method, or R-Curve, is widely applied in characterizing various materials including, but not limited to, metal, polymer, rock, and composite. This research R-Curve method introduces asphalt concrete through a stepwise approach. First, in chapter one, there is a literature review of the history of fracture mechanics, fracture research in asphalt concrete, and an examination of the role of R-Curve application …

Exploring The Black Space Of Compressive And Shear Modulus, Airam Marlee Morales Vega

Graduate Theses and Dissertations

Uniaxial dynamic modulus is a standard test used to determine the viscoelastic behavior of asphalt pavement materials, with the standard analysis generating a Master Curve. One alternative to the master curve approach is a Black Space diagram, which is a rheological plot that can delineate either dynamic modulus |E*| or shear modulus |G*| vs. phase angle (δ). In this study, four asphalt binders were tested with one aggregate blend. One of these four binders was unmodified and the other three were modified with polymers and acids. Additionally, Polyphosphoric acid (PPA) is compared to the more traditional SBS polymer modification. PPA …

Impact Of Extreme Summer Temperatures On Bridge Structures, Ryan Hagedorn

Graduate Theses and Dissertations

Climate change and its effect on weather in the United States is a well-documented phenomenon. In particular, extreme heat waves have become more intense, more frequent, and longer lasting, especially in the southern United States. As with much of America’s transportation infrastructure, prestressed concrete bridge girders experience the effects of these heat waves. Uneven heating of optimized bridge girder sections results in large non-linear temperature gradients. In this study, temperature was monitored in three different AASHTO I-girders to determine the vertical and transverse temperature gradients in a pre-deck placement condition. It was determined that the current design standard, which uses …

Nanofiltration Rejection Of Contaminants Of Emerging Concern From Municipal Water Resource Recovery Facility Secondary Effluents For Potable Reuse Applications, Steven Michael Jones

Graduate Theses and Dissertations

As reuse of municipal water resource recovery facility (WRRF) effluent becomes vital to augment diminishing fresh drinking water resources, concern exists that conventional barriers may prove deficient and the upcycling of contaminants of emerging concern (CECs) could prove harmful to human health and aquatic species if more effective and robust treatment barriers are not in place.

There are no federal Safe Drinking Water Act (SDWA) regulations in place specifically for direct potable reuse (DPR) of WRRF effluent. Out of necessity, some states are developing their own DPR reuse regulations. Currently, reverse osmosis (RO) is the default full advanced treatment (FAT) …

Structural Identification Of An Elevated Water Tower, James Thomas Norris

Graduate Theses and Dissertations

Elevated water tanks are generally located at higher elevations within a particular geographic area. The location and height of these structures often makes them desirable for installing wireless and cellular communications antennas. The impact of this practice on the long-term serviceability performance of the primary structure is not clear and could be an important consideration deserving further analysis. This paper presents a case study of an elevated water tank that was motivated by this particular consideration. The structure had been retrofitted with cellular antennas during its service and later experienced fatigue cracking at the fill pipe-tank interface. The owner wished …

Evaluation Of Poisson’S Ratio Of Asphalt Concrete, Elvis Alexander Castillo Camarena

Graduate Theses and Dissertations

Poisson´s ratio can be defined as the negative ratio of strains perpendicular to the load direction to the strains parallel to the loading direction. If elastic or viscoelastic models are used, Poisson´s ratio, together with elastic modulus, is a main input used to predict distresses in flexible pavement structures such as rutting and cracking. In asphalt concrete, Poisson’s ratio is commonly measured using two different testing configurations: indirect tension (IDT) and uniaxial. However, results from these two testing configuration can potentially have differences. Design methodologies such as the Mechanistic Empirical Design Guide (MEPDG, now PavementME) have been shown to be …

Field Observations And Computer Modeling Of Tornado-Terrain Interaction And Its Effects On Tornado Damage And Path, Nawfal Shihab Ahmed

Graduate Theses and Dissertations

Tornado forces on structures have been a research focus for the past decades, and some comparisons have been made to distinguish between straight boundary layer (SBL) wind and tornado wind forces on specific structures. However, very little attention has been paid to terrain effects on tornado damage and path. Available damage investigation data for four tornado locations (Joplin-2011, Tuscaloosa-2011, Parish-2011 and Mayflower-2014) is utilized to explore terrain effects on tornado damage and path. Google Earth, site visits and aerial images are employed to study the influence of terrain on an extent of damage and path variation. Additionally, a three dimensional …

Development Of The Masw Method For Pavement Evaluation, Benjamin J. Davis

Graduate Theses and Dissertations

The purpose of this research is to establish a recommended procedure for performing multichannel analysis of surface waves (MASW) on pavements as well as evaluating the ability of MASW to detect a change in shear wave velocity as damage in concrete increases. The tests for establishing a recommended procedure for performing MASW on pavements was conducted at five sites at the University of Arkansas Engineering Research Center in Fayetteville, Arkansas. The five sites consisted of three materials: asphalt, concrete, and soil (two sites were on asphalt, two were on concrete, and one was on soil). The methods evaluated at these …

Local Delivery Of Ctla-4 Blockade Inhibits Growth Of Pancreatic Tumors, Jack Baltz

Biomedical Engineering Undergraduate Honors Theses

Immune checkpoint blockade has demonstrated great potential in activating antitumor immunity. Ipilimumab is a monoclonal antibody which targets cytotoxic T-lymphocyte antigen-4. CTLA-4 belongs to the CD28 class of receptors and is found on the surface of CD4⁺ and CD8⁺ T cells. CTLA-4 acts to suppress the immune system when bound to CD80 and CD86 receptors on antigen presenting cells. Ipilimumab, or anti-CTLA-4, has shown to be effective in significantly extending the survival of patients with metastatic melanoma. However, systemic delivery of Ipilimumab also induces significant side effects such as: colitis, dermatitis, uveitis, and hypophysitis. In order to minimize …

Localized Immunotherapy Delivery Using Injectable In Situ Forming Chitosan Hydrogel, Seth Washispack

Biomedical Engineering Undergraduate Honors Theses

Cytokine-based cancer immunotherapies stimulate a host’s immune system to fight cancer. In particular, interleukin-12 (IL-12), a potent pro-inflammatory cytokine, has demonstrated the ability to eliminate tumors in a number of preclinical models. Toxicities associated with the systemic delivery of IL-12 have precluded its use in the clinic. We are developing a novel chitosan-based hydrogel to maintain high local concentrations of cytokines, such as IL-12, in the tumor while minimizing its systemic dissemination. This hydrogel was found to form spontaneously within ten seconds of mixing two proprietary components. To increase the usefulness of the hydrogel, an efficient mixing and delivery system …

Intravital Microscopy Of Tumor Oxygenation And Glycolytic Demand, Jesse D. Ivers

Biomedical Engineering Undergraduate Honors Theses

There is growing concern about the over treatment of cancer because treatments are based primarily on tumor anatomy. In this study, we aim to begin the process of addressing that issue by developing an intravital technique for optically analyzing tumor biology. Two traits were identified as having significant importance in the aggression of a tumor, vascular oxygenation (SO2) and glycolytic demand. Dorsal skin flap window chambers were implanted and 4T1 and 67NR cancer cells were injected to provide a tumor model for the development of this intravital quantification technique. This study provides a detailed protocol from instrumentation setup to surgical …

Chitosan As An Antiviral, Tayler Pauls

Biomedical Engineering Undergraduate Honors Theses

There is no broad-based antiviral medication available today; there are specific antivirals, for example, the antiretroviral for HIV. However, these specific antivirals are not available in each country and can be problematic for specific patients. Chitosan is proposed as a possible broad-based antiviral, which has already demonstrated antibacterial properties, antiviral properties in plants, is used for wound healing and as a hydrogel among other medical applications. The methods used are transfection of NIH-3T3 cells with GFP-adenovirus with 0.1%, 0.5%, and 1% chitosan added to virus prior to transfection. Fluorescence microscopy and flow cytometry data has validated that the use of …

Determining The Effect Of Delivery Rate On Glucose Uptake By Cancer Cells, Luke Felton

Biomedical Engineering Undergraduate Honors Theses

Radiation therapy is one of the most commonly performed cancer treatment therapies today. Radiation therapy can cause can changes to tumor vasculature and affect blood flow rates. It is important to determine how changes in blood flow rates affect tumor glycolytic uptake to better understand tumor response to radiation therapy (1). The goal of this study was to use a fluorescent analog of glucose, 2-NBDG, to study the effect of varying flow rates on glucose uptake. A microfluidic device was constructed to flow 2-NBDG through. A murine metastatic breast cancer cell line was then cultured inside this microfluidic channel, and …

Improving Reliability Of Medical Device Tracking Using Unique Device Identification, John A. Bonfanti

Industrial Engineering Undergraduate Honors Theses

The term “disruptive innovation” has been the buzzword of industries looking to create technological advancements in their respective fields ever since the term was first coined in 1995. In order to invest in the future of the industry, companies are beginning to focus on new, innovative ideas that come into the market as a low-cost alternative to the sustaining innovations currently in place. Similar business-models can be seen in the healthcare industry, as physicians look to disruptive innovations to provide methods of diagnosis and treatment that are easier to perform and maintain. Companies, from medical device manufacturers to the hospitals …

Modeling The Impact Of Rfid Technology On The Healthcare Supply Chain, Travis B. Peter

Industrial Engineering Undergraduate Honors Theses

Due to increasing competition in the healthcare industry, healthcare providers must find ways to reduce their costs of operation or potentially lose customers to more affordable options. For many years, the healthcare supply chain has significantly lagged behind the retail supply chain in terms of supply chain efficiency. Certain disruptive technologies that have become widespread in the retail supply chain have yet to be integrated by a significant number of healthcare providers, and as a result, there are large opportunities for improvements in the healthcare supply chain that could lead to both cost and time savings. Radio Frequency Identification (RFID) …

Statistical Learning Tools With Food Science, Jessica C. Hacker

Industrial Engineering Undergraduate Honors Theses

The food science discipline has many issues requiring research within academia in order to protect the food that gets distributed from industry. The team within the Center for Food Safety at the University of Arkansas’ Division of Agriculture has been studying the gastrointestinal microbial community in broiler chickens in order to control pathogenic bacteria and improve gut health within the chickens to promote a healthy adult microbiota. This has many positive effects on the quality of the chickens. The team performs a standard method of analysis on every experiment run within a software called QIIME to determine if a treatment …

Developing A Risk Analysis Model To Improve Study Abroad Awareness, Tyler Spain

Industrial Engineering Undergraduate Honors Theses

As international education opportunities increase in popularity among U.S. college students (McMurtrie, 2007), it is becoming more and more necessary for study abroad organizations to be aware of the risks students face as they travel abroad. While some international cities are riskier than others, it can be difficult to distinguish between cities which truly carry a high degree of risk for visiting students, and which cities are only perceived to be risky based on various personal misconceptions. The University of Arkansas Office of Study Abroad & International Exchange currently lacks a way to quantifiably analyze the risk of study abroad …

Isolation Of Metallic Single-Walled Carbon Nanotubes For Electrically Conductive Tissue Engineering Scaffolds, Jakob Hockman

Biomedical Engineering Undergraduate Honors Theses

Metallic single-walled carbon nanotubes (m-SWNTs) were separated from pristine SWNTs using affinity chromatography for use in electrically conductive tissue engineering scaffolds. Approximately one third of SWNTs have metallic properties. Separations were achieved using a protocol modified from Liu & coworkers (2011) in order to improve the method for cell culture environments. Samples enriched in m-SWNTs were isolated and characterized. However, challenges still remain for the complete separation of m-SWNTs from their semiconducting counterpart (s-SWNTs) using this protocol. Approaches to improve separation and reduce the difficulties associated with processing the nanotubes were suggested. One of the ultimate destinations of these nanotubes …

Development Of A Simple Handheld Biosensor For Waterborne Pathogens, Bryce C. Jones

Chemical Engineering Undergraduate Honors Theses

Current methods of detecting waterborne pathogens involve testing strips which take 24-48 hours to yield results, or require expensive equipment in order to function. In minimalist environments, these two technologies are not always applicable to test water quality. With the emergence of a new method of PCR, named LAMP PCR, it is possible to quickly and accurately detect pathogen DNA in a water sample. In order to scale this technique into a simple device, the aspects of the reaction must be accommodated, and a visual detection method chosen. A handheld device which keeps the isothermal LAMP PCR stable for the …

Optical Analysis And Fabrication Of Micro And Nanoscale Plasmonically Enhanced Devices, Avery M. Hill

Mechanical Engineering Undergraduate Honors Theses

Plasmonic nanostructures have been shown to act as optical antennas that enhance optical devices due to their ability to focus light below the diffraction limit of light and enhance the intensity of the incident light. This study focuses on computational electromagnetic (CEM) analysis of two devices: 1) GaAs photodetectors with Au interdigital electrodes and 2) Au thin-film microstructures. Experiments showed that the photoresponse of the interdigital photodetectors depend greatly on the electrode gap and the polarization of the incident light. Smaller electrode gap and transverse polarization give rise to a larger photoresponse. It was also shown that the response from …

Developing A Logistics Risk Assessment Tool, Daniel C. Fritsche

Industrial Engineering Undergraduate Honors Theses

Economies around the world have thrived in the wake of the development and keen understanding of effective supply chain management practices. As a result, organizations have become more dependent on other organizations to move their products and services to completion due to complex sourcing and shipping arrangements that have precipitated from the formation of sophisticated supply chains. A supply chain is in general a flow of products or services. When this flow is disrupted or halted, disastrous consequences can ensue. In the worst cases, such as with a disaster relief organization like the American Red Cross, disruptions in supply chains …

Engineered Resilient Systems Model Applied To Network Design, Zephan W. Wade

Industrial Engineering Undergraduate Honors Theses

Engineered Resilient Systems (ERS) is a Department of Defense (DoD) program focusing on the effective and efficient design and development of resilient complex engineered systems throughout their lifecycle. There is growing literature with qualitative definitions of resilience and quantitative models for systems, but these focus typically on systems with one performance measure. In application, many systems have multiple functions and multiple performance measures. This research uses a quantitative resilience framework for ERS that includes system design options, reliability, external threats, vulnerabilities, responses, and consequences assessed on multiple system performance measures. This paper applies the ERS framework to designing resilient networks.

Predicting Nonadherence Behavior Towards Mammography Screening Guidelines, Brian L. Trussell

Industrial Engineering Undergraduate Honors Theses

The goal of this research is to examine factors associated with nonadherence behavior toward mammography screening among U.S. women. The 2014 Behavioral Risk Factor Surveillance System (BRFSS) survey data was used for this study, allowing the model to represent a robust sample. A logistic regression model was developed to gain an understanding of influencing factors, including demographic, health-related and behavioral characteristics. Further analysis with logistic regression models stratified by age were conducted to control for the effect of age. The results show that demographic and health related information such as income, number of children, and BMI category can help intervention …

Development And Analysis Of A Statics And Kinematics Demonstration As A Learning Tool In The Biomechanics Classroom, Bethany D. Knight

Biomedical Engineering Undergraduate Honors Theses

This study was done with the objective of determining if students in the biomedical engineering department at the University of Arkansas would gain better understanding of basic biomechanics principles through the implementation of in-class demonstrations. Biomechanics was chosen because it is the first class taken in sequence after the “Introduction to Biomedical Engineering” class. A pre-demonstration survey was administered to gauge how comfortable the students were with the topics on the syllabus. Two demonstrations were done in class and related homework was assigned. The post-semester survey was administered and collected to determine how effective the students felt the presentations to …

Customization Of Titanate Nanofiber Bioscaffolds, Jared Hopkins

Biomedical Engineering Undergraduate Honors Theses

In the field of orthopedic devices implant loosening is a major issue resulting in the majority of device failures. These failures result in the need for costly secondary procedures. To reduce device loosening an improved method of tissue anchoring is required. A previously studied titanate nanofiber bioscaffold has been shown to be safely implantable and to contribute to the differentiation of mesenchymal stem cells to osteocytes. Through the customization of both physical and chemical characteristics this titanate nanofiber bioscaffold was fabricated as a potential means to enhance tissue anchoring for use with orthopedic devices. This customization was enabled by acoustic …

Targeted Drug Delivery Using Peptoid Based Nanospheres, Kaylee J. Smith

Chemical Engineering Undergraduate Honors Theses

While medicine has improved greatly in the last couple of decades, there are negative side effects that accompany many drugs. Undesirable side effects could be greatly reduced if non-systemic drug delivery systems were used because the medicine would harm diseased cells at a much higher rate than it does healthy cells. One possible non-systemic drug delivery system is peptoid nanospheres. These nanospheres will then be linked to another peptoid that is engineered to attach almost exclusively to diseased cells.

This research project is focused on designing peptoids that will form nanospheres in solution. Four specific peptoids were synthesized and tested …

Acceleration Of Ddscat Computation By Parallelization On A Supercomputer, Manoj V. Seeram

Chemical Engineering Undergraduate Honors Theses

The DDSCAT software is enabled for use of MPI or OpenMP to distribute calculation of different particle orientations amongst multiple processors on a high performance system. Run times for these simulations have been tested to take hours or days however and simulating varying orientations is not always necessary. If a simulation with only one particle orientation is submitted, DDSCAT could still potentially parallelize the simulation by wavelength calculations but it is unknown if this is the case. In this paper, we will be (i) quantifying the reduction in computation time that MPI provides relative to an equivalent MPI disabled simulation …