Engineering Commons^™

Studies On Protein Solubility, Ke Li

Doctoral Dissertations

"Solubility is a critical factor of protein-based drugs during processing and patient administration. This study focused on two aspects of solubility: one was the poly (ethylene) glycol (PEG) precipitation of monoclonal antibodies (mAbs) and another was crystallins aggregation that is associated with cataracts. Protein precipitation by PEG is a common technique for downstream processing. The effects of pH, ionic strength and the exclude volume effect on the protein precipitation by PEG were extensively studied, but the effects of glycosylation on protein precipitation by PEG has not been examined. Protein aggregation is not only a problem in downstream processing, but it …

Numerical And Experimental Study Of Mechanical Properties For Laser Metal Deposition (Lmd) Process Part, Lan Li

Doctoral Dissertations

"Laser Metal Deposition (LMD), also called as, Laser Engineered Net Shaping (LENS), Directed Energy Deposition (DED), is a typical Additive Manufacturing (AM) technology, is used for advanced free-form fabrication. It creates parts by directly melting materials and depositing them on the workpiece layer by layer. In this process, the metal powder or fiber is melted within the melting pool by laser beam or electron beam and quickly solidifies to the deposited layer. LMD technology shows great advantages over traditional manufacturing on complex structure fabrication, including high building rates, easy material replacement and reduced material waste. These merits make the wide …

Reveal Wind Loading Of Tornadoes And Hurricanes On Civil Structures Towards Hazard-Resistant Design, Ryan Honerkamp

Doctoral Dissertations

"Extreme winds impacting civil structures lead to death and destruction in all regions of the world. Specifically, tornadoes and hurricanes impact communities with severe devastation. On average, 1200 tornadoes occur in the United States every year. Tornadoes occur predominantly in the Central and Southeastern United States, accounting for an annual $1 billion in economic losses, 1500 injuries, and 90 deaths. The Joplin, MO Tornado in 2011 killed 161 people, injured more than 1000, destroyed more than 8000 structures, and caused $2.8 billion of property loss. Hurricanes occur predominantly on the United States East coast regions and along the coast of …

Multi-Fidelity Modeling For Aerothermal Analysis Of Deployable Planetary Entry Technologies, Mario J. Santos

Doctoral Dissertations

“NASA is developing deployable entry technologies in the form of the Hypersonic Inflatable Aerodynamic Decelerator (HIAD) and the Adaptable Deployable Entry Technology (ADEPT) vehicles to support human exploration of Mars. To ensure that these technologies are reliable under uncertain entry conditions and extreme aerothermal environments, uncertainty quantification must be integrated into the design process which typically requires large number of high-fidelity computational fluid dynamics (CFD) simulations with prohibitively high computational cost. To address this challenge, construction of multi-fidelity aerothermal response predictions which combine low-fidelity correlations with fewer high-fidelity CFD models in a way that produces highly accurate surrogates with reduced …

Effect Of Radiation Damage On Organic Phase Change Materials Thermal Storage Properties, Ryan Phillip Steere

Doctoral Dissertations

"This work discusses the effects of radiation damage on organic phase change materials for use in nuclear reactor containments and space craft. The effects of radiation on the latent heat of polyethylene wax (PEW) and a eutectic of methyl palmitate and lauric acid (EMPaLA) are evaluated. These PCMs were irradiated in three locations: the Missouri University of Science and Technology research reactor (MSTR), the University of Missouri research reactor (MURR) and cyclotron (MUC) up to a total dose of 2826, 2895 and 662 Gy, respectively. The samples irradiated at the MSTR showed latent heat changes up to 15.5% lower than …

Enhanced Heavy Oil Recovery By Low Salinity Polymer Flood Combined With Microgel Treatment, Yang Zhao

Doctoral Dissertations

“Heavy oil resources account for a large portion of the total oil reserves around the world. The target heavy oil reservoir is located on Alaska’s North Slope (ANS). Advantages of low-salinity HPAM polymer (LSP) over high-salinity polymer (HSP) were demonstrated. LSP could recover more oil with 40% less polymer consumption. No additional oil was recovered by HSP after LSP flood. The first-ever polymer flood pilot on ANS showed remarkable success regarding water cut reduction, oil production increase, delayed breakthrough, and projected oil recovery improvement. Polymer alone was insufficient to achieve satisfactory recovery as the reservoirs were highly heterogeneous. Microgels could …

Sensor Data Based Adaptive Models For Assembly Worker Training In Cyber Manufacturing, Md. Al-Amin

Doctoral Dissertations

“Production innovations are occurring faster than ever leading conventional production systems towards cyber manufacturing. Manufacturing workers thus need to frequently learn new methods and skills. In fast-changing, largely uncertain production systems, manufacturers with the ability to comprehend workers’ behavior and assess their operational performance in near real-time will achieve better performance than peers. Recognizing worker actions in near real-time while performing the assembly can serve this purpose. However, reliably recognizing the assembly actions performed by the workers is challenging, because the actions for assembly are complex and workers are not only heterogeneous but sensitive to the variation of the work …

Mining Haul Road Defect Detection -- Advancement In Automated Road Extent And Response Calibration For Improved Maintenance, Alexander David Douglas

Doctoral Dissertations

Mine haul roads degrade rapidly due to extremely heavy loads on sub optimal construction materials. This research tests two methods of defect detection to determine limitations to current technology: optical detection and vehicle vibration response. Optical defect detection was found to have the least significant limitations for surface defect detection and vehicle vibration response modeling has the least significant limitations for subsurface defects. This research proposes novel methods to eliminate the critical limitations of both technologies.

Unmanned Aerial Vehicles (UAV) equipped with GPS and a high-resolution camera is used to create a 3-D point cloud using a structure-from-motion algorithm. This …

Catalytic Carbon Dioxide Hydrogenation To Methanol/Dimethyl Ether Over Copper-Based Catalysts, Xiao Fan

Doctoral Dissertations

Direct synthesis of dimethyl ether (DME) via CO₂ hydrogenation has received great attention, owing to the global warming caused by CO₂ emission and increasing energy demand worldwide. In this works, three major aspects of bifunctional catalysts development were studied: (1) investigation of the roles of interaction in the CuO-ZnO-ZrO₂-Al₂O₃/HZSM-5 bifunctional catalysts, (2) deactivation and regeneration of CuO-ZnO-ZrO₂-Al₂O₃ with different zeolitic catalysts for one-step CO₂ hydrogenation to dimethyl ether, and (3) study on the enhancement of activity and stability of CZZA/HZSM-5 bifunctional catalysts via the introduction of …

Use Of Portable Seismic Property Analyzer And Ground Penetrating Radar To Assess Bridge Decks, Samie Ramadan A Hamad

Doctoral Dissertations

The Montauk Bridge deck was assessed based on the portable seismic property analyzer and ground penetrating radar data. Based on the analysis of the portable seismic property analyzer data, it was determined that over 65% of bridge conditions were rated serious to poor condition with an average compressive strength of less than 2500 psi; less than 35% of bridge deck conditions were rated fair to good with an average compressive strength over 2500 psi. Based on ground penetrating radar data, it was determined that 72% of the bridge deck was in serious to poor condition, and only 28% of the …

Relating Detonation Parameters To The Detonation Synthesis Of Nanomaterials, Martin Langenderfer

Doctoral Dissertations

“This research investigates the physical and chemical processes that contribute to the detonation synthesis of silicon carbide nanoparticles. Bulk production of SiC nanoparticles through detonation is possible due to pressures achieved over 20 GPa and temperatures over 2000 K as well as quenching rates in excess of 13 billion K/second. These conditions catalyze reaction and bottom-up molecular growth while retaining particles < 100 nm in diameter. In this work, detonation synthesis of SiC was demonstrated by incorporation of polycarbosilane, an SiC precursor material, into an RDX/TNT explosive matrix prior to detonation. Detonation Synthesis of SiC was also accomplished by reacting elemental silicon with carbon liberated by the detonation of negatively oxygen balanced TNT. Hydrodynamic simulation of a 60:40 mass ratio RDX/TNT detonation created conditions thermodynamically suitable to produce cubic silicon carbide within the first 500 nanoseconds after the passage of the detonation wave while carbon remains chemically reactive for molecular formation. Simulations and experimental tests indicated that loading configuration and impedance mismatch of the precursor additives used in detonation synthesis results in conditions in the additives that exceed the accepted detonation pressure of the explosive by greater than three times. Finally, a full factorial experimental design showed increasing silicon concentration, reducing silicon size, and reducing oxygen balance by adjusting the ratio of RDX to TNT decreased the explosives detonation pressure by 20% and increased the soot yield and concentration of SiC observed in the detonation products by 82% and 442% respectively”--Abstract, page iv.

Investigation Of Anomalous Data Trends During Coal Dust Explosibilty Testing, Jacob Lee Miller

Doctoral Dissertations

Coal dust explosibility is a health and safety concern that has been a recognized hazard for over 100 years. Initial testing by the Author using a Siwek 20L apparatus recorded a secondary maximum pressure at higher dust concentrations (1,000-7,000g/m³) with Pulverized Pittsburgh Coal (PCC). Higher dust concentrations are beyond the typical ASTM E1226 testing procedure but are possible in mining and processing scenarios. No reference documents have been discovered that show a secondary maximum pressure at higher dust concentrations. Literature reviewed identified that once a coal dust concertation generates a peak pressure, the pressure remains constant or decreases …

An Investigation Of Unsteady Thermal Exchange Processes In Geothermal Heat Exchangers, Ganesh Ravi Shanker

Doctoral Dissertations

“Geothermal heat exchangers, has become one of the highly recognized non conventional heat exchangers as they utilize renewable energy source earth to initiate the thermal energy transfer. However, these heat exchangers suffer from a expensive installation cost due to their conservative design model, thereby facilitating the need to identify and improve the design. In this dissertation, three gaps, which identifies improvement over conservative design were investigated, to assess the heat exchanger performance. In the first approach, borehole thermal and geometrical properties were investigated keeping the outlet leg of the heat exchanger as adiabatic, which neglects the thermal short-circuiting between the …

Investigating The Focusing Effect Of Charge Geometry With Computer Simulations, Witness Plates, And High-Speed Videography, Kelly Ray Williams

Doctoral Dissertations

"Scaled distance is used to calculate a safe standoff radius from the detonation of a known mass of an explosive. It has been shown that varying only the geometry of the charge significantly overdrives regions of the blast wave potentially resulting in hazardous overpressure levels at scaled distance safe radii. Pressure transducers are used to measure overpressure surrounding spherical, cylindrical, and cubic charges to determine if bridge waves were formed at the edges between flat sides as seen in published studies of cylindrical charges. In the fireball field a witness plate is used to evaluate radial energy distribution with a …

Modeling For Off-Chip High-Speed Designs, Siqi Bai

Doctoral Dissertations

”Signal integrity (SI) and power integrity (PI) are essential for datacenter application. A typical datacenter rack consists of a switch on the top of the rack, servers, and storage units. Three SI/PI related problems for datacenter application are analyzed in this research.

The first topic is analysis on power via induced Quasi-quarter-wavelength resonance to reduce crosstalk. Using an analytical model and 3D full-wave simulation models, a physical explanation for the unexpected resonance in the differential signal pairs is proposed. Considering the difficulty in changing the pin map of the IC-package, several PCB layouts to eliminate the power via induced quasi-quarter-wavelength …

Designing Transition Metal Chalcogenides Electrocatalyst Surfaces For High-Efficiency Water Oxidation, Umanga De Silva

Doctoral Dissertations

”The rising demand for energy security and reducing fossil fuel dependence has prompted researchers to search for a clean, sustainable, and efficient energy generation system with low environmental impact. Water electrolysis has been identified as one of the most important processes satisfying the above needs to generate hydrogen as a clean fuel. Two half-cell reactions of oxygen evolution reaction (OER) at the anode and hydrogen evolution reaction (HER) at the cathode comprise the main process of water electrolysis. However, the oxygen evolution reaction is the most crucial step for efficient water splitting. Traditionally, metal oxides have been utilized as catalysts …

Fiber-Optic And Coaxial-Cable Extrinsic Fabry-Perot Interferometers For Sensing Applications, Chen Zhu

Doctoral Dissertations

”The fiber-optic extrinsic Fabry-Perot interferometer (EFPI) is one of the simplest sensing configurations and is widely used in various applications due to its prominent features, such as high sensitivity, immunity to electromagnetic interference, and remote operation capability. In this research, a novel one-dimensional wide-range displacement sensor and a three-dimensional displacement sensor based on fiber-optic EFPIs are demonstrated. These two robust and easy-to-manufacture sensors expand the application scope of the fiber-optic EFPI sensor devices, and have great potential in structural health monitoring, the construction industry, oil well monitoring, and geo-technology.

Furthermore, inspired by the fiber-optic EFPI, a novel and universal ultra-sensitive …

Adaptive Dynamic Programming Methods For Tracking Current Control Of Switched Reluctance Motor Drive, Hamad Alharkan

Doctoral Dissertations

“This research investigates the application of adaptive dynamic programming (ADP) methods for the current control of switched reluctance motors (SRM). Since the traditional current controllers have large current ripples that increase torque ripples and acoustic noise, optimal tracking controllers using reinforcement learning (RL) approaches are introduced as an alternative adaptive technique for SRM drives. The proposed optimal tracking controllers can minimize current ripples and cope with uncertainties within the inductance profile of the SRM. The work is composed of three papers. In the first paper, a novel Q-learning scheduling method for the current controller of a switched reluctance motor (SRM) …

3d-Printed Adsorbents For Gas Separations: A Material Development, Kinetic Assessment, And Process Performance Investigation, Shane Lawson

Doctoral Dissertations

“Adsorbent materials are promising for various gas purification processes, however, forming them into structured contactors is paramount in enhancing mass transfer properties and reducing pressure losses. In this research, various adsorbents were engineered into structured contactors with 3D printing. The overall goal of this research was to improve the formulation methods of 3D-printed adsorbents and understand their performances in gas separation processes. The specific objectives were to 1) develop new adsorbent 3D-printing strategies, 2) understand the kinetic properties of printed adsorbent monoliths, and 3) assess their process performances. Objective one was addressed by developing five 3D printing techniques: i) oxide …

Development Of In-Situ Radiometric Inspection Methods For Quality Assurance In Laser Powder Bed Fusion, Cody S. Lough

Doctoral Dissertations

“Laser Powder Bed Fusion (LPBF) metal Additive Manufacturing (AM) fabricates 3D metal parts layer-by-layer. The process enables production of geometrically complex parts that are difficult to inspect with traditional methods. The LPBF parts experience significant geometry driven thermal variations during manufacturing. This creates microstructure and mechanical property inhomogeneities and can stochastically cause defects. Mission critical applications require part qualification by measuring the defects non-destructively. The layer-to-layer nature of LPBF permits non-intrusive measurement of radiometric signals for a part’s entire volume. These measurements provide thermal features that correlate with the local part health. This research establishes Optical Emission Spectroscopy (OES) and …

Additively Manufactured Metallic Cellular Structures, Okanmisope Aziel Fashanu

Doctoral Dissertations

"Cellular structures are lightweight structures with excellent mechanical, thermal, and acoustic properties. They offer promise in a series of applications, including lightweight applications, sandwich cores, mechanical damping, acoustic absorption, strain isolation, and thermal management. The manufacturing of these complex cellular structures is expensive and time-consuming, which hinders the adoption of these structures in many industries. Advancement in manufacturing technologies, such as additive manufacturing (AM), however, have changed this. AM allows for the rapid and less expensive manufacturing of complex cellular structures. This work aimed to investigate the performance of additively manufactured cellular structures for lightweight and sandwich core applications. In …

Advanced Battery Modeling For Interfacial Phenomena And Optimal Charging, Yaqi Zhu

Doctoral Dissertations

"Lithium-ion batteries are one of the most promising energy storage systems for portable devices, transportation, and renewable grids. To meet the increasing requirements of these applications, higher energy density and areal capacity, long cycle life, fast charging rate and enhanced safety for lithium-ion battery (LIBs) are urgently needed. To solve these challenges, the relevant physics at different length scale need to be understood. However, experimental study is time consuming and limited in small scale’s study. Modeling techniques provide us powerful tools to get a deep understanding of the relevant physics and find optimal solutions. This work focuses on studying the …

Prediction Of Battery Health Dynamics, Damola Martins Ajiboye

Doctoral Dissertations

"The successful market penetration of lithium-ion batteries in the last 30 years has ushered in a new dawn in energy applications. Notwithstanding their widespread use, lithium-ion batteries are affected by a plethora of fundamental issues — safety, cycle life, performance, and cost. In this work, advanced modeling techniques are developed to tackle some of these issues. This dissertation is subdivided into four parts, the first is introduction while the remaining are dedicated to the development of computational techniques for predicting battery health dynamics.

In the second part of this work, we developed fast and accurate algorithms for modeling essential battery …

Studying The Effects Of New Additive Materials For The Improvement Of The Capacity And Cycle Life Performance Of The Lead-Acid Battery, Julian Kosacki

Doctoral Dissertations

"Lead-acid batteries are an established technology with nearly 99% recyclability; however, lead-acid batteries produce only 40% of their theoretical capacity due to poor active mass utilization and PbSO4 pore blockage, and the longevity of the batteries is hampered by secondary reactions during the cycle life such as corrosion and gassing.

Lead-acid batteries were investigated and improved through several different approaches: an alternative electrolyte to mitigate secondary reactions, graphite additives to improve positive active mass (PAM) utilization, and dispersant additives to help the industrial pasting process.

The thermodynamics and chemical reactions of a commercial electrolyte replacement called Tydrolyte^TM were investigated …

Hydromechanical Stress And Internal Erosion Under Earthen Structures, Kerry Allen Magner

Doctoral Dissertations

"Dam failures by seepage and internal erosion have reportedly been attributed to up to 40% of all dam failures in the United States. Backwards piping erosion either through the embankment or foundation soils has been reported to be the major contributing method to seepage and internal erosion dam failures. This proposed research is motivated by the lack of understanding of the complex stress regimes associated with internal erosion in cohesionless soils under earthen structures. The overall goal of this research is to provide a fundamental understanding of internal erosion and the hydromechanical stress conditions necessary for the initiation and continuation …

Sources Of Quality Uncertainty In Laser Powder Bed Fusion Metal Additive Manufacturing, Zachary Young

Doctoral Dissertations

"Powder based additive manufacturing (AM) exhibits tremendous uncertainties, where variations in build quality is present despite utilizing similar build processing parameters. First, this work reports the features and formation mechanisms of five unique types of spatter during the LPBF process by in-situ high-speed, high-energy x-ray imaging. The unique physical characteristics of spatter are determined. The effect of laser scan speed and laser power on spatter formation, ejection, and mitigation are determined. Second, this work addresses the uncertainty challenge by identifying the sources of uncertainty in SLM by in-situ characterization due to variations from the additive manufacturing processing parameters needed for …

Investigating The Impact Of Rock Bridges On The Mechanical Behavior Of Jointed Rock Mass Using Lattice Spring-Based Synthetic Rock Mass (Ls-Srm) Approach, Mariam Salem Alebayat

Doctoral Dissertations

"Rock bridges were defined as a segment of intact rock that separates from discontinuities. Numerous studies are focused on developing methods to quantify their significance in rock mass strength and deformability behavior. This thesis aimed to enhance understanding of the effect of rock bridges on jointed rock masses in both laboratory and slope scales. For this purpose, the lattice spring base Synthetic Rock Mass (LS-SRM) method was adopted to conduct the numerical models, distinguished in computational efficiency, and simulates the brittle failure and roughness of discontinuities.

A robust approach was developed to optimize the calibration procedure to avoid the complex …

Novel Piezo Actuators For Surface Cleaning, Yezad H. Anklesaria

Doctoral Dissertations

"Optical cameras are becoming increasingly common and are used in a variety of applications. With recent progress and transition toward more autonomous systems, the usage of optical systems will be common and widespread. Applications of the optical systems range from autonomous vehicles, home security systems, aviation, extraterrestrial vehicles, spacecraft, and satellites. Imaging systems are used in decision-making in many of these applications. Fouling of the field of view of the imaging system can impede the decision process. An active autonomous cleaning method for the optical surface of the optical systems reliably would be advantageous. The research work focuses on developing …

Convective-Diffusive Transport In Krogh Cylinders: A Model For Pharmacokinetics, Xianjie Qiu

Doctoral Dissertations

"Drug delivery to inside of the tumor is the important problem. The dynamics of drug delivery is presented here. Previously and particularly for directed delivery, a stirred tank model has been used, which appears to have worked well when compared to experiments. However, the stirred tank models do not include all the mass transfer resistances and towards that end we have used a distributed system called Krogh cylinder. This study focuses on the Krogh cylinder model simulation, both on the fluid flow and the mass transfer. The capillary network is broken down into cylindrical cells, each containing a capillary and …

Information-Based Methods And Models For Particle Flow Filtering, Kari Catherine Ward

Doctoral Dissertations

"Recursive estimation methodologies, such as Kalman and Bayesian filters, typically require models of some kind to perform the estimation. This filtering process seeks to improve knowledge surrounding some quantities of interest, or states, over time by incorporation of imperfect observations. The models required pertain to the state dynamics, sensors from which measurements are obtained, and probabilistic models of the underlying stochastic processes. In addition to any number of necessary models, real-world application of a filter is normally accompanied by at least one, if not several, techniques to promote better performance. These methods vary in purpose from expanding the kinds of …