Engineering Commons^™

Adaptive Real-Time Decoding Of Brain Signals For Long-Term Control Of A Neuro-Prosthetic Device, Tushar Ashok Dharampal

Master's Theses (2009 -)

Changes in the statistical properties of neural signals recorded at the brain machine interface (BMI) pose significant challenges for accurate long-term control of prostheses interfaced directly with the brain by continuously altering the relationship between neural responses and desired action. In this thesis, we develop and test an adaptive decoding algorithm that can recover from changes in the statistical properties of neural signals within minutes. The adaptive decoding algorithm uses a Kalman filter as part of a dual-filter design to continuously optimize the relationship between the observed neural responses and the desired action of the prosthesis. Performance of the algorithm …

Examining The Relationships Among Injury Outcomes, Velocity And Grip Strength During Dynamic Platform Perturbation, Braden Cripe

Master's Theses (2009 -)

Studies examining the relationship between inputs and outputs for simulated models of dynamically perturbed horizontal platforms are scarce. Most of these scenarios include a standing operator with upper extremity grip, oftentimes subjected to lateral impulses, which may lead to occupant injury. While the detailed study of these collision scenarios is sparse, the prevalence of their application is great.

This thesis aims to identify how two input parameters, velocity change (ÄV) and grip strength, affect injury assessment reference values (IARVs). This is accomplished by using Mathematical Dynamic Modeling (MADYMO) software to simulate the scenarios defined by those inputs. In the simulation, …

Role Of Tendon Vibration In Multijoint Reflex Coupling In The Hemiparetic Arm Post Stroke, Bani Gadhoke

Master's Theses (2009 -)

Post stroke hemiparesis causes reflex coupling in multiple muscles of the arm, leading to atypical movements that hamper motor control. In particular, people post-stroke can become unstable while holding the arm at the end of a planar motion. Recently, we have found that tendon vibration of the wrist flexors improves the stability of the arm during a hold task. The objective of the current study was to identify the effects of vibration applied to the wrist flexors on the biceps and triceps stretch reflexes, generated using a tendon tapper. In people post-stroke, tendon tap perturbations of the biceps and triceps …

Methods For Detecting High-Frequency Oscillations In Ongoing Brain Signals: Application To The Determination Of Epileptic Seizure Onset Zones, Chiran Dilip Doshi

Master's Theses (2009 -)

Epilepsy is a neurological disorder with varied expression. Patients with focal onset seizures that are resistant to medications can benefit from ablative surgery. However, localization of the seizure onset zone (SOZ) and characterization of propagation to secondary areas can be challenging. The present study aimed at developing the appropriate signal processing methodology to detect bursts of interictal high-frequency oscillations (HFOs), as a possible signature of the SOZ, in patients with drug-resistant partial epilepsy. Additionally, invasive interictal and ictal intracranial electroencephalography (iEEG) data and non-invasive electromagnetic source imaging with magnetoencephalography (MEG) data from three subjects were analyzed. We developed a novel …

Heat And Mass Transfer Correlations For Steam Methane Reforming In Non-Adiabatic, Process-Intensified Catalytic Reactors, Adam Stephen Kimmel

Master's Theses (2009 -)

Because of its high energy density, hydrogen is a desirable energy source for the achievement of a renewable energy landscape. Though production methods like thermolysis, electrolysis and biomass conversion, among others, are thought to be long term renewable solutions, catalytic steam methane reforming (SMR) is currently the predominant mechanism to produce hydrogen on an industrial scale. The highly endothermic, transport-limited reforming process has also been scaled down through process intensification to create efficient small-scale hydrogen-generating systems. One proposed geometry utilizes a catalytic finned cylinder that provides a manufacturable solution to enable high-efficiency heat exchange and SMR reaction. An accurate representation …

Tools For Creating Wide-Field Views Of The Human Retina Using Optical Coherence Tomography, Ashavini M. Pavaskar

Master's Theses (2009 -)

Optical Coherence Tomography (OCT) has allowed in-vivo viewing of details of retinal layers like never before. With the development of spectral domain OCT (SD-OCT) details of nearly 2µm axial resolution and higher imaging speed have been reported. Nevertheless, a single volume scan of the retina is typically restricted to 6mm x 6mm in size. Having a larger field of view of the retina will definitely enhance the clinical utility of the OCT.

A tool was developed for creating wide-field thickness maps of the retina by combining the use of already available tools like i2k Retina (DualAlign, LLC, Clifton Park, NY) …

Modeling And Computational Framework For The Specification And Simulation Of Large-Scale Spiking Neural Networks, David James Herzfeld

Master's Theses (2009 -)

Recurrently connected neural networks, in which synaptic connections between neurons can form directed cycles, have been used extensively in the literature to describe various neurophysiological phenomena, such as coordinate transformations during sensorimotor integration. Due to the directed cycles that can exist in recurrent networks, there is no well-known way to a priori specify synaptic weights to elicit neuron spiking responses to stimuli based on available neurophysiology. Using a common mean field assumption, that synaptic inputs are uncorrelated for sufficiently large populations of neurons, we show that the connection topology and a neuron's response characteristics can be decoupled. This assumption allows …

Surface Preparation Of Naval Ship Construction Steel (Abs-A And Ah-36) Via Bristle Blasting Process, Jorge Andres Martinez

Master's Theses (2009 -)

Bristle blasting is a new and unique corrosion-removal process that is rapidly gaining widespread acceptance among engineers and practitioners in the corrosion/ surface preparation community. Engineers from the ship construction and repair industries face a constant corrosive threat to ships' steel infrastructure and welded joints. To this end, great care is exercised in protecting the vessels' structural integrity and longevity, while maintenance engineers in the ship-building industry seek new methods to improve surface preparation that will not compromise the surface cleanliness and anchor profile required for proper adhesion of paints and coatings.

In this study, the cleanliness and texture of …

Applying Bayesian Forecasting To Predict New Customers' Heating Oil Demand, Tsuginosuke Sakauchi

Master's Theses (2009 -)

This thesis presents a new forecasting technique that estimates energy demand by applying a Bayesian approach to forecasting. We introduce our Bayesian Heating Oil Forecaster (BHOF), which forecasts daily heating oil demand for individual customers who are enrolled in an automatic delivery service provided by a heating oil sales and distribution company. The existing forecasting method is based on linear regression, and its performance diminishes for new customers who lack historical delivery data. Bayesian methods, on the other hand, respond effectively in the start-up situation where no prior data history is available.

Our Bayesian Heating Oil Forecaster uses forecasters' past …

Development Of An Experimental Model To Quantify Lumbar Spine Kinematics During Military Seat Ejection, Steven George Storvik

Master's Theses (2009 -)

The initial phase of a military ejection sequence exerts substantial axial loads on the spinal column. Eccentric inertial loading on the thoracolumbar spine can lead to injury. Most serious injuries due to ejection are in the form of a vertebral fracture, most commonly occurring at the thoracolumbar junction. The objective of the current study was to understand characteristics of a military seat ejection by employing an experimental model designed to simulate the boost or in-rail phase. The model incorporates realistic boundary conditions and is capable of quantifying metrics associated with injury tolerance such as applied accelerations and resultant loads and …

Direct Numeric Simulation Of Shock Wave Structures Without The Use Of Artificial Viscosity, Kenneth Bernard Jordan

Dissertations (1934 -)

The purpose of this work is to directly simulate shock wave structures without the use of artificial viscosity. The commonly used artificial viscosity model is replaced with an irreversibility model. Irreversibilities are not typically taken into account when modeling the shock processes because shocks are resolved in a large domain where the thickness of the shock is thin compared to the numeric grid resolution. The result is the shock is poorly resolved. In addition processes other than shock processes are adiabatic and reversible. The result is artificial viscosity, a form of irreversibility, is added to the numeric cells near the …

Detection Of Specific Biological Antigens Using Ac Electrochemical Impedance Spectroscopy, Darrel Angelo Mazzari

Dissertations (1934 -)

When certain antigens are present in our environment, a rapid, on-site, accurate, selective, and repeatable detection method can be invaluable in preventing illness or saving lives. Rapid detection of these antigens is important to avert spreading infections.

Currently, capturing a sample and sending it to a laboratory can take weeks to get results, which can be much too long. Conventional sensing methodologies include various electrical measurements as capacitive, potentiometric, piezoelectric, surface plasmon resonance (SPR), and quartz crystal microbalance (QCM). Of particular power and interest is Alternating Current (AC) Electrochemical Impedance Spectroscopy (EIS) which provides for the characterization of the electrical …

Differential Responses Of Targeted Lung Redox Enzymes To Rat Exposure To 60 Or 85% Oxygen, Zhuohui Gan, David L. Roerig, Anne V. Clough, Said H. Audi

Biomedical Engineering Faculty Research and Publications

Rat exposure to 60% O₂ (hyper-60) or 85% O₂ (hyper-85) for 7 days confers susceptibility or tolerance, respectively, of the otherwise lethal effects of exposure to 100% O₂. The objective of this study was to determine whether activities of the antioxidant cytosolic enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) and mitochondrial complex III are differentially altered in hyper-60 and hyper-85 lungs. Duroquinone (DQ), an NQO1 substrate, or its hydroquinone (DQH₂), a complex III substrate, was infused into the arterial inflow of isolated, perfused lungs, and the venous efflux rates of DQH₂ and DQ were measured. …

Noninvasive Imaging Of The Human Rod Photoreceptor Mosaic Using A Confocal Adaptive Optics Scanning Ophthalmoscope, Alfredo Dubra, Yusufu N. Sulai, Jennifer L. Norris, Robert F. Cooper, Adam M. Dubis, David R. Williams, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

The rod photoreceptors are implicated in a number of devastating retinal diseases. However, routine imaging of these cells has remained elusive, even with the advent of adaptive optics imaging. Here, we present the first in vivo images of the contiguous rod photoreceptor mosaic in nine healthy human subjects. The images were collected with three different confocal adaptive optics scanning ophthalmoscopes at two different institutions, using 680 and 775 nm superluminescent diodes for illumination. Estimates of photoreceptor density and rod:cone ratios in the 5°–15° retinal eccentricity range are consistent with histological findings, confirming our ability to resolve the rod mosaic by …

Novel Microelectromechanical Systems Image Reversal Fabrication Process Based On Robust Su-8 Masking Layers, Scott A. Ostrow Ii, Ronald A. Coutu Jr.

Electrical and Computer Engineering Faculty Research and Publications

This paper discusses a novel fabrication process that uses a combination of negative and positive photoresists with positive tone photomasks, resulting in masking layers suitable for bulk micromachining high-aspect ratio microelectromechanical systems (MEMS) devices. MicroChem's negative photoresist Nano™ SU-8 and Clariant's image reversal photoresist AZ 5214E are utilized, along with a barrier layer, to effectively convert a positive photomask into a negative image. This technique utilizes standard photolithography chemicals, equipment, and processes, and opens the door for creating complementary MEMS structures without added fabrication delay and cost. Furthermore, the SU-8 masking layer is robust enough to withstand aggressive etch chemistries …

Effect Of Ankle Orientation On Heel Loading And Knee Stability For Post-Stroke Individuals Wearing Ankle-Foot Orthoses, M. Barbara Silver-Thorn

Biomedical Engineering Faculty Research and Publications

Background: Those who experience lower extremity weakness or paralysis following a stroke often exhibit gait deviations caused by the inability to completely lift their foot during swing. An ankle-foot orthosis (AFO) is commonly prescribed for individuals post stroke with this mobility impairment.

Study design: Randomized controlled trial.

Objectives: To determine whether significant differences could be observed in post-stroke individuals ambulating with an experimental AFO set at three different ankle orientations.

Methods: Gait analysis was conducted for eight post-stroke individuals ambulating with an experimental AFO set in three different randomly selected ankle orientations: 5° dorsiflexion, 5° plantarflexion, and neutral alignment. Temporospatial …

On The Relative Sensitivity Of Mass-Sensitive Chemical Microsensors, Luke A. Beardslee, S. Truax, J.-J. Su, Stephen M. Heinrich, Fabien Josse Phd, O. Brand

Civil and Environmental Engineering Faculty Research and Publications

In this work, the chemical sensitivity of mass-sensitive chemical microsensors with a uniform layer sandwich structure vibrating in their lateral or in-plane flexural modes is investigated. It is experimentally verified that the relative chemical sensitivity of such resonant microsensors is -to a first order- independent of the microstructure's in-plane dimensions and the flexural eigenmode used, and only depends on the layer thicknesses and densities as well as the sorption properties of the sensing film. Important implications for the design of mass-sensitive chemical microsensors are discussed, whereby the designer can focus on the layer stack to optimize the chemical sensitivity and …

Multispectral Classification With Bias-Tunable Quantum Dots-In-A-Well Focal Plane Arrays, Biliana S. Paskaleva, Woo-Yong Jang, Yagya D. Sharma, Sanjay Krishna, Majeed M. Hayat

Electrical and Computer Engineering Faculty Research and Publications

Mid-wave and long-wave infrared (IR) quantum-dots-in-a-well (DWELL) focal plane arrays (FPAs) are promising technology for multispectral (MS) imaging and sensing. The DWELL structure design provides the detector with a unique property that allows the spectral response of the detector to be continuously, albeit coarsely, tuned with the applied bias. In this paper, a MS classification capability of the DWELL FPA is demonstrated. The approach is based upon: 1) imaging an object repeatedly using a sequence of bias voltages in the tuning range of the FPA and then 2) applying a classification algorithm to the totality of readouts, over multiple biases, …

Fault-Tolerant Technique For Δ-Connected Ac-Motor Drives, Ahmed Mohamed Sayed Ahmed, Behrooz Mirafzal, Nabeel Demerdash

Electrical and Computer Engineering Faculty Research and Publications

A fault-tolerant technique for motor-drive systems is introduced in this paper. The technique is merely presented for ac motors with Δ-connected circuits in their stator windings. In this technique, the faulty phase is isolated by solid-state switches after the occurrence of a failure in one of the stator phases. Then, the fault-tolerant technique manages current-flow in the remaining healthy phases. This technique is to significantly mitigate torque pulsations, which are caused by an open-Δ configuration in the stator windings. The performance of the fault-tolerant technique was experimentally verified using a 5-hp 460-V induction motor-drive system and the results are presented …

Influence Of Non-Ideal Clamping In Microcantilever Resonant Frequency Estimation, L. Fadel-Taris, Cedric Ayela, Isabelle Dufour, Fabien Josse, Stephen M. Heinrich, D. Saya, O. Brand

Civil and Environmental Engineering Faculty Research and Publications

Among the most promising sensing platforms are resonating microcantilevers due to their high sensitivity and wide application range. A key parameter of the device implementation is the predicted value of the resonant frequency that depends on the modeling and considerations of relevant physical phenomena. In fact, the estimation based on the conventional, perfectly clamped, Bernoulli-Euler cantilever beam does not lead to satisfactory accuracy in certain cases. Hence this work investigates two system characteristics that may affect the re sonant frequency (a support effect and a so-called rim effect) and provides solutions for a straightforward estimation of rim dimension using resonance …

Damping And Mass Sensitivity Of Laterally Vibrating Resonant Microcantilevers In Viscous Liquid Media, Russell Cox, Jinjin Zhang, Fabien Josse, Stephen M. Heinrich, Isabelle Dufour, Luke A. Beardslee, Oliver Brand

Civil and Environmental Engineering Faculty Research and Publications

The effect of liquid viscosity and density on the characteristics of laterally excited microcantilevers is investigated and compared to transversely excited microcantilevers. When immersed into a viscous liquid medium such as water from air, the resonant frequency of laterally (in-plane) vibrating microcantilevers is shown to decrease by only 5-10% as compared to ~50% reduction for transversely (out-of-plane) vibrating microcantilevers. Furthermore, as the viscosity of the medium increases the resonant frequency of a laterally vibrating beam is shown to decrease at a slower rate than that of a transversely vibrating beam. The decreased viscous damping also leads to increases in the …

What Is Inverse-Geometry Ct?, Taly Gilat Schmidt

Biomedical Engineering Faculty Research and Publications

Inverse-geometry computed tomography (IGCT) systems are being developed to provide improved volumetric imaging. In conventional multislice CT systems, x-rays are emitted from a small area and irradiate a large-area detector. In an IGCT system, x-ray sources are distributed over a large area, with each beam irradiating a small-area detector. Therefore, in the inverse geometry, a series of narrow x-ray beams are switched on and off while the gantry rotates. In conventional CT geometry, cone-beam and scatter artifacts increase with the imaged volume thickness. An inverse geometry may be less susceptible to scatter effects, because only a fraction of the field …

A Rapid And Computationally Inexpensive Method To Virtually Implant Current And Next-Generation Stents Into Subject-Specific Computational Fluid Dynamics Models, Timothy J. Gundert, Shawn C. Shadden, Andrew R. Williams, Bon-Kwon Koo, Jeffrey A. Feinstein, John F. Ladisa

Biomedical Engineering Faculty Research and Publications

Computational modeling is often used to quantify hemodynamic alterations induced by stenting, but frequently uses simplified device or vascular representations. Based on a series of Boolean operations, we developed an efficient and robust method for assessing the influence of current and next-generation stents on local hemodynamics and vascular biomechanics quantified by computational fluid dynamics. Stent designs were parameterized to allow easy control over design features including the number, width and circumferential or longitudinal spacing of struts, as well as the implantation diameter and overall length. The approach allowed stents to be automatically regenerated for rapid analysis of the contribution of …

Salen Mn Complexes Mitigate Radiation Injury In Normal Tissues, Rosalind A. Rosenthal, Brian Fish, Richard P. Hill, Karl D. Huffman, Zelmira Lazarova, Javed Mahmood, Meetha Medhora, Robert C. Molthen, John E. Moulder, Stephen T. Sonis, Philip J. Tofilon, Susan R. Doctrow

Biomedical Engineering Faculty Research and Publications

Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are investigating whether these compounds can mitigate injury to normal tissues caused by ionizing radiation. This review describes some of this research, focusing on several tissues of therapeutic interest, namely kidney, lung, skin, and oral mucosa. These studies have demonstrated suppression of delayed radiation injury in animals treated with EUK-189 and/or EUK-207. While an antioxidant mechanism of action is postulated, it …

Mitochondrial Approaches To Protect Against Cardiac Ischemia And Reperfusion Injury, Amadou K.S. Camara, Martin Bienengraeber, David F. Stowe

Biomedical Engineering Faculty Research and Publications

The mitochondrion is a vital component in cellular energy metabolism and intracellular signaling processes. Mitochondria are involved in a myriad of complex signaling cascades regulating cell death vs. survival. Importantly, mitochondrial dysfunction and the resulting oxidative and nitrosative stress are central in the pathogenesis of numerous human maladies including cardiovascular diseases, neurodegenerative diseases, diabetes, and retinal diseases, many of which are related. This review will examine the emerging understanding of the role of mitochondria in the etiology and progression of cardiovascular diseases and will explore potential therapeutic benefits of targeting the organelle in attenuating the disease process. Indeed, recent advances …

Reliability Testing Of Algan/Gan Hemts Under Multiple Stressors, Bradley D. Christiansen, Ronald A. Coutu Jr., Eric R. Heller, Brian S. Poling, Glen D. Via, Ramakrishna Vetury, Jeffrey B. Shealy

Electrical and Computer Engineering Faculty Research and Publications

We performed an experiment on AlGaN/GaN HEMTs with high voltage and high power as stressors. We found that devices tested under high power generally degraded more than those tested under high voltage. In particular, the high-voltage-tested devices did not degrade significantly as suggested by some papers in the literature. The same papers in the literature also suggest that high voltages cause cracks and pits. However, the high-voltage-tested devices in this study do not exhibit cracks or pits in TEM images, while the high-power-tested devices exhibit pits.

Micromachined Differential Scanning Calorimeter For Cellular Differentiation And Metabolism Monitoring, Robert Blise

Master's Theses (2009 -)

This thesis presents a micromachined differential scanning calorimeter (DSC) for cellular differentiation and metabolism monitoring. The misregulation of cell physiology due to disease increases the metabolic rate of the cell and therefore its heat output. Observing or monitoring the cell's heat output will lead to a method to detect diseased cells and distinguish them from normal cells.

The calorimetric chambers of the DSC were fabricated on a silicon nitride thin film, which allows for rapid thermal equilibrium and insulation. The temperature sensing element was a resistive temperature detector fabricated from nickel. The DSC incorporated integrated nickel resistive heaters to apply …

The Effect Of Cryogenic Treatment On The Fatigue Life Of Chrome Silicon Steel Compression Springs, Debra Lynn Smith

Dissertations (1934 -)

The purpose of this dissertation is to explore the effect of cryogenic treatment on the fatigue life of compression springs. Product manufacturers are constantly searching for ways to make their products last longer. This dissertation addresses three questions: (1) What is the effect of cryogenic treatment on the fatigue life of chrome silicon steel compression springs? Does the life increase, decrease, or remain the same? (2) What is the effect of cryogenic treatment on the Percent Load Loss (Stress Relaxation) of chrome silicon steel compression springs? (3) What are the possible changes in the material that cause these effects?

The …

A Novel Approach To The Part Orientation Problem For Robotic Assembly Applications, Brian James Slaboch

Master's Theses (2009 -)

SCARA (Selective Compliant Assembly Robot Arm) type robots are the most common type of assembly robots. These robots have four degrees of freedom (three rotational and one translational). Typically these robots are used for assembly tasks that take place along a vertical axis. Many times, however, assembly tasks take place along a non-vertical axis. To account for non- vertical axis assembly, parts must be fed in a proper orientation to allow for correct assembly. Parts feeders and specialized end-effectors are typically used to feed parts in their proper orientation. This thesis investigates a novel end-effector that can be used to …

Propagation Of Plate Acoustic Waves In Contact With Fluid Medium, Nagaraj Ghatadi Suraji

Master's Theses (2009 -)

The characteristics of acoustic waves propagating in thin piezoelectric plates in the presence of a fluid medium contacting one or both of the plate surfaces are investigated. If the velocity of plate wave in the substrate is greater than velocity of bulk wave in the fluid, then a plate acoustic wave (PAW) traveling in the substrate will radiate a bulk acoustic wave (BAW) in the fluid. It is found that, under proper conditions, efficient conversion of energy from plate acoustic waves to bulk acoustic waves and vice versa can be obtained. For example, using the fundamental anti symmetric plate wave …