Engineering Commons^™

Diffusion Tensor Imaging Of The Central Nervous System Following An Injury To The Spinal Cord And Cell Transplant, Michael Jirjis

Dissertations (1934 -)

The purpose of this dissertation research was to characterize the use of magnetic resonance diffusion tensor imaging (DTI) as a diagnostic and prognostic tool in understanding the changes that occur throughout the spinal cord and brain following a spinal cord injury (SCI) and following stem cell transplant. The diffusion of water inside the nervous system is dramatically altered around the lesion site following a traumatic SCI. However, following damage to the spinal cord, little is known about the diffusion characteristics away from an injury and even less is understood about DTI's sensitivity to structural changes that occur following regenerative transplant …

Foot And Ankle Motion Analysis Using Dynamic Radiographic Imaging, Benjamin Donald Mchenry

Dissertations (1934 -)

Lower extremity motion analysis has become a powerful tool used to assess the dynamics of both normal and pathologic gait in a variety of clinical and research settings. Early rigid representations of the foot have recently been replaced with multi-segmental models capable of estimating intra-foot motion. Current models using externally placed markers on the surface of the skin are easily implemented, but suffer from errors associated with soft tissue artifact, marker placement repeatability, and rigid segment assumptions. Models using intra-cortical bone pins circumvent these errors, but their invasive nature has limited their application to research only. Radiographic models reporting gait …

Mechanisms Of Sensorimotor Impairment In Multiple Sclerosis, Matthew Cheeming Chua

Dissertations (1934 -)

Sensorimotor impairments in people with multiple sclerosis (MS) might alter coordination and balance strategy during functional movements. People with MS often have symptoms such as weakness and discoordination in the lower limbs, resulting in poor walking and balance function. This decrease in function can result in falls, decreased community activity, unemployment, and reduced quality of life. As MS is a progressive disease resulting in a range of dysfunction, the amount of lower limb impairment can cause changes to walking and balance strategies to maintain functional performance. The overall objective of this dissertation was to quantify the impairment at the hip …

Evening Methane Emission Pulses From A Boreal Wetland Correspond To Convective Mixing In Hollows, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Spatial and temporal heterogeneity of methane flux from boreal wetlands makes prediction and up-scaling challenging, both within and among wetland systems. Drivers of methane production and emissions are also highly variable, making empirical model development difficult and leading to uncertainty in methane emissions estimates from wetlands. Previous studies have examined this problem using point-scale (static chamber method) and ecosystem-scale (flux tower methods) measurements, but few studies have investigated whether different processes are observed at these scales. We analyzed methane emissions from a boreal fen, measured by both techniques, using data from the Boreal Ecosystem-Atmosphere Study. We sought to identify driving …

A Simple Model For The In-Plane Rotational Response Of A Disk Resonator In Liquid: Resonant Frequency, Quality Factor, And Optimal Geometry, Mohomad S. Sotoudegan, Stephen M. Heinrich, Fabien Josse, Nicholas J. Nigro, Isabelle Dufour, Oliver Brand

Civil and Environmental Engineering Faculty Research and Publications

No abstract provided.

Cantilever-Based Resonant Gas Sensors With Integrated Recesses For Localized Sensing Layer Deposition, C. Carron, P. Getz, J. J. Su, D. S. Gottfried, Fabien Josse, Stephen M. Heinrich

Civil and Environmental Engineering Faculty Research and Publications

This work presents mass-sensitive hammerhead resonators with integrated recesses as a gas-phase chemical microsensor platform. Recesses are etched into the head region of the resonator to locally deposit chemically sensitive polymers by ink-jet printing. This permits the sensing films to be confined to areas that (a) are most effective in detecting mass loading and (b) are not strained during the in-plane vibrations of the resonator. As a result of the second point, even 5-μm thick polymer coatings on resonators with a 9-12 μm silicon thickness barely affect the Q-factor in air. This translates into higher frequency stability and ultimately higher …

Timoshenko Beam Effects In Lateral-Mode Microcantilever-Based Sensors In Liquids (Proceedings), Joshua A. Schultz, Stephen M. Heinrich, Fabien Josse, Nicholas J. Nigro, Isabelle Dufour, Luke A. Beardslee, Oliver Brand

Civil and Environmental Engineering Faculty Research and Publications

No abstract provided.

Evaluation Of Bridge Maintenance Interventions Under Changing Deterioration Rates: A Markovian-Based Methodology, Dilum Fernando, Baolin Wan, Scott Walbridge

Civil and Environmental Engineering Faculty Research and Publications

Markovian transition probability matrices employing condition states are often used in bridge management systems to determine optimal intervention strategies. This approach assumes a constant deterioration matrix throughout the entire analysis period. However, in order to adequately model and evaluate intervention options such as fiber-reinforced polymer (FRP) strengthening, it is necessary to model the impact of the intervention on the deterioration rate. This paper presents a Markovian based approach to model interventions that impact deteriorating rates. A model employing this approach is proposed. A methodology to determine the optimal intervention strategy based on steady state probabilities is then presented. The proposed …

Introducing Adaptive Incremental Dynamic Analysis: A New Tool For Linking Ground Motion Selection And Structural Response Assessment, Ting Lin, Jack W. Baker

Civil and Environmental Engineering Faculty Research and Publications

Adaptive Incremental Dynamic Analysis (AIDA) is a novel ground motion selection scheme that adaptively changes the ground motion suites at different ground motion intensity levels to match hazard-consistent properties for structural response assessment. Incremental DynamicAnalysis (IDA), a current dynamic response history analysis practice in Performance-Based Earthquake Engineering (PBEE), uses the same suite of ground motions at all Intensity Measure (IM) levels to estimate structural response. Probabilistic Seismic Hazard Analysis (PSHA) deaggregation tells us, however, that the target distributions of important ground motion properties change as the IM levels change. To match hazard-consistent ground motion properties, ground motions can be re-selected …

Effect Of Support Compliance On The Resonant Behavior Of Microcantilever-Based Sensors In Viscous Fluids, Rabin Maharjan

Dissertations (1934 -)

Resonant microcantilevers are often considered for use in chemical sensing and biosensing applications. However, when excited in the conventional transverse flexural mode, their performance in liquids is severely compromised. Theoretical and experimental studies have shown that the detrimental effects of the liquid may be mitigated by operating the microcantilever in lateral flexure, especially for microbeams having smaller length-to-width (L/b) ratios. However, for these most promising geometries the predictions of existing models tend to diverge from experimental data for resonant frequency (f_res) and quality factor (Q). A likely reason for these discrepancies is support compliance, which has been neglected …

Influence Of Fluid-Structure Interaction On Microcantilever Vibrations: Applications To Rheological Fluid Measurement And Chemical Detection, Isabelle Dufour, E. Lemaire, B. Caillard, H. Debeda, C. Lucat, Stephen M. Heinrich, Fabien Josse, Oliver Brand

Civil and Environmental Engineering Faculty Research and Publications

At the microscale, cantilever vibrations depend not only on the microstructure’s properties and geometry but also on the properties of the surrounding medium. In fact, when a microcantilever vibrates in a fluid, the fluid offers resistance to the motion of the beam. The study of the influence of the hydrodynamic force on the microcantilever’s vibrational spectrum can be used to either (1) optimize the use of microcantilevers for chemical detection in liquid media or (2) extract the mechanical properties of the fluid. The classical method for application (1) in gas is to operate the microcantilever in the dynamic transverse bending …

White Matter Structural Connectivity Is Associated With Sensorimotor Function In Stroke Survivors, Benjamin Kalinosky, Sheila M. Schindler-Ivens, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

Purpose

Diffusion tensor imaging (DTI) provides functionally relevant information about white matter structure. Local anatomical connectivity information combined with fractional anisotropy (FA) and mean diffusivity (MD) may predict functional outcomes in stroke survivors. Imaging methods for predicting functional outcomes in stroke survivors are not well established. This work uses DTI to objectively assess the effects of a stroke lesion on white matter structure and sensorimotor function.

Methods

A voxel-based approach is introduced to assess a stroke lesion's global impact on motor function. Anatomical T1-weighted and diffusion tensor images of the brain were acquired for nineteen subjects (10 post-stroke and 9 …

Biomechanical Modeling Of Pediatric Clubfoot, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Improving Brain–Machine Interface Performance By Decoding Intended Future Movements, Francis R. Willett, Aaron J. Suminski, Andrew H. Fagg, Nicholas G. Hatsopoulos

Biomedical Engineering Faculty Research and Publications

Objective. A brain–machine interface (BMI) records neural signals in real time from a subject's brain, interprets them as motor commands, and reroutes them to a device such as a robotic arm, so as to restore lost motor function. Our objective here is to improve BMI performance by minimizing the deleterious effects of delay in the BMI control loop. We mitigate the effects of delay by decoding the subject's intended movements a short time lead in the future. Approach. We use the decoded, intended future movements of the subject as the control signal that drives the movement of our BMI. This …

Sand Penetration: A Near Nose Investigation Of A Sand Penetration Event, Andrew Van Vooren, John Borg, Joshua Felts

Mechanical Engineering Faculty Research and Publications

This paper presents experimental and computational results of a long-rod penetrating dry granular sand at velocities near 100 m/s. The objective of this work is to develop a fundamental understanding of the formation and transmission of dynamic force chains, and the motion and fracture of the individual sand grains as the projectile passes. This is accomplished by launching a projectile along a view window, backed by sand, in order to directly view and photograph the projectile/sand interactions. Within the sand system, a two-wave structure was observed, composed of a compaction wave (bow shock) that detaches from the dart and moves …

Abundance And Diversity Of Organohalide-Respiring Bacteria In Lake Sediments Across A Geographical Sulfur Gradient, Patrick J. Mcnamara, Benjamin B. Crary, Paige J. Novak, Mark J. Krzmarzick

Civil and Environmental Engineering Faculty Research and Publications

Across the U.S. Upper Midwest, a natural geographical sulfate gradient exists in lakes. Sediment grab samples and cores were taken to explore whether this sulfur gradient impacted organohalide-respiring Chloroflexi in lake sediments. Putative organohalide-respiring Chloroflexi were detected in 67 of 68 samples by quantitative polymerase chain reaction. Their quantities ranged from 3.5 × 10⁴ to 8.4 × 10¹⁰ copies 16S rRNA genes g⁻¹ dry sediment and increased in number from west to east, whereas lake sulfate concentrations decreased along this west-to-east transect. A terminal restriction fragment length polymorphism (TRFLP) method was used to corroborate this inverse relationship, …

3d Micron-Scale Imaging Of The Cortical Bone Canal Network In Human Osteogenesis Imperfecta (Oi), John R. Jameson, Carolyne Albert, Bjoern Busse, Peter A. Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Osteogenesis imperfecta (OI) is a genetic disorder leading to increased bone fragility. Recent work has shown that the hierarchical structure of bone plays an important role in determining its mechanical properties and resistance to fracture. The current study represents one of the first attempts to characterize the 3D structure and composition of cortical bone in OI at the micron-scale. A total of 26 pediatric bone fragments from 18 individuals were collected during autopsy (N_c=5) or routing orthopaedic procedures (N_OI=13) and imaged by microtomography with a synchrotron light source (SRµCT) for several microstructural parameters including cortical porosity …

Time Resolved Gain And Excess Noise Properties Of Ingaas/Inalas Avalanche Photodiodes With Cascaded Discrete Gain Layer Multiplication Regions, Georges M. Williams, David A. Ramirez, Majeed M. Hayat, Andrew S. Huntington

Electrical and Computer Engineering Faculty Research and Publications

To predict pulse detection performance when implemented in high speed photoreceivers, temporally resolved measurements of a 10-stage InAlAs/InGaAs single carrier multiplication (SCM) avalanche photodiode (APD)'s avalanche response to short multi-photon laser pulses were explained using instantaneous (time resolved) pulse height statistics of the device's impulse response. Numeric models of the junction carrier populations as a function of the time following injection of a primary photo-electron were used to create the probability density functions (pdfs) of the instances of the avalanche buildup process. The numeric pdfs were used to generate low frequency gain and excess noise models, which were in good …

Rotor Bar Fault Monitoring Method Based On Analysis Of Air-Gap Torques Of Induction Motors, Aderiano Da Silva, Nabeel Demerdash, Richard J. Povinelli

Electrical and Computer Engineering Faculty Research and Publications

A robust method to monitor the operating conditions of induction motors is presented. This method utilizes the data analysis of the air-gap torque profile in conjunction with a Bayesian classifier to determine the operating condition of an induction motor as either healthy or faulty. This method is trained offline with datasets generated either from an induction motor modeled by a time-stepping finite-element (TSFE) method or experimental data. This method can effectively monitor the operating conditions of induction motors that are different in frame/class, ratings, or design from the motor used in the training stage. Such differences can include the level …

In Vivo Dark-Field Imaging Of The Retinal Pigment Epithelium Cell Mosaic, Drew Scoles, Yusufu N. Sulai, Alfredo Dubra

Biomedical Engineering Faculty Research and Publications

Non-invasive reflectance imaging of the human RPE cell mosaic is demonstrated using a modified confocal adaptive optics scanning light ophthalmoscope (AOSLO). The confocal circular aperture in front of the imaging detector was replaced with a combination of a circular aperture 4 to 16 Airy disks in diameter and an opaque filament, 1 or 3 Airy disks thick. This arrangement reveals the RPE cell mosaic by dramatically attenuating the light backscattered by the photoreceptors. The RPE cell mosaic was visualized in all 7 recruited subjects at multiple retinal locations with varying degrees of contrast and cross-talk from the photoreceptors. Various experimental …

Safety And Efficacy Of Ranolazine For The Treatment Of Chronic Angina Pectoris, Mohammed Aldakkak, David F. Stowe, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Coronary heart disease is a global malady and it is the leading cause of death in the United States. Chronic stable angina is the most common manifestation of coronary heart disease and it results from the imbalance between myocardial oxygen supply and demand due to reduction in coronary blood flow. Therefore, in addition to lifestyle changes, commonly used pharmaceutical treatments for angina (nitrates, ß-blockers, Ca2+ channel blockers) are aimed at increasing blood flow or decreasing O2 demand. However, patients may continue to experience symptoms of angina. Ranolazine is a relatively new drug with anti-anginal and anti-arrhythmic effects. Its anti-anginal mechanism …

3d Visualization Of Reference-Point Indentation In Human And Murine Bone, John Jameson, Alex Proctor, Carolyne Albert, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Brittle Bone Fracture Risk With Transverse Isotropy, Jessica M. Fritz, Nicole M. Grosland, Peter A. Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Markerless Analysis Of Upper Extremity Kinematics During Standardized Pediatric Functional Assessment With A Low-Cost Motion Analysis System, Gerald F. Harris, Susan A. Riedel

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Bone Properties By Nanoindentation In Mild And Severe Osteogenesis Imperfecta, Carolyne Albert, John Jameson, Jeffrey M. Toth, Peter Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Background

Osteogenesis imperfecta is a heterogeneous genetic disorder characterized by bone fragility. Previous research suggests that impaired collagen network and abnormal mineralization affect bone tissue properties, however, little data is yet available to describe bone material properties in individuals with this disorder. Bone material properties have not been characterized in individuals with the most common form of osteogenesis imperfecta, type I.

Methods

Bone tissue elastic modulus and hardness were measured by nanoindentation in eleven osteotomy specimens that were harvested from children with osteogenesis imperfecta during routine surgeries. These properties were compared between osteogenesis imperfecta types I (mild, n = …

Equation Of State And Isentropic Releasem Of Aluminum Foam And Fluoropolymer Composites, John Borg, Warren R. Maines, Mike Nixon, Lalit Chhabildas

Mechanical Engineering Faculty Research and Publications

There is considerable interest in developing a better understanding of the dynamic behavior of heterogeneous materials. This study investigates and compares the dynamic response of 20 and 47% dense aluminum foam systems with and without a polytetrafluoroethylene (PTFE or Teflon) fill. Experiments on 47% foam were conduced in a 60 mm bore gun in a reverse ballistic configuration at velocities ranging from 350 m/s to 2.5 km/s. The particle velocity of the backside of the anvil was monitored with a VISAR system. Mesoscale simulations are in good agreement with the available experimental data. Both the experimental and simulated data are …

Using Remote Access For Sharing Experiences In A Machine Design Laboratory, Mark L. Nagurka, Fernando Rodriguez Anton, Richard W. Marklin Jr.

Mechanical Engineering Faculty Research and Publications

A new Machine Design Laboratory at Marquette University has been created to foster student exploration and promote “hands-on” and “minds-on” learning. Laboratory experiments have been developed to give students practical experiences and expose them to physical hardware, actual tools, and design challenges. Students face a range of real-world tasks: identify and select components, measure parameters (dimensions, speed, force), distinguish between normal and used (worn) components and between proper and abnormal behavior, reverse engineer systems, and justify design choices. The experiments serve to motivate the theory, spark interest, and promote discovery learning in the subject of machine design.

This paper presents …

Discovery Learning Experiments In A New Machine Design Laboratory, Mark L. Nagurka, Fernando Rodriguez Anton

Mechanical Engineering Faculty Research and Publications

A new Machine Design Laboratory at Marquette University has been created to foster student exploration with hardware and real-world systems. The Laboratory incorporates areas for teaching and training, and has been designed to promote “hands-on” and “minds-on” learning. It reflects the spirit of transformational learning that is a theme in the College of Engineering.

The goal was to create discovery learning oriented experiments for a required junior-level “Design of Machine Elements” course in mechanical engineering that would give students practical experiences and expose them to physical hardware, actual tools, and real-world design challenges. In the experiments students face a range …

Modeling And Testing Of An R-23/R-134a Mixed Refrigerant System For Low Temperature Refrigeration, Nicholas Hugh, Margaret Mathison, Anthony Bowman

Mechanical Engineering Faculty Research and Publications

Low temperature refrigeration storage equipment in the biotechnology industry typically uses cascade refrigeration to achieve evaporating temperatures of -80 °C (-112 °F) or below. Current systems utilize multiple compressors leading to high energy consumption. Equipment operating costs contribute significantly to the total operating costs of biotechnology companies and therefore motivate the development of more efficient alternatives for low temperature refrigeration. This paper describes a single compressor R-23/R-134a mixed refrigerant cycle that has been designed to extract a load of 0.256 kW (873.5 Btu/hr) from a conditioned space at -80 °C (-112 °F). The designed system compresses a mixture of the …

Effect Of Hydrodynamic Force On Microcantilever Vibrations: Applications To Liquid-Phase Chemical Sensing, I. Dufour, E. Lemaire, B. Caillard, H. Debeda, C. Lucat, Stephen M. Heinrich, Fabien Josse, O. Brand

Electrical and Computer Engineering Faculty Research and Publications

At the microscale, cantilever vibrations depend not only on the microstructure’s properties and geometry but also on the properties of the surrounding medium. In fact, when a microcantilever vibrates in a fluid, the fluid offers resistance to the motion of the beam. The study of the influence of the hydrodynamic force on the microcantilever’s vibrational spectrum can be used to either (1) optimize the use of microcantilevers for chemical detection in liquid media or (2) extract the mechanical properties of the fluid. The classical method for application (1) in gas is to operate the microcantilever in the dynamic transverse bending …