Engineering Commons^™

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing, Navid Djassemi

Master's Theses

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing

Navid Djassemi

Tissue engineering blood vessel mimics has been proposed as a method to analyze the endothelial cell response to intravascular devices that are used in today’s clinical settings for the treatment of cardiovascular disease. Thus, the development of in vitro blood vessel mimics (BVMs) in Cal Poly’s Tissue Engineering Lab has introduced the possibility of assessing the characteristics of cellular response to past, present, and future intravascular devices that aim at treating coronary artery disease.

This thesis aimed at improving the methods and procedures utilized in …

Hot-Wire Anemometer For The Boundary Layer Data System, William D. Neumeister

Master's Theses

Hot-wire anemometry has been routinely employed for laboratory measurements of turbulence for decades. This thesis presents a hot-wire anemometer suitable for use with the Boundary Layer Data System (BLDS). BLDS provides a unique platform for in- flight measurements because of its small, self-contained, robust design and flexible architecture. Addition of a hot-wire anemometer would provide BLDS with a sensor that could directly measure flow velocity fluctuations caused by turbulence. Hot-wires are commonly operated in constant-temperature mode for high frequency response, but require a carefully tuned bridge. The constant-voltage anemometer (CVA) uses a simple op-amp circuit to improve frequency response over …

The Double Pendulum: Construction And Exploration, Benjamin J. Knudson

Physics

The exploration of a nonlinear mechanical system, the Double Pendulum, a physical pendulum on the end of a physical pendulum, using analytic and experimental approaches. Also included discussion of the design and construction of the Double Pendulum apparatus to work with Vernier LabPro and LoggerPro. The apparatus outputs live data of the angles to a LoggerPro which collects and produces time evolution graphs as well as a corresponding animation lending itself to comparison with theoretical models. Normal mode frequencies are found both analytically and experimentally for the the general (real) double pendulum. Examples of both simple (periodic) and complex (chaotic) …

Development Of In Vitro Tissue Engineered Blood Vessel Mimics In Complex Geometries For Coronary Stent Testing, Robert Dalton Chavez

Master's Theses

Coronary heart disease is the leading cause of death in the United States and occurs when plaque occludes coronary arteries. Coronary stents, which may be used to treat coronary occlusions, are small metal tubes that are implanted in coronary arteries to restore blood flow. After stent implantation, endothelial cells grow over the stent so that blood contacts the endothelial cells instead of the stent surface; this event is known as re-endothelialization. Re-endothelialization prevents blood from clotting on the stent surface and is a good predictor of stent success. Blood vessel mimics (BVMs) are in vitro tissue engineered models of human …

Characterization Of Tight Junction Formation In An In-Vitro Model Of The Blood-Brain Barrier, Michael Robert Machado

Master's Theses

Active and passive transport of substances between the microcirculation in the brain and the central nervous system is regulated by the Blood-Brain Barrier (BBB). This barrier allows for chronic and acute modulation of the CNS microenvironment, and protects the brain from potentially noxious compounds carried in the circulatory system. In-vitro modeling of the BBB has become the target of much research over the past decade, as there are many unanswered questions regarding modulations in the permeability of this barrier. Additionally, the development of a practical and inexpensive model of the BBB would facilitate a much more efficient drug development process. …

Development And Characterization Of An In-House Custom Bioreactor For The Cultivation Of A Tissue Engineered Blood-Brain Barrier, Amin Hadi Mirzaaghaeian

Master's Theses

The development of treatments for neurological disorders such as Alzheimer’s and Parkinson’s disease begins by understanding what these diseases affect and the consequences of further manifestation. One particular region where these diseases can produce substantial problems is the blood-brain barrier (BBB). The BBB is the selective diffusion barrier between the circulating blood and the brain. The barrier’s main function is to maintain CNS homeostasis and protect the brain from the extracellular environment. The progression of BBB research has advanced to the point where many have modeled the BBB in vitro with aims of further characterizing and testing the barrier. Particularly, …

Traffic Signal Optimization Using Ant Colony Algorithm, David Renfrew, Xiao-Hua Yu

Electrical Engineering

Traffic signal control is an effective way to improve the efficiency of traffic networks and reduce users’ delays. Ant Colony Optimization (ACO) is a meta-heuristic algorithm based on the behavior of ant colonies searching for food. ACO has successfully been employed to solve many complicated combinatorial optimization problems and its stochastic and decentralized nature fits well with traffic networks. This research investigates the application of the ant colony algorithm to minimize user delay at traffic intersections. Various ACO algorithms are discussed and a rolling horizon approach is also employed to achieve real-time adaptive control. Computer simulation results show that this …

An Exploratory Investigation Into How Cold Working Can Affect The Acoustic Performance Of Thin Aluminum Foil In A Ribbon Microphone, Alexander (Alex) Stanley

Materials Engineering

Ribbons of 4 μm thin 99.1% pure aluminum foil were cut and corrugated to replace the stock ribbon in an Apex 205 ribbon microphone. Prior to corrugation, half of the ribbons were sandwiched between two KimWipes and two pieces of cardstock then hammered to impart strain hardening. Each ribbon was placed into the microphone capsule and the frequency response of each ribbon was measured. A 10 second sine sweep from 20-20,000 Hz was played through a KRK Rokit 5 speaker and recorded through a ribbon microphone placed 6 inches away from the speaker cone. The signal generated by the ribbon …

Effects Of Annealing/Solution Treating And Aging On Longitudinal And Transverse Properties Of Ti-6al-4v Forgings, Blake Reller

Materials Engineering

Forty-eight subsize round-bar tensile samples (ASTM E8) were machined from 3-in-thick forgings of Ti-6Al-4V. Half of these samples were cut so the axis aligned with the longitudinal (LG) direction of the forging, the other half were cut to align with the transverse (LT) direction. Four samples from each direction were subjected to one of six heat treatments so that a total of eight samples received each treatment. Annealed samples were held at 1350°F for two hours, then air cooled. Solution treated and aged (STA) samples were solution treated at one of five temperatures between 1785°F and 1435°F for one hour …

Wireless Temperature Monitoring System For The Cal Poly Pilot Winery, Caitlin Devaney

Materials Engineering

This project, with an interdisciplinary group of two computer engineers and one materials engineer, was seeking to implement an automated temperature monitoring system which is affordable and easy to use, as well as adaptable to any arrangement and scale of a winemaker’s fermentation setup. My goal, as the materials engineer, was to design, fabricate, and test the enclosure, for the wireless nodes that are placed in the wine fermentation tanks, and the materials used for the node enclosure. For the enclosure of the system, materials selection was completed using CES software using limitations of only polymer materials which absorb less …

Electric Aircraft Propulsion System, Austin J. Doupe

Aerospace Engineering

This report specifies the purpose, assembly, operation, and data collection of a testing apparatus to characterize small electric aircraft propulsion systems designed for commercial use. This apparatus was constructed with the goal of determining overall system characteristics and efficiencies. The apparatus was pushed to a safety limit as deemed by advisor John Dunning and the results of the experiment were an output power of 3.2kW (25% of max rated power) and a system efficiency of 58.6%, both of which occurred at 2200 RPM. Currently the apparatus needs improvement. It should have an upgraded structure to mount to (instead of the …

High-Fidelity Low-Thrust Trajectory Determination Research And Analysis, Tyler Hill

Aerospace Engineering

This document discusses a numerical analysis method for low thrust trajectory propagation known as the proximity quotient or Q-Law. The process uses a Lyapunov feedback control law developed by Petropoulos^[1] to propagate trajectories of spacecraft by minimizing the user defined function at the target orbit. A simplified propagator is created from the core mechanics of this method in MATLAB and tested in several user defined cases to demonstrate its capabilities. Several anomalies arose in test cases where variations in eccentricity, inclination, right ascension of the ascending node, and argument of perigee were specified. Solutions to these anomalies are discussed …

Low Cost Vacuum Chamber Design For Electromagnetic Railgun Operation, Andrew W. Bothwell, David J. Foster

Aerospace Engineering

This report describes the design and fabrication of a low cost vacuum chamber capable of supporting the operation of an electromagnetic railgun. This would be used to simulate the impact of high velocity impacts in space. The vacuum chamber was constructed out of 10in diameter 10ft PVC pipe with a Wye fitting for viewing impacts during testing. The chamber was designed to accommodate a 6.5in X 6.5in X 60in railgun. The vacuum chamber feedthroughs were designed to be able to carry 1-2Mamps at 8kV to the railgun. The vacuum chamber is capable of reaching 50 Torr and remaining under 100 …

Interstellar Mission To Gliese 581, Brock Schmalzel, Brian Tsoi

Aerospace Engineering

This report details a conceptual design for a one-way, interstellar mission, based upon assumed technological advances over the next few hundred years. It addresses the unique challenges associated with an interstellar mission, looking at both developed and theoretical technologies. This report looks specifically at propulsion systems required to reach an exoplanet. In addition, the power, communication, and orbital trajectories are analyzed to see the differences and technological advancements necessary for future missions and the proposed interstellar mission. The destination for the interstellar mission in Gliese 581, a star system located 20.3 light years away and has 5 known planets and …

Accelerating Lambert's Problem On The Gpu In Matlab, Nathan Parrish

Aerospace Engineering

The challenges and benefits of using the GPU to compute solutions to Lambert’s Problem are discussed. Three algorithms (Universal Variables, Gooding’s algorithm, and Izzo’s algorithm) were adapted for GPU computation directly within MATLAB. The robustness of each algorithm was considered, along with the speed at which it could be computed on each of three computers. All algorithms used were found to be completely robust. Computation time was measured for computation within a for-loop, a parfor-loop, and a call to the MATLAB command ‘arrayfun’ with gpuArray-type inputs. Then, a Universal Variables Lambert’s solver was written in CUDA and compiled for use …

Test And Verification Of Vortex Shedding For A 3d Bluff Body, Paul D. Innes, Charles E. Carlson

Aerospace Engineering

Testing of a 3D bluff body with and without end plate tabs was performed in the California Polytechnic State University 3x4 ft low speed wind tunnel. The C_P values were obtained for the test case with no end plate tabs for speeds of 10, 15, 20, and 30 m/s. It was observed that stronger vortex shedding ocured at the higher speed test cases. The model was shimmed to be at approximately 5° angle of attack in order to obtain symmetrical negative C_P spikes for the top and bottom of the model without tabs. Trends were observed and compared …

Instrument Panel Design, Martin Bialy, Amber Carney, Michael Roche

Aerospace Engineering

This project focused on the design and implementation of an Electronic Flight Instrument System for a home built experimental aircraft known as a CH-701. Older aircraft use manual gauges and dials based on varying internal instruments such as gyro’s and the like but many of these traditional instruments to a singular GUI displaying multiple instruments data at one time. These devices are aimed at helping the pilot stay more alert and aware when flying between automatic warnings when in dangerous flying conditions / configurations as well as simplifying the instrument panel to only display what is absolutely necessary. These programs …

Global Launch Vehicle Selector, Keisuke Suzuki

Aerospace Engineering

No abstract provided.

The Numerical Open-Source Many-Body Simulator (Noms), Jason Lloyd Daniel, Javen Kyle Foster-O'Neal

Aerospace Engineering

This paper outlines the setup and creation of an object-oriented N-body simulator as part of a continued project to explore physical phenomenon and human-computer natural interaction technologies. The tools and processes required to build an N-body simulator are also included. Several integrators were evaluated based on their ability to maintain system energy The 2nd order integrator Verlet and 3rd order integrator Hermite algorithms had the greatest accuracy to model large-scale N-body dynamics for their given computation time. Other algorithms required significantly shorter time steps to achieve similar short-term accuracy. At present, NOMS can reasonably simulate 10,000 particles at less than …

Comprehensive Matlab Gui For Determining Barycentric Orbital Trajectories, Steve Katzman

Aerospace Engineering

When a 3-body gravitational system is modeled using a rotating coordinate frame, interesting applications become apparent. This frame, otherwise known as a barycentric coordinate system, rotates about the system’s center of mass. Five unique points known as Lagrange points rotate with the system and have numerous applications for spacecraft operations. The goal of the Matlab GUI was to allow easy manipulation of trajectories in a barycentric coordinate system to achieve one of two end goals: a free-return trajectory or a Lagrange point rendezvous. Through graphical user input and an iterative solver, the GUI is capable of calculating and optimizing both …

Effect Of Multifunctional Material On The Mechanical Behavior Of Composite Structure Using Finite Element Analysis, Nicholas A. Romonoski

Aerospace Engineering

No abstract provided.

Development Of A Pyrotechnic Shock Simulation Apparatus For Spacecraft Applications, Joseph Binder, Matthew Mccarty, Chris Rasmussen

Aerospace Engineering

This report details the research, design, construction, and testing of a pyrotechnic shock simulation apparatus for spacecraft applications. The apparatus was developed to be used in the Space Environments Lab at California Polytechnic State University. It will be used for testing spacecraft components with dimensions up to 24”x12”x12” as well as CubeSats. Additionally, it may be used as an instructional or demonstrational tool in the Aerospace Department’s space environments course. The apparatus functions by way of mechanical impact of an approximately 20 lb stainless steel swinging hammer. Tests were performed to verify the simulator’s functionality. Suggestions for improvement and further …

Thermal Vacuum Integration For Cal Poly's Space Environments Laboratory, Chelsea Barackman, Steven Jackowski

Aerospace Engineering

The purpose of the senior project is to construct a thermal vacuum by utilizing a preexisting vacuum chamber in the Space Environments Lab, and a donated Advanced Thermal Sciences (ATS) chiller. While a thermal vacuum is already available on campus, building one for the Space Environments Lab would grant undergraduates access to the equipment, allowing a much better understanding of testing methods and procedures in use by the aerospace industry. This paper explains the design and analysis of the thermal vacuum (T-VAC) project as well as the operation and procedures required for the ATS chiller and fill/drain tank. The thermal …

Enhanced Hydrocarbon Biodegradation Using Bioaugmentation With Biowish™-Aqua Fog, Michael Robert Lehrer

Master's Theses

This study was done to determine the effectiveness of a commercially available bioaugmentation product, BiOWiSH^TM-Aqua FOG, for remediating petroleum-contaminated sandy soil. Biodegradation enhancement by BiOWiSH^TM-Aqua FOG was evaluated in laboratory microcosms by directly measuring total petroleum hydrocarbon (TPH) and indirectly using respirometry. Attempts were made to enrich hydrocarbon-degrading bacteria in BiOWiSH^TM-Aqua FOG, and the resulting enrichment cultures were screened using respirometry as well. Potential hydrocarbon-degrading bacteria in BiOWiSH^TM-Aqua FOG were isolated. Experiments were performed at bench-scale using microcosm bottles containing sand contaminated with either motor oil or No. 2 diesel fuel. The …

Fabrication And Characterization Of Torsional Micro-Hinge Structures, Mike Madrid Marrujo

Master's Theses

ABSTRACT

Fabrication and Characterization of Torsional Micro-Hinge Structures

Mike Marrujo

There are many electronic devices that operate on the micrometer-scale such as Digital Micro-Mirror Devices (DMD). Micro actuators are a common type of DMD that employ a diaphragm supported by torsional hinges, which deform during actuation and are critical for the devices to have high stability and reliability. The stress developed within the hinge during actuation controls how the actuator will respond to the actuating force. Electrostatically driven micro actuators observe to have a fully recoverable non-linear viscoelastic response. The device consists of a micro-hinge which is suspended by two …

The Effect Of Polarization And Ingan Quantum Well Shape In Multiple Quantum Well Light Emitting Diode Heterostructures, Patrick M. Mcbride

Master's Theses

Previous research in InGaN/GaN light emitting diodes (LEDs) employing semi-classical drift-diffusion models has used reduced polarization constants without much physical explanantion. This paper investigates possible physical explanations for this effective polarization reduction in InGaN LEDs through the use of the simulation software SiLENSe. One major problem of current LED simulations is the assumption of perfectly discrete transitions between the quantum well (QW) and blocking layers when experiments have shown this to not be the case. The In concentration profile within InGaN multiple quantum well (MQW) devices shows much smoother and delayed transitions indicative of indium diffusion and drift during …

Effect Of Oxidation On Weld Strengthof Dissimilar Resistance Weld Interface Between 304 Stainless Steeland Near Equiatomic Austenitic Nitinol Guide Wire, Matthew Rudow

Master's Theses

Abbott Vascular encountered strength and variability issues when attempting to resistively weld 304 Stainless Steel to equiatomic Nitinol. Initial observations suggested that passivation layer (Cr₂O₃, TiO₂) formation affected the weld interface. One hundred 304 Stainless Steel/Nitinol pairs were allowed to oxidize in air at room temperature for allowed periods of time (.1, 1, 3, 5, 7, 12, 16, 24, 168, and 336 hours). Each pair was welded resistively with constant current. A Miyachi/Unitek Advanced Data Analysis Monitor (ADAM) recorded the peak resistance at the instance the weld was made. Resistances were compared to Instron …

Deposition, Characterization, And Fabrication Of A Zinc Oxide Piezoelectric Thin Film Microspeaker Using Dc Reactive Sputtering, Adam Olzick

Master's Theses

A piezoelectric microspeaker device that could be used in a variety of acoustic applications was designed and fabricated using a thin film ZnO layer that was reactively DC sputtered onto a single crystalline n-type silicon substrate. When tested the microspeaker did not produce sound due to complications in the etching process, the thickness of the diaphragms, and clamping effects. Instead, a characterization approach was taken and the structural, optical, electrical, and piezoelectric properties of the ZnO were investigated. Scanning electron microscopy, x-ray diffraction, and atomic force microscopy were utilized to discover the ZnO’s structural properties. Using the XRD and SEM, …

The Synergistic Integration Of Computational Fluid Dynamics And Experimental Fluid Dynamics For Ground Effect Aerodynamics Studies, Tj Barber, G Doig, C Beves, I Watson, S Diasinos

Aerospace Engineering

This article highlights the ‘synergistic’ use of experimental fluid dynamics (EFD) and computational fluid dynamics (CFD), where the two sets of simulations are performed concurrently and by the same researcher. In particular, examples from the area of ground effect aerodynamics are discussed, where the major facility used was also designed through a combination of CFD and EFD. Three examples are than outlined, to demonstrate the insight that can be obtained from the integration of CFD and EFD studies. The case studies are the study of dimple flow (to enhance aerodynamic performance), the analysis of a Formula-style front wing and wheel, …

Aerodynamics Of An Aerofoil In Transonic Ground Effect: Methods For Blowdown Wind Tunnel Scale Testing, G. Doig, T. J. Barber, A. J. Neely, D. D. Myre

Aerospace Engineering

No abstract provided.