Engineering Commons^™

Modeling And Experimental Investigation Of Rheological Properties Of Injectable Poly(Lactide Ethylene Oxide Fumarate)/Hydroxyapatite Nanocomposites, Alireza Sarvestani, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Animal Models Of Spinal Cord Injury For Evaluation Of Tissue Engineering Treatment Strategies, R. Talac, J. Friedman, M. Moore, Lichun Lu, Esmaiel Jabbari, Anthony Windebank, Bradford Currier, Michael Yaszemski

Esmaiel Jabbari

No abstract provided.

Synthesis And Gelation Characteristics Of Photo-Crosslinkable Star Poly(Ethylene Oxide-Co-Lactide-Glycolide Acrylate) Macromonomers, Seyedsina Moeinzadeh, Saied Khorasani, Junyu Ma, Xuezhong He, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Osteonectin-Derived Peptide Increases The Modulus Of A Bone-Mimetic Nanocomposite, Alireza Sarvestani, Xuezhong He, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Three-Dimensional Engineered Matrix To Study Cancer Stem Cells And Tumorsphere Formation: Effect Of Matrix Modulus, Xiaoming Yang, Samaneh Sarvestani, Seyedsina Moeinzadeh, Xuezhong He, Esmaiel Jabbari

Esmaiel Jabbari

Maintenance of cancer stem cells (CSCs) is regulated by the tumor microenvironment. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment. The objective of this work was to investigate the effect of matrix modulus on tumorsphere formation by breast cancer cells and maintenance of CSCs in an inert microenvironment without the interference of other factors. In that regard, 4T1 mouse breast cancer cells were encapsulated in inert polyethylene glycol diacrylate hydrogels and the effect of matrix modulus on tumorsphere formation and expression of CSC markers was investigated. The gel …

Nanoscale Tissue Engineering: Spatial Control Over Cell-Materials Interactions, Ian Wheeldon, Arash Farhadi, Alexander Bick, Esmaiel Jabbari, Ali Khademhosseini

Esmaiel Jabbari

No abstract provided.

Combined Effect Of Osteopontin And Bmp-2 Derived Peptides Grafted To An Adhesive Hydrogel On Osteogenic And Vasculogenic Differentiation Of Marrow Stromal Cells, Xuezhong He, Xiaoming Yang, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Migration Of Marrow Stromal Cells In Response To Sustained Release Of Stromal-Derived Factor-1Α From Poly(Lactide Ethylene Oxide Fumarate) Hydrogels, Xuezhong He, Junya Ma, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

The Role Of Filler-Matrix Interaction On Viscoelastic Response Of Biomimetic Nanocomposite Hydrogels, Alireza Sarvestani, Xuezhong He, Esmaiel Jabbari

Esmaiel Jabbari

The effect of a glutamic acid (negatively charged) peptide (Glu6), which mimics the terminal region of the osteonectin glycoprotein of bone on the shear modulus of a synthetic hydorgel/apatite nanocomposite, was investigated. One end of the synthesized peptide was functionalized with an acrylate group (Ac-Glu6) to covalently attach the peptide to the hydrogel phase of the composite matrix. The addition of Ac-Glu6 to hydroxyapatite (HA) nanoparticles (50 nm in size) resulted in significant reinforcement of the shear modulus of the nanocomposite (~100% increase in elastic shear modulus). The reinforcement effect of the Glu6 peptide, a sequence in the terminal region …

Targeted Delivery With Peptidomimetic Conjugated Self-Assembled Nanoparticles, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Effect Of Surface Polarity On Wettability And Friction Coefficient Of Silicone Rubber/Poly(Acrylic Acid) Hydrogel Composite, Saeid Kheirandish, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

In Vitro Osteogenic Differentiation Of Marrow Stromal Cells Encapsulated In Biodegradable Hydrogels, Johnna Temenoff, Hansoo Park, Esmaiel Jabbari, Tiffany Sheffield, Richard Lebaron, Catherine Ambrose, Antonios Mikos

Esmaiel Jabbari

No abstract provided.

Swelling Behavior Of Acrylic Acid Hydrogels Prepared By Γ-Radiation Crosslinking Of Polyacrylic Acid In Aqueous Solution, Esmaiel Jabbari, Samyra Nozari

Esmaiel Jabbari

No abstract provided.

Gelation And Degradation Characteristics Of In Situ Photo-Crosslinked Poly(L-Lactide-Co-Ethylene Oxide-Co-Fumarate) Hydrogels, Alireza Sarvestani, Weijie Xu, Xuezhong He, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Nanostructure Formation And Transition From Surface To Bulk Degradation In Polyethylene Glycol Gels Chain-Extended With Short Hydroxy Acid Segments, Seyedsina Moeinzadeh, Danial Barati, Samaneh Kamali Sarvestani, Ozan Karaman, Esmaiel Jabbari

Esmaiel Jabbari

No abstract provided.

Development Of Biodegradable Poly(Propylene Fumarate)/Poly(Lactic-Co-Glycolic Acid) Blend Microspheres. Ii. Controlled Drug Release And Microsphere Degradation, Diederik Kempen, Lichun Lu, Xun Zhu, Choll Kim, Esmaiel Jabbari, Wouter Dhert, Bradford Currier, Michael Yaszemski

Esmaiel Jabbari

No abstract provided.

Supporting Teacher Orchestration In Ubiquitous Learning Environments: A Study In Primary Education, Juan Muñoz Cristóbal, Ivan Jorrín Abellán, Juan Asensio Perez, Alejandra Martínez Monés, Luis Prieto, Yannis Dimitriadis

Ivan M. Jorrín Abellán

During the last decades, educational contexts have transformed into complex technological and social ecologies, with mobile devices expanding the scope of education beyond the traditional classroom, creating so-called Ubiquitous Learning Environments (ULEs). However, these new technological opportunities entail an additional burden for teachers, who need to manage and coordinate the resources involved in such complex educational scenarios in a process known as “orchestration”. This paper presents the evaluation of the orchestration support provided by GLUEPS-AR, a system aimed to help teachers in the coordination of across-spaces learning situations carried out in ULEs. The evaluation, following an interpretive research perspective, relied …

Coming Down To Earth: Helping Teachers Use 3d Virtual Worlds In Across-Spaces Learning Situations, Juan Muñoz Cristóbal, Luis Prieto, Juan Asensio Pérez, Alejandra Martínez Monés, Ivan Jorrín Abellán, Yannis Dimitriadis

Ivan M. Jorrín Abellán

Different approaches have explored how to provide seamless learning across multiple ICT-enabled physical and virtual spaces, including three-dimensional virtual worlds (3DVW). However, these approaches present limitations that may reduce their acceptance in authentic educational practice: The difficulties of authoring and sharing teacher-created designs across different 3DVW platforms, or the lack of integration of 3DVWs with existing technologies in the classroom ecosystem (e.g., widespread web-based learning platforms such as Moodle, or mobile augmented reality applications). Focusing on a specific kind of 3DVW (virtual globes, such as Google Earth, used like 3DVWs), we propose a system that enables teachers to deploy across-spaces …

Analysis Of Low-Field Isotropic Vortex Glass Containing Vortex Groups In Yba2cu3o7−X Thin Films Visualized By Scanning Squid Microscopy, Frederick Wells, Alexey Pan, Renshaw Wang, Sergey Fedoseev, Hans Hilgenkamp

Frederick S Wells

The glass-like vortex distribution in pulsed laser deposited YBa₂Cu₃O_{7 − x} thin films is observed by scanning superconducting quantum interference device microscopy and analysed for ordering after cooling in magnetic fields significantly smaller than the Earth's field. Autocorrelation calculations on this distribution show a weak short-range positional order, while Delaunay triangulation shows a near-complete lack of orientational order. The distribution of these vortices is finally characterised as an isotropic vortex glass. Abnormally closely spaced groups of vortices, which are statistically unlikely to occur, are observed above a threshold magnetic field. The origin of these groups …

Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo

Nima Rahbar

This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …

Wikis For Group Work: Encouraging Transparency, Benchmarking And Feedback, Amir Abdekhodaee, Dini Kourosh, Farnaz Modarres, Anne-Marie Chase, Bella Ross

Dr Anne-Marie Chase

Use Of Linear Viscoelastic Theory To Predict Resilient Behavior Of Unbound Granular Materials, Sung-Hee Kim, Kevin Mcfall, Jidong Yang, Jin-Hoon Jeong

Kevin McFall