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Articles 1021 - 1050 of 5086
Full-Text Articles in Engineering
Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy, Kaisheng Ming, Xiaofang Bi, Jian Wang
Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy, Kaisheng Ming, Xiaofang Bi, Jian Wang
Department of Mechanical and Materials Engineering: Faculty Publications
Solute segregation at dislocations can impede the motion of dislocations, strengthening materials. Here, we study the formation and role of solute segregation at dislocations in CrFeCoNiMo high-entropy alloys (HEAs) by high-angle annular dark-field scanning transmission electron microscopy imaging and mechanical testing both deformed and annealed samples. Mo atoms exhibit pronounced segregation into the planar-extended core of dislocations, i.e. stacking faults, causing the increase in the yield strength while the loss of the ductility. This work suggests that mechanical properties of HEAs can be tailored by alloying additional elements that are in favor of segregation into dislocations.
Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi
Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi
Department of Mechanical and Materials Engineering: Faculty Publications
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry. Developing an effective and efficient method for screening small molecules or compounds is critical to accelerate the discovery of ligands for enzymes, receptors and other pharmaceutical targets. Here, we report developments of methods to increase the signal-to-noise ratio (SNR) for screening protein-protein interactions using atomic force microscopy (AFM) force spectroscopy. We have demonstrated the effectiveness of these developments on detecting the binding process between focal adhesion kinases (FAK) with protein kinase B (Akt1), which is a target for potential cancer drugs. These developments …
Local Control Robotic Surgical Devices And Related Methods, Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Michael Farritor
Local Control Robotic Surgical Devices And Related Methods, Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Michael Farritor
Department of Mechanical and Materials Engineering: Faculty Publications
The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices.
Medical Inflation, Attachment And Delivery Devices And Related Methods, Mark Rentschler, Shane Michael Farritor
Medical Inflation, Attachment And Delivery Devices And Related Methods, Mark Rentschler, Shane Michael Farritor
Department of Mechanical and Materials Engineering: Faculty Publications
The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.
Test 2209a: New Holland Wormaster 70, Nebraska Tractor Test Lab
Test 2209a: New Holland Wormaster 70, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2216: Kubota M7-172, Nebraska Tractor Test Lab
Test 2216: Kubota M7-172, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2214: Kubota M7-132, Nebraska Tractor Test Lab
Test 2214: Kubota M7-132, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Influence Of Micro-Nucleate Boiling On Annular Flow Regime Heat Transfer Coefficient Values And Flow Parameters – For High Heat-Flux Flow Boiling Of Water, Soroush Sepahyar
Influence Of Micro-Nucleate Boiling On Annular Flow Regime Heat Transfer Coefficient Values And Flow Parameters – For High Heat-Flux Flow Boiling Of Water, Soroush Sepahyar
Dissertations, Master's Theses and Master's Reports
Analysis of results from steady and steady-in-the-mean high heat-flux (15 - 70 W/cm2, with water as working fluid) shear driven annular flow-boiling experiments presented here - and low heat-flux (0.1- 1 W/cm2, with FC-72 as working fluid) experiments presented elsewhere – together lead to a key conclusion. The conclusion is that heat carrying nucleation rates go often undetected by the typically used visualization approaches for flow boiling – as such flows often involve µm- to sub- µm scale bubble diameters in millimeter-scale ducts. These nucleation rates play a significant role in most of the so-called convective …
Experimental Characterization Of Hydraulic System Sound, Ben Kolb
Experimental Characterization Of Hydraulic System Sound, Ben Kolb
Dissertations, Master's Theses and Master's Reports
The purpose of this research was to establish test methods for characterizing the interaction between the hydraulic fluid and hydraulic hose at clipping points in mobile heavy equipment hydraulic systems. A simple hydraulic circuit test bench was developed and the laboratory axial piston pump was characterized using ISO 10767-1. A direct relationship between the fluidborne noise and structureborne noise present at each hose clip location was observed for a specific operating condition using operating deflection shapes and structureborne noise measurements. This result shows that optimal hose clip placement can be a viable solution to structureborne noise reduction. Additionally, a modal …
Development Of A Fused Deposition 3d Printed Buoy And Method For Quantifying Wave Tank Reflections, Samantha G. Swartzmiller
Development Of A Fused Deposition 3d Printed Buoy And Method For Quantifying Wave Tank Reflections, Samantha G. Swartzmiller
Dissertations, Master's Theses and Master's Reports
Testing model scale prototypes is integral to the development of wave energy converter (WEC) technology. Model scale WECs are tested in wave tanks where they are subjected to repeatable wave fields. Their presence in water creates radiated waves that eventually reflect off tank walls disrupting the intended wave field. Fabrication of model scale WECs is another developing aspect of tank testing. Often model WECs are built of foam. Additive manufacturing is a promising alternative although the most common method, fused deposition modeling (FDM) 3D printing, does not typically produce waterproof parts. The goals of this work were 1) develop a …
Nebraska Summary: S1178 Fendt 933, Nebraska Tractor Test Lab
Nebraska Summary: S1178 Fendt 933, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Development Of Physics Based Machine Learning Algorithms, Rob Jennings
Development Of Physics Based Machine Learning Algorithms, Rob Jennings
Master’s Theses
In this study, a baseball pitch was examined to try to understand its behavior, and make a predictive model of it. A baseball pitch was tested experimentally with a wind tunnel and modeled computationally with COMSOL CFD software. Five input variables (spin rate, sting angle, seam orientation: Y axis, seam orientation: Z axis, and air velocity) were controlled, with force in three axes recorded as outputs. The experimental and computational results were examined and seen to be interdependent for all input variables. Experimental and computational data were both insufficient for predicting system behavior. Experimental data collection would have required an …
Analysis And Control Of Fiber-Reinforced Elastomeric Enclosures (Frees), Soheil Habibian
Analysis And Control Of Fiber-Reinforced Elastomeric Enclosures (Frees), Soheil Habibian
Master’s Theses
While rigid robots are extensively used in various applications, they are limited in the tasks they can perform and can be unsafe in close human-robot interactions. Soft robots on the other hand surpass the capabilities of rigid robots in several ways, such as compatibility with the work environments, degrees of freedom, manufacturing costs, and safe interactions with the environment. This thesis studies the behavior of Fiber-Reinforced Elastomeric Enclosures (FREEs) as a particular type of soft pneumatic actuator that can be used in soft manipulators. A dynamic lumped-parameter model is created to simulate the motion of a single FREE under various …
Center Lift Trailer Support Structure, Carson Corle, Anthony M. Hayes, Bryan A. Truax
Center Lift Trailer Support Structure, Carson Corle, Anthony M. Hayes, Bryan A. Truax
Williams Honors College, Honors Research Projects
Center lift pontoon trailers have a high center of gravity, therefore have the potential for the pontoon and trailer to tip while cornering. There is need for a component to stabilize the pontoon on the trailer while towing. Different concepts of a support system were sketched to determine the best option. The characteristics that were deemed important for the support system were narrowed down to determine the best concept and the connections of the best design were sketched in greater detail. The forces that the support system would have to withstand to stabilize the pontoon on the trailer were calculated. …
Fluid Power Vehicle Competition, Madison Graham, Wayne Ritchie, Emily Dicks, Ariana Cupello
Fluid Power Vehicle Competition, Madison Graham, Wayne Ritchie, Emily Dicks, Ariana Cupello
Williams Honors College, Honors Research Projects
Our senior design project for the Honors College and the Department of Mechanical Engineering was to design a fluid powered vehicle. Our design was tested in an official capacity against other universities’ vehicles at the Fluid Powered Vehicle Challenge hosted and funded by the National Fluid Power Association (NFPA) and its industry partners. This competition had six different evaluations for our vehicle design; three race events, midway presentation, final presentation, and safety inspection. The three different race events were the sprint race, the efficiency race, and the endurance race. The sprint race was a 475 feet speed test, the efficiency …
Laser Ablation Of Aluminum, Erika Nosal, Zachary Rahe, Arthur Pamboukis
Laser Ablation Of Aluminum, Erika Nosal, Zachary Rahe, Arthur Pamboukis
Williams Honors College, Honors Research Projects
The laser ablation of metal carries relevance in a variety of engineering industries. This includes, but is not limited to, processes such as micromachining, or implementation on aircraft weaponry. The latter application is the reasoning for why aluminum is the specific metal in consideration, as it is commonly used for the construction of aircraft components.
The scope of this project was to optimize the energy dispersed through laser ablation on aluminum by mathematical modeling. The transient conduction process in the aluminum was modeled using a 2-dimensional cylindrical coordinate system in both MATLAB and ANSYS/Fluent. These models were adopted to simulate …
Hydro-Aeroponic Design, Megan J. Doll, Nathan J. Boring, Meredith B. Taylor, Chancelor L. Sunkle
Hydro-Aeroponic Design, Megan J. Doll, Nathan J. Boring, Meredith B. Taylor, Chancelor L. Sunkle
Williams Honors College, Honors Research Projects
“Aeroponics” is a plant cultivation technique where roots hang suspended in the air while the nutrient solution is delivered in the form of a fine mist. NASA has done experiments in space and found out that plants grow very well with aeroponic technology. However, “Hydroponics” is the most preferred method, where plants are grown in a non-soil medium, and mostly in nutrient liquid that flows through rectangular channels. There are advantages and disadvantages to each system. With the intention of combining the efficiency of aeroponics and the compactness of hydroponics, a hydro-aeroponic system was created to grow spinach and lettuce. …
Expendable 3d Printed Rescue Drone, Matthew Chapman, Nathan Knutty, Matthew Chapman
Expendable 3d Printed Rescue Drone, Matthew Chapman, Nathan Knutty, Matthew Chapman
Williams Honors College, Honors Research Projects
This project team designed a 3D printed, expendable drone capable of flying for 80 minutes with a 5 lb payload in order to deliver rescue supplies to individuals in distress.
Recumbent Bicycle Balancing Aid, James Hager
Recumbent Bicycle Balancing Aid, James Hager
Williams Honors College, Honors Research Projects
For our senior design project, our team will be consulting to create a balancing aid system intended for the recumbent bicycle shown below in Figure 1. The owner of the bicycle is Robert Henderson, a former United States Navy sailor from Northeast Ohio who picked up biking and skiing while he was stationed in Maine in the late 80’s. While there, he took to the mountains on the rugged terrain and brought this passion of biking back home to share with his wife, Johanna once he completed his service to his country. Biking became an integral part of the …
Interlaminar Damage Detection In Composite Materials, Hariharan Rangarajan
Interlaminar Damage Detection In Composite Materials, Hariharan Rangarajan
Williams Honors College, Honors Research Projects
Using ceramic matrix composites (CMCs) for high-temperature applications in jet engines increases durability and reduces weight and cooling requirements resulting in improved efficiency and fuel savings. Understanding, detecting, and monitoring different types of damage is essential to achieve optimal performance of CMC components. The Direct Current Potential Drop (DCPD) method is a non-destructive technique of estimating damage in composite materials.
DCPD technique works by measuring nodal potential differences when current is flown through the material. Direct current spreading in different woven and laminate composites is modeled to follow a ladder resistor network in which the nodal voltages decrease exponentially as …
Resonant Acoustic Wave Assisted Spin-Transfer-Torque Switching Of Nanomagnets, Austin R. Roe
Resonant Acoustic Wave Assisted Spin-Transfer-Torque Switching Of Nanomagnets, Austin R. Roe
Theses and Dissertations
We studied the possibility of achieving an order of magnitude reduction in the energy dissipation needed to write bits in perpendicular magnetic tunnel junctions (p-MTJs) by simulating the magnetization dynamics under a combination of resonant surface acoustic waves (r-SAW) and spin-transfer-torque (STT). The magnetization dynamics were simulated using the Landau-Lifshitz-Gilbert equation under macrospin assumption with the inclusion of thermal noise. We studied such r-SAW assisted STT switching of nanomagnets for both in-plane elliptical and circular perpendicular magnetic anisotropy (PMA) nanomagnets and show that while thermal noise affects switching probability in in-plane nanomagnets, the PMA nanomagnets are relatively robust to the …
High Strength, Deformable Nanotwinned Al–Co Alloys, S. Xue, Qiang Li, D. Y. Xie, Y. F. Zhang, Han Wang, Haiyan Wong, J. Wang, Xinghang Zhang
High Strength, Deformable Nanotwinned Al–Co Alloys, S. Xue, Qiang Li, D. Y. Xie, Y. F. Zhang, Han Wang, Haiyan Wong, J. Wang, Xinghang Zhang
Department of Mechanical and Materials Engineering: Faculty Publications
Aluminum (Al) alloys have been widely used in the transportation industry. However, most highstrength Al alloys to date have limited mechanical strength, on the order of a few hundred MPa, which is much lower than the flow stress of high-strength steels. In this study, we show the fabrication of nanocrystalline Al alloys with high-density growth twins enabled by a few atomic percent of Co solute. In situ uniaxial compression tests show that the flow stress of Al–Co solid solution alloys exceeds 1.5 GPa, while good work hardening capability is maintained. This study provides a new perspective on the design of …
A Sensorless Force-Feedback System For Robot-Assisted Laparoscopic Surgery, Baoliang Zhao, Carl A. Nelson
A Sensorless Force-Feedback System For Robot-Assisted Laparoscopic Surgery, Baoliang Zhao, Carl A. Nelson
Department of Mechanical and Materials Engineering: Faculty Publications
The existing surgical robots for laparoscopic surgery offer no or limited force feedback, and there are many problems for the traditional sensor-based solutions. This paper builds a teleoperation surgical system and validates the effectiveness of sensorless force feedback. The tool-tissue interaction force at the surgical grasper tip is estimated using the driving motor’s current, and fed back to the master robot with a position-force bilateral control algorithm. The stiffness differentiation experiment and tumor detection experiment were conducted. In the stiffness differentiation experiment, 43 out of 45 pairs of ranking relationships were identified correctly, yielding a success rate of 96%. In …
Effects Of Compositional Tailoring On Drug Delivery Behaviours Of Silica Xerogel/Polymer Core-Shell Composite Nanoparticles, Wenfei Huang, Chi Pong Tsui, Chak Yin Tang, Linxia Gu
Effects Of Compositional Tailoring On Drug Delivery Behaviours Of Silica Xerogel/Polymer Core-Shell Composite Nanoparticles, Wenfei Huang, Chi Pong Tsui, Chak Yin Tang, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
Conventional core-shell polymer nanoparticles usually exhibit a rapid release rate with their release kinetics mainly adjusted through changing composition of the polymer shells, limiting their applications for prolonged drug delivery. As a solution to these problems, silica xerogel/polymer core-shellstructured composite nanoparticles have been proposed. Different with our previous work centring on studying process variables, we here focused on investigating the effects of key compositional variables on essential properties of the composite nanoparticles. The drug release profiles (in vitro) were well interpreted by the Baker and Lonsdale model on a predicted two-stage basis. The first stage (<1 day) was well controlled from 18.6% to 45.9%; the second stage (1–14 days) was tailored in a range from 28.7 to 58.2% by changing the composition of the silica xerogel cores and polymeric shells. A substantial achievement was reducing the release rate by more than 40 times compared with that of conventional polymer nanoparticles by virtue of the silica xerogel cores. A semi-empirical model was also established in the first attempt to describe the effects of polymer concentration and drug loading capacity on the size of the composite nanoparticles. All these results indicated that the composite nanoparticles are promising candidates for prolonged drug delivery applications.
Unveiling The Operation Mechanism Of Layered Perovskite Solar Cells, Yun Lin, Yanjun Fang, Jingjing Zhao, Yuchuan Shao, Samuel J. Stuard, Masrur Morshed Nahid, Harald Ade, Qi Wang, Jeffrey E. Shield, Ninghao Zhou, Andrew M. Moran, Jinsong Huang
Unveiling The Operation Mechanism Of Layered Perovskite Solar Cells, Yun Lin, Yanjun Fang, Jingjing Zhao, Yuchuan Shao, Samuel J. Stuard, Masrur Morshed Nahid, Harald Ade, Qi Wang, Jeffrey E. Shield, Ninghao Zhou, Andrew M. Moran, Jinsong Huang
Department of Mechanical and Materials Engineering: Faculty Publications
Layered perovskites have been shown to improve the stability of perovskite solar cells while its operation mechanism remains unclear. Here we investigate the process for the conversion of light to electrical current in high performance layered perovskite solar cells by examining its real morphology. The layered perovskite films in this study are found to be a mixture of layered and three dimensional (3D)-like phases with phase separations at micrometer and nanometer scale in both vertical and lateral directions. This phase separation is explained by the surface initiated crystallization process and the competition of the crystallization between 3D-like and layered perovskites. …
Monolithic Heat-Transfer Device, Sidy Ndao, George Gogos, Dennis Alexander, Troy Anderson, Craig Zuhlke
Monolithic Heat-Transfer Device, Sidy Ndao, George Gogos, Dennis Alexander, Troy Anderson, Craig Zuhlke
Department of Mechanical and Materials Engineering: Faculty Publications
A monolithic heat-transfer device can include a container wall configured to retain a working fluid, where the container wall is formed of a single material. The container wall also includes an interior surface configured to be in fluid communication with the working fluid. The monolithic heat-transfer device also includes a channel disposed in the interior surface of the container wall, where the channel comprises a microstructure and a nanostructure. The microstructure and the nanostructure are materially contiguous with the single material forming the container wall. In some embodiments, the nanostructure comprises one or more layers of nanoparticles. The monolithic heat-transfer …
Higher-Order Overtone Thickness-Shear Vibrations Of Multilayered Thin-Film Acoustic Wave Resonators And Angular Rate Sensing, Hui Chen, Ji Wang, Jianke Du, Jiashi Yang
Higher-Order Overtone Thickness-Shear Vibrations Of Multilayered Thin-Film Acoustic Wave Resonators And Angular Rate Sensing, Hui Chen, Ji Wang, Jianke Du, Jiashi Yang
Department of Mechanical and Materials Engineering: Faculty Publications
We propose a new structure for piezoelectric gyroscopes. It is made from multilayered thin films of AlN or ZnO with alternating c-axes along the film thickness. It is shown theoretically that when such a film is electrically driven into higher-order overtone thickness-shear vibration in one of the two in-plane directions of the film and is rotating about the film normal, the Coriolis force due to the rotation causes a higher-order overtone thicknessshear vibration in a perpendicular direction with an electrical output that can be used to measure the angular rate of the rotation. Different from existing thickness-shear mode piezoelectric gyroscopes …
3d Printing Of Hybrid Mos2-Graphene Aerogels As Highly Porous Electrode Materials For Sodium Ion Battery Anodes, Emery Brown, Pengli Yan, Halil Tekik, Ayyappan Elangovan, Jian Wang, Dong Lin, Jun Li
3d Printing Of Hybrid Mos2-Graphene Aerogels As Highly Porous Electrode Materials For Sodium Ion Battery Anodes, Emery Brown, Pengli Yan, Halil Tekik, Ayyappan Elangovan, Jian Wang, Dong Lin, Jun Li
Department of Mechanical and Materials Engineering: Faculty Publications
This study reports a 3D freeze-printing method that integrates inkjet printing and freeze casting to control both the microstructure and macroporosity via formation of ice microcrystals during printing. A viscous aqueous ink consisting of a molecular MoS2 precursor (ammonium thiomolybdate) mixed with graphene oxide (GO) nanosheets is used in the printing process. Post-treatments by freeze-drying and reductive thermal annealing convert the printed intermediate mixture into a hybrid structure consisting of MoS2 nanoparticles anchored on the surface of 2D rGO nanosheets in a macroporous framework, which is fully characterized with FESEM, TEM, XRD, Raman spectroscopy and TGA. The resulting …
Three-Dimensional Character Of The Deformation Twin In Magnesium, Y. Liu, P.Z. Tang, M.Y. Gong, R.J. Mccabe, J. Wang, C.N. Tome
Three-Dimensional Character Of The Deformation Twin In Magnesium, Y. Liu, P.Z. Tang, M.Y. Gong, R.J. Mccabe, J. Wang, C.N. Tome
Department of Mechanical and Materials Engineering: Faculty Publications
Deformation twins are three-dimensional domains, traditionally viewed as ellipsoids because of their two-dimensional lenticular sections. In this work, we performed statistical analysis of twin shapes viewing along three orthogonal directions: the ‘dark side’ (DS) view along the twin shear direction (η1), the twinning plane normal (TPN) view (k1) and the ‘bright side’ (BS) view along the direction λ(=k1 × η1). Our electron back-scatter diffraction results show that twins in the DS and BS views normally exhibit a lenticular shape, whereas they show an irregular shape in the TPN view. Moreover, the findings in the TPN view revealed that twins grow …
Spatiotemporal Characterizations Of Spontaneously Beating Cardiomyocytes With Adaptive Reference Digital Image Correlation, Akankshya Shradhanjali, Brandon D. Riehl, Bin Duan, Ruiguo Yang, Jung Yul Lim
Spatiotemporal Characterizations Of Spontaneously Beating Cardiomyocytes With Adaptive Reference Digital Image Correlation, Akankshya Shradhanjali, Brandon D. Riehl, Bin Duan, Ruiguo Yang, Jung Yul Lim
Department of Mechanical and Materials Engineering: Faculty Publications
We developed an Adaptive Reference-Digital Image Correlation (AR-DIC) method that enables unbiased and accurate mechanics measurements of moving biological tissue samples. We applied the AR-DIC analysis to a spontaneously beating cardiomyocyte (CM) tissue, and could provide correct quantifications of tissue displacement and strain for the beating CMs utilizing physiologically-relevant, sarcomere displacement length-based contraction criteria. The data were further synthesized into novel spatiotemporal parameters of CM contraction to account for the CM beating homogeneity, synchronicity, and propagation as holistic measures of functional myocardial tissue development. Our AR-DIC analyses may thus provide advanced non-invasive characterization tools for assessing the development of spontaneously …