Engineering Commons^™

Development Of 3d Printed And 3d Metal-Based Micro/Nanofabricated, And Nano-Functionalized, Microelectrode Array (Mea) Biosensors For Flexible, Conformable, And In Vitro Applications, Charles Didier

Electronic Theses and Dissertations

Emerging fields such as "Organs on a Chip", disease modeling in vitro, stem cell manufacturing and wearable bioelectronics are demanding rapid development of 3D Microelectrode Arrays (MEAs) for electrical interfacing with biological constructs. The work reported in this thesis focuses on two developmental tracks: "Dynamic 3D MEAs" and metal microfabrication for 3D MEAs. In the first part of the thesis, we explore the capabilities and limitations of 3D printed microserpentines (µserpentines) and utilize these structures to develop dynamic 3D microelectrodes. Analytical modeling of µserpentines flexibility followed by integration into a flexible Kapton® package and PDMS insulation are demonstrated. These 3D …

Santa Clara Magazine, Volume 61 Number 1, Winter 2019, Santa Clara University

Santa Clara Magazine

14 - IN THE BEGINNING An interview with Santa Clara University President Kevin O’Brien, S.J. on what's next and noticing what we swim in. Matt Morgan

22 - ADAM, EVE, AND THE APPLE If making—and appreciating—art makes us human, what happens when we get help making a masterpiece from something unhuman? Lauren Loftus.

28 - BEDROCK When faced with tough decisions, Santa Clara values stand as good guides, says Leon Panetta ’60, J.D. ’63. Leslie Griffy.

Evaluation Of Hydrometric Network Efficacy And User Requirements In The Republic Of Ireland Via Expert Opinion And Statistical Analysis, Paul Hynds, Ahmed Nasr, Jean O'Dwyer

Articles

Decreased funding and shifting governmental priorities have resulted in a contraction of hydrometric measurement in many regions over the past two decades. Moreover, concerns exist with respect to appropriate data usage and (transboundary) exchange, in addition to the compatibility and extent of existing hydrometric datasets. These issues are undoubtedly magnified due to enhanced data demands and increased financial pressures on network managers, thus requiring new approaches to optimising the societal benefits and overall efficacy of hydrometric information for future socio-hydrological resilience. The current study employed a quantitative cross-sectional expert elicitation of 203 respondents to collate, analyse and assess hydrometric network …

Tolle Lege Works Published In 2019, Mcquade Library

Bibliographies

Compiled Tolle Lege bibliography of works published by members of the Merrimack College Community in 2019. Works include journal articles, books, book chapters, conference presentations and posters, and more.

Healthcare Robotics: Key Factors That Impact Robot Adoption In Healthcare, Sujatha Alla, Pilar Pazos

Engineering Management & Systems Engineering Faculty Publications

In the current dynamic business environment, healthcare organizations are focused on improving patient satisfaction, performance, and efficiency. The healthcare industry is considered a complex system that is highly reliant of new technologies to support clinical as well as business processes. Robotics is one of such technologies that is considered to have the potential to increase efficiency in a wide range of clinical services. Although the use of robotics in healthcare is at the early stages of adoption, some studies have shown the capacity of this technology to improve precision, accessibility through less invasive procedures, and reduction of human error during …

Journal Of The Arkansas Academy Of Science - Volume 73, 2019, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Keynote Address And Meeting Program, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Instructions To Authors, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Walking Biomechanics And Energetics Of Individuals With A Visual Impairment: A Preliminary Report, Hunter J. Bennett, Kevin A. Valenzuela, Kristina Fleenor, Steven Morrison, Justin A. Haegele

Human Movement Studies & Special Education Faculty Publications

Purpose.

Although walking gait in sighted populations is well researched, few studies have investigated persons with visual impairments (VIs). Given the lack of physical activity in people with VIs, it is possible that reduced efficiency in walking could adversely affect activity. The purposes of this preliminary study were to (1) examine the biomechanics and energetics utilized during independent and guided walking in subjects with VIs, and (2) compare gait biomechanics between people with VIs and sighted controls.

Methods.

Three-dimensional motion capture and force platforms were used during independent and guided walking at self-selected speeds. Joint angles, moments, external work, and …

Initiation Of Action Potential In Murine Ventricular Myocytes By Bursts Of Nanosecond Pulses, Iurii Semenov

Bioelectrics Publications

[First slide] Current situation

I. Among 300,000 persons die from sudden cardiac arrest every year over 40% are victims of fibrillation

II. Defibrillation by an electric shock is the effective therapy against sudden cardiac death

III. Current approach to stop fibrillation may involve disruption of plasma membrane (PM) by an electroporation

IV. Electroporation is damaging, it can: I. Induce post shock arrhythmias II. Complicate patient's recovery III. Lead to death after initially successful resuscitation

Intratumoral Delivery Of Plasmid Il12 Via Electroporation Leads To Regression Of Injected And Noninjected Tumors In Merkel Cell Carcinoma, Shailender Bhatia, Natalie V. Longino, Natalie J. Miller, Rima Kulikauskas, Jayasri G. Iyer, Dafina Ibrani, Astrid Blom, David R. Byrd, Upendra Parvathaneni, Christopher Twitty, Jean S. Campbell, Mai H. Le, Sharron Gargosky, Robert H. Pierce, Richard Heller, Adil Daud, Paul Nghiem

Bioelectrics Publications

Purpose: Interleukin-12 (IL12) promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic administration leads to severe adverse events (AE), including death. This pilot trial investigated safety, efficacy, and immunologic activity of intratumoral delivery of IL12 plasmid DNA (tavo) via in vivo electroporation (i.t.-tavo-EP) in patients with Merkel cell carcinoma (MCC), an aggressive virus-associated skin cancer.

Experimental Design: Fifteen patients with MCC with superficial injectable tumor(s) received i.t.-tavo-EP on days 1, 5, and 8 of each cycle. Patients with locoregional MCC (cohort A, N = 3) received one cycle before definitive surgery in week 4. …

Nanosecond Pulsed Electric Fields Induce Endoplasmic Reticulum Stress Accompanied By Immunogenic Cell Death In Murine Models Of Lymphoma And Colorectal Cancer, Alessandra Rossi, Olga N. Pakhomova, Peter A. Mollica, Maura Casciola, Uma Mangalanathan, Andrei G. Pakhomov, Claudia Muratori

Bioelectrics Publications

Depending on the initiating stimulus, cancer cell death can be immunogenic or non-immunogenic. Inducers of immunogenic cell death (ICD) rely on endoplasmic reticulum (ER) stress for the trafficking of danger signals such as calreticulin (CRT) and ATP. We found that nanosecond pulsed electric fields (nsPEF), an emerging new modality for tumor ablation, cause the activation of the ER-resident stress sensor PERK in both CT-26 colon carcinoma and EL-4 lymphoma cells. PERK activation correlates with sustained CRT exposure on the cell plasma membrane and apoptosis induction in both nsPEF-treated cell lines. Our results show that, in CT-26 cells, the activity of …

Étude Exploratoire Sur Les Pratiques Des Fabricants De Machines Au Québec En Lien Avec L’Intégration De La Sécurité Des Machines Dès Leur Conception, Yuvin Chinniah, François Gauthier, George Abdul-Nour, Sabrina Jocelyn, Barthélemy Aucourt, Guy Bordeleau

Rapports de recherche scientifique

Le présent rapport est destiné principalement à tout organisme québécois œuvrant en matière de prévention des lésions professionnelles (ex. : la Commission des normes, de l’équité, de la santé et de la sécurité du travail (CNESST), les associations sectorielles paritaires (ASP)), pour un ou plusieurs secteurs industriels donnés. Il porte sur une étude exploratoire concernant l’intégration de la sécurité dès la conception des machines et qui a été réalisée auprès de fabricants. Ce rapport intéressera également les concepteurs et fabricants désireux de se renseigner sur la manière dont la sécurité est prise en compte dans la mise en œuvre de …

Iact Undergraduate Certificate In Applied Creativity (Year 2 - 2019), Brian Laduca

IACT Certificate Program

At the Institute of Applied Creativity for Transformation (IACT) at ArtStreet, we seek to empower a creatively confident 21st-century student with the ability to discover, invent and innovate ambiguous ideas through a disruptive design process that will impact today’s ever-changing global world regardless of degree focus.

IACT is home to the nation’s first undergraduate certificate in Applied Creativity for Transformation. Open to undergraduate students of any major, the certificate is a first step in achieving the University of Dayton’s vision of innovation, applied creativity, entrepreneurship and community engagement for the common good.

Assessment Of Physicochemical Characteristics, Thermal Stability And Release Profile Of Ascorbic Acid Microcapsules Obtained By Complex Coacervation, Michele Cristina Rodrigues Da Cruz, João Luiz Andreotti Dagostin, Camila Augusto Perussello, Maria Lúcia Masson

Articles

The aim of this study was to determine the physicochemical characteristics, thermal stability and release profile of ascorbic acid (AA) microcapsules obtained by complex coacervation. Gelatin and gum arabic were used as wall materials in concentrations of 2.5, 5.0 and 7.5 g% (w/v). The coacervate microcapsules were freeze-dried and assessed for physicochemical characteristics, thermal behavior and stability during 60 days of storage. The release profile was evaluated at different pH values (1.1, 2.2, 5.4, 7.4, 9.6 and 12). The encapsulation efficiency ranged from 27.3 to 93.8%. The microcapsules of AA presented good characteristics for application in food matrices, such as …

Harnessing Smart Technology For Private Well Risk Assessment And Communication, Tanner Hoffman, Paul Hynds, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Anna Majury

Articles

Unregulated, privately owned water supplies, including groundwater wells, are relied upon extensively, particularly in rural and remote regions. While adequate stewardship behaviors (water testing, treatment, and maintenance) have been shown to decrease the incidence and frequency of faecal indicator organism (FIO) presence and, by extension, the risk of pathogenic ingress, contaminated private water supplies continue to constitute a significant public health risk. Recognizing that innovative approaches are needed to bolster well stewardship, this paper identifies and assesses 35 tools (smartphone and web-based applications) to better understand components, functionality, strengths, and weaknesses. Applications for both data collection and risk communication were …

Building A Risk Model For The Patient-Centred Care Of Multiple Chronic Diseases, Stephane Deparis, Pierpaolo Tommasi, Alessandra Pascale, Hicham Rifai, Julie Doyle, John Dinsmore

Conference papers

With the increase of multimorbidity due to population ageing, managing multiple chronic health conditions is a rising challenge. Machine-learning can contribute to a better understanding of persons with multimorbidity (PwMs) and how to design an effective framework of care and support for them. We present a risk model of older PwMs that was derived from the TILDA dataset, a longitudinal study of the ageing Irish population. This model is based on a 26-nodes Bayesian network that represents patients possibly having one or more chronic conditions among diabetes, chronic obstructive pulmonary disease and arthritis, through a joint probability distribution of demographic, …

Proceedings Of The 2019 Undergraduate Research Conference, Ryan C. Winters, Courtney A. Suire, Dillard University, Grambling State University, Louisiana State University, Loyola University New Orleans, Mcneese State University, Nicholls State University, Northwestern State University Of Louisiana, Southeastern Louisiana University, Southern University And A&M College, University Of Louisiana At Lafayette

Advance: Student Research Experience

Proceedings of the 2019 Undergraduate Research Conference, University of Louisiana at Lafayette, November 22-23, 2019

Special Collection On Electroporation-Based Therapies: A Selection Of Papers From The Second World Congress On Electroporation, Richard Heller, Rafael V. Davalos

Bioelectrics Publications

No abstract provided.

Connecting The Pieces: How Low Back Pain Alters Lower Extremity Biomechanics And Shock Attenuation In Active Individuals, Alexa Johnson

Theses and Dissertations--Rehabilitation Sciences

Low back pain in collegiate athletes has been reported at a rate of 37% from a wide array of sports including soccer, volleyball, football, swimming, and baseball. Whereas, in a military population the prevalence of low back pain is 70% higher than the general population. Compensatory movement strategies are often used as an attempt to reduce pain. Though compensatory movement strategies may effectively reduce pain, they are often associated with altered lower extremity loading patterns. Those who suffer from chronic low back pain tend to walk and run slower and with less trunk and pelvis coordination and variability. Individuals with …

Designing Biomimetic Implant Surfaces To Promote Osseointegration Under Osteoporotic Conditions By Revitalizing Mechanisms Coupling Bone Resorption To Formation, Ethan M. Lotz

Theses and Dissertations

In cases of compromised bone remodeling like osteoporosis, insufficient osseointegration occurs and results in implant failure. Implant retention relies on proper secondary fixation, which is developed during bone remodeling. This process is disrupted in metastatic bone diseases like osteoporosis. Osteoporosis is characterized low bone mass and bone strength resulting from either accelerated osteoclast-mediated bone resorption or impaired osteoblast-mediated bone formation. These two processes are not independent phenomena. In fact, osteoporosis can be viewed as a breakdown of the cellular communication connecting bone resorption to bone formation. Because bone remodeling occurs at temporally generated specific anatomical sites and at different times, …

A Brain-Computer Interface For Closed-Loop Sensory Stimulation During Motor Training In Patients With Tetraplegia, Sarah Helen Thomas

Theses and Dissertations--Biomedical Engineering

Normal movement execution requires proper coupling of motor and sensory activation. An increasing body of literature supports the idea that incorporation of sensory stimulation into motor rehabilitation practices increases its effectiveness. Paired associative stimulation (PAS) studies, in which afferent and efferent pathways are activated in tandem, have brought attention to the importance of well-timed stimulation rather than non-associative (i.e., open-loop) activation. In patients with tetraplegia resulting from spinal cord injury (SCI), varying degrees of upper limb function may remain and could be harnessed for rehabilitation. Incorporating associative sensory stimulation coupled with self-paced motor training would be a means for supplementing …

Effectiveness Of Physiological Alarm Management Strategies To Prevent Alarm Fatigue, Amy Clemens

Walden Dissertations and Doctoral Studies

There is limited clinical research on the effectiveness of alarm management strategies and nursing behaviors related to alarms in clinical settings. As many as 76% of physiological monitor alarms are overlooked as clinically insignificant by nursing staff. Excessive alarms may impact patient outcomes and cause cognitive overload for nurses that can result in medical errors and missed patient resuscitations. The purpose of this systematic review was to rate alarm management studies on level of evidence for interventions, nursing responses to alarms, and impact on alarm fatigue behavior. The nursing role effectiveness model guided this project. Twenty-seven studies were reviewed to …

Calibrated Short Tr Recovery Mri For Rapid Measurement Of Brain-Blood Partition Coefficient And Correction Of Quantitative Cerebral Blood Flow, Scott William Thalman

Theses and Dissertations--Biomedical Engineering

The high prevalence and mortality of cerebrovascular disease has led to the development of several methods to measure cerebral blood flow (CBF) in vivo. One of these, arterial spin labeling (ASL), is a quantitative magnetic resonance imaging (MRI) technique with the advantage that it is completely non-invasive. The quantification of CBF using ASL requires correction for a tissue specific parameter called the brain-blood partition coefficient (BBPC). Despite regional and inter-subject variability in BBPC, the current recommended implementation of ASL uses a constant assumed value of 0.9 mL/g for all regions of the brain, all subjects, and even all species.

The …

Improving Safety Performance Of Highway Maintenance Crews Through Pre-Task Safety Toolbox Talks, Zamaan Al-Shabbani

Theses and Dissertations--Civil Engineering

The dangerous work environment in the construction industry and the inherent high risks associated with construction work make it the focus of safety training and regulations. Highway construction and maintenance has unique hazards but seemingly less directly applicable safety standards, regulations, and programs. Department of Transportation (DOT) employees working in highway maintenance are exposed to a variety of unique hazards specifically associated with their work and not relating to the adjacent traffic. Yet, highway construction and maintenance work has not received sufficient attention in terms of safety research and programs. The lack of safety training and education in highway construction …

Procedure To Measure The Penetration Of One Mechanical Filter For Nanoparticles: Validation By Comparison, Pooya Abdolghader, Clothilde Brochot, Fariborz Haghighat, Ali Bahloul

Études primaires

Nanoparticles (NPs) are particles of less than or equal to 100 nm in diameter. Due to their size, they have a significant effect on health and safety of people. Capture of these NPs in general ventilation systems by filters remains one of the most widely used means of protection due to its relative simplicity of implementation and its effectiveness for capturing various size of particles. In North America, filters used in general ventilation systems are tested by the ANSI/ASHRAE Standard 52.2 and are graded according to their efficiency, which is a function of particle diameter. However, the current standard limits …

Shaping The Future Of Trusted Digital Identity: The Idef Registry With Health Information Use Cases, Noreen Y. Whysel

Publications and Research

No abstract provided.

A Note From The Executive Editor, Yolander Youngblood

Pursue: Undergraduate Research Journal

No abstract provided.

Academy Presidents And Institutional Members List, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Table Of Contents, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.