Engineering Commons^™

Using Peripheral Venous Pressure Waveforms To Predict Key Hemodynamic Parameters, Ali Zohair A Alalawi

Graduate Theses and Dissertations

Analysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two cohorts were used to study the hemodynamics change of the body state and its influence on the PVP using (1) dehydration setting with infants suffering from pyloric stenosis and (2) hemorrhage setting during a craniosynostosis elective surgery. The goal of this research is to develop a minimally invasive method of analyzing the PVP waveforms and find correlations with volume loss.

Twenty-three pyloric stenosis patients PVP were acquired at five stages and were divided into euvolemic, normal fluid volume, and hypovolemic, significant fluid loss. Seven …

The Impacts Of Administering Metabolites Of Saccharomyces Cerevisiae On Broiler Performance, Yields And Salmonella Content Of Component Portions, Bill Douglas Potter

Graduate Theses and Dissertations

The impacts of using health-promoting Saccharomyces cerevisiae fermentation metabolites in poultry production and processing can be measured in respect to multiple measures of success. Traditionally this yeast-based compound has been administered to poultry, livestock, poultry, and other species to improve animal performance and production volume output. In addition, Saccharomyces cerevisiae fermentation metabolites have also been shown in more recent research to reduce colonization of pathogenic bacteria in the host organism’s gastro-intestinal tract. In this dissertation, the impacts of administering a functional ingredient containing Saccharomyces cerevisiae metabolites on broiler performance measures and pathogen reduction were measured. One of the studies in …

The Effect Of Mechanical Agitator Geometry On Catheter Directed Thrombectomy, Sanghun Alex Lee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Venous thromboembolism (VTE) is a vascular disease in which a blood clot forms inside of a vein, most often deep in the legs, groin, or arm. Two types of VTE exist, deep vein thrombosis (DVT) and pulmonary embolism (PE). DVT occurs when a clot in a deep vein forms, risking embolism and causing swelling as the clot obstructs blood flow. An embolism occurs when a part or all the thrombus breaks off and travels in the circulation, getting lodged in the lungs. A pulmonary embolism is a very serious medical condition and can be fatal if not treated immediately. Current …

Brain Image Clustering By Wavelet Energy And Cbsso Optimization Algorithm, Hasan Hosseinzadeh, Mohammad Sedaghat

Journal of Mind and Medical Sciences

Previously, the diagnosis of brain abnormality was significantly important in the saving of social and hospital resources. Wavelet energy is known as an effective feature detection which has great efficiency in different utilities. This paper suggests a new method based on wavelet energy to automatically classify magnetic resonance imaging (MRI) brain images into two groups (normal and abnormal), utilizing support vector machine (SVM) classification based on chaotic binary shark smell optimization (CBSSO) to optimize the SVM weights.

The results of the suggested CBSSO-based KSVM are compared favorably to several other methods in terms of better sensitivity and authenticity. The proposed …

Forecasting Model For Disease Propensity Using Ehr Data, Soodabeh Sarafrazi, Omar Sharif, Matthew Domingo, Jie Han, Michael Chang, Omid Khazaie, Anil Kemisetti

Creative Activity and Research Day - CARD

Many diseases such as diabetes and cardiovascular diseases are actionable, i.e. they are preventable by early intervention. One to two years of early warning would represent a huge advance in dealing with these conditions and could help prevent further complications such as heart disease, stroke, kidney failure, blindness, and amputation. In this project, we are developing an extensible condition forecasting model to assess the risk of diabetes and heart problems in patients in advance. Using TensorFlow, Elastic MapReduce (EMR), and AWS Sagemaker, we are training a Wide and Deep Neural Network on a dataset of more than 170 million electronic …

Deep Learning, Medical Physics And Cargo Cult Science., Miguel Romero Phd, Gilmer Valdes Phd, Timothy Solberg Phd, Yannet Interian Phd

Creative Activity and Research Day - CARD

Deep learning algorithms have become widely popular, with considerable success in fields where datasets have hundreds of thousands or million points. As deep learning is increasingly applied to the fields of medical physics and radiation oncology, a reasonable question follows: are these techniques the best approach, given the unique conditions in our field? In this study, we investigate the dependence of dataset size on the performance of deep learning algorithms compared with more traditional radiomics-based methods.

The Santa Clara, 2019-04-25, Santa Clara University

The Santa Clara

No abstract provided.

The Santa Clara, 2019-04-18, Santa Clara University

The Santa Clara

No abstract provided.

All-Optical Control Of Lead Halide Perovskite Microlasers, Nan Zhang, Yubin Fan, Kaiyang Wang, Zhiyuan Gu, Yuhan Wang, Li Ge, Shumin Xiao, Qinghai Song

Publications and Research

Lead halide perovskites based microlasers have recently shown their potential in nanophotonics. However, up to now, all of the perovskite microlasers are static and cannot be dynamically tuned in use. Herein, we demonstrate a robust mechanism to realize the alloptical control of perovskite microlasers. In lead halide perovskite microrods, deterministic mode switching takes place as the external excitation is increased: the onset of a new lasing mode switches off the initial one via a negative power slope, while the main laser characteristics are well kept. This mode switching is reversible with the excitation and has been explained via cross-gain saturation. …

An Arm And A Leg: Medtech Perspectives On Human-Centered Design, Evan D. Poff

Marriott Student Review

The art of human-centered design accounts for both technological and emotional specifications in order to deliver meaningful products that meet the specific needs of the individual customer. Every business professional can deepen his or her understanding of human-centered design – regardless of our industry of choice – by looking to perspectives that the business of medical technology offers. To that end, this article draws upon interviews with three figures in this remarkable field, distilling their insights on how to cultivate businesses that produce human-centered solutions.

Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin

Nanoscience and Microsystems ETDs

Cystic fibrosis (CF) is the most common genetic disease resulting in the morbidity and mortality of Caucasian children and adults worldwide. Due to a genetic mutation resulting in malfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, CF patients produce highly viscous mucus in their respiratory tract. This leads to impairment of the mucociliary clearance of inhaled microbes. In addition to reduced microbial clearance, anoxic environmental conditions in the lungs promote biofilm-mode growth of the pathogenic bacterial species Pseudomonas aeruginosa. Chronic infections of P. aeruginosa begin in early childhood and typically persist until respiratory failure and death result. The …

Incorporation Of Egfr And Ron Receptors Into Nanodiscs, Cristina Flores-Cadengo

Biomedical Engineering ETDs

Understanding the structure-function relationship of membrane receptors is essential to comprehend the crosstalk between key signaling pathways. Aberrant trans-activation between receptors can lead to tumorigenesis. Two of these receptors known to be involved in cancer development are receptor tyrosine kinases (RTKs), RON (Recepteur d'Origine Nantais) and EGFR (Epidermal Growth Factor Receptor). There has been evidence of heterodimerization and crosstalk between these two receptors based on co-immunoprecipitation, however the structural requirements behind these interactions remain unknown. Structural studies could provide insights into these RTKs’ modes of dimerization and structure-function relationship. However, structural studies of full-length membrane proteins are often difficult due …

Program And Proceedings: Nebraska Academy Of Sciences 1880–2019, 139th Anniversary Year, One Hundred-Twenty-Ninth Annual Meeting, April 12, 2019

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Collegiate Academy: Biology

Biological and Medical Sciences

Chemistry and Physics

Teaching and Learning the Dynamics of Cellular Respiration Using Interactive Computer Simulations Workshop

Life After College: Building Your Resume for the Future Workshop

Collegiate Academy: Chemistry and Physics

Aeronautics and Space Science, Poster Session

Maiben Memorial Lecture: David Swanson

Anthropology

Applied Science and Technology

Earth Science

Environmental Sciences

Teaching of Science and Math

The Santa Clara, 2019-04-11, Santa Clara University

The Santa Clara

No abstract provided.

12th Annual Research Week--Event Proceedings, Office Of Research And Sponsored Projects Operations

Excellence Summit (Research Week) Archived Proceedings

12th Annual Research Week

"A Celebration of Student Research"

Search And Rescue: The Importance Of Using Tracking Systems In Rural 135 Operations, April Larsen, Brent D. Bowen

Student Works

In January 2020, under the NextGen initiative put in place by the Federal Aviation Administration (FAA), all aircraft flying in controlled airspace, both general aviation and commercial operations, will be required to have an Automatic Dependent Surveillance – Broadcast (ADS–B) system installed and operational. However, this is not required for Title 14 Code of Federal Regulations (CFR) Part 135 operations taking place outside of controlled airspace. Part 135 of the Federal Aviation Regulations (FAR) refers to aircraft operating as on-demand or air taxi services. A substantial amount of these operator’s bases, as well as flights, are conducted outside of controlled …

The Santa Clara, 2019-04-04, Santa Clara University

The Santa Clara

No abstract provided.

Surface-Controlled Dissolution Rates: A Case Study Of Nanoceria In Carboxylic Acid Solutions, Eric A. Grulke, Matthew J. Beck, Robert A. Yokel, Jason M. Unrine, Uschi M. Graham, Matthew L. Hancock

Chemical and Materials Engineering Faculty Publications

Nanoparticle dissolution in local milieu can affect their ecotoxicity and therapeutic applications. For example, carboxylic acid release from plant roots can solubilize nanoceria in the rhizosphere, affecting cerium uptake in plants. Nanoparticle dispersions were dialyzed against ten carboxylic acid solutions for up to 30 weeks; the membrane passed cerium-ligand complexes but not nanoceria. Dispersion and solution samples were analyzed for cerium by inductively coupled plasma mass spectrometry (ICP-MS). Particle size and shape distributions were measured by transmission electron microscopy (TEM). Nanoceria dissolved in all carboxylic acid solutions, leading to cascades of progressively smaller nanoparticles and producing soluble products. The dissolution …

Fluoride Removal From Water Using A 3d Printed Calcium Carbonate Filter, Sophia Bakar, David Kahler, Benjamin S. Goldschmidt

Undergraduate Research and Scholarship Symposium

Groundwater containing high concentrations of fluoride is the most common source of drinking water in rural areas in parts of east Africa, India, and China. The elevated levels of fluoride cause skeletal and dental fluorosis, which is the weakening and decay of bone structures due to the leeching of calcium from the body as calcium and fluoride bond by the process of adsorption. Over 150 million people are suffering from some form of fluorosis due to the consumption of groundwater. Calcium carbonate has been demonstrated to influence fluoride removal in several forms. To make fluoride removal a cost-effective and user-friendly …

Quantifying Iron Overload Using Mri, Active Contours, And Convolutional Neural Networks, Andrea Sajewski, Stacey Levine

Undergraduate Research and Scholarship Symposium

Iron overload, a complication of repeated blood transfusions, can cause tissue damage and organ failure. The body has no regulatory mechanism to excrete excess iron, so iron overload must be closely monitored to guide therapy and measure treatment response. The concentration of iron in the liver is a reliable marker for total body iron content and is now measured noninvasively with magnetic resonance imaging (MRI). MRI produces a diagnostic image by measuring the signals emitted from the body in the presence of a constant magnetic field and radiofrequency pulses. At each pixel, the signal decay constant, T2*, can be calculated, …

Santa Clara Magazine, Volume 60 Number 2, Spring 2019 [Print Issue V. 60:1], Santa Clara University

Santa Clara Magazine

28 - TECHNOLOGY, WONDER & US We’re at the epicenter of the biggest ecosystem of information exchange in history. How do we ensure tech fosters human flourishing? By Dorian Llywelyn, S.J. Illustrations by Derek Brahney.

36 - QUERY RESULTS What questions should we be asking about ethics and AI? Here are six. By Irina Raicu J.D. ’09. Illustrations by Paul Blow.

40 - A CURIOUS CASE If you want to innovate for the world, you need the room to do it. Sanjiv Das and a tale of machine learning, mortgages, and mistaken identity. By Deborah Lohse. Illustrations by Ellen Weinstein. …

Design And Manufacture Of An Inertial Cascade Impactor For Industrial Hygiene Purposes, Hector Joel Gortaire

Mechanical & Aerospace Engineering Theses & Dissertations

Inertial cascade impactors are devices commonly used for industrial hygiene and pharmaceutical studies. Their main purpose is to separate particulate matter suspended in aerosols according to their sizes, which can vary from over 10 µm to 0.5 µm. Their versatility and ease of operation make them suitable for on-site sampling; however, designing them requires a careful consideration of the different geometric parameters that characterize them.

In this thesis, a 5-stage inertial cascade impactor was designed, modelled, constructed, and tested. The main design parameter was the volumetric flow rate, 40 l/min, which was provided by a vacuum pump. By continuous iterations, …

Spring 2019, Joëlle Walls

The Investigator Research Magazine

We are excited to launch The Investigator, a new magazine which will be produced annually by the Office of Research at Kennesaw State University. You will find stories that span the spectrum and which impact the community through the research, service and creative activities conducted by KSU faculty, staff and students.

One feature describes how Jonathan McMurry and John Salerno partnered to create KSU’s first incubator company, New Echota Biotechnology. Another feature details the first year success of KSU Upward Bound programs, implemented in Polk and Paulding county high schools which help prepare students for college.

You will read how …

Three-Dimensional Plasma Cell Survival Microniche In Multiple Myeloma, Katrina A. Harmon

Theses and Dissertations

Multiple myeloma (MM) is an incurable malignancy characterized by the uncontrolled proliferation of long-lived plasma cells (PCs) in the bone marrow (BM), which constitute at least 10% of BM cellularity. Normally, long-lived plasma cells make up less than 1% of BM cells. Plasma cells become neoplastic when a clonal PC population produces a monoclonal immunoglobulin protein. A diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is made when there is an increase in monoclonal PCs within the BM, but less than 10%, and the patient does not present with end-organ damage, which is associated with active MM. Though not considered …

Proceedings Of The Cuny Games Conference 5.0, Robert O. Duncan, Joe Bisz, Julie Cassidy, Kathleen Offenholley, Carolyn Stallard, Deborah Sturm, Anders A. Wallace

Publications and Research

The CUNY Games Network is an organization dedicated to encouraging research, scholarship and teaching in the developing field of games-based learning. We connect educators from every campus and discipline at CUNY and beyond who are interested in digital and non-digital games, simulations, and other forms of interactive teaching and inquiry-based learning. The CUNY Games Conference distills its best cutting-edge interactive presentations into a two-day event to promote and discuss game-based pedagogies in higher education, focusing particularly on non-digital learning activities that faculty can use in the classroom every day. The conference will include workshops lead by CUNY Games Organizers on …

(Poster) Design And Fabrication Of A Custom Wrist Orthosis For Enhanced Patient Comfort, Marko Tasic, Matthew Hansen, Mang Lian, Demetre Mitchell, Rashedul Sarker, Renny Fernandez, Erin Peterson, Joseph Herzog, David Olawale, Najmus Saqib

ASEE IL-IN Section Conference

This custom wrist orthosis project is the continuation of efforts made by students in the R.B Annis School of Engineering during the 2017-2018 academic year. Throughout this project, we have implemented the Design for Six Sigma (DFSS) methodology to guide the design process. Within the R.B. Annis School of Engineering, this methodology has been adapted into guide the DesignSpine process. We have designed a new orthosis that is custom fabricated for enhanced patient comfort. In the occupational therapy field, patients have reportedly not been wearing their prescribed orthoses/braces, which are designed to stabilize injured areas so that they heal properly. …

Investigating Air Pollution And Equity Impacts Of A Proposed Transportation Improvement Program For Tampa, Talha Kemal Kocak

USF Tampa Graduate Theses and Dissertations

Transportation infrastructure is important for human mobility and population well-being. However, it can also have detrimental impacts on health and equity, including through increased air pollution and its unequal social distribution. There is a need for better understanding of these impacts and for better approaches that improve health and equity outcomes of transportation planning programs. In this study, we are investigating the air pollution and health equity impacts of an ongoing large-scale metropolitan transportation improvement program, Tampa Bay Next (TBNext). Specific objectives are: 1) to characterize and quantify the air pollution levels and population exposures resulting from the roadway expansion …

Threats To Adhesive/Dentin Interfacial Integrity And Next Generation Bio-Enabled Multifunctional Adhesives, Paulette Spencer, Qiang Ye, Linyong Song, Ranganathan Parthasarathy, Kyle Boone, Anil Misra, Candan Tamerler

Civil and Architectural Engineering Faculty Research

Nearly 100 million of the 170 million composite and amalgam restorations placed annually in the United States are replacements for failed restorations. The primary reason both composite and amalgam restorations fail is recurrent decay, for which composite restorations experience a 2.0–3.5-fold increase compared to amalgam. Recurrent decay is a pernicious problem—the standard treatment is replacement of defective composites with larger restorations that will also fail, initiating a cycle of ever-larger restorations that can lead to root canals, and eventually, to tooth loss. Unlike amalgam, composite lacks the inherent capability to seal discrepancies at the restorative material/tooth interface. The low-viscosity adhesive …

Å-Indentation For Non-Destructive Elastic Moduli Measurements Of Supported Ultra-Hard Ultra-Thin Films And Nanostructures, Filippo Cellini, Yang Gao, Elisa Riedo

Publications and Research

During conventional nanoindentation measurements, the indentation depths are usually larger than 1–10 nm, which hinders the ability to study ultra-thin films (<10 >nm) and supported atomically thin two-dimensional (2D) materials. Here, we discuss the development of modulated Å-indentation to achieve sub-Å indentations depths during force-indentation measurements while also imaging materials with nanoscale resolution. Modulated nanoindentation (MoNI) was originally invented to measure the radial elasticity of multi-walled nanotubes. w, by using extremely small amplitude oscillations (<<1 Å) at high frequency, and stiff cantilevers, we show how modulated nano/Å-indentation (MoNI/ÅI) enables non-destructive measurements of the contact stiffness and indentation modulus of ultra-thin ultra-stiff films, including CVD diamond films (~1000 GPa stiffness), as well as the transverse modulus of 2D materials. Our analysis demonstrates that in presence of a standard laboratory noise floor, the signal to noise ratio of MoNI/ÅI implemented with a commercial atomic force microscope (AFM) is such that a dynamic range of 80 dB –– achievable with commercial Lock-in amplifiers –– is sufficient to observe superior indentation curves, having indentation depths as small as 0.3 Å, resolution in indentation <0.05 Å, and in normal load <0.5 nN. Being implemented on a standard AFM, this method has the potential for a broad applicability.

Managing Healthcare Data Assets As A Complex Adaptive System, Katie Clifton

Systems Science Friday Noon Seminar Series

A major project is underway to develop a shared platform for data and analytics in a highly federated healthcare delivery organization. In the status quo data environment, analysts have integrated information from various domains — medical records, claims, membership — to produce a multitude of reports and analysis. Duplicative, mis-aligned, and siloed datasets were created as an unintended consequence.

One objective of the project is to produce outcomes (reports, analysis) that are more standardized and efficient than the status quo without sacrificing adaptability. Standards and practices are being intentionally developed as a mechanism for this emerging system to achieve more …