Engineering Commons^™

A Fully-Automated, Deep Learning-Based Framework For Ct-Based Localization, Segmentation, Verification And Planning Of Metastatic Vertebrae, Tucker Netherton, Tucker James Netherton

Dissertations and Theses (Open Access)

Palliative radiotherapy is an effective treatment for the palliation of symptoms caused by vertebral metastases. Visible evidence of disease is localized on medical images as part of the treatment planning process. However, complicating factors such as time pressures, anatomic variants in the spine, and similarities in adjacent vertebrae are associated with wrong level treatments of the spine. In addition, erroneous manual contouring of anatomic structures is a major failure mode in radiotherapy treatment planning.

The purpose of this study is to mitigate the challenges associated with treatment planning of the spine by automating the treatment planning process for three-dimensional conformal …

Development Of Quantitative Ultrasound-Mediated Molecular Imaging Of The Tumor Microenvironment, Trevor Mitcham

Dissertations and Theses (Open Access)

While conventional diagnostic imaging modalities provide anatomical information to clinicians, these techniques are not sensitive to critical physiological processes. In order to properly classify cancer, it is necessary to investigate noninvasive methods which can provide insight into these processes, allowing clinicians to determine personalized therapeutic options. Therefore, molecular imaging is focused on visualization and characterization of biomarkers within the tumor microenvironment (TME), which can then be combined with the anatomical information provided from diagnostic imaging.

Two such biomarkers of interest are blood oxygen saturation (SO₂) and cell receptor expression. SO₂ is a measure of the fraction of …

Cortical Dynamics Of Language, Kiefer Forseth

Dissertations and Theses (Open Access)

The human capability for fluent speech profoundly directs inter-personal communication and, by extension, self-expression. Language is lost in millions of people each year due to trauma, stroke, neurodegeneration, and neoplasms with devastating impact to social interaction and quality of life. The following investigations were designed to elucidate the neurobiological foundation of speech production, building towards a universal cognitive model of language in the brain. Understanding the dynamical mechanisms supporting cortical network behavior will significantly advance the understanding of how both focal and disconnection injuries yield neurological deficits, informing the development of therapeutic approaches.

Improving Treatment Of Local Liver Ablation Therapy With Deep Learning And Biomechanical Modeling, Brian Anderson, Kristy Brock, Laurence Court, Carlos Eduardo Cardenas, Erik Cressman, Ankit Patel

Dissertations and Theses (Open Access)

In the United States, colorectal cancer is the third most diagnosed cancer, and 60-70% of patients will develop liver metastasis. While surgical liver resection of metastasis is the standard of care for treatment with curative intent, it is only avai lable to about 20% of patients. For patients who are not surgical candidates, local percutaneous ablation therapy (PTA) has been shown to have a similar 5-year overall survival rate. However, PTA can be a challenging procedure, largely due to spatial uncertainties in the localization of the ablation probe, and in measuring the delivered ablation margin.

For this work, we hypothesized …

Development Of Biomaterials For Drug Delivery, Raquel De Castro

Graduate Theses and Dissertations

Drug delivery systems (DDS) have highly evolved in the last decades with the development of hydrogels and nanoparticles. However, high systemic uptake, side effects, low bioavailability, and encapsulation efficiency continue to be a major hurdle faced by such DDSs.

Nanoparticles and hydrogels can be specifically designed for targeted DDSs to mitigate some of the problems. This dissertation aimed to design two DDSs for ocular drug delivery and one for cancer treatment. The first project sought to develop chitosan nanoparticles (Cs-NP) using PEGDA as a copolymer to encapsulate gentamicin (GtS) for ocular drug delivery. Cs-NPs contain positive charges that can interact …

Computational Sentiment Analysis Of An Online Left Ventricular Assist Device Support Forum: Positivity Predominates, Melissa Austin, Abhiraj Saxena, Thomas O'Malley, Elizabeth Maynes, Henry Moncure, Nathan Ott, H. Todd Massey, Francesco Moscato, Antonio Loforte, John M Stulak, Vakhtang Tchantchaleishvili

Division of Cardiology Faculty Papers

Background: The impact of left ventricular assist device (LVAD) complications on the individual patient, overall sentiment, and its effect on referral patterns, is not fully understood. We sought to better understand patient attitudes towards LVAD therapy using a computational sentiment analysis approach.

Methods: Posts, comments, and titles were parsed from MyLVAD.com's HTML as a text file using custom Python scripts (version 3.6). Individual word frequency was computed with word classification as 'positive', 'negative', or 'neutral'. Data transformation and cleaning, sentiment determination, and analysis was performed with a binary dictionary package using R software (version 3.6).

Results: Sixty-six thousand eight hundred …

App Development For Wearable Sensors, Connor Pittman, Christopher Chappie, Patrick A. Tetreault

Thinking Matters Symposium

The objective of this research project was to create a wearable device that monitors bodily functions for the user to view on their smartphone. Sensor data is processed using the Arduino Nano 33 BLE microcontroller. The sensors used in this project include: proximity, temperature, humidity, heart rate, pressure, and skin impedance. This project takes advantage of the Arduino's Bluetooth low energy (BLE) capabilities so that all the data can be transmitted to a smartphone. This presentation shows the challenges faced during the project and how they were overcome. Some of these challenges include: programming, how heart rate sensors work, and …

Bibliometric Analysis Of Emerging Technologies In The Field Of Computer Science Helping In Ovarian Cancer Research, Sonali Kothari Dr., Anvita Gupta, Muskaan Agrawal Agrawal, Kajal Jaggi, Adhiraj Dev Goswami, Ketan Kotecha, M. Karthikeyan Dr., Vijayshri Khedkar

Library Philosophy and Practice (e-journal)

This study is carried out to provide an analysis of the literature available at the intersection of ovarian cancer and computing. A comprehensive search was conducted using Scopus database for English-language peer-reviewed articles. The study administers chronological, domain clustering and text analysis of the articles under consideration to provide high-level concept map composed of specific words and the connections between them.

2021- The Twenty-Fifth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-fifth Annual Symposium of Student Scholars, held on April 29, 2021. Includes abstracts from the presentations and posters.

Quantitative Analysis Of Research On Artificial Intelligence In Retinopathy Of Prematurity, Ranjana Agrawal, Manasi Anup Agrawal, Sucheta Kulkarni, Ketan Kotecha, Rahee Walambe

Library Philosophy and Practice (e-journal)

Retinopathy of Prematurity (ROP) is a disease of the eye and a potential source of blindness in low birth weight preterm infants. It is preventable if diagnosed and treated on time. Artificial Intelligence (AI) has played an important role in developing automated screening systems to assist medical experts. There are many traditional literature review articles available that focus on the scientific content of ROP-AI. The researchers also require a bibliometric analysis to become acquainted with the competing groups and new trends in this field. This paper gives a brief overview of ROP and AI systems for ROP screening with a …

Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price

Honors Theses

ABSTRACT JASON BLAKE PRICE: Surface-Eroding Drug Delivery Films for Sequential and/or

Intermittent Release of Psychoactive Drugs For patients with psychiatric diseases, adherence to medication schedules, medication

errors, and abuse are common issues. Promising new forms of therapy for these patients, such as micro-dosed lysergic acid diethylamide (LSD), where patients receive 10-20% of a full dose every third day, present further drug delivery challenges. Sequential or intermittent release of drugs from an implanted device could ensure long-term drug compliance, automate drug dosing during the life of the implant, and eliminate potential for abuse and medication errors. To this end, we generated …

Understanding The Effect Of Adaptive Mutations On The Three-Dimensional Structure Of Rna, Justin Cook

Undergraduate Research and Scholarship Symposium

Single-nucleotide polymorphisms (SNPs) are variations in the genome where one base pair can differ between individuals.¹ SNPs occur throughout the genome and can correlate to a disease-state if they occur in a functional region of DNA.¹According to the central dogma of molecular biology, any variation in the DNA sequence will have a direct effect on the RNA sequence and will potentially alter the identity or conformation of a protein product. A single RNA molecule, due to intramolecular base pairing, can acquire a plethora of 3-D conformations that are described by its structural ensemble. One SNP, rs12477830, which …

Développement D'Une Méthode De Mesure De L'Exposition Sonore Effective Intraauriculaire Pour Une Utilisation En Milieu De Travail, Hugues Nélisse, Fabien Bonnet, Marcos Nogarolli, Jérémie Voix

Rapports de recherche scientifique

De nombreux travailleurs sont exposés quotidiennement à des niveaux de bruit susceptibles d'endommager leur audition. De ce fait, la mesure de l'exposition sonore est essentielle afin d'identifier et d’évaluer des solutions correctives pour protéger adéquatement les travailleurs. Cependant, les méthodes et les technologies de mesure actuelles ne permettent généralement pas de déterminer avec précision l'exposition au bruit subie par un individu sur son lieu de travail. La dosimétrie intraauriculaire est une solution prometteuse pour pallier un certain nombre de problèmes liés aux méthodes de mesure conventionnelles, mais cette méthodologie est fragilisée de trois façons : 1) l'exposition sonore mesurée dans …

"Inclusive Inquiry." 14th Annual Research Week: Event Proceedings, University Of The Incarnate Word

Excellence Summit (Research Week) Archived Proceedings

Presentations of completed and ongoing research activity conducted by graduate and undergraduate students and faculty at University of the Incarnate Word. Coordinated and presented by the Office of Research and Graduate Studies.

Automatic Generation And Novel Validation Of Patient-Specific, Anatomically Inclusive Scoliosis Models For Biomechanics-Informed Surgical Planning, Austin Tapp, Michel Audette, James Bennett

College of Engineering & Technology (Batten) Posters

Scoliosis is an abnormal spinal curvature of greater than 10 degrees. Severe scoliotic deformities are addressed with highly invasive procedures: anterior or posterior spinal fusion approaches. This invasiveness is due, in part, to the constraints of current surgical planning, which utilizes computed tomography (CT) scans unable to discern spinal ligaments that are dissected to make the spine sufficiently compliant for correction. If localization of ligaments and soft tissues were achieved pre-operatively, corrective procedures could become safer and more efficient by using finite element (FE) biomechanical simulations to determine decreased incidences of ligament releases. This research aims to achieve ligament localization …

Ceramic Studio Assistant, Allison Jones, Adam Yungbluth

2021 Celebration of Student Scholarship - Oral Presentations

The research project will focus on learning the various activities involved in running a college level Ceramics Studio. Activities will include clay mixing for Ceramics 1 courses, mixing studio glazes & slips, firing bisque, reduction, soda, & wood kiln, and other activities to improve the Ceramics Studio.

The Art Of Preservation, Sinclaire Dorsey, Melissa Yungbluth

2021 Celebration of Student Scholarship - Oral Presentations

Proper preservation of creative works is imperative to sustaining documentation for future generations’ education. Exhibition designers, such as the students awarded with the undergraduate research fellowship for the Golding-Yang gallery, must be mindful of the environmental factors that impact creative works. For instance, light sensitivity of the materials can be overwhelmed by ultraviolet and infrared radiation produced by the sun. Atmospheric humidity, when not regulated, will destroy irreplaceable artwork that could provide future historians a better understanding of modern culture. Extreme temperatures are devastating to the preservation of artistic works. The regulation of these environmental factors will provide future generations …

Low Stress Handling Techniques In Shelter Animals And The Overall Effects On Physiological Parameters, Ashley Swim, Courtney Smart, Amy Staton

2021 Celebration of Student Scholarship - Oral Presentations

Animal shelters tend to be a very stressful environment for dogs as there are many new sounds, smells, and animals. This stress is not only bad for their psychological health and can lead to behavioral issues, but it can also have an impact on their physical health. Stress impacts multiple systems of the body, resulting in increased heart rate, blood pressure, respiratory rate, temperature and even blood glucose levels in dogs. The impact stress has on these systems can lead to a compromised immune system and increases the probabilities of the dog becoming ill. However, by using Fear Free methods, …

Adverse Experiences, Depression, And Parenting Sensitivity., Lauren Oldiges, Savannah Gillis, Tiffany Hicks, Shari Kidwell

2021 Celebration of Student Scholarship - Oral Presentations

Parental sensitivity is a key determinant of attachment security and child well-being. Yet many parents in our region face challenges to parenting, such as increased exposure to adverse experiences and depression. Both cumulative exposure to adverse experiences and depression symptoms have been associated with increased risk to parenting (Hays-Grudo & Wilson, 2020). The present study explores connections between parents’ sensitivity/synchrony scores on the Toddler CARE-Index (TCI: Crittenden, 2007), Adverse Childhood Experiences (ACEs) amongst parents, and parental depression. As part of a larger longitudinal study of Eastern Kentucky families, 35 children (mean age 4.5 years) and their parents participated in the …

French Textbook Illustrations, Abigail Hall, Nicholas Anderson, Karen Taylor

2021 Celebration of Student Scholarship - Oral Presentations

This project has been an update of an introductory French textbook in order to make the work more cohesive illustratively. Each week we were given a drawing task to go with a chapter or vocabulary assignment to replace, revamp or develop new art work of greater value than the preexisting illustrations.

Relation Among Potential Predictors Of Drug Abuse Risk In Rats, Emma Brock

2021 Celebration of Student Scholarship - Oral Presentations

Animal models have been used to investigate behavioral processes and mechanisms that underlie addiction. A variety of measures have been developed for rats that are modest predictors of drug abuse risk. The purpose of this pilot study was to begin to assess whether several established and potential measures of drug abuse vulnerability were correlated. The subjects were eight adult male Wistar rats. The rats were run on procedures that yielded measures of anxiety, sensation seeking, short term responsive to acutely administered drug, and sensitivity to conditioned stimuli. These measures were correlated with a potential new measure of drug abuse vulnerability—withdrawal …

Improving Patient Outcomes With High Nurse To Patient Ratios: A Quality Improvement Study, Alexis Bradshaw, Morgan Minton, Brenna Murphy, Abigail Ross, Hannah Dorton, Carson Jones, Cierra Connelly, Haley Nyderek

2021 Celebration of Student Scholarship - Oral Presentations

According to the United States Registered Nurse Workforce Report Card and Shortage Forecast: A Revisit published in the May/June 2018 issue of the American Journal of Medical Quality, a shortage of registered nurses is projected to spread across the country between 2016 and 2030. Surveyed nurses see the shortage in the future as a catalyst for increasing stress on nurses (98%), lowering patient care quality (93%) and causing nurses to leave the profession (93%) (American Association of Colleges of Nursing, 2021). A thorough literature review was conducted, and 40 studies were reviewed. Common themes that emerged include: high nurse to …

The Impact Of Power Yoga Training On Baseball Throwing Velocity, John Bakke

2021 Celebration of Student Scholarship - Oral Presentations

The purpose of this study was to examine the impact of yoga on baseball pitching velocity, and the factors that affect throwing velocity such as power, flexibility, speed, and mobility. Thirteen volunteer collegiate baseball pitchers were pre-tested on their power, flexibility, speed, mobility, and throwing velocity. The intervention included a 10-week yoga training, with the goal of three sessions per week. Participants were then post-tested under the same conditions. Analysis included dependent t-tests for each of the fitness assessments, with alpha set at .05 a priori. The group was unable to reach the goal of three yoga sessions per week, …

Increasing Student Engagement In Introductory Physics Hybrid Classes, Breanna Epperson

2021 Celebration of Student Scholarship - Oral Presentations

The demand for online instruction is on the rise. In a classroom setting, research shows that student interactions are important for overcoming common misconceptions, but it is challenging to achieve the same level of engagement in an online setting. To try to improve online interactions in a hybrid physics class at Morehead State University, the Fall 2020 online class was required to post a total of three times about a closed, multiple choice, conceptual physics question in each assignment while following certain criteria. In the Spring of 2021, the discussion format was kept the same, but was moved to a …

Genetically Screening For Gain Of Function Mutations In Telomerase Rna, Jose Childers

2021 Celebration of Student Scholarship - Oral Presentations

Telomeres are DNA structures located at the ends of linear chromosomes. They function, in part, to allow DNA ends to be copied before cells divide. Since the standard DNA replication machinery can’t fully copy telomeres, most eukaryotic cells require the vital ribonucleoprotein enzyme telomerase. Telomerase is composed of a TERT (telomerase reverse transcriptase protein) and telomerase RNA. As we age, telomeres shorten since most human cells do not express telomerase. If telomeres grow too short, it triggers a cell-cycle arrest known as senescence, which can ultimately result in cell death. On the other hand, >85% of human cancers show over-expression …

A Portable Analyzer For Rapid And Sensitive Protein Detection By Ac Electrokinetics Capacitive Sensing, Allie Skaggs

2021 Celebration of Student Scholarship - Oral Presentations

Capacitive bioparticle detection is a promising method for point-of-care diagnosis. There are a wide range of applications for such a device: diagnostics, pharmacology, and medical science. The end goal of this project is to develop a portable capacitive sensing platform for rapid and sensitive bioparticles detection. When bioparticles bind to receptors located on the surface of the electrode there would be a change in the interfacial capacitance, which indicate the presence of the bioparticle. The ADuCM355 – a precision analog microcontroller with a chemical sensor interface – is being used to perform biased electrochemical impedance spectroscopy (EIS). An AC potential …

Preservation Of Morehead State History, Jacob Bush

2021 Celebration of Student Scholarship - Oral Presentations

This project is being undertaken in an effort to preserve the buildings and history of Morehead State University. It is the goal of this project to make additions to the historic district of MSU by adding qualifying buildings to the National Register of Historic Places. By adding buildings to the Register, they would be recognized on the federal level as historic sites and receive support for their preservation. The Register seeks to protect sites of importance through many ways including the gifting of funding to ensure preservation. The goals of this project will be achieved using historical texts from our …

Analytical Method Development For The Analysis Of Biomass Degradation Products, Calista Dean

2021 Celebration of Student Scholarship - Oral Presentations

The goal of this project is to study the kinetics of hydrothermal liquefaction of biomass. Biomass contains stored chemical energy that can be converted to renewable liquid and gaseous fuels through various processes, but an in-depth understanding of the kinetics of these processes is important in order for them to be feasible on a large scale. Since biomass degradation products depend on the type of biomass used as well as the reaction conditions, this task can be quite complicated. To minimize complications in our initial studies, we will use D-glucose as the starting material. To better understand the degradation pathway’s …

Comparing Growth Of Mutant Strains Of Acinetobacter Baumannii To Wild Type After Treatment With Mitomycin C, Kaylee Compton, Deborah Cook

2021 Celebration of Student Scholarship - Oral Presentations

In Acinetocbacter baumannii bacteria, an error-prone DNA damage repair response is induced by the self-cleavage of the UmuDAb protein. Previous experiments indicating that a ddrR mutant becomes growth sensitive after DNA damage suggested that ddrR is also involved in this process. To explore this relationship, eight mutant strains of A. baumannii were made with different combinations of mutations in either ddrR and/or the adjacent gene, A1S_3662. Our experiment compared the growth of wild type cells to strains containing various mutations: DC4 (no gene mutations, just an antibiotic resistance marker, Kanr), DC5 (stop codon mutation in ddrR), and DC6 (both the …

Ekap Update: Rethinking The Presentation Of Historic Sites, Elizabeth Debord

2021 Celebration of Student Scholarship - Oral Presentations

The Eastern Kentucky Art Project was founded in 2007 as a way to connect communities with resources pertaining to visual arts and music in Eastern Kentucky. One significant type of resources EKAP features is information regarding historic architecture in Eastern Kentucky. Understanding cultural landmarks in people’s own communities can foster an inclusive and healthy community identity, but it became clear through recent efforts to update the EKAP website that information surrounding the preservation of historic sites is often difficult to access and understand for a general audience. Previous efforts to educate and encourage preservation of important sites was often tied …