Engineering Commons^™

Methods For Inference And Analysis Of Gene Networks From Rna Sequencing Data, Himangi Srivastava

Theses and Dissertations

RNA (Ribonuceic Acid) sequencing technology is a powerful technology used to give re- searchers essential information about the functionality of genes. The transcriptomic study and downstream analysis highlight the functioning of the genes associated with a specific biological process/treatment. In practice, differentially expressed genes associated with a particular treatment or genotype are subjected to downstream analysis to find some critical set of genes. This critical set of genes/ genes pathways infers the effect of the treatment in a cell or tissue. This disserta- tion describes the multiple stages framework of finding these critical sets of genes using different analysis methodologies …

Torque Vectoring To Maximize Straight-Line Efficiency In An All-Electric Vehicle With Independent Rear Motor Control, William Blake Brown

Theses and Dissertations

BEVs are a critical pathway towards achieving energy independence and meeting greenhouse and pollutant gas reduction goals in the current and future transportation sector [1]. Automotive manufacturers are increasingly investing in the refinement of electric vehicles as they are becoming an increasingly popular response to the global need for reduced transportation emissions. Therefore, there is a desire to extract the most fuel economy from a vehicle as possible. Some areas that manufacturers spend much effort on include minimizing the vehicle’s mass, body drag coefficient, and drag within the powertrain. When these values are defined or unchangeable, interest is driven to …

Evaluation Of Hyperspectral Band Selection Techniques For Real-Time Applications, Samantha Butler

Theses and Dissertations

Processing hyperspectral image data can be computationally expensive and difficult to employ for real-time applications due to its extensive spatial and spectral information. Further, applications in which computational resources may be limited can be hindered by the volume of data that is common with airborne hyperspectral image data. This paper proposes utilizing band selection to down-select the number of spectral bands to consider for a given classification task such that classification can be done at the edge. Specifically, we consider the following state of the art band selection techniques: Fast Volume-Gradient-based Band Selection (VGBS), Improved Sparse Subspace Clustering (ISSC), Maximum-Variance …

Unmanned Ground Vehicle System To Collect Soil Moisture Data, Austin Edward Flynt

Theses and Dissertations

With an increased interest in precision agriculture, it is important to identify efficient ways to monitor soil moisture. Soil moisture can be monitored using handheld sensors, but this method is laborious and time consuming. Remote methods, such as radar systems can be used as well, but these methods require ground truth data to verify their accuracy. It becomes clear that to collect this data regularly and reliably, a mobile robotic device is necessary. This thesis proposes to implement mobile robot take soil moisture measurements with less human effort than existing methods while maintaining the same accuracy. This soil moisture data …

Enhancing Situational Awareness For Rotorcraft Pilots Using Virtual And Augmented Reality, Ardit Pranvoku

Theses and Dissertations

Rotorcraft pilots often face the challenge of processing a multitude of data, integrating it with prior experience and making informed decisions in complex, rapidly changing multisensory environments. Virtual Reality (VR), and more recently Augmented Reality (AR) technologies have been applied for providing users with immersive, interactive and navigable experiences. The research work described in this thesis demonstrates that VR/AR are particularly effective in providing real-time information without detracting from the pilot's mission in both civilian and military engagements. The immersion of the pilot inside of the VR model provides enhanced realism. Interaction with the VR environment allows pilots to practice …

An Insurance Framework For Cyber-Physical Power Systems Considering Integrated Cybersecurity-Reliability Assessment, Pikkin Lau

Theses and Dissertations

Due to the development of cyber-physical systems for modernizing power grids, vulnerabilityassessment has become an emerging focus in power system security studies. With the increasing application of cyber-enabled technologies in power systems, modern power system is prevalently exposed to a wide gamut of cybersecurity threats. In this dissertation, the power supply reliability is evaluated considering the strategic allocation of defense resources and smart technologies. The optimal mixed strategies are formulated by the Stackelberg Security Game to allocate the defense resources on multiple targets subject to cyberattacks. Smart monitoring with preventive and corrective measures is able to boost the substation availability …

Advanced Analytics In Smart Manufacturing: Anomaly Detection Using Machine Learning Algorithms And Parallel Machine Scheduling Using A Genetic Algorithm, Meiling He

Theses and Dissertations

Industry 4.0 offers great opportunities to utilize advanced data processing tools by generating Big Data from a more connected and efficient data collection system. Making good use of data processing technologies, such as machine learning and optimization algorithms, will significantly contribute to better quality control, automation, and job scheduling in Smart Manufacturing. This research aims to develop a new machine learning algorithm for solving highly imbalanced data processing problems, implement both supervised and unsupervised machine learning auto-selection frameworks for detecting anomalies in smart manufacturing, and develop a genetic algorithm for optimizing job schedules on unrelated parallel machines. This research also …

A Deep Recurrent Neural Network With Iterative Optimization For Inverse Image Processing Applications, Masaki Ikuta

Theses and Dissertations

Many algorithms and methods have been proposed for inverse image processing applications, such as super-resolution, image de-noising, and image reconstruction, particularly with the recent surge of interest in machine learning and deep learning methods.

As for Computed Tomography (CT) image reconstruction, the most recently proposed methods are limited to image domain processing, where deep learning is used to learn the mapping between a true image data set and a noisy image data set in the image domain. While deep learning-based methods can produce higher quality images than conventional model-based algorithms, these methods have a limitation. Deep learning-based methods used in …

Design, Control, And Development Of A Multilevel Converter Medium Voltage Ac To Low Voltage Dc For Fleet Electric Vehicle Charge Station, Garry Jean-Pierre

Theses and Dissertations

There is a shift in the technology of vehicles from gas and diesel engines to electric vehicles(EVs). Approximately ten million EVs were available globally in 2020 and it is projected that number will reach 145 million by 2030. To power the increasing number of EVs, the number of EV charging stations is growing at a significant rate. In order to provide flexibility and longer driving ranges to customers, the trend is to install DC fast charging stations. These chargers demand high power at low voltage, which our existing electrical distribution system cannot accommodate without major upgrades. Currently, bulky transformers are …

Common-Mode Modeling Of Neutral Point Clamped Converter Based Dual Active Bridge, Ryan James Olson

Theses and Dissertations

Modern power converters designed with wide-bandgap semiconductors are known to generate substantial conducted electromagnetic interference as a side effect of high edge rate and high frequency switching. With the advancement in power electronic converters, the significant EMI challenges need to be addressed for distribution level power systems. The goal is to provide a computationally efficient method of EMI characterization for conducted emissions for this future generation of power distribution systems. The first step in making this possible is through creating an accurate EMI characterization platform for the neutral point clamped dual active bridge. In this thesis, a formalized common-mode modeling …

Network Management, Optimization And Security With Machine Learning Applications In Wireless Networks, Mariam Nabil

Theses and Dissertations

Wireless communication networks are emerging fast with a lot of challenges and ambitions. Requirements that are expected to be delivered by modern wireless networks are complex, multi-dimensional, and sometimes contradicting. In this thesis, we investigate several types of emerging wireless networks and tackle some challenges of these various networks. We focus on three main challenges. Those are Resource Optimization, Network Management, and Cyber Security. We present multiple views of these three aspects and propose solutions to probable scenarios. The first challenge (Resource Optimization) is studied in Wireless Powered Communication Networks (WPCNs). WPCNs are considered a very promising approach towards sustainable, …

A High-Bandwidth, Spectrally Broad Photodetector Based On Optically-Induced Seebeck Effect, Niloufar Yavarishad

Theses and Dissertations

In this thesis, we engineered a fast response high bandwidth self-powered infrared photodetector based on optically induced Seebeck effect in Cd3As2 operating at room temperature. The metal-semimetal-metal device was subject to transient photo-response tests using high-frequency lock-in modulation techniques. Our photodetector demonstrates a Seebeck voltage under the off-center illumination of a laser with the wavelength of 1064 nm, due to a temperature gradient. The photocurrent is readily registered at a modulation frequency of 6 kHz and further analysis indicates the sensor intrinsic bandwidth is predicted to approach the terahertz range. The responsivity of the sensor is 0.27 mA/W at room …

Smart Metering Communication Protocols And Performance Under Cyber Security Vulnerabilities, Oscar A. Alvarez

Theses and Dissertations

The communication process is the key that characterizes the modern concept of smart grid, a new technology that introduced a “two-way communication” in energy measurement systems and can be best represented through the smart meters. Hence, the goal of smart metering communication is to ensure a secure and reliable transmission of information that can only be accessed by end users and energy supplying companies. With the goal of improving the information security in smart energy grids, the research presented in this work focused on studying different advanced metering infrastructure communication protocols and, it showcases a series of experiments performed on …

Characteristics Analysis Of Electrochemical Impedance Spectroscopy (Eis) For Different Electrode Patterns, Shanzida Kabir

Theses and Dissertations

Electrochemical impedance spectroscopy (EIS) is a rapidly developing technique used in characterizing materials and interfaces. Using equivalent circuits as models can determine the electrical properties of heterogeneous systems like membranes or electrolytes. Different electrochemical processes like the electron transfer rate of a specific reaction or the capacitive behavior of the system, or even the diffusion-limited response can coincide. EIS is applicable to determine different electrochemical processes that can happen simultaneously. The purpose of this research is to find the optimal operating range for other AC electrokinetic mechanisms. Analysis of EIS can be helpful in both fundamental examinations of electrokinetic transport …

Development Of Metamaterial-Based Near-Zero Refractive Index Structures In The Optical Regime, Andres Ochoa

Theses and Dissertations

Multilayer combinations of plasmonic and dielectric materials can be designed as subwavelength structures to create a medium with unique parameters, but the development of optical metamaterials for the visible spectrum is hindered by the lack of plasmonic materials with suitable properties. A method to understand and design metamaterials for optical applications is examined as a solution for shifting the operating range from ultraviolet light to visible light. Special points of interest and corresponding parameters are identified to understand their effects on propagation. A hyperbolic near-zero refractive index metamaterial composed of alternating layers of metal and perovskite thin films is proposed …

Data Analytics For Google Trend Search Result Of Illness Symptoms, Md Jakir Hossain

Theses and Dissertations

The outbreak of COVID-19 has escalated from March 2020. Since then, people from all over the world are curiously searching different types of illness symptoms including corona virus. Before the outbreak, people were also searching different types of symptoms at different times. Both diseases share same symptoms, but in the flu season. If certain types of symptoms are visible at summer season, then these symptoms are for corona virus. The main purpose of our study is to find out this discriminative information from these search result. We will discuss some mathematical concepts and then develop an algorithm based on those …

Ionospheric F-Layer Dipole Flute Instability Effects On Electromagnetic Scattering In A Magnetohydrodynamic Plasma, Andrew J. Knisely

Theses and Dissertations

The ionosphere has significant impact on radio frequency (RF) applications such as satellites, over-the-horizon radar, and commercial communication systems. The dynamic processes effecting the behavior of the ionic content leads to a variety of instabilities that adversely affect the quality of RF signals. In the F-layer ionosphere, flute instability persists, appearing as two radial regions of high and low density perturbations elongated along the earth's geomagnetic field lines. The sizes of flute structures are comparable to the wavelengths in the high frequency spectrum. The objective is to characterize the high frequency scattering of an incident field by developing a 3D …

The Effect Of Low Dose Penicillin On Tumor Development In ApcMin/+ Mice, Kinsey Ann Sierra Meggett

Theses and Dissertations

Antibiotics have been our most effective weapon against bacterial infections since their discovery in the early 1900s. Their use has been critical in reducing mortality rate from infectious diseases. However, in the last few decades, the overuse of antibiotics, beginning at an early age and into adulthood, has become a growing concern globally. Penicillin is one of many extensively used antibiotics in early childhood that has been used to treat childhood infections. Recent studies showed that exposure to low dose penicillin can have adverse effects leading to chronic illness such as diabetes, allergies, inflammation, and susceptibility to obesity, with the …

Operating Strategies And Disturbance Characterization For Dc Microgrids, Miles Leonard-Albert

Theses and Dissertations

The present state of the electrical grid is unable to meet the demands of transmission. Digital twin technology provides a promising solution to this problem by allowing for analysis and control of distributed energy resources. This thesis presents initial work towards development of a digital twin for a DC power system. Two versions of the DC power system are created and evaluated against randomly generated load profiles. System performance is evaluated on the basis of the quantity of the load that is unserviced by the generation and energy storage. Energy storage operating strategies that modify the model to prioritize different …

Ultrawide Bandgap Algan-Channel Metal Oxide Semiconductor Heterostructure Field Effect Transistors With High-K Gate Dielectrics, Md Abu Shahab Mollah

Theses and Dissertations

Ultra-wide Band Gap (UWBG) (E_G > 3.4 eV) Al_xGa_1-xN channel devices are promising candidates for compact next-generation power electronics due to the scaling of the breakdown field with alloy composition. The huge opportunity in consumer electronics is the major driving force behind the recent developments of UWBG AlGaN-channel HEMTs. One of the most critical issues limiting the device performance at high power level is device degradation primarily caused by gate leakage current. Use of SiO₂ gate insulator is a standard method to suppress gate leakage but it causes threshold voltage shift towards more negative requiring …

A Novel Model To Study Adipose-Derived Stem Cell Differentiation, Austin N. Worden

Theses and Dissertations

The use of three-dimensional (3D) culture systems (hydrogels) and adipose-derived stem cells (ADSCs) in regenerative medicine to advance early-stage investigation and modeling of the mechanisms of diseases, treatments, targets, etc. has recently increased. ADSCs, specifically, are utilized due to their innate programming during embryogenesis and in adult tissues in addition to their ability to differentiate into mesodermal, endodermal, and ectodermal cell-specific lineages. Of importance is that these advancements do not involve a model specimen (i.e. mice or rats) and simulate the numerous conflicting signals a migrating cell is exposed to in vivo such as chemokines, extracellular matrix (ECM), growth factors, …

Role Of Estrogen In Regulating Diet-Induced Obesity In Females, Ahmed Aladhami

Theses and Dissertations

Menopause puts a female at risk for several chronic diseases, including an increased risk of obesity. Estrogens are major sex hormones of females that dramatically decrease during menopause. Several murine studies have established the crucial role of estrogen and estrogen receptor alpha (ERα) on energy homeostasis, glucose metabolism, and insulin action. However, previous works have produced contradicting findings, hence, further work is needed to optimize better outcomes. Therefore, my dissertation focuses on optimizing and characterizing different estrogen-deficient models, as well as using novel double transgenic inducible and tissue-specific models that overexpress aromatase (estrogen producing enzyme) and estrogen receptor isomers alpha …

Study Of The Effect Of B-Cell-Intrinsic Mhcii Antigen Presentation On Germinal Center B Cell Evolution Using The Brainbow Mouse Model, Nia Hall

Theses and Dissertations

Major histocompatibility complex class II (MHCII) are molecules that are essential for B cell activation, as well as clonal competition among activated B cell clones during germinal center (GC) reactions. However, it is unknown to what extent MHCII drives the selection of some clones over others. This is of particular importance since MHCII is highly polymorphic with the ability to indirectly alter gutmicrobiome composition by altering the immunoglobulin A (IgA) repertoire. To study this, we utilized a novel triple-transgenic mouse model to assess how B-cellintrinsic MHCII influences GC responses and GC clonal diversity, with an eyeforward to understanding the relevance …

The Role Pde11a4 Signaling And Compartmentalization In Social Behavior, Kaitlyn Pilarzyk

Theses and Dissertations

People tend to be social by nature. Being socially connected not only helps people live longer and healthier lives, but being an engaged and contributing member of society strengthens our communities overall. Maintaining intact social behaviors is key to maintaining this wellbeing, with disruptions negatively affecting both mental and physical health. Indeed, social isolation and feelings of loneliness can significantly increase a person’s risk of premature death, heart disease, and stroke as well as depression, anxiety, suicide, and dementia. Maintaining the ability to create and store social memory with age is, therefore, key to maintaining proper social behaviors. Unfortunately, individuals …

Real Time Simulation And Hardware In The Loop Methods For Power Electronics Power Distribution Systems, Michele Difronzo

Theses and Dissertations

System level testing of Power Electronics Power Distribution Systems (PEPDS) can be challenging when fine temporal resolution is required (time step below 100-200ns). In the recent years, our research group has proposed various methods to simulate in real-time PEPDS using FPGAs and time step as small as 50ns. While the proposed methods allow achieving the desired temporal resolution, they are extremely demanding in terms of resources usage and the size of the PEPDS that can be simulated on a single FPGA is strongly limited.

In this dissertation -work that takes as an example application the US Navy electric Ship Zonal …

Increased Detectivity And Low Temperature Performance Analysis Of Sub-20Μm Micropixel Array A1gan Uv Photodiodes, Samia Islam

Theses and Dissertations

This thesis is divided into two sections. At first, we demonstrate ~1.5x detectivity increase in AlGaN photodiodes on sapphire using distributed micropixel arrays with 5-15 µm pixel diameter. This is due to the ~10x larger chip footprint of the 5um diameter micropixel arrays compared to planar control structures with identical p contact area. The responsivity of the larger areas was the same as that of the control structure despite the larger footprint while the dark currents, an indicator of noise, remained unchanged. The photocurrent generated between pixels was collected due to transmission line effects connecting the pixels separated by 5um, …

Impact Of Acetylcholine On Internal Pathways To Basal Amygdala Pyramidal Neurons, Tyler Daniel Anderson-Sieg

Theses and Dissertations

The basolateral nuclear complex of the amygdala (BNC) – consisting of the lateral (LA), basolateral (BL), and basomedial nuclei (BM) – detects salient environmental stimuli (cue-detection) and motivates appropriate behavioral responses to their implied meaning (cue-guided behavior) via a precise pattern of internal circuitry. Glutamatergic signals representing environmental stimuli enter the LA and split into parallel streams that activate pyramidal neurons (PNs) in the anterior and posterior BL (BLa and BLp), which putatively mediate negative and positive emotions, respectively. The BL is the most densely innervated target of the cholinergic basal forebrain (CBF) and ACh transients (phasic ACh) in cortex …

Impaired Metabolic Flexibility In A Mouse Model Of Leigh Syndrome, Richard Sterling Mccain Jr

Theses and Dissertations

Metabolic dysfunction burdens tissues with high energy demands, particularly the brain. Leigh syndrome is a mitochondrial encephalopathy stemming from genetic defects in the electron transport chain. Leigh syndrome patients develop lactic acidosis, ataxia, bilateral necrotizing lesions in the brainstem and basal ganglia, lesion microgliosis, and eventually death due to respiratory failure. The NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 (NDUFS4) knockout mouse is an established model of Leigh syndrome due to impaired assembly of mitochondrial Complex I that develops motoric deficits and necrotizing lesions in the brainstem vestibular nuclei and olfactory bulb. In addition to the Complex I-derived bioenergetics defect, altered …

Unsupervised Learning For Anomaly Detection In Remote Sensing Imagery, Husam A. Alfergani

Theses and Dissertations

Landfill fire is a potential hazard of waste mismanagement, and could occur both on and below the surface of active and closed sites. Timely identification of temperature anomalies is critical in monitoring and detecting landfill fires, to issue warnings that can help extinguish fires at early stages. The overarching objective of this research is to demonstrate the applicability and advantages of remote sensing data, coupled with machine learning techniques, to identify landfill thermal states that can lead to fire, in the absence of onsite observations. This dissertation proposed unsupervised learning techniques, notably variational auto-encoders (VAEs), to identify temperature anomalies from …

Collaborative All-Source Navigation With Integrity, Jonathon S. Gipson

Theses and Dissertations

The novel ARMAS-SOM framework fuses collaborative all-source sensor information in a resilient manner with fault detection, exclusion, and integrity solutions recognizable to a GNSS user. This framework uses a multi-filter residual monitoring approach for fault detection and exclusion and is augmented with an additional "observability" EKF sub-layer for resilience. We monitor the a posteriori state covariances in this sub-layer to provide intrinsic awareness when navigation state observability assumptions required for integrity are in danger. This is used to selectively augment the framework with offboard information to preserve resilience. By maintaining split parallel collaborative and proprioceptive estimation instances and employing a …