Engineering Commons^™

The Effect Of Αct-1 Peptide On Bone Marrow Stromal Cells Following Injury, Adam Clay Vandergriff

Theses and Dissertations

Connexin43 (Cx43) is a component of gap junctions and is involved in intercel- lular signaling following injury to tissues. The carboxyl terminus of Cx43 binds to the PDZ2 domain of ZO-1 in order to form gap junction plaques and connect to the cytoskeleton. A biomimetic peptide known as αCT-1, replicating the last 9 amino acids found in the carboxyl terminus of CX43, has been shown to improve wound healing by preferentially binding to the PDZ2 domain of ZO-1. A possible mecha- nism for its action is through the Epithelial-Mesenchymal Transformation (EMT). Scratch assays were performed on rat bone marrow stromal …

High Resistivity Amorphous Selenium Alloy Semiconductors For Radiation Detection Applications, Abhinav Mehta

Theses and Dissertations

High resolution noninvasive tools of diagnosis has always derived and enabled scientific and medical research to probe and better understand subtleties of matter, intangible to the human eye. Radiation detection systems are highly dependent on advancements in materials and devices with front-end electronics. There are various discrete applications of these radiation detectors and each application imposes certain requirements so there is no single optimum radiation detector.

Flat panel x-ray imagers have gained high demand in the past decade because of exponential improvement in readout electronics. We have synthesized and investigated stabilized amorphous selenium (a-Se) alloys suitable for high resolution flat …

A Method For Evaluating Power Generation Concepts Considering The Optimal Concept Of Operations, Tianlei Zhang

Theses and Dissertations

When trying to select an appropriate power generation plant for a micro-grid power distribution system like an electric ship, designers must consider both the physical characteristics (e.g., weight, volume, power ratings) and performance characteristics (e.g., fuel consumption, quality of service) of all the design alternatives. Comparing the design alternatives in terms of the physical characteristics is relatively straightforward, but in terms of performance characteristics each design alternative has to be evaluated within its own optimal performance points to make a fair comparison. However, at present no effective method or software tools exist to enable this evaluation at the earliest design …

Development Of Proteomic Characterization And Speciation Techniques Utilizing Tryptic Peptides With Maldi-Tof Ms And Lc-Esi Ms-Ms, Jennifer Marie Kooken

Theses and Dissertations

The characterization of microbes which can be opportunists and pathogens (e.g., methicillin resistant Staphylococcus aureus (MRSA)) is important in understanding and potentially treating diseases caused by various bacterial species. Common genera found in the human skin micro-biome include Micrococcus and Staphylococcus, but there only a limited number of tests to differentiate these genera and/or species. My research reflects methods development from distinguishing one closely related genera from another and then expanded to species identification. Tryptic peptides were analyzed by MALDI TOF MS and the mass profiles compared with those of a reference strain in both genus and species identification. Aconitate …

Investigation Of Start Domain Proteins In Human Luteinized Cells And Cos-1 Cells, Bo Shi

Theses and Dissertations

After the luteinizing hormone surge of the menstrual cycle, the ovarian follicular granulosa and theca cells terminally differentiate to form the luteal cells of the corpus luteum. During this process known as luteinization, granulosa cells begin to synthesize large quantities of progesterone, a hormone essential for pregnancy. The rate limiting step for the de novo synthesis of pregnenolone (the precursor to progesterone) is the transport of cholesterol from the outer to the inner mitochondrial membrane, a process mediated by STARD1. STARD1 contains a C-terminal lipid binding domain holding one molecule of cholesterol, and an N-terminal domain targeting STARD1 to the …

Accelprint:Accelerometers Are Different By Birth, Sanorita Dey

Theses and Dissertations

This paper submits a hypothesis that smartphone accelerometers possess unique fingerprints. We believe that the fingerprints arise from hardware imperfections during the sensor manufacturing process, causing every sensor chip to respond differently to the same motion stimulus. The differences in responses are subtle enough that they do not affect most of the higher level functions computed on them. Nonetheless, upon close inspection, these fingerprints emerge with consistency, and can even be somewhat independent of the stimulus that generates them. Measurements and classification on 80 standalone accelerometer chips, 25 Android phones, and 2 tablets, show precision and recall upward of 96%, …

High Fat Diet Induced Obesity In A Mouse Model For Colorectal Cancer, Kennerly Clinton Patrick

Theses and Dissertations

Obesity is widely correlated with the incidence of colorectal cancer (CRC). The exact mechanisms that link obesity to CRC risk have not yet been fully established, and only a limited number of animal models are available to study pathways involved in obesity-related colon carcinogenesis. The objective of this study was to determine the influence of HFD-induced obesity on AOM/DSS-mediated colorectal tumorigenesis, tumor proliferation, and symptom severity. Male C57BL/6 mice were fed a novel high fat diet, designed to mimic the standard American diet (12 % saturated fat & 28 % unsaturated fat), at 4 weeks of age until 16 weeks …

Modeling Of Sic Power Semiconductor Devices For Switching Converter Applications, Ruiyun Fu

Theses and Dissertations

Thanks to recent progress in SiC technology, SiC JFETs, MOSFETs and Schottky diodes are now commercially available from several manufactories such as Cree, GeneSiC and Infineon. SiC devices hold the promise of faster switching speed compared to Si devices, which can lead to superior converter performance, because the converter can operate at higher switching frequencies with acceptable switching losses, so that passive filter size is reduced. However, the ultimate achievable switching speed is determined not only by internal semiconductor device physics, but also by circuit parasitic elements. Therefore, in order to accurately predict switching losses and actual switching waveforms, including …

Passive Equalizer Topology Analysis For Signal Integrity Applications, Kuo-Lun Yen

Theses and Dissertations

In high-speed, high density PCB bus systems, high frequency signal losses and crosstalk can have great impacts on signal integrity and digital timing, which can distort transmitted signals, worsen eye diagrams, and attenuate signal amplitudes. Also, these impacts make digital signals and their energy smearing over multiple bit positions as known as jitters, and cause the phenomenon of inter-symbol interference (ISI) in digital signal transmissions.

The main objective of this thesis is to analyze and develop efficient topology circuits for compensating bus system high frequency losses by using equalization techniques. The thesis has focused on study of various practical and …

Dislocation Reduction In Silicon Doped High Aluminum Content Algan Layers For Deep Uv Optoelectronic Devices, Hung-Chi Chen

Theses and Dissertations

III-Nitride based deep ultraviolet (UV) light emitting diodes (LEDs) are prospective candidates to replace the conventional bulky, expensive and environmentally harmful mercury lamp as new UV light sources, used in the applications of water and air purification, germicidal and biomedical instrumentation systems, etc. Due to the lack of native substrates and poor carrier injection, AlGaN-based deep UV LED is suffering from low optical power and low overall efficiency, which prevents the availability of low cost, high efficiency deep UV LED on the market.

This dissertation is focused on improving the efficiency of deep UV LEDs, by improving the base template …

Effects Of N-Type Doping On Algan Material Quality, Devendra Diwan

Theses and Dissertations

The field of group III-nitride semiconductors has seen incredible developments during last couple of decades. They are recognized as the most promising materials for a wide field of optoelectronics and electronic devices. Their bandgap ranges from 6.2 eV for AlN to 0.7 eV for InN, covering a wide spectral range from infrared (1.77 mm) to deep ultraviolet (200 nm). Their direct bandgap makes them useful for fabricating optoelectronic devices such as light emitting diodes (LEDs), laser diodes (LDs), and photodetectors. III-nitride semiconductor materials also possess strong bond strengths and exhibit good structural, chemical and thermal stability. These properties make it …

Ultrawideband (Uwb) And Reconfigurable Antennas - New Concepts For Conformal Load Bearing Antenna Structures (Clas), Nicholas Bishop

Theses and Dissertations

Conformal antennas have been increasingly playing an important role in a vast number wireless of communication applications. More specifically, Conformal Load Bearing Antenna Structures (CLAS) have drawn a great deal of interest among researchers and engineers because of their advantages of multiple functionality, e.g. antenna and structure both. The objectives of this thesis are to investigate and design innovative conformal Ultrawideband (UWB) endfire antenna arrays and reconfigurable aperture coupled pixel patch antennas both of which are good candidates for CLAS. First, a broadband VHF-UHF end-fire Yagi-Uda array is proposed for possible air vehicle integration and operation within the 240-465 MHz …

Polyspectral Signal Analysis Techniques For Condition Based Maintenance Of Helicopter Drive-Train System, Mohammed Ahmed Hassan Mohammed

Theses and Dissertations

For an efficient maintenance of a diverse fleet of air- and rotorcraft, effective condition based maintenance (CBM) must be established based on rotating components monitored vibration signals.

In this dissertation, we present theory and applications of polyspectral signal processing techniques for condition monitoring of critical components in the AH-64D helicopter tail rotor drive train system. Currently available vibration-monitoring tools are mostly built around auto- and cross-power spectral analysis which have limited performance in detecting frequency correlations higher than second order. Studying higher order correlations and their Fourier transforms, higher order spectra, provides more information about the vibration signals which helps …

Fault Aware Soft Restart Of An Islanded Microgrid Using An Inverter Coupled Energy Storage System, Asif Anwar

Theses and Dissertations

This research developed a method for autonomous operation of an inverter-coupled energy storage system for safe islanding- re-energization - and reconnection of the facility-island or microgrid to the utility / distribution circuit in a seamless manner in the event of a fault. This enables the energy storage system to function as an autonomous source within the utility power distribution system without the need to re-engineer the existing protection coordination in the distribution system. Fault detection based on voltage measurements from the inverter terminals are used to detect a fault and isolate the energy storage-powered facility with negligible power feed into …

Crystal Growth, Characterization And Fabrication Of Cdznte-Based Nuclear Detectors, Ramesh Madhu Krishna

Theses and Dissertations

In today's world, nuclear radiation is seeing more and more use by humanity as time goes on. Nuclear power plants are being built to supply humanity's energy needs, nuclear medical imaging is becoming more popular for diagnosing cancer and other diseases, and control of weapons-grade nuclear materials is becoming more and more important for national security. All of these needs require high-performance nuclear radiation detectors which can accurately measure the type and amount of radiation being used. However, most current radiation detection materials available commercially require extensive cooling, or simply do not function adequately for high-energy gamma-ray emitting nuclear materials …

Wireless Pressure Sensor System For Medical Applications, Xuehe Wang

Theses and Dissertations

Telemedicine in the modern era is a rapidly developing industry. In a telemedicine system, sensor is the key elements and play important role in any telemedicine applications, especially implantable sensors. Unlike traditional in vitro sensors, there are some special requirements for them like battery-less, compact, and bio-friendly. Therefore, many researchers in institutes as well as in industry are continually developing implantable sensor and sensor system to fulfill the requirements of medical applications.Nine in one thousand people in the United States are born with congenital heart defects and sixty percent die before one year old. As a result, it will be …

Electromagnetic Modeling Of Gan Varactor Microwave Switches, Yi-Hsuan Yang

Theses and Dissertations

Microwave switches are important components which have been widely used in many microwave systems, such as electronic products, satellites communications, antennas, and radars etc. Traditionally, microwave switches are fabricated using pin diodes or MEMS, Si MOSFETs or GaAs HEMTs. These devices, due to the material limitations are suffering from a low breakdown voltage and are unable to handle high power. III-Nitride based varactor microwave switches provide opportunities for high power microwave devices, due to highly conducting 2D electron gas in the channel and high breakdown electric field.

Designing microwave switches typically involves modeling and simulation using tools such as MATLAB, …

Microencapsulation Of A Connexin-43 Mimetic Peptide As A Novel Wound Healing Agent In An Ocular Injury Model, Keith Brian Moore

Theses and Dissertations

Corneal transplantation and related surgical procedures are areas of tissue replacement which have seen promising advances. Currently, cornea transplants are one of the most common surgical procedures, with approximately 40,000 occurring each year in the United States. Still, problems exist with a 20% rejection rate, post surgical infections, and the need for a constant supply of donors. The ability to safely and quickly heal and regenerate corneal epithelia fills an area of advancement in regenerative medicine, with implications reaching beyond the scope of vision therapies toward healing of a wide range of tissues and wounds. In vivo corneal wounds were …

Fault Protection In Dc Distribution Systems Via Coordinated Control Of Power Supply Converters And Bus Tie Switches, Pietro Cairoli

Theses and Dissertations

A new fault protection method responds to the current needs of emerging dc power distribution systems by coordinating electronic power converters and mechanical contactors to rapidly isolate short circuit faults while maintaining continuity of power to loads. This work is important because the increasing performance, higher efficiency, and decreasing cost of electronic power converters have spurred a rediscovery and proliferation of dc power distribution systems. Although dc distribution offers advantages such as higher transmission efficiency, higher power density, higher reliability, and ease of interfacing asynchronous sources, enthusiasm for adopting dc technologies suffers from widespread concern over the means to protect …

Resveratrol Attenuates The Development Of Trans-Aortic Constriction (Tac) Induced Heart Failure In Mice, Prakash Kumar Gupta

Theses and Dissertations

Heart failure (HF) still remains the leading cause of morbidity and mortality and imposes severe global affliction and enormous cost on the healthcare system. Although current pharmacological therapies have shown to slow down the progression of HF, but seems to have reached their limits in improving overall patient prognosis. Thus, an immediate call for novel alternate therapies are needed which act independently as well as in conjunction with current treatment modality. Studies were performed in the well-established transverse aortic constriction (TAC) model of chronic pressure overload (PO) in mice. In the first series of studies, Male C57BL6 mice (26-28 g) …

Accelerating Short Read Mapping Using A Dsp Based Coprocessor, Shaun I. Gause

Theses and Dissertations

Advances in next generation sequencing technologies have allowed short reads to be generated at an increasing rate, shifting the bottleneck of the sequencing process to the short read mapping computations. High costs and extended processing times drive researchers to pursue more efficient solutions with an overall goal of a short read mapping architecture capable of processing short reads as they are generated. Digital signal processors have shown high performance capabilities while maintaining low power consumption in a wide field of applications. This thesis explores the use of a DSP accelerated exact match short read mapping algorithm, focusing on a performance …

Analysis Of Modulation And Voltage Balancing Strategies For Modular Multilevel Converters, Ryan Blackmon

Theses and Dissertations

Modular multilevel converters are an emerging voltage source converter topology suitable for many applications. The increased utilization of HVDC power transmission solutions has resulted in modular multilevel converters becoming a more common converter type. Other applications include interfacing renewable energy power sources to the grid and motor drives. Modular multilevel converters are beneficial for medium voltage motor drives because the properties of this converter topology, such as low distortion, allow for an efficient motor drive design.

Modular multilevel converters are designed where instead of using 6 IGBTs as in a conventional voltage source converter, numerous low-rated IGBTs are used to …

Walkcompass: Finding Walking Direction Leveraging Smartphone's Inertial Sensors, Nirupam Roy

Theses and Dissertations

Determining moving direction with smartphone's inertial sensors is a well known problem in the field of location service. Compass alone cannot solve this problem because smartphone's compass cannot achieve high accuracy. Moreover GPS is not suitable in indoor scenario. Another well known approach is dead-reckoning but dead-reckoning needs to know phones initial orientation and over time it keeps accumulating errors and after some time the estimation becomes to noisy to use. To overcome these limitations, we propose a solution called WalkCompass which is specially designed for pedestrians keeping in mind the variation of force during normal human walk. Therefore the …

Stabilizing Controller Design For A Dc Power Distribution System Using A Passivity-Based Stability Criterion, Antonino Riccobono

Theses and Dissertations

In modern times there has been an increased penetration of power electronic converters into Power Distribution Systems. In particular, there has been a strong interest in DC Power Distribution Systems as opposed to conventional AC Power distribution systems. These DC Power Distribution Systems are enabled by power electronics converters. The strong interest is motivated by improvements in power electronic converter technology, like advances in power semiconductor devices, magnetics, control, and converter topologies which have made possible to build high-performance converters at low cost. In many systems, such as cars, ships and airplanes, there has also been a trend towards the …

Mass Spectrometry And Tandem Mass Spectrometry Characterization Of Protein Patterns, Protein Markers And Whole Proteomes For Pathogenic Bacteria, Jennifer Intelicato-Young

Theses and Dissertations

There have been many recent reviews published on MALDI-TOF MS (matrix assisted laser desorption/ionization time-of-flight) MS (mass spectrometry) for identification of bacteria particularly with relevance to clinical microbiology. MALDI-TOF MS is now a mature technique for bacterial identification with great promise. The purpose of this review is to put into perspective MALDI-TOF MS and other widely used mass spectrometry methods for characterization of proteins. MALDI-TOF MS is used for rapid determination of a mass pattern of proteins for bacterial characterization; these proteins

are generally not identified. Alternatively, after gel separation, MALDI TOF-TOF MSMS (tandem mass spectrometry) or on-line LC-ESI MS-MS …

Coordinated Control Of Power Electronic Converters In An Autonomous Microgrid, Gholamreza Dehnavi

Theses and Dissertations

Advances in power electronics and generation technologies have increased the viability of distributed generation systems. A microgrid is a special category of distributed generation systems that is distinguished by its size and the ability to operate independently as an islanded system. As long as a microgrid is connected to a large grid, quality of the voltage is supported by the main grid and each power source connected to the microgrid generates independently. In contrast, in the islanded operation of microgrids and in electrical islands such as shipboard distribution systems, dynamics are strongly dependent on the connected sources and on the …

Osteon-Mimetic Nanocomposite Materials For Bone Regeneration, Ozan Karaman

Theses and Dissertations

The limitations of large bone defect regeneration has brought the focus of Bone Tissue Engineering research on fabricating three-dimensional bone-mimetic grafts that could enhance osteogenesis and vascularization. Osteons composed of apatite-deposited aligned collagen nanofiber layers are the fundamental building blocks of cortical bone. In natural cortical bone, mineralization is mediated by extracellular matrix (ECM) proteins with amino acid sequences rich in glutamic acid. This dissertation is focused on the establishment of a novel biomimetic approach to engineer scaffolds for healing large bone defects.

In the first part, we investigated the effect of calcium phosphate (CaP) deposition on aligned surface-modified nanofibers …

An Analysis Of Constructive Network Formation Models, Gary Fredericks

Theses and Dissertations

We study a family of network formation models to determine how payment rules affect the final network topologies that emerge. In our model a set of nodes starts out without any edges and the nodes must pay for the creation of edges using one of several different payment mechanisms. Example payment mechanisms include one node paying for the whole edge, and the cost being shared equally between the two nodes. We show how the set of networks formed by some payment rules are subsets of those formed by other rules. We also perform extensive empirical tests on networks of up …

Plc Code Vulnerabilities Through Scada Systems, Sidney E. Valentine, Jr.

Theses and Dissertations

Supervisory Control and Data Acquisition (SCADA) systems are widely used in automated manufacturing and in all areas of our nation's infrastructure. Applications range from chemical processes and water treatment facilities to oil and gas production and electric power generation and distribution. Current research on SCADA system security focuses on the primary SCADA components and targets network centric attacks. Security risks via attacks against the peripheral devices such as the Programmable Logic Controllers (PLCs) have not been sufficiently addressed.

Our research results address the need to develop PLC applications that are correct, safe and secure. This research provides an analysis of …

Fault Location In Power Networks Using Synchronized Phasor Measurements, Cuong Nguyen

Theses and Dissertations

Faults in electric power systems can lead to cascading power outages which cause tremendous loss to the economy and affect people’s lives. Technical reports of recent blackout events in the United States pointed out the lack of situational awareness as one of the main causes of widespread outages. Time synchronized phasor measurement is recommended as a technology that can improve the monitoring of power system condition. By knowing exactly where a fault occurs, necessary actions can be taken in a timely manner and thus, damage caused by that fault can be limited. In this thesis, first, a method for precise …